Stilstaan bij beweging : over de hardware en software problemen van het bewegen

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Modulation of macrophage antitumor cytostasis by endogenous leukotrienes

Using resident peritoneal macrophages, this study was focussed on the activating role of endogenous leukotrienes in the regulation of macrophage antitumor cytostatic activity in response to inflammatory stimuli. Inhibitors and inducers of leukotrienes synthesis were used to modulate the macrophage antitumor cytostatic function and to identify the essential leukotriene(s) and enzymes involved in inhibition of tumor cell growth by activated macrophages. Induction of high macrophage antitumor activity by modulation of leukotriene biosynthesis might represent an efficient immunotherapeutic tool. - The main aim of the present work was to study the possible interrelationship between induction of antitumor cytostasis and of production of prostanoids and leukotrienes by murine peritoneal macrophages stimulated with the calcium ionophore A23187. A method of cell separation by velocity sed~mentation was adapted for obtaining macrophage-enriched preparations from the resident peritoneal macrophage populatio

Periodic fever associated with intermittent rhytmic delta activity : a syndrome of hypothalamic origin?

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Does Deep Brain Stimulation of the Subthalamic Nucleus Prolong Survival in Parkinson's Disease?

Neurological Motor Disorder

SPES/SCOPA and MDS-UPDRS: Formulas for converting scores of two motor scales in Parkinson’s disease

AbstractBackgroundMotor impairment in Parkinson’s disease (PD) can be evaluated with the Short Parkinson’s Evaluation Scale/Scales for Outcomes in Parkinson’s disease (SPES/SCOPA) and the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The aim of this study was to determine equation models for the conversion of scores from one scale to the other.Methods148 PD patients were evaluated with the SPES/SCOPA-motor and the MDS-UPDRS motor examination. Linear regression was used to develop equation models.ResultsScores on both scales were highly correlated (r = 0.88). Linear regression revealed the following equation models (explained variance: 78%):1.MDS-UPDRS motor examination score = 11.8 + 2.4 ∗ SPES/SCOPA-motor score2.SPES/SCOPA-motor score = −0.5 + 0.3 ∗ MDS-UPDRS motor examination score.ConclusionWith the equation models identified in this study, scores from SPES/SCOPA-motor can be converted to scores from MDS-UPDRS motor examination and vice versa

Optical Hand Tracking: A Novel Technique for the Assessment of Bradykinesia in Parkinson's Disease

Neurological Motor Disorder

Loss of integrity and atrophy in cingulate structural covariance networks in Parkinson's disease

Neuro Imaging Researc

Fecal microbiota transplantation for Parkinson's disease using levodopa-carbidopa intestinal gel percutaneous endoscopic gastro-jejunal tube

We report a patient with a 5-year diagnosis of akinetic-rigid Parkinson's disease under treatment with Levodopa-Carbidopa Intestinal Gel therapy through a PEG-J tube due to motor complications, in which, in the context of a clinical study, we successfully and safely administered fecal microbiota transplant through a PEG-J.Cellular mechanisms in basic and clinical gastroenterology and hepatolog