Stress management in composite biopolymer networks

Living tissues show an extraordinary adaptiveness to strain, which is crucial for their proper biological functioning. The physical origin of this mechanical behaviour has been widely investigated using reconstituted networks of collagen fibres, the principal load-bearing component of tissues. However, collagen fibres in tissues are embedded in a soft hydrated polysaccharide matrix which generates substantial internal stresses whose effect on tissue mechanics is unknown. Here, by combining mechanical measurements and computer simulations, we show that networks composed of collagen fibres and a hyaluronan matrix exhibit synergistic mechanics characterized by an enhanced stiffness and delayed strain-stiffening. We demonstrate that the polysaccharide matrix has a dual effect on the composite response involving both internal stress and elastic reinforcement. Our findings elucidate how tissues can tune their strain-sensitivity over a wide range and provide a novel design principle for synthetic materials with programmable mechanical properties

Structural characterizations of the navigational expressiveness of relation algebras on a tree

Given a document D in the form of an unordered node-labeled tree, we study the expressiveness on D of various basic fragments of XPath, the core navigational language on XML documents. Working from the perspective of these languages as fragments of Tarski's relation algebra, we give characterizations, in terms of the structure of D, for when a binary relation on its nodes is definable by an expression in these algebras. Since each pair of nodes in such a relation represents a unique path in D, our results therefore capture the sets of paths in D definable in each of the fragments. We refer to this perspective on language semantics as the "global view." In contrast with this global view, there is also a "local view" where one is interested in the nodes to which one can navigate starting from a particular node in the document. In this view, we characterize when a set of nodes in D can be defined as the result of applying an expression to a given node of D. All these definability results, both in the global and the local view, are obtained by using a robust two-step methodology, which consists of first characterizing when two nodes cannot be distinguished by an expression in the respective fragments of XPath, and then bootstrapping these characterizations to the desired results.Comment: 58 Page

Similarity and bisimilarity notions appropriate for characterizing indistinguishability in fragments of the calculus of relations

Motivated by applications in databases, this paper considers various fragments of the calculus of binary relations. The fragments are obtained by leaving out, or keeping in, some of the standard operators, along with some derived operators such as set difference, projection, coprojection, and residuation. For each considered fragment, a characterization is obtained for when two given binary relational structures are indistinguishable by expressions in that fragment. The characterizations are based on appropriately adapted notions of simulation and bisimulation.Comment: 36 pages, Journal of Logic and Computation 201

Reliability analysis of semi-automatic train door systems in service on today's rolling stock of the SNCB

This article analyses the reliability of semi-automatic train door systems that are in use on today’s rolling stock of the SNCB. For the analysis several databases of the SNCB concerning both operation and maintenance were thoroughly screened. These databases are briefly explained and scaling factors are applied to compare the performance of different series of rolling stock relative to each other. Conclusions are made out of the available data

Relative Expressive Power of Navigational Querying on Graphs

Motivated by both established and new applications, we study navigational query languages for graphs (binary relations). The simplest language has only the two operators union and composition, together with the identity relation. We make more powerful languages by adding any of the following operators: intersection; set difference; projection; coprojection; converse; and the diversity relation. All these operators map binary relations to binary relations. We compare the expressive power of all resulting languages. We do this not only for general path queries (queries where the result may be any binary relation) but also for boolean or yes/no queries (expressed by the nonemptiness of an expression). For both cases, we present the complete Hasse diagram of relative expressiveness. In particular the Hasse diagram for boolean queries contains some nontrivial separations and a few surprising collapses.Comment: An extended abstract announcing the results of this paper was presented at the 14th International Conference on Database Theory, Uppsala, Sweden, March 201

Temperature-Responsive Polyelectrolyte Complexes for Bio-Inspired Underwater Adhesives

Adhesive proteins of marine organisms contain significant amounts of hydrophobic amino acids. Therefore, inter- and intramolecular hydrophobic interactions are expected to play an important role in both adhesion and cohesion. Here, we mimic the hydrophobicity of adhesive proteins by using temperature-responsive polyelectrolyte complexes (TERPOCs) with a high poly(N-isopropylacrylamide) (PNIPAM) content. Upon mixing aqueous solutions of PNIPAM-b-poly(acrylic acid)-b-PNIPAM and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA), complexation between the oppositely charged polyelectrolytes occurs. At low temperatures, complex coacervate core micelles (C3Ms) with a PNIPAM corona are formed, and upon a temperature increase, the solution turns into a hydrogel by the formation of a network of hydrophobic PNIPAM domains. Consequently, an abrupt increase in viscosity is observed upon heating which facilitates injectability of the adhesive. The gelation temperature, Tgel, and (adhesive) strength of the TERPOC can be adjusted by altering the salt and polymer concentration, which changes the balance between the electrostatic and hydrophobic interactions. Despite the importance of hydrophobic groups in strong underwater adhesives, we conclude that TERPOCs with a high PNIPAM content (70 wt%) are unstable due to water release. Consequently, there is a limited amount of hydrophobic groups that can be inserted in this type of systems. Nevertheless, TERPOCs show promising and tunable properties for application as injectable underwater adhesives, for example in biomedical applications

Controlled mixing of lanthanide(III) ions in coacervate core micelles

This article presents a facile strategy to combine Eu3+ and Gd3+ ions into coacervate core micelles in a controlled way with a statistical distribution of the ions. Consequently, the formed micelles show a high tunability between luminescence and relaxivity. These highly stable micelles present great potential for new materials, e.g. as bimodal imaging probes