Using resident peritoneal macrophages, this
study was focussed on the activating role of endogenous
leukotrienes in the regulation of macrophage antitumor
cytostatic activity in response to inflammatory stimuli.
Inhibitors and inducers of leukotrienes synthesis were used to
modulate the macrophage antitumor cytostatic function and to
identify the essential leukotriene(s) and enzymes involved in
inhibition of tumor cell growth by activated macrophages.
Induction of high macrophage antitumor activity by modulation
of leukotriene biosynthesis might represent an efficient
immunotherapeutic tool.
- The main aim of the present work was to study the
possible interrelationship between induction of antitumor
cytostasis and of production of prostanoids and leukotrienes by
murine peritoneal macrophages stimulated with the calcium
ionophore A23187. A method of cell separation by velocity
sed~mentation was adapted for obtaining macrophage-enriched
preparations from the resident peritoneal macrophage
populatio
