Astrophysical and Cosmological Tests of Quantum Theory

We discuss several proposals for astrophysical and cosmological tests of quantum theory. The tests are motivated by deterministic hidden-variables theories, and in particular by the view that quantum physics is merely an effective theory of an equilibrium state. The proposed tests involve searching for nonequilibrium violations of quantum theory in: primordial inflaton fluctuations imprinted on the cosmic microwave background, relic cosmological particles, Hawking radiation, photons with entangled partners inside black holes, neutrino oscillations, and particles from very distant sources.Comment: 25 pages. Amendment to section 7. Contribution to: "The Quantum Universe", special issue of Journal of Physics A, dedicated to Prof. G.-C. Ghirardi on the occasion of his seventieth birthda

EXPERIMENTAL AND MODELLING APPROACHES TO INVESTIGATE OPTICAL PROPERTIES OF ATMOSPHERIC AEROSOL

The aerosol scientific community has a strong interest in improving knowledge about aerosol physical-chemical properties and measurement methodologies due to the large uncertainties still affecting estimates of aerosol optical properties and their impact on climate, visibility, and air quality. Therefore, in this PhD work, the contribution to this research field was mainly devoted to the study and implementation of experimental and modelling approaches aiming at filling some gaps in the current knowledge about absorption and scattering properties of atmospheric aerosols. On-line and off-line instrumentation was employed to investigate aerosol optical properties. The set-up and operation of the polar photometer developed by the Environmental Physics research group of the University of Milan (PP_UniMI) were optimised for the analyses of several filter samples of various types and sizes, collected during different campaigns also in the frame of collaborative projects. Several approaches were developed and exploited to investigate biases affecting outputs of widespread on-line instrumentation; truncation error correction in scattering measurements was deeply examined and in-situ techniques to measure aerosol absorption coefficient were analysed and compared to filter-based methods (both on-line and off-line), obtaining results that could be of large interest for the scientific community and deserve further investigation. The application of the widespread IMPROVE algorithm - used to estimate light extinction - at polluted urban sites was investigated, and a tailored approach was developed for typical characteristics of wintertime aerosol in Milan (Italy). The aerosol extinction coefficient reconstructed with this model for a PM1 dataset was apportioned among emission sources identified applying a receptor model. High-time resolved multi-wavelength aerosol optical properties measured in Rome (Italy) during the collaborative project CARE (Carbonaceous Aerosol in Rome and Environs) were investigated to find out an original methodology to distinguish aerosol types based on the combination of several intensive optical parameters. This approach could be useful in monitoring networks to discriminate in near-real-time between pollution vs. natural sources-driven high PM events

Cepstral analysis based on the Glimpse proportion measure for improving the intelligibility of HMM-based synthetic speech in noise

In this paper we introduce a new cepstral coefficient extraction method based on an intelligibility measure for speech in noise, the Glimpse Proportion measure. This new method aims to increase the intelligibility of speech in noise by modifying the clean speech, and has applications in scenarios such as public announcement and car navigation systems. We first explain how the Glimpse Proportion measure operates and further show how we approximated it to integrate it into an existing spectral envelope parameter extraction method commonly used in the HMM-based speech synthesis framework. We then demonstrate how this new method changes the modelled spectrum according to the characteristics of the noise and show results for a listening test with vocoded and HMM-based synthetic speech. The test indicates that the proposed method can significantly improve intelligibility of synthetic speech in speech shaped noise. Index Terms — cepstral coefficient extraction, objective measure for speech intelligibility, Lombard speech, HMM-based speech synthesis 1

Inflationary Cosmology as a Probe of Primordial Quantum Mechanics

We show that inflationary cosmology may be used to test the statistical predictions of quantum theory at very short distances and at very early times. Hidden-variables theories, such as the pilot-wave theory of de Broglie and Bohm, allow the existence of vacuum states with non-standard field fluctuations ('quantum nonequilibrium'). We show that inflationary expansion can transfer microscopic nonequilibrium to macroscopic scales, resulting in anomalous power spectra for the cosmic microwave background. The conclusions depend only weakly on the details of the de Broglie-Bohm dynamics. We discuss, in particular, the nonequilibrium breaking of scale invariance for the primordial (scalar) power spectrum. We also show how nonequilibrium can generate primordial perturbations with non-random phases and inter-mode correlations (primordial non-Gaussianity). We address the possibility of a low-power anomaly at large angular scales, and show how it might arise from a nonequilibrium suppression of quantum noise. Recent observations are used to set an approximate bound on violations of quantum theory in the early universe.Comment: 44 pages. Minor changes in v

Microarray gene expression profiling of neural tissues in bovine spastic paresis

Abstract: Background: Bovine Spastic Paresis (BSP) is a neuromuscular disorder which affects both male and female cattle. BSP is characterized by spastic contraction and overextension of the gastrocnemious muscle of one or both limbs and is associated with a scarce increase in body weight. This disease seems to be caused by an autosomal and recessive gene, with incomplete penetration, although no genes clearly involved with its onset have been so far identified. We employed cDNA microarrays to identify metabolic pathways affected by BSP in Romagnola cattle breed. Investigation of those pathways at the genome level can help to understand this disease. Results: Microarray analysis of control and affected individuals resulted in 268 differentially expressed genes. These genes were subjected to KEGG pathway functional clustering analysis, revealing that they are predominantly involved in Cell Communication, Signalling Molecules and Interaction and Signal Transduction, Diseases and Nervous System classes. Significantly enriched KEGG pathway's classes for the differentially expressed genes were calculated; interestingly, all those significantly under-expressed in the affected samples are included in Neurodegenerative Diseases. To identify genome locations possibly harbouring gene(s) involved in the disease, the chromosome distribution of the differentially expressed genes was also investigated. Conclusions: The cDNA microarray we used in this study contains a brain library and, even if carrying an incomplete transcriptome representation, it has proven to be a valuable tool allowing us to add useful and new information to a poorly studied disease. By using this tool, we examined nearly 15000 transcripts and analysed gene pathways affected by the disease. Particularly, our data suggest also a defective glycinergic synaptic transmission in the development of the disease and an alteration of calcium signalling proteins. We provide data to acquire knowledge of a genetic disease for which literature still presents poor results and that could be further and specifically analysed in the next future. Moreover this study, performed in livestock, may also harbour molecular information useful for understanding human diseases