A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue

Myeloma is characterized by a highly variable clinical outcome. Despite the effectiveness of high-dose therapy, 15% of patients relapse within 1 year. We show that these cases also have a significantly shorter post-relapse survival compared to the others (median 14.9 months vs. 40 months, p = 8.03 × 10(- 14)). There are no effective approaches to define this potentially distinct biological group such that treatment could be altered. In this work a series of uniformly treated patients with myeloma were used to develop a gene expression profiling (GEP)-based signature to identify this high risk clinical behavior. Gene enrichment analyses applied to the top differentially expressed genes showed a significant enrichment of epigenetic regulators as well as "stem cell" myeloma genes. A derived 17-gene signature effectively identifies patients at high risk of early relapse as well as impaired overall survival. Integrative genomic analyses showed that epigenetic mechanisms may play an important role on transcription of these genes

Beroepsgeheim hindert hulp na ramp onnodig: Autoriteiten kunnen niet zonder slachtofferinformatie

Na incidenten zoals op Koninginnedag in Apeldoorn is er grote behoefte aan informatie over de slachtoffers. De autoriteiten krijgen die informatie echter maar lastig los van de ziekenhuizen

Network density and diene conversion in peroxide-cured gumstock EPDM rubbers. A solid-state NMR study

Peroxide-cross-linked EPM and EPDM rubbers have been investigated with magic-angle spinning 1H NMR spectroscopy and static 1H NMR relaxometry. The results yield a consistent nanoscale picture of the chemical and physical network properties in terms of chemical cross-links formed via macro-radical combination, chemical cross-links formed via addition to the double bonds, and physical cross-links resulting from chain entanglements.status: publishe

Postmodernisme

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