Ribbon Turbulence

We investigate the non-linear equilibration of a two-layer quasi-geostrophic flow in a channel forced by an imposed unstable zonal mean flow, paying particular attention to the role of bottom friction. In the limit of low bottom friction, classical theory of geostrophic turbulence predicts an inverse cascade of kinetic energy in the horizontal with condensation at the domain scale and barotropization on the vertical. By contrast, in the limit of large bottom friction, the flow is dominated by ribbons of high kinetic energy in the upper layer. These ribbons correspond to meandering jets separating regions of homogenized potential vorticity. We interpret these result by taking advantage of the peculiar conservation laws satisfied by this system: the dynamics can be recast in such a way that the imposed mean flow appears as an initial source of potential vorticity levels in the upper layer. The initial baroclinic instability leads to a turbulent flow that stirs this potential vorticity field while conserving the global distribution of potential vorticity levels. Statistical mechanical theory of the 1-1/2 layer quasi-geostrophic model predict the formation of two regions of homogenized potential vorticity separated by a minimal interface. We show that the dynamics of the ribbons results from a competition between a tendency to reach this equilibrium state, and baroclinic instability that induces meanders of the interface. These meanders intermittently break and induce potential vorticity mixing, but the interface remains sharp throughout the flow evolution. We show that for some parameter regimes, the ribbons act as a mixing barrier which prevent relaxation toward equilibrium, favouring the emergence of multiple zonal jets

Regime Change Behaviour During Asian Monsoon Onset

This is the final version of the article. Available from American Meteorological Society via the DOI in this record.As the ITCZ moves off the equator on an aquaplanet, the Hadley circulation transitions from an equinoctial regime with two near symmetric, significantly eddy-driven cells, to a monsoon-like regime with a strong, thermally direct cross-equatorial cell, intense low-latitude precipitation, and a weak summer hemisphere cell. Dynamical feedbacks appear to accelerate the transition. This study investigates the relevance of this behavior to monsoon onset by using primitive-equation model simulations ranging from aquaplanets to more realistic configurations with Earth’s continents and topography. A change in the relationship between ITCZ latitude and overturning strength is identified once the ITCZ moves poleward of about ∼ 7 ◦ . Monsoon onset is associated with off-equatorial ascent, in regions of non-negligible planetary vorticity, and this is found to generate a vortex stretching tendency that reduces upper level absolute vorticity. In an aquaplanet, this causes a transition to the cross-equatorial, thermally direct regime, intensifying the overturning circulation. Analysis of the zonal momentum budget suggests a stationary wave, driven by topography and land-sea contrast, can trigger a similar transition in the more realistic model configuration, with the wave extending the ascent region of the Southern Hemisphere Hadley cell northward, and enhanced overturning then developing to the south. These two elements of the circulation resemble the East and South Asian monsoons.The work was supported by the UK-China Research & Innovation Partnership Fund, through the Met Office Climate Science for Service Partnership (CSSP) China, as part of the Newton Fund. GKV also acknowledges support from the Royal Society (Wolfson Foundation), the Leverhulme Trust, and NERC

Large-scale circulation with small diapycnal diffusion: The two-thermocline limit

The structure and dynamics of the large-scale circulation of a single-hemisphere, closed-basin ocean with small diapycnal diffusion are studied by numerical and analytical methods. The investigation is motivated in part by recent differing theoretical descriptions of the dynamics that control the stratification of the upper ocean, and in part by recent observational evidence that diapycnal diffusivities due to small-scale turbulence in the ocean thermocline are small (≈0.1 cm2 s−1). Numerical solutions of a computationally efficient, three-dimensional, planetary geostrophic ocean circulation model are obtained in a square basin on a mid-latitude β-plane. The forcing consists of a zonal wind stress (imposed meridional Ekman flow) and a surface heat flux proportional to the difference between surface temperature and an imposed air temperature. For small diapycnal diffusivities (vertical: κv ≈0.1 – 0.5 cm2 s−1, horizontal: κh ≈105 – 5 × 106 cm2 s−1), two distinct thermocline regimes occur. On isopycnals that outcrop in the subtropical gyre, in the region of Ekman downwelling, a ventilated thermocline forms. In this regime, advection dominates diapycnal diffusion, and the heat balance is closed by surface cooling and convection in the northwest part of the subtropical gyre. An ‘advective’ vertical scale describes the depth to which the wind-driven motion penetrates, that is, the thickness of the ventilated thermocline. At the base of the wind-driven fluid layer, a second thermocline forms beneath a layer of vertically homogeneous fluid (‘mode water’). This ‘internal’ thermocline is intrinsically diffusive. An ‘internal boundary layer’ vertical scale (proportional to κv1/2) describes the thickness of this internal thermocline. Two varieties of subtropical mode waters are distinguished. The temperature difference across the ventilated thermocline is determined to first order by the meridional air temperature difference across the subtropical gyre. The temperature difference across the internal thermocline is determined to first order by the temperature difference across the subpolar gyre. The diffusively-driven meridional overturning cell is effectively confined below the ventilated thermocline, and driven to first order by the temperature difference across the internal thermocline, not the basin-wide meridional air temperature difference. Consequently, for small diapycnal diffusion, the abyssal circulation depends to first order only on the wind-forcing and the subpolar gyre air temperatures. The numerical solutions have a qualitative resemblance to the observed structure of the North Atlantic in and above the main thermocline (that is, to a depth of roughly 1500 m). Below the main thermocline, the predicted stratification is much weaker than observed

Processes and Timescales in Onset and Withdrawal of 'Aquaplanet Monsoons'

This is the final version. Available from American Meteorological Society via the DOI in this record.Data availability: The research materials supporting this publication can be accessed by contacting Ruth Geen ([email protected]).Aquaplanets with low heat capacity slab ocean boundary conditions can exhibit rapid changes in the regime of the overturning circulation over the seasonal cycle, which have been connected to the onset of Earth’s monsoons. In spring, as the ITCZ migrates off the Equator, it jumps poleward and a sudden transition occurs from an eddy-driven, equinoctial regime with two weak Hadley cells, to a near angular momentum conserving, solstitial regime with a strong, cross-equatorial winter hemisphere cell. Here, the controls on the transition latitude and rate are explored in idealised moist aquaplanet simulations. It is found that the transition remains rapid relative to the solar forcing when year length and slab ocean heat capacity are varied, and, at Earth’s rotation rate, always occurs when the ITCZ reaches approximately 7°. This transition latitude is, however, found to scale inversely with rotation rate. Interestingly, the transition rate varies non-monotonically with rotation, with a maximum at Earth’s rotation rate, suggesting that Earth may be particularly disposed to a fast monsoon onset. The fast transition relates to feedbacks in both the atmosphere and the slab ocean. In particular, an evaporative feedback between the lower-level branch of the overturning circulation and the surface temperature is identified. This accelerates monsoon onset and slows withdrawal. Lastly, comparing eddy-permitting and axisymmetric experiments shows that, in contrast with results from dry models, in this fully moist model the presence of eddies slows the migration of the ITCZ between hemispheres.UK-China Research and Innovation Partnership FundRoyal SocietyLeverhulme Trus

Targeting telomerase with radiolabeled inhibitors

The expression of telomerase in approximately 85% of cancers and its absence in the majority of normal cells makes it an attractive target for cancer therapy. However the lag period between initiation of telomerase inhibition and growth arrest makes direct inhibition alone an insufficient method of treatment. However, telomerase inhibition has been shown to enhance cancer cell radiosensitivity. To investigate the strategy of simultaneously inhibiting telomerase while delivering targeted radionuclide therapy to cancer cells, 123I-radiolabeled inhibitors of telomerase were synthesized and their effects on cancer cell survival studied. An 123I-labeled analogue of the telomerase inhibitor MST-312 inhibited telomerase with an IC50 of 1.58 μM (MST-312 IC50: 0.23 μM). Clonogenic assays showed a dose dependant effect of 123I-MST-312 on cell survival in a telomerase positive cell line, MDA-MB-435

Optimally coherent sets in geophysical flows: A new approach to delimiting the stratospheric polar vortex

The "edge" of the Antarctic polar vortex is known to behave as a barrier to the meridional (poleward) transport of ozone during the austral winter. This chemical isolation of the polar vortex from the middle and low latitudes produces an ozone minimum in the vortex region, intensifying the ozone hole relative to that which would be produced by photochemical processes alone. Observational determination of the vortex edge remains an active field of research. In this letter, we obtain objective estimates of the structure of the polar vortex by introducing a new technique based on transfer operators that aims to find regions with minimal external transport. Applying this new technique to European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-40 three-dimensional velocity data we produce an improved three-dimensional estimate of the vortex location in the upper stratosphere where the vortex is most pronounced. This novel computational approach has wide potential application in detecting and analysing mixing structures in a variety of atmospheric, oceanographic, and general fluid dynamical settings

Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis

AbstractThe GTPase dynamin plays an essential role in clathrin-mediated endocytosis [1–3]. Substantial evidence suggests that dynamin oligomerisation around the necks of endocytosing vesicles and subsequent dynamin-catalysed GTP hydrolysis is responsible for membrane fission [4,5]. The pleckstrin homology (PH) domain of dynamin has previously been shown to interact with phosphoinositides, but it has not been determined whether this interaction is essential for dynamin's function in endocytosis [6–9]. In this study, we address the in vivo function of the PH domain of dynamin by assaying the effects of deletions and point mutations in this region on transferrin uptake in COS-7 fibroblasts. Overexpression of a dynamin construct lacking its entire PH domain potently blocked transferrin uptake, as did overexpression of a dynamin construct containing a mutation in the first variable loop of the PH domain. Structural modelling of this latter mutant suggested that the lysine residue at position 535 (Lys535) may be critical in the coordination of phosphoinositides, and indeed, the purified mutant no longer interacted with lipid nanotubes. Interestingly, the inhibitory phenotype of cells expressing this dynamin mutant was partially relieved by a second mutation in the carboxy-terminal proline-rich domain (PRD), one that prevents dynamin from binding to the Src homology 3 (SH3) domain of amphiphysin. These data demonstrate that dynamin's interaction with phosphoinositides through its PH domain is essential for endocytosis. These findings also support our hypothesis that PRD–SH3 domain interactions are important in the recruitment of dynamin to sites of endocytosis

On variational principles for coherent vortex structures

Different approaches are discussed of variational principles characterizing coherent vortex structures in two-dimensional flows. Turbulent flows seem to form ordered structures in the large scales of the motion and the self-organization principle predicts asymptotic states realizing an extremal value of the energy or a minimum of enstrophy. On the other hand the small scales take care of the increase of entropy, and asymptotic results can be obtained by applying the theory of equilibrium statistical mechanics

Inferring directed climatic interactions with renormalized partial directed coherence and directed partial correlation

ACKNOWLEDGMENTS This work was supported in part by Spanish MINECO/FEDER (FIS2015-66503-C3-2-P) and ITN LINC (FP7 289447). C.M. also acknowledges partial support from ICREA ACADEMIAPeer reviewedPublisher PD