2,526 research outputs found

    Leadership Styles in NCAA Division I Athletic Administration and Their Relationships to Job Satisfaction

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    As an industry, college athletics has become a focal point of much attention and scrutiny as a result of increasing moral and ethical scandals, as well as lucrative media and personnel contracts. Scandals such as admissions fraud, academic cheating, and financial crimes are a cause for concern regarding the leadership within Division I athletic departments. Organizational and individual outcomes have been associated with leadership. While extant research has focused on the leadership of coaches and the athletic director, the leadership of the senior-level leadership team has been largely neglected. Given the structure of many Division I athletic departments, the senior-level leadership team has significant supervisory responsibilities and is therefore worth examination. This dissertation explores the leadership styles of senior-level athletic administrators by surveying their mid-level followers. Utilizing three leadership scales for servant leadership, transactional leadership, and transformational leadership, descriptive statistics reveal which leadership behaviors were observed by followers and to what extent. Further, a job satisfaction scale was used to assess followers’ job satisfaction. Correlational tests were conducted to explore the relationships between three leadership styles—transactional, transformational, and servant—and followers’ job satisfaction. Additionally, multiple regression analyses were conducted to discover the relationships between leadership styles and job satisfaction while controlling for race and gender. The data produced by this study revealed that the three leadership styles were observed to a similar extent. Moreover, all three leadership styles were moderately correlated with job satisfaction, with servant leadership having the strongest relationship. For the covariates of race and gender, the data revealed that White respondents and male respondents reported the highest job satisfaction in association with transformational leadership. Servant leadership was associated with the highest job satisfaction for Black iv respondents and female respondents, and transactional leadership saw the highest job satisfaction for Asian respondents. This study fills gaps in the extant literature by focusing on the leadership of the senior-level leadership team, and the results can inform the leadership development of senior-level administrators to improve job satisfaction among followers

    Cultivating The Chicano/Latina/O/X Faculty Pipeline Across Hispanic Serving Institutions (HSI) Systems: The Potential Role Of HSRIs In Transforming The Professoriate

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    The production of Chicano/Latino faculty has remained stagnant over the past 20 years, in part due to limitations in the production of doctoral students, hiring Latino faculty, and uneven experiences in graduate school. This article provides important findings related to the production of Latinx doctoral students and faculty in California, at a time when all public systems of education are HSI systems in the state. Latinx ladder rank faculty remain below five percent and doctoral student enrollment has remained stagnant, between 9 to 11% since 1998. Implications and recommendations for improving Latinx graduate student outcomes are also presented

    Sentinel lymph node biopsy and axillary reverse mapping: a tailoring axillary staging in breast cancer

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    peer reviewedThe status of the axillary lymph nodes is one of the most important prognostic factors in women with early stage breast cancer. Histologic examination of removed lymph nodes is the most accurate method for assessing spread of disease to these nodes. Axillary lymph node dissection (ALND) remains the standard approach for women who have clinically palpable axillary nodes. The benefits of ALND include its impact on disease control (axillary recurrence and survival), its prognostic value, and its role in treatment selection. However, the anatomic disruption caused by ALND may result in lymphedema, nerve injury, and shoulder dysfunction, which compromise functionality and quality of life. For patients who have clinically negative axillary lymph nodes, sentinel lymph node (SLN) biopsy offers a less morbid method to determine if there are positive nodes, in which case axillary node dissection would be necessary. Patients who are SLN-positive should undergo complete ALND. Axillary reverse mapping (ARM) is a recent improvement of ALND which, like the biopsy of the GS, would reduce morbidity

    EnMonitor: Experimentation over Large-scale Semantically Annotated Federated IoT data environment

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    Submitted to WWW 2018 Demo TrackIoT applications are usually built on top of proprietary platforms that collect data from IoT devices. Furthermore, most applications rely on proprietary datasets, coming from their own sources. Thereby needing to deal with issues like interoperability and heterogeneity in the data. A solution is to add another layer (a platform in the middle that addresses the above-mentioned issues) and then build applications that use data made available via such platforms. As a proof of concept, we present EnMonitor, a prototype application, that is built on top of one such platform, called FIESTA-IoT. The application provides citizens with an understanding of the environment they live in with both local and global surrounding view

    Translating Evidence-Based Policy to Practice: A Multilevel Partnership Using the Interactive Systems Framework

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    This is the published version, made available with the permission of the publisher.Despite increases in federal allocations, little is known about how to ensure successful implementation of evidence-based programs. This descriptive case study using the Interactive Systems Framework for Dissemination and Implementation illustrates the Prevention Support System (PSS) implemented for one federal evidence-based policy initiative. Exploring perspectives of intermediary organizations, the article describes the impetus for promoting evidence-based programming, multilevel systemic change, and the collaborations to develop strategic partnerships between national and state entities. Two early adopters, Kansas and Nebraska, illustrate the general capacity-building technical assistance activities conducted to build a multilevel PSS. The article concludes with outcomes, lessons learned, and recommendations for building stronger implementation capacity

    Characterisation of the Stromal Microenvironment in Lobular Breast Cancer

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    SIMPLE SUMMARY: Invasive lobular breast cancer (ILC) accounts for approximately 5–15% of breast cancers, and although response rates to treatments are initially good, an ILC diagnosis is associated with adverse long-term outcomes; better treatments, specifically targeted to this sub-type of breast cancer, are required to improve patient survival. The tumor microenvironment (TME) plays an important role in determining how cancers respond to treatment, and in this study, we carried out an in-depth analysis of the TME in ILC following laser-capture microdissection of the tumor stroma, and analysis of primary cancer-associated fibroblasts (CAFs), which comprise the majority of non-malignant cells within tumors. This identified changes in genes involved in regulation of the extracellular matrix and also growth factor signaling pathways that were differentially regulated in ILC. Further analysis of breast cancer datasets showed that two of these genes which encode a secreted metalloproteinase (PAPPA) and a metalloproteinase inhibitor (TIMP2) were associated with survival outcomes in ILC. ABSTRACT: Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer, and it exhibits a number of clinico-pathological characteristics distinct from the more common invasive ductal carcinoma (IDC). We set out to identify alterations in the tumor microenvironment (TME) of ILC. We used laser-capture microdissection to separate tumor epithelium from stroma in 23 ER+ ILC primary tumors. Gene expression analysis identified 45 genes involved in regulation of the extracellular matrix (ECM) that were enriched in the non-immune stroma of ILC, but not in non-immune stroma from ER+ IDC or normal breast. Of these, 10 were expressed in cancer-associated fibroblasts (CAFs) and were increased in ILC compared to IDC in bulk gene expression datasets, with PAPPA and TIMP2 being associated with better survival in ILC but not IDC. PAPPA, a gene involved in IGF-1 signaling, was the most enriched in the stroma compared to the tumor epithelial compartment in ILC. Analysis of PAPPA- and IGF1-associated genes identified a paracrine signaling pathway, and active PAPP-A was shown to be secreted from primary CAFs. This is the first study to demonstrate molecular differences in the TME between ILC and IDC identifying differences in matrix organization and growth factor signaling pathways

    An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT(TM) is functionally superior to Freund's adjuvant

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    Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, the chronically immunosuppressed, pregnant women, infants and those with chronic diseases. The aim of this study was to optimise current methods used to generate ovine polyclonal antibodies. Polyclonal antibodies to baculovirus-expressed recombinant influenza haemagglutinin from A/Puerto Rico/8/1934 H1N1 (PR8) were elicited in sheep using various immunisation regimens designed to investigate the priming immunisation route, adjuvant formulation, sheep age, and antigen dose, and to empirically ascertain which combination maximised antibody output. The novel adjuvant CoVaccine HT™ was compared to Freund’s adjuvant which is currently the adjuvant of choice for commercial production of ovine polyclonal Fab therapies. CoVaccine HT™ induced significantly higher titres of functional ovine anti-haemagglutinin IgG than Freund’s adjuvant but with fewer side effects, including reduced site reactions. Polyclonal hyperimmune sheep sera effectively neutralised influenza virus in vitro and, when given before or after influenza virus challenge, prevented the death of infected mice. Neither the age of the sheep nor the route of antigen administration appeared to influence antibody titre. Moreover, reducing the administrated dose of haemagglutinin antigen minimally affected antibody titre. Together, these results suggest a cost effective way of producing high and sustained yields of functional ovine polyclonal antibodies specifically for the prevention and treatment of globally significant diseases.Natalie E. Stevens, Cara K. Fraser, Mohammed Alsharifi, Michael P. Brown, Kerrilyn R. Diener, John D. Haybal

    Regulatory and demo assessment of proposed integrated markets

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    This deliverable, which is part of the Horizon 2020 OneNet project, outlines the alignment activities carried out in OneNet Task 3.4, focusing on integrating the proposed electricity market concepts with demonstrator findings and regulatory aspects. It includes a regulatory study on demand response in electricity markets and ancillary services, consultations within the project, and an external workshop. The study delves into three issues, which are currently attracting much debate: baselining of demand response, prequalification of flexiblity resources, and local market operation, providing insights from literature and OneNet demonstrator experiences. Choices in these areas impact simplicity, accuracy, and integrity. The consultations addressed market integration issues, while the external workshop gathered feedback from external stakeholders to refine proposed solutions and market designs. The document highlights ongoing developments in EU regulations and initiatives related to flexibility.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 957739

    Light-intensity physical activity and cardiometabolic biomarkers in US adolescents

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    BackgroundThe minimal physical activity intensity that would confer health benefits among adolescents is unknown. The purpose of this study was to examine the associations of accelerometer-derived light-intensity (split into low and high) physical activity, and moderate- to vigorous-intensity physical activity with cardiometabolic biomarkers in a large population-based sample.MethodsThe study is based on 1,731 adolescents, aged 12&ndash;19 years from the 2003/04 and 2005/06 National Health and Nutrition Examination Survey. Low light-intensity activity (100&ndash;799 counts/min), high light-intensity activity (800 counts/min to &lt;4 METs) and moderate- to vigorous-intensity activity (&ge;4 METs, Freedson age-specific equation) were accelerometer-derived. Cardiometabolic biomarkers, including waist circumference, systolic blood pressure, diastolic blood pressure, HDL-cholesterol, and C-reactive protein were measured. Triglycerides, LDL- cholesterol, insulin, glucose, and homeostatic model assessments of &beta;-cell function (HOMA-%B) and insulin sensitivity (HOMA-%S) were also measured in a fasting sub-sample (n=807).ResultsAdjusted for confounders, each additional hour/day of low light-intensity activity was associated with 0.59 (95% CI: 1.18&ndash;0.01) mmHG lower diastolic blood pressure. Each additional hour/day of high light-intensity activity was associated with 1.67 (2.94&ndash;0.39) mmHG lower diastolic blood pressure and 0.04 (0.001&ndash;0.07) mmol/L higher HDL-cholesterol. Each additional hour/day of moderate- to vigorous-intensity activity was associated with 3.54 (5.73&ndash;1.35) mmHG lower systolic blood pressure, 5.49 (1.11&ndash;9.77)% lower waist circumference, 25.87 (6.08&ndash;49.34)% lower insulin, and 16.18 (4.92&ndash;28.53)% higher HOMA-%S.ConclusionsTime spent in low light-intensity physical activity and high light-intensity physical activity had some favorable associations with biomarkers. Consistent with current physical activity recommendations for adolescents, moderate- to vigorous-intensity activity had favorable associations with many cardiometabolic biomarkers. While increasing MVPA should still be a public health priority, further studies are needed to identify dose-response relationships for light-intensity activity thresholds to inform future recommendations and interventions for adolescents.</div
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