Stem and standing heights in bantu and white South Africans: their significance in relation to pulmonary function values

Sitting and standing heights have been recorded for Bantu and Whites, males and females. It !Vas found that Bantu males and females have relatively longer lower extremities than White South African males and females. Anthropometric differences account for only about 15% of the actual observed difference in spirometrically determined lung volumes of Bantu and Whites in the groups observe

Соціально-правова та етична природа мусульманської сім‘ї

Relative sea-level variations during the late Pleistocene can only be reconstructed with the knowledge of ice-sheet history. On the other hand, the knowledge of regional and global relative sea-level variations is necessary to learn about the changes in ice volume. Overcoming this problem of circularity demands a fully coupled system where ice sheets and sea level vary consistently in space and time and dynamically affect each other. Here we present results for the past 410 000 years (410 kyr) from the coupling of a set of 3-D ice-sheet-shelf models to a global sea-level model, which is based on the solution of the gravitationally self-consistent sea-level equation. The sea-level model incorporates the glacial isostatic adjustment feedbacks for a Maxwell viscoelastic and rotating Earth model with coastal migration. Ice volume is computed with four 3-D ice-sheet-shelf models for North America, Eurasia, Greenland and Antarctica. Using an inverse approach, ice volume and temperature are derived from a benthic δ18O stacked record. The derived surface-air temperature anomaly is added to the present-day climatology to simulate glacial–interglacial changes in temperature and hence ice volume. The ice-sheet thickness variations are then forwarded to the sea-level model to compute the bedrock deformation, the change in sea-surface height and thus the relative sea-level change. The latter is then forwarded to the ice-sheet models. To quantify the impact of relative sea-level variations on ice-volume evolution, we have performed coupled and uncoupled simulations. The largest differences of ice-sheet thickness change occur at the edges of the ice sheets, where relative sea-level change significantly departs from the ocean-averaged sea-level variations

Stabilizing nuclear spins around semiconductor electrons via the interplay of optical coherent population trapping and dynamic nuclear polarization

We experimentally demonstrate how coherent population trapping (CPT) for donor-bound electron spins in GaAs results in autonomous feedback that prepares stabilized states for the spin polarization of nuclei around the electrons. CPT was realized by excitation with two lasers to a bound-exciton state. Transmission studies of the spectral CPT feature on an ensemble of electrons directly reveal the statistical distribution of prepared nuclear spin states. Tuning the laser driving from blue to red detuned drives a transition from one to two stable states. Our results have importance for ongoing research on schemes for dynamic nuclear spin polarization, the central spin problem and control of spin coherence.Comment: 5 pages, 4 figure

Simulation of a fully coupled 3D glacial isostatic adjustment – ice sheet model for the Antarctic ice sheet over a glacial cycle

Glacial isostatic adjustment (GIA) has a stabilizing effect on the evolution of the Antarctic ice sheet by reducing the grounding line migration following ice melt. The timescale and strength of this feedback depends on the spatially varying viscosity of the Earth's mantle. Most studies assume a relatively long and laterally homogenous response time of the bedrock. However, the mantle viscosity is spatially variable, with a high mantle viscosity beneath East Antarctica and a low mantle viscosity beneath West Antarctica. For this study, we have developed a new method to couple a 3D GIA model and an ice sheet model to study the interaction between the solid Earth and the Antarctic ice sheet during the last glacial cycle. With this method, the ice sheet model and GIA model exchange ice thickness and bedrock elevation during a fully coupled transient experiment. The feedback effect is taken into account with a high temporal resolution, where the coupling time steps between the ice sheet and GIA model are 5000 years over the glaciation phase and vary between 500 and 1000 years over the deglaciation phase of the last glacial cycle. During each coupling time step, the bedrock elevation is adjusted at every ice sheet model time step, and the deformation is computed for a linearly changing ice load. We applied the method using the ice sheet model ANICE and a 3D GIA finite element model. We used results from a regional seismic model for Antarctica embedded in the global seismic model SMEAN2 to determine the patterns in the mantle viscosity. The results of simulations over the last glacial cycle show that differences in mantle viscosity of an order of magnitude can lead to differences in the grounding line position up to 700 km and to differences in ice thickness of the order of 2 km for the present day near the Ross Embayment. These results underline and quantify the importance of including local GIA feedback effects in ice sheet models when simulating the Antarctic ice sheet evolution over the last glacial cycle.</p

Quantitative live-cell imaging and computational modelling shed new light on endogenous WNT/CTNNB1 signaling dynamics

WNT/CTNNB1 signaling regulates tissue development and homeostasis in all multicellular animals, but the underlying molecular mechanism remains incompletely understood. Specifically, quantitative insight into endogenous protein behavior is missing. Here, we combine CRISPR/Cas9-mediated genome editing and quantitative live-cell microscopy to measure the dynamics, diffusion characteristics and absolute concentrations of fluorescently tagged, endogenous CTNNB1 in human cells under both physiological and oncogenic conditions. State-of-the-art imaging reveals that a substantial fraction of CTNNB1 resides in slow-diffusing cytoplasmic complexes, irrespective of the activation status of the pathway. This cytoplasmic CTNNB1 complex undergoes a major reduction in size when WNT/CTNNB1 is (hyper)activated. Based on our biophysical measurements, we build a computational model of WNT/CTNNB1 signaling. Our integrated experimental and computational approach reveals that WNT pathway activation regulates the dynamic distribution of free and complexed CTNNB1 across different subcellular compartments through three regulatory nodes: the destruction complex, nucleocytoplasmic shuttling, and nuclear retention

Coupling of climate models and ice sheet models by surface mass balance gradients: application to the Greenland Ice Sheet

It is notoriously difficult to couple surface mass balance (SMB) results from climate models to the changing geometry of an ice sheet model. This problem is traditionally avoided by using only accumulation from a climate model, and parameterizing the meltwater run-off as a function of temperature, which is often related to surface elevation (&lt;i&gt;H&lt;/i&gt;&lt;sub&gt;s&lt;/sub&gt;). In this study, we propose a new strategy to calculate SMB, to allow a direct adjustment of SMB to a change in ice sheet topography and/or a change in climate forcing. This method is based on elevational gradients in the SMB field as computed by a regional climate model. Separate linear relations are derived for ablation and accumulation, using pairs of &lt;i&gt;H&lt;/i&gt;&lt;sub&gt;s&lt;/sub&gt; and SMB within a minimum search radius. The continuously adjusting SMB forcing is consistent with climate model forcing fields, also for initially non-glaciated areas in the peripheral areas of an ice sheet. When applied to an asynchronous coupled ice sheet – climate model setup, this method circumvents traditional temperature lapse rate assumptions. Here we apply it to the Greenland Ice Sheet (GrIS). Experiments using both steady-state forcing and glacial-interglacial forcing result in realistic ice sheet reconstructions

Mapping technique of climate fields between GCM's and ice models

Here, we present a mapping method OBLIMAP, which projects and interpolates fields like surface temperature, surface mass balance, and surface height between a geographical based coordinate system of a General Circulation Model (GCM) and a rectangular based Ice Model (IM). We derive an oblique stereographic projection and its inverse, which holds for any area at the Earth's surface, and which can be combined with two different interpolation methods. The first one is suited to interpolate the projected fields of a coarse GCM grid on a fine meshed IM grid. The second one is appropriate for the opposite case. Both grids are allowed to be arbitrary and irregularly spaced. Therefore the OBLIMAP technique is suitable for any GCM-IM combination. After a first scan of the GCM grid coordinates and the specification of the IM grid, fast mapping of various fields is possible. To and fro (GCM-IM-GCM) mapping tests with the Climate Community System Model (CCSM) at T42 resolution (~313 km) and the Regional Atmospheric Climate Model (RACMO) at ~11 km and ~55 km, show average temperature differences of less than 0.1 K with small standard deviations. OBLIMAP, available at GMD, is an accurate, robust and well-documented mapping method for coupling an IM with a GCM or to map state of the art initial and forcing fields available at geographical coordinates to any local IM grid with an optimal centered oblique projection. Currently, the oblique stereographic and the oblique Lambert azimuthal equal-area projections for both the sphere and the ellipsoid are implemented in OBLIMAP

The Synthesis of 5-, 6-, 7- and 8-Membered Oxygen-containing Benzo-fused Rings using Alkene Isomerization and Ring-closing Metathesis Reactions

A number of benzo-fused oxygen-containing heterocycles were synthesized from allyl-3-isopropoxy- 4-methoxybenzaldehyde using metathesis or an alkene isomerization-metathesis sequence as key synthetic steps. Benzo-fused compounds thus formed included a 3,6-dihydro-1H-2-benzoxocine, 1,3-dihydro- benzo[c]oxepine, 1H-isochromene, 2,3-dihydro-benzo[b]oxepine, benzofuran and 2H-chromene skeleton, demonstrating the versatility of this methodology.KEYWORDS: Ring-closing metathesis, isomerization, ruthenium, benzo-fused compounds