An automatic deep learning approach for coronary artery calcium segmentation

Coronary artery calcium (CAC) is a significant marker of atherosclerosis and cardiovascular events. In this work we present a system for the automatic quantification of calcium score in ECG-triggered non-contrast enhanced cardiac computed tomography (CT) images. The proposed system uses a supervised deep learning algorithm, i.e. convolutional neural network (CNN) for the segmentation and classification of candidate lesions as coronary or not, previously extracted in the region of the heart using a cardiac atlas. We trained our network with 45 CT volumes; 18 volumes were used to validate the model and 56 to test it. Individual lesions were detected with a sensitivity of 91.24%, a specificity of 95.37% and a positive predicted value (PPV) of 90.5%; comparing calcium score obtained by the system and calcium score manually evaluated by an expert operator, a Pearson coefficient of 0.983 was obtained. A high agreement (Cohen's k = 0.879) between manual and automatic risk prediction was also observed. These results demonstrated that convolutional neural networks can be effectively applied for the automatic segmentation and classification of coronary calcifications

Low cycle fatigue predictions of a space thruster built with a new refractory high entropy alloy

Directional thrusters are designed to provide force for short time periods. • New generation of thrusters could be made using a High Entropy Alloy (HEA). • Predicting fatigue damage initiation for this kind of metallic structure subjected to cyclic loads is important. • Design for fatigue resistance relies on empirical with high financial costs. • Unified Mechanics Theory (UMT) will be used to predict fatigue damage initiation of a material system without having experimental fatigue dat

2001 SN263-the contribution of their irregular shapes on the neighbourhood dynamics

The first proposed Brazilian mission to deep space, the ASTER mission, has the triple asteroid system (153591) 2001 SN263 as a target. One of the mission's main goals is to analyse the physical and dynamical structures of the system to understand its origin and evolution. This work aims to analyse how the asteroid's irregular shape interferes with the stability around the system. The results show that the irregular shape of the bodies plays an important role in the dynamics nearby the system. For instance, the perturbation due to the (153591) 2001 SN263 Alpha's shape affects the stability in the (153591) 2001 SN263 Gamma's vicinity. Similarly, the (153591) 2001 SN263 Beta's irregularity causes a significant instability in its nearby environment. As expected, the prograde case is the most unstable, while the retrograde scenario presents more stability. Additionally, we investigate how the solar radiation pressure perturbs particles of different sizes orbiting the triple system. We found that particles with a 10-50 cm radius could survive the radiation pressure for the retrograde case. Meanwhile, to resist solar radiation, the particles in prograde orbit must be larger than the particles in retrograde orbits, at least one order of magnitude.This study was financed in part by the Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES), in the scope of the Program CAPES-PrInt, process number 88887.310463/2018-00, International Cooperation Project number 3266, Fundaçao de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP) - Proc. 2016/24561-0 and Proc. 2019/23963-5, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) - Proc. 305210/2018-1. RS acknowledges support by the DFG German Research Foundation (project 446102036). We also would like to thanks the referee, Alex B Davis, for a suggestion that impro v ed the paper

Dynamics around the binary system (65803) Didymos

Didymos and Dimorphos are primary and secondary, respectively, asteroids who compose a binary system that make up the set of Near Earth Asteroids (NEAs). They are targets of the Double Asteroid Redirection Test (DART), the first test mission dedicated to study of planetary defense, for which the main goal is to measure the changes caused after the secondary body is hit by a kinect impactor. The present work intends to conduct a study, through numerical integrations, on the dynamics of massless particles distributed in the vicinity of the two bodies. An approximate shape for the primary body was considered as a model of mass concentrations (mascons) and the secondary was considered as a massive point. Our results show the location and size of stable regions, and also their lifetime

Surgical management of cervico-mediastinal goiters: Our experience and review of the literature

We analyze and discuss the clinical presentation, the diagnostic procedures and the surgical technique in relation to post-operative complications and results in cervico-mediastinal thyroid masses admitted in Thoracic Surgery Unit of AOU Second University of Naples from 1991 to 2006 and in Thoracic Surgery Unit of AOU "S. Giovanni di Dio & Ruggi D'Aragona" of Salerno over a period of 3 years (2011-2014)

Experience of 170 cases of ductal carcinoma in ' (DCIS)

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Atypical mature T-cell neoplasms: The relevance of the role of flow cytometry

Lymphoproliferative disorders are a heterogeneous group of malignant clonal proliferations of lymphocytes whose diagnosis remains challenging, despite diagnostic criteria are now well established, due to their heterogeneity in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are more rarely seen than B-cell entities and more difficult to diagnose for the absence of a specific immunophenotypic signature. Flow cytometry is a useful tool in diagnosing T-cell lymphoproliferative disorders since it is not only able to better characterize T-cell neoplasms but also to resolve some very complicated cases, in particular those in which a small size population of neoplastic cells is available for the analysis. Here, we report three patients with mature T-cell neoplasms with atypical clinical and biological features in which analysis of peripheral blood and bone marrow specimens by means of multicolor flow cytometry was very useful to identify and characterize three rare T-cell lymphoproliferative disorders, such as angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma not otherwise specified and T-cell prolym-phocytic leukemia. The aim of this case series report is not only to describe three rare cases of lymphoproliferative neoplasms but also to raise awareness that a fast, highly sensitive, and reproducible procedure, such as flow cytometry immunophenotyping, can have a determinant diagnostic role in these patients