Effects of a neuromuscular controller on a powered ankle exoskeleton during human walking

Wearable devices to assist abnormal gaits require controllers that interact with the user in an intuitive and unobtrusive manner. To design such a controller, we investigated a bio-inspired walking controller for orthoses and prostheses. We present (i) a Simulink neuromuscular control library derived from a computational model of reflexive neuromuscular control of human gait with a central pattern generator (CPG) extension, (ii) an ankle reflex controller for the Achilles exoskeleton derived from the library, and (iii) the mechanics and energetics of healthy subjects walking with an actuated ankle orthosis using the proposed controller. As this controller was designed to mimic human reflex patterns during locomotion, we hypothesize that walking with this controller would lead to lower energetic costs, compared to walking with the added mass of the device only, and allow for walking at different speeds without explicit control. Preliminary results suggest that the neuromuscular controller does not disturb walking dynamics in both slow and normal walking cases and can also reduce the net metabolic cost compared to transparent mode of the device. Reductions in tibialis anterior and soleus activity were observed, suggesting the controller could be suitable, in future work, for augmenting or replacing normal walking functions. We also investigated the impedance patterns generated by the neuromuscular controller. The validity of the equivalent variable impedance controller, particularly in stance phase, can facilitate serving subject-specific features by linking impedance measurement and neuromuscular controller

Neuromuscular Controller Embedded in a Powered Ankle Exoskeleton:Effects on Gait, Clinical Features and Subjective Perspective of Incomplete Spinal Cord Injured Subjects

Powered exoskeletons are among the emerging technologies claiming to assist functional ambulation. The potential to adapt robotic assistance based on specific motor abilities of incomplete spinal cord injury (iSCI) subjects, is crucial to optimize Human-Robot Interaction (HRI). Achilles, an autonomous wearable robot able to assist ankle during walking, was developed for iSCI subjects and utilizes a NeuroMuscular Controller (NMC). NMC can be used to adapt robotic assistance based on specific residual functional abilities of subjects. The main aim of this pilot study was to analyze the effects of the NMC-controlled Achilles, used as an assistive device, on chronic iSCI participants' performance, by assessing gait speed during 10-session training of robot-aided walking. Secondary aims were to assess training impact on participants' motion, clinical and functional features and to evaluate subjective perspective in terms of attitude towards technology, workload, usability and satisfaction. Results showed that 5 training sessions were necessary to significantly improve robot-aided gait speed on short paths and consequently to optimize HRI. Moreover, the training allowed participants who initially were not able to walk for 6 minutes, to improve gait endurance during Achilles-aided walking and to reduce perceived fatigue. Improvements were obtained also in gait speed during free walking, thus suggesting a potential rehabilitative impact, even if Achilles-aided walking was not faster than free walking. Participants' subjective evaluations indicated a positive experience

Modeling trans-spinal direct current stimulation for the modulation of the lumbar spinal motor pathways

Objective: Trans-spinal direct current stimulation (tsDCS) is a potential new technique for the treatment of spinal cord injury (SCI). TsDCS aims to facilitate plastic changes in the neural pathways of the spinal cord with a positive effect on SCI recovery. To establish tsDCS as a possible treatment option for SCI, it is essential to gain a better understanding of its cause and effects. We seek to understand the acute effect of tsDCS, including the generated electric field (EF) and its polarization effect on the spinal circuits, to determine a cellular target. We further ask how these findings can be interpreted to explain published experimental results. Approach: We use a realistic full body finite element volume conductor model to calculate the EF of a 2.5 mA direct current for three different electrode configurations. We apply the calculated electric field to realistic motoneuron models to investigate static changes in membrane resting potential. The results are combined with existing knowledge about the theoretical effect on a neuronal level and implemented into an existing lumbar spinal network model to simulate the resulting changes on a network level. Main results: Across electrode configurations, the maximum EF inside the spinal cord ranged from 0.47 V m-1 to 0.82 V m-1. Axon terminal polarization was identified to be the dominant cellular target. Also, differences in electrode placement have a large influence on axon terminal polarization. Comparison between the simulated acute effects and the electrophysiological long-term changes observed in human tsDCS studies suggest an inverse relationship between the two. Significance: We provide methods and knowledge for better understanding the effects of tsDCS and serve as a basis for a more targeted and optimized application of tsDCS

Differences in chunking behavior between young and older adults diminish with extended practice

Previous research found reduced motor chunking behavior in older adults compared to young adults. However, it remains unclear whether older adults are unable to use a chunking strategy or whether they are just slower in developing them. Our goal was to investigate the effect of extended practice on the development of chunking behavior in healthy older adults. A group of young and a group of healthy older adults between 74 and 85 years of age visited the lab on 2 days. A sequence of 3 and a sequence of 6 elements were both practiced 432 times in a discrete sequence production task. We found that age differences in chunking behavior, as measured by the difference between initiation and execution of the sequence, diminish with extended practice. Furthermore, in older, but not in young adults, slow responses that are often interpreted as the first response of a next motor chunk were associated with a finger that was also slow during performance of the random sequences. This finding calls for more attention to biomechanical factors in future theory about aging and sequence learning

Sagittal-plane balance perturbations during very slow walking: Strategies for recovering linear and angular momentum

Spatiotemporal gait characteristics change during very slow walking, a relevant speed considering individuals with movement disorders or using assistive devices. However, we lack insights in how very slow walking affects human balance control. Therefore, we aimed to identify how healthy individuals use balance strategies while walking very slow. Ten healthy participants walked on a treadmill at an average speed of 0.43 m s−1, while being perturbed at toe off right by either perturbations of the whole-body linear momentum (WBLM) or angular momentum (WBAM). WBLM perturbations were given by a perturbation on the pelvis in forward or backward direction. The WBAM was perturbed by two simultaneous perturbations in opposite directions on the pelvis and upper body. The given perturbations had magnitudes of 4, 8, 12 and 16 % of the participant's body weight, and lasted for 150 ms. After perturbations of the WBLM the centre of pressure placement was modulated using the ankle joint, while keeping the moment arm of the ground reaction force (GRF) with respect to the centre of mass (CoM) small. After the perturbations of the WBAM a quick recovery was initiated, using the hip joint and adjusting the horizontal GRF to create a moment arm with respect to the CoM. These findings suggest no fundamental differences in the use of balance strategies at very slow walking compared to normal speeds. Still as the gait phases last longer, this time was exploited to counteract perturbations in the ongoing gait phase.</p

Centre of pressure modulations in double support effectively counteract anteroposterior perturbations during gait

Centre of mass (CoM) motion during human balance recovery is largely influenced by the ground reaction force (GRF) and the centre of pressure (CoP). During gait, foot placement creates a region of possible CoP locations in the following double support (DS). This study aims to increase insight into how humans modulate the CoP during DS, and which CoP modulations are theoretically possible to maintain balance in the sagittal plane. Three variables sufficient to describe the shape, length and duration of the DS CoP trajectory of the total GRF, were assessed in perturbed human walking. To counteract the forward perturbations, braking was required and all CoP variables showed modulations correlated to the observed change in CoM velocity over the DS phase. These correlations were absent after backward perturbations, when only little propulsion was needed to counteract the perturbation. Using a linearized inverted pendulum model we could explore how the observed parameter modulations are effective in controlling the CoM. The distance the CoP travels forward and the instant the leading leg was loaded largely affected the CoM velocity, while the duration mainly affected the CoM position. The simulations also showed that various combinations of CoP parameters can reach a desired CoM position and velocity at the end of DS, and that even a full recovery in the sagittal plane within DS would theoretically have been possible. However, the human subjects did not exploit the therefore required CoP modulations. Overall, modulating the CoP trajectory in DS does effectively contributes to balance recovery.Biomechatronics & Human-Machine Contro

Whole Body Center of Mass Feedback in a Reflex-Based Neuromuscular Model Predicts Ankle Strategy during Perturbed Walking

Active prosthetic and orthotic devices have the potential to increase quality of life for individuals with impaired mobility. However, more research into human-like control methods is needed to create seamless interaction between device and user. In forward simulations the reflex-based neuromuscular model (RNM) by Song and Geyer shows promising similarities with real human gait in unperturbed conditions. The goal of this work was to validate and, if needed, extend the RNM to reproduce human kinematics and kinetics during walking in unperturbed and perturbed conditions. The RNM was optimized to reproduce joint torque, calculated with inverse dynamics, from kinematic and force data of unperturbed and perturbed treadmill walking of able-bodied human subjects. Torques generated by the RNM matched closely with torques found from inverse dynamics analysis on human data for unperturbed walking. However, for perturbed walking the modulation of the ankle torque in the RNM was opposite to the modulation observed in humans. Therefore, the RNM was extended with a control module that activates and inhibits muscles around the ankle of the stance leg, based on changes in whole body center of mass velocity. The added module improves the ability of the RNM to replicate human ankle torque response in response to perturbations. This reflex-based neuromuscular model with whole body center of mass velocity feedback can reproduce gait kinetics of unperturbed and perturbed gait, and as such holds promise as a basis for advanced controllers of prosthetic and orthotic devices

Effect of perturbation timing on recovering whole-body angular momentum during very slow walking

Humans prioritize regulation of the whole-body angular momentum (WBAM) during walking. When perturbed, modulations of the moment arm of the ground reaction force (GRF) with respect to the centre of mass (CoM) assist in recovering WBAM. For sagittal-plane perturbations of the WBAM given at toe off right (TOR), horizontal GRF modulations and not centre of pressure (COP) modulations were mainly responsible for these moment arm modulations. In this study, we aimed to find whether the instant of perturbations affects the contributions of the GRF and/or CoP modulations to the moment arm changes, in balance recovery during very slow walking. Perturbations of the WBAM were applied at three different instants of the gait cycle, namely at TOR, mid-swing (MS), and heel strike right (HSR). Forces equal to 16% of the participant's body weight were applied simultaneously to the pelvis and upper body in opposite directions for a duration of 150 ms. The results showed that the perturbation onset did not significantly affect the GRF moment arm modulation. However, the contribution of both the CoP and GRF modulation to the moment arm changes did change depending on the perturbation instant. After perturbations resulting in a forward pitch of the trunk a larger contribution was present from the CoP modulation when perturbations were given at MS or HSR, compared to perturbations at TOR. After backward pitch perturbations given at MS and HSR the CoP modulation counteracted the moment arm required for WBAM recovery. Therefore a larger contribution from the horizontal GRF was needed to direct the GRF posterior to the CoM and recover WBAM. In conclusion, the onset of WBAM perturbations does not affect the moment arm modulation needed for WBAM recovery, while it does affect the way CoP and GRF modulation contribute to that recovery.Support Biomechanical Engineerin

Recovery from sagittal-plane whole body angular momentum perturbations during walking

Healthy individuals highly regulate their whole body angular momentum (WBAM) during walking. Since WBAM regulation is essential in maintaining balance, a better understanding is required on how healthy individuals recover from WBAM perturbations. We therefore studied how healthy individuals recover WBAM in the sagittal plane. WBAM can be regulated by adjusting the moment arm of the ground reaction force (GRF) vector with respect to the whole-body centre of mass (CoM). In principle this can be done by centre of pressure (CoP) modulation and/or adjustments of the GRF direction. Two simultaneous perturbations of the same magnitude were applied in opposite direction to the pelvis and upper body (0.34m apart) to perturb WBAM but not the whole body linear momentum (WBLM), while participants walked on a treadmill. The perturbations were given at toe off right, had a magnitude of 4, 8, 12 and 16% of the participant's body weight, and lasted for 150ms. A recovery of the WBAM was seen directly after the perturbations, induced by adapting the moment arm of the GRF with respect to the CoM. The hip joint of the stance leg played an important role in achieving the WBAM recovery. A change in the direction of the GRF vector and not a contributing CoP modulation, caused the change in moment arm. However, the change in GRF direction came from a change in the horizontal GRF, which also affects the WBLM. This suggest that regulating WBAM may take precedence over the WBLM in early recovery.Biomechatronics & Human-Machine Contro