1,837 research outputs found
Unraveling the MNE wage premium
Whereas IB has extensively studied MNEsâ generic (positive) impact on host economies, but rarely on employee wages, economics research has only shown an overall MNE wage premium. We âunravelâ this premium, considering multiple levels of analysis and accounting for host-country contextual contingencies, to unveil MNEs different (positive or negative) distributional effects. Using unique micro-level data from over 40,000 employees in 13 countries, we examine MNEsâ distributional effects for employeesâ gender, experience, and immigrant status; the influence of host-country property rights protection and labor regulation; and interplays with region and industry effects. MNEsâ distributional effects show marked differences that largely depend on the host-country context, and that are positive for experienced and foreign-born employees in developed countries but negative for females working in developing countries. Whereas in developed countries the gender wage gap is smaller in MNEs than in domestic firms as hypothesized, we find evidence of a larger wage gap in developing countries. The analysis also reveals that the higher host-countriesâ level of property rights protection, the lower the MNE wage premium. Our study points at the need to reassess statements about the generic positive impact of MNEs in host countries, particularly in developing countries, and discusses (further) research implications
PEN as self-vetoing structural Material
Polyethylene Naphtalate (PEN) is a mechanically very favorable polymer.
Earlier it was found that thin foils made from PEN can have very high
radio-purity compared to other commercially available foils. In fact, PEN is
already in use for low background signal transmission applications (cables).
Recently it has been realized that PEN also has favorable scintillating
properties. In combination, this makes PEN a very promising candidate as a
self-vetoing structural material in low background experiments. Components
instrumented with light detectors could be built from PEN. This includes
detector holders, detector containments, signal transmission links, etc. The
current R\&D towards qualification of PEN as a self-vetoing low background
structural material is be presented.Comment: 4 pages, 7 figures, contribution to Proceedings of the sixth workshop
on Low Radioactivity Techniques 2017, 23-27 May 2017 Seoul, to be published
at AIP, editor: D. Leonar
Three method factors explaining the low correlations between assessment center dimension ratings and scores on personality inventories
In general, correlations between assessment centre (AC) ratings and personality inventories are low. In this paper, we examine three method factors that may be responsible for these low correlations: differences in (i) rating source (other versus self), (ii) rating domain (general versus specific), and (iii) rating format (multi- versus single item). This study tests whether these three factors diminish correlations between AC exercise ratings and external indicators of similar dimensions. Ratings of personality and performance were combined in an analytical framework following a 2 à 2 à 2 (source, domain, format) completely crossed, within subjects design. Results showed partial support for the influence of each of the three method factors. Implications for future research are discussed. Copyright © 2004 John Wiley & Sons, Ltd
Charge dependent azimuthal correlations in Pb--Pb collisions at TeV
Separation of charges along the extreme magnetic field created in non-central
relativistic heavy--ion collisions is predicted to be a signature of local
parity violation in strong interactions. We report on results for charge
dependent two particle azimuthal correlations with respect to the reaction
plane for Pb--Pb collisions at TeV recorded in 2010 with
ALICE at the LHC. The results are compared with measurements at RHIC energies
and against currently available model predictions for LHC. Systematic studies
of possible background effects including comparison with conventional
(parity-even) correlations simulated with Monte Carlo event generators of
heavy--ion collisions are also presented.Comment: Published in the proceedings of "Quark Matter 2011", Annecy-Franc
CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age
Clinical resistance to chemotherapy in acute myeloid leukemia (AML) is associated with the expression of the multidrug resistance (MDR) proteins P-glycoprotein, encoded by the MDR1/ABCB1 gene, multidrug resistant-related protein (MRP/ABCC1), the lung resistance-related protein (LRP), or major vault protein (MVP), and the breast cancer resistance protein (BCRP/ABCG2). The clinical value of MDR1, MRP1, LRP/MVP, and BCRP messenger RNA (mRNA) expression was prospectively studied in 154 newly diagnosed AML patients â„60Â years who were treated in a multicenter, randomized phase 3 trial. Expression of MDR1 and BCRP showed a negative whereas MRP1 and LRP showed a positive correlation with high white blood cell count (respectively, pâ<â0.05, pâ<â0.001, pâ<â0.001 and pâ<â0.001). Higher BCRP mRNA was associated with secondary AML (pâ<â0.05). MDR1 and BCRP mRNA were highly significantly associated (pâ<â0.001), as were MRP1 and LRP mRNA (pâ<â0.001) expression. Univariate regression analyses revealed that CD34 expression, increasing MDR1 mRNA as well as MDR1/BCRP coexpression, were associated with a lower complete response (CR) rate and with worse event-free survival and overall survival. When adjusted for other prognostic actors, only CD34-related MDR1/BCRP coexpression remained significantly associated with a lower CR rate (pâ=â0.03), thereby identifying a clinically resistant subgroup of elderly AML patients
Large Process Models: Business Process Management in the Age of Generative AI
The continued success of Large Language Models (LLMs) and other generative
artificial intelligence approaches highlights the advantages that large
information corpora can have over rigidly defined symbolic models, but also
serves as a proof-point of the challenges that purely statistics-based
approaches have in terms of safety and trustworthiness. As a framework for
contextualizing the potential, as well as the limitations of LLMs and other
foundation model-based technologies, we propose the concept of a Large Process
Model (LPM) that combines the correlation power of LLMs with the analytical
precision and reliability of knowledge-based systems and automated reasoning
approaches. LPMs are envisioned to directly utilize the wealth of process
management experience that experts have accumulated, as well as process
performance data of organizations with diverse characteristics, e.g., regarding
size, region, or industry. In this vision, the proposed LPM would allow
organizations to receive context-specific (tailored) process and other business
models, analytical deep-dives, and improvement recommendations. As such, they
would allow to substantially decrease the time and effort required for business
transformation, while also allowing for deeper, more impactful, and more
actionable insights than previously possible. We argue that implementing an LPM
is feasible, but also highlight limitations and research challenges that need
to be solved to implement particular aspects of the LPM vision
Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility
Background In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. Methods We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1germline mutation for germline variants affecting CTNNA1, MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes. Results Predicted deleterious germline variants were not encountered in MYD88, but recurrently observed in CTNNA1 (n=2) and MAP3K6 (n=3) in our cohort of patients with GC. In contrast to deleterious variants in CTNNA1, deleterious variants in MAP3K6 also occur frequently in the general population. Conclusions Based on our results MAP3K6 should no longer be considered a GC predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility as no additional cases were identified.This study was funded by KWF Kankerbestrijding (grant number KUN2013-5876, RSvdP)
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