311 research outputs found

    DPD Linearization Complexity Reduction of Remote Radio Heads in C-RAN with Radio over Fiber Fronthaul

    Get PDF
    Radio-over-Fiber (RoF) is a suitable technology for efficiently developing the cloud-RAN concept in Fifth Generation (5G) deployments based on Long Term Evolution Advanced LTE-A. Distortion coming out from the radiofrequency (RF) power amplifier should be taken into account in order to achieve the desired performance at the base station. In this paper, a complexity reduction technique based on a variable degree polynomial predistorter is proposed. The obtained results show that it is possible to achieve a reduction of operations with a penalty of 1.6 dB in ACLR and negligible impact on the EVM

    Donovanosis en mujeres indígenas

    Get PDF
    La donovanosis es una rara infección causada por la bacteriaCalymmatobacteriumgranulomatisque produce importantes lesiones ulcero-granulomatosas, preferentemente en la zonaanogenital.Considerada como enfermedad de trasmisión sexual, no es ésta la única vía detrasmisión, siendo también importantes las condiciones higiénicas, socioeconómicas y ambientalesen su etiopatogenia.Afecta áreas tropicales de varios continentes, incluido el americano, donde hayseries descriptas en varios países. En el Paraguay ha sido poco reportada, por lo que esta serie decuatro pacientes mujeres, jóvenes, indígenas de varias parcialidades, con lesiones exuberantes enzona anogenital, de larga evolución, tres de ellas embarazadas y dos con extensión a órganosinternos, es importante. El objetivo de este trabajo es llamar la atención sobre un problema de granmorbilidad y que exige mejorar la cobertura de salud y condiciones de vida de estas comunidadesindígenas

    In vivo cell tracking with 52Mn PET: Targetry, Separation, and Applications

    Get PDF
    Introduction 52Mn (t½ =5.59 d, β+ = 29.6%, Eβmax = 0.58 MeV) has great potential as a long lived PET isotope for use in cell tracking studies, observation of immunologic response to disease states, or as an alternative to manganese-based MRI contrast agents. Its favorable max positron energy leads to superb imaging resolution, comparable to that of 18F.[1] Manganese is naturally taken up by cells via a multitude of pathways including the divalent metal transporter (DMT1), ZIP8, transferrin receptors (TfR), store-operated Ca2+ channels (SOC-Ca2+), and ionotropic glutamate receptor Ca2+ channels (GluR).[2] These natural transport mechanisms make 52Mn an attractive isotope for applications necessitating non-perturbative cell uptake. In particular, cell tracking is critical to the development and translation of stem cell therapies in regenerative medicine. Alternative-ly, 52Mn could be used in immunotherapy techniques such as adoptive cellular therapy (ACT) to evaluate the ability of external immune cells to reach their intended target. Material and Methods 52Mn was produced by natCr(p,x)52Mn using 16 MeV protons. The average thick target production yield was 0.23 mCi/µA-h with less than 0.25% co-production of 54Mn. Small amounts of 51Cr were observed in the target, but were absent from the radiochemically separated product. Target construction consisted of a water jet cooled chromium disc (3/4” diameter, 0.4” thick). Targets were purchased from Kamis Inc, and are 99.95% pure. Targets withstood beam currents of 30 µA with no visible aberration. Chromium targets were etched by concentrated HCl following bombardment. Mn2+ ions were extracted from 9M HCl to 0.8M trioctylamine in cyclohexane leaving the bulk chromium in the aqueous phase. After isolating the organic phase, 0.001M NH4OH was used to back-extract the Mn2+ ions to aqueous phase. This purification cycle was conducted a total of three times for each 52Mn production. Results and Conclusion For a starting bulk chromium mass of 456 ± 1 mg, a post-separation chromium mass of 5.35 ± 0.04 ng was measured by microwave plasma atomic emission spectrometry (MP-AES). This mass reduction corresponds to an average separation factor of 440 for a single purification cycle. Each purification cycle had a 52Mn recovery efficiency of 73 ± 7 % (n = 6), resulting in an overall separation efficiency of approximately 35 %. These efficiencies and separation factors agree reasonably well with the work conducted by Lahiri et. al.[3] Prior to use, the product was passed through a C-18 Sep-Pak to remove any residual organic phase. After four target irradiations and etchings, some pitting became noticeable on the target face. These have not yet compromised the o-ring seal with the target deplater, but it is possible that target replacement after every 6–9 52Mn productions will be necessary moving forward. Following the successful separation of 52Mn from chromium, in vitro experiments were conducted to demonstrate the uptake of 52Mn by human stem cells and mouse tumor cells. A linear uptake response was observed as a function of the amount of activity exposed to the cells for both cell models. These experiments have shown great promise for 52Mn as a long-lived PET isotope in cell tracking studies. Details will be presented

    A Network Perspective for Community Assembly

    Get PDF
    Species interactions are responsible for many key mechanisms that govern the dynamics of ecological communities. Variation in the way interactions are organized among species results in different network structures, which translates into a community's ability to resist collapse and change. To better understand the factors involved in dictating ongoing dynamics in a community at a given time, we must unravel how interactions affect the assembly process. Here, we build a novel, integrative conceptual model for understanding how ecological communities assemble that combines ecological networks and island biogeography theory, as well as the principles of niche theory. Through our conceptual model, we show how the rate of species turnover and gene flow within communities will influence the structure of ecological networks. We conduct a preliminary test of our predictions using plant-herbivore networks from differently-aged sites in the Hawaiian archipelago. Our approach will allow future modeling and empirical studies to develop a better understanding of the role of the assembly process in shaping patterns of biodiversity

    Perceived discrimination and cancer screening behaviors in US Hispanics: the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study

    Get PDF
    Perceived discrimination has been associated with lower adherence to cancer screening guidelines. We examined whether perceived discrimination was associated with adherence to breast, cervical, colorectal, and prostate cancer screening guidelines in US Hispanic/Latino adults
    corecore