Manfredo Tafuri. Studi, incontri, opere 1935-1994

Il documento presenta una geografia del pensiero, degli scritti, degli studi e delle figure che più hanno caratterizzato la vita e la ricerca di Manfredo Tafuri. Il periodo scelto è quello di tutto l'arco della sua vita, dalla nascita nel 1935 alla sua prematura scomparsa nel 1994

Results, questions, perspectives of a study on human polyomavirus BK and molecular actors in prostate cancer development

Background: Prostate cancer (PC) is a common tumor in Western countries. Several risk factors play significant roles. MYC, BIRC5/survivin, CDC25 and P53 may contribute to PC risk. As demonstrated, human Polyomavirus BK (BKV) could affect cellular homeostasis contributing to PC pathogenesis. Materials and Methods: Biological samples were collected from PC patients. Viral RNA was searched using quantitative polymerase chain reaction (PCR), whereas a qualitative PCR was employed to find particular viral sequences. Proper size amplicons were analyzed. Single nucleotide polymorphisms (SNPs) were detected in p53 coding regions by means of a specific PCR. C-MYC, BIRC5/survivin and CDC25 gene expression was investigated using a Retro Transcriptional Quantitative PCR. Results: Viral DNA copy number was higher in cancer tissues taken from Gleason score 9 patients with Gleason score 7. Different p53 mutated compared to patients exons were found according to tumor advanced stage and a statistical significant correlation was found between Gleason score and p53 mutational rate. C-MYC, BIRC5/survivin and CDC25 expression was de-regulated according to the literature. Conclusion: The presence of BKV and its variants in transformed cells does not exclude viral pressure in cell immortalization. Expression of other target genes evidenced a significant change in their regulation, useful for cancer drug discovery and therapies

High frequency of JCV DNA detection in prostate cancer tissues

BACKGROUND: Prostate cancer (PC) represents the most frequently diagnosed cancer in men. Exposure to infectious agents has been considered to induce prostatic inflammation and cancerous transformation. Controversial data exist concerning the role of the human polyomaviruses BK (BKV) and JC (JCV) in PC etiology. Therefore, a possible association between these polyomaviruses and PC was investigated. MATERIALS AND METHODS: Urine, blood and fresh prostatic tissue specimens were collected from 26 patients with PC. The presence of BKV and JCV, the possible non-coding control region (NCCR) variations and the genotyping analysis of viral protein 1 (VP1) of both viruses were assessed. RESULTS: Data showed a preferential viral re-activation in the urinary compartment and a statistically significant prevalence of JC viruria and of BKV in PC tissues. A BKV DDP-like NCCR sequence was isolated in two patients, whereas JCV NCCR was consistently of an archetypal structural organization. A prevalence of the European genotypes was observed for both viruses. CONCLUSION: Our data demonstrated the presence of JCV DNA in 14/24 (58.3%) cancerous prostatic tissue specimens, confirming the results obtained in a previous study, in which JCV has been defined as common inhabitant of the prostate, and opening the discussion about its potential role in PC

LA INTERCOMPRENSIÓN EN LENGUAS GERMÁNICAS EN EL CONTEXTO HISPANOHABLANTE

El presente trabajo describe tres etapas del proyecto “Intercomprensión en Lenguas Germánicas para Hispanohablantes: inglés, alemán y neerlandés”, que se lleva a cabo en la Facultad de Lenguas de la Universidad Nacional de Córdoba en Argentina, desde 2012. En sus etapas 2012-2013 y 2014-2015, el objetivo principal fue el diseño de materiales para el desarrollo de la lectura comprensiva simultánea en las lenguas meta; estas etapas culminaron con la publicación de un manual, primero y único de estas características. Actualmente, el equipo, conformado por docentes, egresadas y estudiantes de las secciones inglés y alemán de la mencionada institución, se encuentra abocado al estudio de las estrategias que aplican los alumnos meta en la intercomprensión

Principios Metodológico - didácticos en Interger : manual de intercomprensión en lenguas germánicas para hispanohablantes

El presente trabajo se centra en la descripción y fundamentación de las características del primer manual de intercomprensión en lenguas germánicas para hispanohablantes con conocimientos de inglés producido en el mundo hispanoparlante. Se trata de Interger: Manual de intercomprensión en Lenguas Germánicas (Lauría de Gentile, Merzig, Trovarelli, van Muylem y Wilke, 2016), diseñado por un equipo de investigación en el área de la Lingüística Aplicada de la Facultad de Lenguas en la Universidad Nacional de Córdoba, el cual entre 2012 y 2015 estuvo abocado al desarrollo de materiales de aprendizaje para la intercomprensión en alemán y neerlandés, para hispanohablantes con conocimientos básicos de inglés. La investigación en diseño de materiales contó con varias instancias de investigación cualitativa que permitieron la puesta a prueba, evaluación, posteriores ajustes y edición final de los materiales. Esta ponencia describe las diversas fases que involucró el diseño de este manual, así como los principios metodológicos que subyacen al mismo y que le confieren las características distintivas que se describirán brevemente.https://ieslvf-caba.infd.edu.ar/sitio/upload/Actas_IV_Jornadas_Internacionales_2017.pdfFil: Wilke, Valeria. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Fil: Lauría de Gentile, Patricia. Universidad Nacional de Córdoba. Facultad de Lenguas; Argentina.Otras Lengua y Literatur

Unilateral NMR: a Noninvasive Tool for Monitoring In Situ the Effectiveness of Intervention to Reduce the Capillary Raise of Water in an Ancient Deteriorated Wall Painting

Portable unilateral NMR was used to quantitatively map in a fully noninvasive way the moisture distribution in an ancient deteriorated wall painting before and after an intervention to reduce the capillary raise of water through the wall. Maps obtained at a depth of 0.5 cm clearly showed the path of the capillary raise and indicated that, after the intervention, the moisture level was reduced. Maps obtained by measuring the first layers of the wall painting were affected by the critical environmental conditions of the second hypogeous level of St. Clement Basilica, Rome, and by the presence of salts efflorescence and encrustations on the surface of the wall painting. The morphology and the elemental composition of salts investigated by SEM-EDS indicated that efflorescences and encrustations were mostly constituted of gypsum and calcite. The presence of these salts is explained with the presence of high concentration of carbon dioxide and sulphur-rich particles due to pollution which, along with the high-moisture level and the extremely feeble air circulation, cause recarbonation and sulphation processes on the plaster surface

El modelo TPACK, la Investigación en ILG y el diseño de materiales digitales.

Este trabajo se propone describir el proyecto de investigación “Intercomprensión en lenguas germánicas (ILG) para hispanohablantes: Diseño de materiales digitales” presentado en el marco de la nueva convocatoria de proyectos de la SECyT, UNC, que se lleva a cabo entre 2018 y 2021. Tendrá como objetivo general el diseño de una propuesta metodológica para un curso de ILG en un entorno virtual destinado a alumnos adultos hispanohablantes con conocimientos básicos de inglés (nivel A2). Nuestro equipo de investigación tiene una trayectoria amplia en el estudio de laIntercomprensión en Lenguas Germánicas y en el diseño de materiales en formato papel. Sin embargo, el desarrollo de materiales digitales se presenta como un desafío que es necesario afrontar, dados los cambios generados en todos los ámbitos de la sociedad a raíz de la omnipresencia de las TIC, y en los que la educación no constituye la excepción. Estos cambios conllevan el desarrollo de nuevas formas de enseñar y aprender. Un curso en línea permitirá el acceso a la lectura comprensiva simultánea en las lenguas emparentadas, alemán y neerlandés, a todo adulto hispanohablante que posea conocimientos de inglés, que funcionará como lengua puente. Consideramos que el curso virtual que se diseñe como resultado de este proyecto constituirá una herramienta de acceso libre a la intercomprensión en el contexto latinoamericano hispanoparlante

Maternal alexithymia and attachment style: Which relationship with their children's headache features and psychological profile?

Introduction: A growing body of literature has shown an association between somatic symptoms and insecure "attachment style." In a recent study, we found a relationship between migraine severity, ambivalent attachment style, and psychological symptoms in children/adolescents. There is evidence that caregivers' attachment styles and their way of management/expression of emotions can influence children's psychological profile and pain expression. To date, data dealing with headache are scarce. Our aim was to study the role of maternal alexithymia and attachment style on their children's migraine severity, attachment style, and psychological profile. Materials and methods: We enrolled 84 consecutive patients suffering from migraine without aura (female: 45, male: 39; mean age 11.8 ± 2.4 years). According to headache frequency, children/adolescents were divided into two groups: (1) high frequency (patients reporting from weekly to daily attacks), and (2) low frequency (patients having ≤3 episodes per month). We divided headache attacks intensity into two groups (mild and severe pain). SAFA "Anxiety," "Depression," and "Somatization" scales were used to explore children's psychological profile. To evaluate attachment style, the semi-projective test SAT for patients and ASQ Questionnaire for mothers were employed. Maternal alexithymia traits were assessed by TAS-20. Results: We found a significant higher score in maternal alexithymia levels in children classified as "ambivalent," compared to those classified as "avoiding" (Total scale: p = 0.011). A positive correlation has been identified between mother's TAS-20 Total score and the children's SAFA-A Total score (p = 0.026). In particular, positive correlations were found between maternal alexithymia and children's "Separation anxiety" (p = 0.009) and "School anxiety" (p = 0.015) subscales. Maternal "Externally-oriented thinking" subscale correlated with children's school anxiety (p = 0.050). Moreover, we found a correlation between TAS-20 Total score and SAFA-D "Feeling of guilt" subscale (p = 0.014). Our data showed no relationship between TAS-20 and ASQ questionnaires and children's migraine intensity and frequency. Conclusion: Maternal alexithymia and attachment style have no impact on children's migraine severity. However, our results suggest that, although maternal alexithymic traits have no causative roles on children's migraine severity, they show a relationship with patients' attachment style and psychological symptoms, which in turn may impact on migraine severity