Results of adolescent health risk assesment on exposure to habitat water peroral factor in conditions of a large industrial city

Results of the non-carcinogenic risk assessment on ingestion of chemical substances with drinking water showed that the risk value corresponded to the allowable level of the non-carcinogenic risk (HQ ( 1) for the major part of elements in all zones. The excess of the allowable level is observed only in oil products in the 1st zone (2.05) and the 4th zone (1.04). However, the total hazard index (HI) on combined peroral ingestion of chemical compounds and elements with drinking water in selected zones of the city of Kazan implies a low risk level for adolescents living in the 1st and the 4th zones (3.7 and 3.59) correspondingly, and is dangerous for health. According to the results of analysis carried out in all zones, the following basic critical organs and systems were identified: blood, CNS, kidneys, endocrine system, cardiovascular system, skeletal system and teeth. The total hazard indices in the 1st and the 4th zones deserve particular attention

Association of gene polymorphisms with body weight changes in prediabetic patients

Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146. Knowledge of the association between these single nucleotide polymorphisms (SNPs) and body weight changes in different forms of prediabetes treatment is still limited. The aim of this study was to investigate the association of polymorphisms within the MC4R, PPARG, and TCF7L2 genes on the risk of carbohydrate metabolism disorders and body composition changes in overweight or obese patients with early carbohydrate metabolism disorders. From 327 patients, a subgroup of 81 prediabetic female patients (48.7 ± 14.8 years) of Eastern European descent participated in a 3-month study comprised of diet therapy or diet therapy accompanied with metformin treatment. Bioelectrical impedance analysis and genotyping of MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146 polymorphisms were performed. The MC4R CC and TCF7L2 TT genotypes were associated with increased risk of T2D (OR = 1.46, p = 0.05 and OR = 2.47, p = 0.006, respectively). PPARG CC homozygotes experienced increased weight loss; however, no additional improvements were experienced with the addition of metformin. MC4R TT homozygotes who took metformin alongside dietary intervention experienced increased weight loss and reductions in fat mass (p < 0.05). We have shown that the obesity-protective alleles (MC4R T and PPARG C) were positively associated with weight loss efficiency. Furthermore, we confirmed the previous association of the MC4R C and TCF7L2 T alleles with T2D risk. [Abstract copyright: © 2022. The Author(s).

Risk assessment of the rural population health from exposure to polluted food products

In the diet of the rural population, milk, dairy products, meat and meat products, fish, bread, and bread products make the largest contribution to the exposition of cadmium, arsenic, and mercury. The cardiovascular, hormonal, central nervous, immune, reproductive systems, blood, and kidneys are most at risk. Non-carcinogenic risk for imported food products is determined by the systems: Blood, hormonal, central nervous, and reproductive. Materials and Methods: Statistical analysis of the obtained data was implemented operating system Windows 2007 with the application of standard application program packages Excel 2007 and "Statistics v.6.0". Result and Discussion: Comparative analysis of the obtained data revealed that the Republic of Tatarstan had higher indices in the content of pollutants in the fruit and vegetable products

Comprehensive assessment of the carcinogenic risk to adolescent health of chemicals

The value of total carcinogenic risk on peroral, inhalation and dermal routes of entry for the adolescent population in all zones under study corresponded to high risk level, the highest values being observed in the 1st zone (the Kirovsky district), and the lowest ones in the 4th zone (the Privolzhsky district). The priority routes of carcinogen entry into the human body were peroral and inhalation routes. Foods and drinking water, as well as atmospheric air were revealed to be the leading substance transport media in forming individual carcinogenic risk. The major carcinogens forming risk were lead (1.36Е-04), chloroform (1.20Е-04) and cadmium (7.09E-04) entering with water and arsenic (8.38Е-05) &ndash; with soil. The leading position among atmospheric air carcinogens in all city zones under study belonged to soot (5.51Е-04). The priority pollutant present in foods and defining carcinogenic health risk was lead (2.02E-03). Complex assessment of carcinogenic risk in case of multimedium routes of the chemicals&rsquo; entry showed that there was a risk of developing carcinogenic effects for the adolescents&rsquo; health on daily intake of contaminants, which made TНCR=0.01632

Results of adolescent health risk assesment on exposure to habitat water peroral factor in conditions of a large industrial city

Results of the non-carcinogenic risk assessment on ingestion of chemical substances with drinking water showed that the risk value corresponded to the allowable level of the non-carcinogenic risk (HQ ( 1) for the major part of elements in all zones. The excess of the allowable level is observed only in oil products in the 1st zone (2.05) and the 4th zone (1.04). However, the total hazard index (HI) on combined peroral ingestion of chemical compounds and elements with drinking water in selected zones of the city of Kazan implies a low risk level for adolescents living in the 1st and the 4th zones (3.7 and 3.59) correspondingly, and is dangerous for health. According to the results of analysis carried out in all zones, the following basic critical organs and systems were identified: blood, CNS, kidneys, endocrine system, cardiovascular system, skeletal system and teeth. The total hazard indices in the 1st and the 4th zones deserve particular attention