6 research outputs found
Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial
- Author
- Abaci Adnan
- Abaci Adnan
- Abhaichand Rajpal
- Abhaichand Rajpal
- Adams Kirkwood
- Adams Kirkwood
- Akin Mustafa
- Akin Mustafa
- Alvarenga Pablo
- Alvarenga Pablo
- Apro Dezso
- Apro Dezso
- Arneja Jaspal
- Arneja Jaspal
- Aron Wilma
- Aron Wilma
- Babcak Marian
- Babcak Marian
- Babilonia Noe A.
- Babilonia Noe A.
- Badak Ozer
- Badak Ozer
- Banker Darshan
- Banker Darshan
- Barbiero Mario
- Barbiero Mario
- Barnard Denise
- Barnard Denise
- Baschiera Fabio
- Bassan Roberto
- Bassan Roberto
- Behrens Steffen
- Behrens Steffen
- Belohlavek Jan
- Belohlavek Jan
- Bergin James
- Bergin James
- Berkovich Olga
- Berkovich Olga
- Berkowski Piotr
- Berkowski Piotr
- Bharani Anil
- Bharani Anil
- Blumberg Eduardo Salmon
- Blumberg Eduardo Salmon
- Boccanelli Alessandro
- Boccanelli Alessandro
- Bodanese Luiz
- Bodanese Luiz
- Boldueva Svetlana
- Boldueva Svetlana
- Borghi Claudio
- Borghi Claudio
- Boyarkin Mikhail
- Boyarkin Mikhail
- Brabec Tomas
- Brabec Tomas
- Branzi Angelo
- Branzi Angelo
- Braun-Dullaeus Ruediger
- Braun-Dullaeus Ruediger
- Brottman Michael
- Brottman Michael
- Brown Christopher
- Brown Christopher
- Brunotte Richard
- Brunotte Richard
- Bueno Manuel Gomez
- Bueno Manuel Gomez
- Burnham Kenneth
- Burnham Kenneth
- Böhm Michael
- Cabrera Jose Angel
- Cabrera Jose Angel
- Callister Tracy
- Callister Tracy
- Canesin Manoel
- Canesin Manoel
- Cangemi Dott Francesco
- Cangemi Dott Francesco
- Castagnino Jorge
- Castagnino Jorge
- Cavallini Claudio
- Cavallini Claudio
- Chang Kuan-Cheng
- Chang Kuan-Cheng
- Cherng Wen-Jin
- Cherng Wen-Jin
- Chockalingam Kulasekaran
- Chockalingam Kulasekaran
- Chung Eugene
- Chung Eugene
- Cizinsky Stella
- Cizinsky Stella
- Cohen Ariel
- Cohen Ariel
- Comin Josep
- Comin Josep
- Costard-Jaeckle Angelika
- Costard-Jaeckle Angelika
- Cotes Carlos
- Cotes Carlos
- Dan Gheorghe
- Dan Gheorghe
- De Keulenaer Gilles
- De Keulenaer Gilles
- De Lorenzi Ettore
- De Lorenzi Ettore
- de Sa Esteban Lopez
- de Sa Esteban Lopez
- De Santis Fernando
- De Santis Fernando
- De Servi Stefano
- De Servi Stefano
- Dendale Paul
- Dendale Paul
- Di Biase Matteo
- Di Biase Matteo
- Di Somma Salvatore
- Di Somma Salvatore
- Diez Mirta
- Diez Mirta
- Dizeo Claudio
- Dizeo Claudio
- Dluzniewski Miroslaw
- Dluzniewski Miroslaw
- Dorobantu Maria
- Dorobantu Maria
- Dragulescu Stefan
- Dragulescu Stefan
- Duengen Hans-Dirk
- Duengen Hans-Dirk
- Dunlap Stephanie
- Dunlap Stephanie
- Dzielinska Zofia
- Dzielinska Zofia
- Ebelt Henning
- Ebelt Henning
- Ebinc Haksun
- Ebinc Haksun
- Echeverria Luis
- Echeverria Luis
- Eisen Howard
- Eisen Howard
- Ershova Olga
- Ershova Olga
- Felix Stephan
- Felix Stephan
- Fernandez Alberto
- Fernandez Alberto
- Ferrolino Arthur M.
- Ferrolino Arthur M.
- Figulla Hans-Reiner
- Figulla Hans-Reiner
- Fischer Sven
- Fischer Sven
- Floresta Agata
- Floresta Agata
- Florez Noel
- Florez Noel
- Fomin Igor
- Fomin Igor
- Fonarow Gregg C.
- Freire Ramon Bover
- Freire Ramon Bover
- French William
- French William
- Fulmer James
- Fulmer James
- Gadkari Milind
- Gadkari Milind
- Galinier Michel
- Galinier Michel
- Garcia Magali
- Garcia Magali
- Geiss Ernst
- Geiss Ernst
- Gheorghiade Mihai
- Giannetti Nadia
- Giannetti Nadia
- Gimpelewicz Claudio R.
- Goette Andreas
- Goette Andreas
- Goloschekin Boris
- Goloschekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Gonzalez Juanatey Jose Ramon
- Gonzalez Juanatey Jose Ramon
- Gordeev Ivan
- Gordeev Ivan
- Gordienko Alexander
- Gordienko Alexander
- Gosse Philippe
- Gosse Philippe
- Graf Kristof
- Graf Kristof
- Graham Susan
- Graham Susan
- Greco Dott Cosimo
- Greco Dott Cosimo
- Greco Oswaldo
- Greco Oswaldo
- Greene Stephen J.
- Gregor Pavel
- Gregor Pavel
- Guerrero Rodolfo Ahuad
- Guerrero Rodolfo Ahuad
- Gunawardena D.R.
- Gunawardena D.R.
- Gupta Vishal
- Gupta Vishal
- Habet Kalim
- Habet Kalim
- Haddad Haissam
- Haddad Haissam
- Hagerman Inger
- Hagerman Inger
- Hamann Frank
- Hamann Frank
- Hambrecht Rainer
- Hambrecht Rainer
- Hasbani Eduardo
- Hasbani Eduardo
- Hazelrigg Monica
- Hazelrigg Monica
- Heilman Karl
- Heilman Karl
- Heitzer Thomas
- Heitzer Thomas
- Hengstenberg Christian
- Hengstenberg Christian
- Henry Philippe
- Henry Philippe
- Herczeg Bela
- Herczeg Bela
- Hiremath Jagdish
- Hiremath Jagdish
- Hoffmann Stefan
- Hoffmann Stefan
- Hojerova Silvia
- Hojerova Silvia
- Hominal Miguel
- Hominal Miguel
- Hoppe Uta
- Hoppe Uta
- Hradec Jaromir
- Hradec Jaromir
- Hua Tsushung A.
- Hutyra Martin
- Hutyra Martin
- Huynh Thao
- Huynh Thao
- Ibañez Julio
- Ibañez Julio
- Isnard Richard
- Isnard Richard
- Izzo Joseph L.
- Izzo Joseph L.
- Jankowski Piotr
- Jankowski Piotr
- Jansky Petr
- Jansky Petr
- Jaramillo MĂłnica
- Jaramillo MĂłnica
- Joseph Susan
- Joseph Susan
- Jourdain Patrick
- Jourdain Patrick
- Juneman Elizabeth
- Juneman Elizabeth
- Kaeaeb Stefan
- Kaeaeb Stefan
- Karpov Yurii
- Karpov Yurii
- Kasperova Viera
- Kasperova Viera
- Katz Amos
- Katz Amos
- Katz Richard
- Katz Richard
- Keren Andre
- Keren Andre
- Kettner Jiri
- Kettner Jiri
- Khan Aziz
- Khan Aziz
- Kislyak Oxana
- Kislyak Oxana
- Kisters Klaus
- Kisters Klaus
- Klapholz Marc
- Klapholz Marc
- Kleinrok Andrzej
- Kleinrok Andrzej
- Knebel Fabian
- Knebel Fabian
- Kornacewicz-Jac Zdzislawa
- Kornacewicz-Jac Zdzislawa
- Kostenko Victor
- Kostenko Victor
- Kovar Frantisek
- Kovar Frantisek
- Krauze-Wielicka Magdalena
- Krauze-Wielicka Magdalena
- Kruells-Muench Juergen
- Kruells-Muench Juergen
- Kuchmin Alexey
- Kuchmin Alexey
- Kumbla Makund
- Kumbla Makund
- Kuo Chi-Tai
- Kuo Chi-Tai
- Kuo Jen-Yuan
- Kuo Jen-Yuan
- Kycina Peter
- Kycina Peter
- Lai Wen-Ter
- Lai Wen-Ter
- Lama Manuel Geraldia
- Lama Manuel Geraldia
- Le Tan Ju
- Le Tan Ju
- Lembo Giuseppe
- Lembo Giuseppe
- Lesogor Anastasia
- Leutermann-Oei Marie-Louise
- Leutermann-Oei Marie-Louise
- Lewis Basil
- Lewis Basil
- Lewis Eldrin F.
- Lippolis Nicholas
- Lippolis Nicholas
- Livarek Bernard
- Livarek Bernard
- Lopez Alejandro
- Lopez Alejandro
- Lopez MĂłnica
- Lopez MĂłnica
- Lueders Stephan
- Lueders Stephan
- Luna Alejandra
- Luna Alejandra
- Lundbye Justin
- Lundbye Justin
- Lupkovics Geza
- Lupkovics Geza
- Luquez Hugo
- Luquez Hugo
- Maggioni Aldo P.
- Mahajan Vijay
- Mahajan Vijay
- Maniyal Vijayakukmar
- Maniyal Vijayakukmar
- Manlutac Benjamin
- Manlutac Benjamin
- Marechal Patrick
- Marechal Patrick
- Marino Roberto Luis
- Marino Roberto Luis
- Marmor Alon
- Marmor Alon
- Marquez Lilia Lobo
- Marquez Lilia Lobo
- Martsevich Sergey
- Martsevich Sergey
- Masini Dott Franco
- Masini Dott Franco
- Mathur Atul
- Mathur Atul
- Matoltsy Andras
- Matoltsy Andras
- Mazurek Walentyna
- Mazurek Walentyna
- Mendoza Fernan
- Mendoza Fernan
- Metra Marco
- Metra Marco
- Meymandi Sheba
- Meymandi Sheba
- Milesi Rodolfo
- Milesi Rodolfo
- Militaru Constantin
- Militaru Constantin
- Miriuka Santiago
- Miriuka Santiago
- Mitrovic Veselin
- Mitrovic Veselin
- Mody Freny
- Mody Freny
- Moe Gordon
- Moe Gordon
- Moiseev Valentin
- Moiseev Valentin
- Monhart Zdenek
- Monhart Zdenek
- Mortara Andrea
- Mortara Andrea
- Murali Srinivas
- Murali Srinivas
- Muth Gerhard
- Muth Gerhard
- Najjar Samer
- Najjar Samer
- Nanjappa Manjunath
- Nanjappa Manjunath
- Neuder Yannick
- Neuder Yannick
- Neuenschwande Fernando
- Neuenschwande Fernando
- Nienaber Christoph
- Nienaber Christoph
- Nikolaidis Lazaros
- Nikolaidis Lazaros
- Novikova Nina
- Novikova Nina
- Nowalany-Kozie Ewa
- Nowalany-Kozie Ewa
- Nyman Kai
- Nyman Kai
- Olbrich Hans-Georg
- Olbrich Hans-Georg
- Oliveira Mucio
- Oliveira Mucio
- Omary Muhamad
- Omary Muhamad
- Ong Hean Yee
- Ong Hean Yee
- Oren Ron
- Oren Ron
- Orlikova Olga
- Orlikova Olga
- Pajari Risto
- Pajari Risto
- Pajes Giuseppe
- Pajes Giuseppe
- Pakhomova Inna
- Pakhomova Inna
- Palinkas Attila
- Palinkas Attila
- Parish David
- Parish David
- Patki Nitin
- Patki Nitin
- Peberdy Mary Ann
- Peberdy Mary Ann
- Percoco Dott Giovanni
- Percoco Dott Giovanni
- Perlman Richard
- Perlman Richard
- Perna Eduardo
- Perna Eduardo
- Peterka Martin
- Peterka Martin
- Peura Jennifer
- Peura Jennifer
- Phillips Roland
- Phillips Roland
- Picard François
- Picard François
- Pietilä Mikko
- Pietilä Mikko
- Pinna Jorge Garcia
- Pinna Jorge Garcia
- Piovaccari Giancarlo
- Piovaccari Giancarlo
- Pirelli Salvatore
- Pirelli Salvatore
- Poliacik Pavol
- Poliacik Pavol
- Poy Carlos
- Poy Carlos
- Premchand Rajendra
- Premchand Rajendra
- Prondzinsky Roland
- Prondzinsky Roland
- Quintero Adalberto
- Quintero Adalberto
- Ramos Silvina
- Ramos Silvina
- Ravikishore A.G.
- Ravikishore A.G.
- Reddy P. Naveen
- Reddy P. Naveen
- Reichert Petr
- Reichert Petr
- Reis Gilmar
- Reis Gilmar
- Remppis Bjoern
- Remppis Bjoern
- Roehnisch Jens-Uwe
- Roehnisch Jens-Uwe
- Romanowski Witold
- Romanowski Witold
- Rosocha Stefan
- Rosocha Stefan
- Rossol Siegbert
- Rossol Siegbert
- Rotter Achim
- Rotter Achim
- Santini Alberto
- Santini Alberto
- Santosh M.J.
- Santosh M.J.
- Saraiva Jose
- Saraiva Jose
- Schaufelberger Maria
- Schaufelberger Maria
- Schellong Sebastian
- Schellong Sebastian
- Schwinger Robert
- Schwinger Robert
- Schygiel Pablo
- Schygiel Pablo
- Selles Manuel Martinez
- Selles Manuel Martinez
- Severi Silvia
- Severi Silvia
- Sheppard Richard
- Sheppard Richard
- Shochat Michael
- Shochat Michael
- Shogenov Zaur
- Shogenov Zaur
- Shvarts Yury
- Shvarts Yury
- Simanenkov Vladimir
- Simanenkov Vladimir
- Sirotiakova Jana
- Sirotiakova Jana
- Sitnikova Maria
- Sitnikova Maria
- Skalina Ivan
- Skalina Ivan
- Smolders Walter
- Smolders Walter
- Solar Miroslav
- Solar Miroslav
- Solomon Scott D.
- Soriano FranciscoRidocci
- Soriano FranciscoRidocci
- Sosa Carlos
- Sosa Carlos
- Spinar Jindrich
- Spinar Jindrich
- Stancak Branislav
- Stancak Branislav
- Stawowy Philipp
- Stawowy Philipp
- Stewart Robert
- Stewart Robert
- Striekwold Harry
- Striekwold Harry
- Sussex Bruce
- Sussex Bruce
- Szachniewicz Joanna
- Szachniewicz Joanna
- Szelemej Roman
- Szelemej Roman
- Szentivanyi Miroslav
- Szentivanyi Miroslav
- Tebbe Ulrich
- Tebbe Ulrich
- Tereschenko Sergey
- Tereschenko Sergey
- Tomcsanyi Janos
- Tomcsanyi Janos
- Torres Adriana
- Torres Adriana
- Toth Kalman
- Toth Kalman
- Toth Peter
- Toth Peter
- Tranquilino Francisco P.
- Tranquilino Francisco P.
- Tyrenko Vadim
- Tyrenko Vadim
- Tyurina Tatiana
- Tyurina Tatiana
- Ullman Bengt
- Ullman Bengt
- Ural Dilek
- Ural Dilek
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhaecke Johan
- Vanhaecke Johan
- Vassanelli Corrado
- Vassanelli Corrado
- Vertes Andras
- Vertes Andras
- Vervoort Geert
- Vervoort Geert
- Vicho Raul
- Vicho Raul
- Vico Marisa
- Vico Marisa
- Viecca Maurizio
- Viecca Maurizio
- Vintila Marius
- Vintila Marius
- Visconti Luigi Oltrona
- Visconti Luigi Oltrona
- Vishnevsky Alexandr
- Vishnevsky Alexandr
- Vita Nestor
- Vita Nestor
- Vladoianu Mircea
- Vladoianu Mircea
- Volpe Massimo
- Volpe Massimo
- von Scheidt Wolfgang
- von Scheidt Wolfgang
- Vrolix Mathias
- Vrolix Mathias
- Werner Dierk
- Werner Dierk
- Werner Nikos
- Werner Nikos
- Wexler Dov
- Wexler Dov
- Wierzchowiecki Jerzy
- Wierzchowiecki Jerzy
- Williams Celeste
- Williams Celeste
- Winterton John
- Winterton John
- Wong Raymond
- Wong Raymond
- Wysokinski Andrzej
- Wysokinski Andrzej
- Yigit Zerrin
- Yigit Zerrin
- Yilmaz Mehmet
- Yilmaz Mehmet
- Yokusoglu Mehmet
- Yokusoglu Mehmet
- Yu Wen-Chung
- Yu Wen-Chung
- ZacĂ Valerio
- ZacĂ Valerio
- Zadionchenko Vladimir
- Zadionchenko Vladimir
- Zamolyi Karoly
- Zamolyi Karoly
- Zannad Faiez
- Zolty Ronald
- Zolty Ronald
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D
Anti IgE antibody as treatment of allergic bronchopulmonary aspergillosis in a patient with cystic fibrosis.
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Allergic bronchopulmonary aspergillosis (ABPA) occurs in 7-9% of patients with cystic fibrosis (CF) and causes a worsening of lung function and respiratory symptoms. Standard treatment of ABPA consists of oral steroids; however, higher corticosteroid therapy associated to antifungal agent (itraconazole) long-term treatments are often required to reduce respiratory exacerbations and to prevent progressive lung damage. Here we describe the case of a girl with CF who experienced clinical and functional improvement over 12-months treatment with omalizumab. At birth, our patient was diagnosed with mild-to-moderate CF and from childhood she underwent annual cycles of antibiotic and corticosteroid therapies. At 12 years, she presented with a worsening respiratory condition, asthma symptoms and reduced lung function (FEV1 of 78%). Blood tests showed an increased concentration of plasma total IgE and positive specific IgE antibodies to Aspergillus fumigatus; allergic skin tests were also positive for A. fumigatus. The patient started steroid therapy but had impaired glucose tolerance due to long-term steroid use. Subcutaneous omalizumab 300 mg every two weeks was initiated and after 14 weeks she had improved respiratory symptoms (FEV1 99%) and a marked reduction in the use of systemic antibiotic and corticosteroid therapies. No side effects were reported. Our case shows that therapy with omalizumab for a prolonged period can resolve symptoms of asthma
Impatto dei farmaci modulatori della proteina CFTR sulle alterazioni dell’asse GH – IGF-1 in pazienti adulti affetti da Fibrosi Cistica
- Author
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Allelic Variants Relate to Shifts in Faecal Microbiota of Cystic Fibrosis Patients
- Author
- A Schwiertz
- AA Pezzulo
- AF Goddard
- Antonella Gagliardi
- Antonella Stamato
- C Castellani
- C De Filippo
- C Wiuf
- CD Packey
- CW Lees
- D Borowitz
- DN Frank
- EF Tizzano
- EG Zoetendal
- EG Zoetendal
- Floriana Santangelo
- G Biasucci
- G Casaccia
- G Duytschaever
- G Le Blay
- GB Rogers
- H Roh
- H Sokol
- J Chow
- J Chow
- JL Fridge
- JM Lee
- LE Gibson
- M Li
- M Lucarelli
- M Marzorati
- Marco Lucarelli
- Maria Pia Conte
- MJ Cox
- MP Conte
- N Ahmed
- N Lewiston
- Neeraj Vij
- PB Davis
- R Harper-Owen
- RC Boucher
- RE Ley
- RF Wang
- Riccardo Valerio De Biase
- RK Rowntree
- S Keely
- S Schippa
- S Schippa
- Serena Quattrucci
- Serena Schippa
- Serenella Bertasi
- T Matsuki
- U Nubel
- V Iebba
- V Iebba
- Valerio Iebba
- WE Moore
- ZA Khachatryan
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
- Author
- Adriana Agostinone
- Adriano Basile
- Adriano Gravina
- Adriano Gravina
- Adriano Peris
- Agata Belsito
- Agostino Tafuri
- Alarico Ariani
- Alberto Baratta
- Alberto Catania
- Alberto Guerra
- Alberto Maraolo
- Alberto Papi
- Alberto Ricchiardi
- Alberto Rossi
- Alberto Scala
- Alberto Tedeschi
- Aldo Roccaro
- Alessandra Brocchieri
- Alessandra Cattaneo
- Alessandra Ferrari
- Alessandra Manini
- Alessandra Maria Cemuschi
- Alessandra Mecozzi
- Alessandra Prozzo
- Alessandra Tebaldi
- Alessandra Versaci
- Alessandro Bordonali
- Alessandro Cerutti
- Alessandro Di Filippo
- Alessandro Ferrari
- Alessandro Mastroianni
- Alessandro Meli
- Alessandro Morettini
- Alessandro Olivetti
- Alessandro Scartabellati
- Alessia Pisterna
- Alessia Zunino
- Alessio Lipari
- Alessio Maroccia
- Alessio Pampaloni
- Alessio Peregrinelli
- Alex Hofer
- Alfonso Masullo
- Alfonso Savio
- Alfredo Marinelli
- Alfredo Molteni
- Alfredo Molteni
- Alfredo Vallone
- Alice Moroni
- Alice Repossi
- Amalia Buglione
- Ambrogio Curtolo
- Amelia Filippelli
- Anacleto Romano
- Anaflorina Matei
- Andrea Angheben
- Andrea Ansuini
- Andrea Antonini
- Andrea Ballarin
- Andrea Ballotta
- Andrea Bellone
- Andrea Bianchin
- Andrea Biondi
- Andrea Boschi
- Andrea Calcagno
- Andrea Caruso
- Andrea Castellan
- Andrea Dalbeni
- Andrea De Monte
- Andrea De Vito
- Andrea Di Lorenzo
- Andrea Doria
- Andrea Fadda
- Andrea Frascati
- Andrea Gallo
- Andrea Giachi
- Andrea Magnaca
- Andrea Manzi
- Andrea Marco Machiavelli
- Andrea Marino
- Andrea Montisci
- Andrea Nico
- Andrea Pignatti
- Andrea Tedesco
- Andrea Ticinesi
- Andrea Tosti
- Andrea Verhovez
- Andrea Vianello
- Andrea Zuccarini
- Angel Bianchetti
- Angela Beltrame
- Angela Daniela Zeme
- Angela Iuorio
- Angela Succu
- Angelo Amaglio
- Angelo Gardellini
- Angelo Regazzetti
- Angelo Storti
- Angelo Vetica
- Anna Annunziata
- Anna Carraro
- Anna Gandino
- Anna Laura Nardecchia
- Anna Lingua
- Anna Mandelli
- Anna Maria Bella
- Anna Maria Caputo
- Anna Maria Cattelan
- Anna Maria Di Carlo
- Anna Maria Marata
- Anna Maria Salerno
- Anna Paini
- Anna Panaccione
- Anna Pensa
- Anna Petrone
- Annalisa Brianti
- Annalisa Campomori
- Annalisa Filtz
- Annalisa Mancini
- Annalisa Saracino
- Annamaria Corsaro
- Annamaria Romano
- Annamaria Ruggieri
- Annunziata De Rosa
- Anselmo Riccio
- Antoenlla Grisolia
- Antonella Bianco
- Antonella Caminati
- Antonella D'arminio Monforte
- Antonella Farina
- Antonella Frattari
- Antonella Lucci
- Antonella Nava
- Antonella Puorto
- Antonella Rossati
- Antonella Sangiovanni
- Antonella Sarni
- Antonella Vincenti
- Antonello Ciccone
- Antonello Pietrangelo
- Antonia Del Giudice
- Antonia Nucera
- Antonia Nuceri
- Antonia Sdanganelli
- Antonia Ursillo
- Antonietta Barone
- Antonina Carai
- Antonina Franco
- Antonino Mazzone
- Antonio Arcidiacono
- Antonio Capuozzo
- Antonio Carlotto
- Antonio Cherubini
- Antonio Daniele
- Antonio Fioravanti
- Antonio Greco
- Antonio Maria Agrati
- Antonio Mastroianni
- Antonio Messina
- Antonio Nouvenne
- Antonio Pepe
- Antonio Ponticiello
- Antonio Riccardo Buonomo
- Antonio Scarafino
- Arianna Manini
- Aristodemo Ricioppo
- Armando Alborghetti
- Armando Leone
- Armando Santoro
- Arturo Ciccullo
- Arturo Montineri
- Attilio Antonio Montano Bianchi
- Augusta Consorte
- Balan Dorina
- Barabara Baronio
- Barbara Cimolato
- Barbara Fiorini
- Barbara Mantovani
- Barbara Rossetti
- Barbara Zanini
- Beatrice Gasperini
- Benedetto Maurizio Celesia
- Bernadetta Pasquino
- Bernardino Mastropasqua
- Bianca Iengo
- Blanca Martinez Lopez De Arroyabe
- Blangetti Ilaria
- Blerta Kertusha
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- Publication venue
- Publication date
- 01/01/2021
- Field of study
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
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- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
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- Charles Koo
- Charles Lovell
- Charles Treasure
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- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
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- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
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- Rostislav Polasek
- Ruben Omar Garcia Duran
- Rudolf Smik
- Rudolf Spacek
- Rudolf Uhliar
- Russell Scott
- Ruud van de Wal
- Ryszard Sciborski
- RĂ©mi Sabatier
- Saad Ahmad
- Sabine Genth-Zotz
- Salvador Leon Gonzalez
- Salvador Rassi
- Sana M Al-Khatib
- Sandra Chaparro
- Sanem Nalbantgil
- Sanjay Malhotra
- Sanjeev Saxena
- Sara Llerena
- Sara Soares Goncalves
- Satoru Sakagami
- Scott D Solomon
- Scott Feitell
- Scott Franczek
- Scott McKenzie
- Sebastian Velez Pelaez
- Seigo Masuda
- Seiichiro Gohara
- Sergey Boytsov
- Sergey Tereschenko
- Sergio Leonardi
- Sergio Potthoff
- Serpytis P.
- Shafiq Mamdani
- Shahid Mahmood
- Shamaila Aslam
- Sharpsten L.
- Shaumik Adhya
- Shawn Robinson
- Shelley Zieroth
- Sherryn Roth
- Shigeru Fujii
- Shigeru Fukuzawa
- Shin-Ichi Momomura
- Shinichiro Miura
- Shitoshi Hiroi
- Shogo Oishi
- Shouyan Zhang
- Shreyansh Shah
- Shuaib Abdullah
- Shuichi Taguchi
- Shumei Ma
- Shunsuke Tatebe
- Shuntaro Kagiyama
- Siddique Abbasi
- Silvia Lopez Fernandez
- Sliwa K.
- Snezhanka Tisheva-Gospodinova
- Solomon S. D.
- Sonia Mirabet Perez
- Sonia Sassone
- Soren Vraa
- Sorin Stamate
- Sotirios Patsilinakos
- Sourin Banerji
- Spinar J.
- Stavros Drakos
- Stefan Berglund
- Stefan Störk
- Stephan von Haehling
- Stephanie Olsen
- Stephen Gottlieb
- Stephen Halpern
- Stephen Rennyson
- Steven Forman
- Steven Hearne
- Steven Krueger
- Steven Lupovitch
- Steven Shayani
- Sunder Rao
- Sunil Pauwaa
- Susan Joseph
- Suter T. M.
- Svetlana Dovgolis
- Svetlana Villevalde
- Syed Hasni
- Takaaki Isshiki
- Takahiro Okumura
- Takahiro Tanaka
- Takashi Matsumoto
- Takashi Takenaka
- Takayuki Hidaka
- Takayuki Inomata
- Takeshi Serikawa
- Takeshi Yoshida
- Tamas Forster
- Tariq Haddad
- Tatiana Duarte
- Tayfun Sahin
- Teerlink J. R.
- Terence Hart
- Terrence O'Brien
- Tetsuo Sakai
- Tetsuro Miyazaki
- Tetsuya Amano
- Thao Huynh
- Theodore Frank
- Theodore Takata
- Thibaud Damy
- Thierry Laperche
- Thomas Ashcom
- Thomas Duythuc To
- Thomas Horacek
- Thomas Hucko
- Thomas J Povsic
- Thomas Suter
- Thomas Vanhecke
- Tianfa Li
- Tienush Rassaf
- Timothy Doyle
- Tina Sichrovsky
- Tiziano Moccetti
- Tjeerd Römer
- Tokushi Koga
- Tom Smilde
- Tomas Brabec
- Tomasz Blicharski
- Tomasz Borkowski
- Tomcsanyi J.
- Tomohiro Kawasaki
- Tomohiro Ogawa
- Tomohiro Sakamoto
- Tomomi Koizumi
- Tonny Nielsen
- Tor Biering-Sørensen
- Toru Kubota
- Toshiaki Kadokami
- Toshio Kasai
- Toshiro Terasaki
- Ulf Dahlstrom
- Umit Guray
- Uwe Zeymer
- Valentina Mincheva
- Valerio Zaca
- Valery Popov
- Vandekerckhove H.
- Varin C.
- Vasilios Papademetriou
- Vedampattu Ganeshram
- Venkatesh Nadar
- Vernon Hunter
- Veselin Mitrovic
- Viacheslav Mareev
- Vicente Eduardo Climent Paya
- Victor Aboyans
- Victor Alfonso Jimenez Diaz
- Victor Areli Saavedra Gajardo
- Viktor Kostenko
- Vilma Machova
- Vinay Malhotra
- Vinay Thohan
- Vinereanu D.
- Viorel Florea
- Vira Tseluyko
- Vittorio Giudici
- Viviane Nguyen
- Vladimir Cech
- Vladimir Cotarlan
- Vladimir Nosov
- Vladimir Rafalskiy
- Vladimir Salukhov
- Vladislav Mitrokhin
- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
- Walter Abhayaratna
- Walter Droogne
- Walter Hermans
- Wataru Shimizu
- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
- Wilder Castaño Osorio
- William Anderson
- William Herzog
- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)