Implementación del Balanced Scorecard (BSC) y su Cuadro de Mando como herramienta de gestión para la Facultad de Salud Pública, de la Escuela Superior Politécnica de Chimborazo para el período 2014 – 2018

Dentro del presente trabajo desarrollado “Implementación del Balanced Scorecard (BSC) y su Cuadro de Mando como herramienta de gestión para la Facultad de Salud Pública, de la Escuela Superior Politécnica de Chimborazo para el período 2014 – 2018”, cuyo objetivo es que las organizaciones en la actualidad ya no dependen solamente de la eficiencia operativa. La metodología usada (analítico-sintético) en el presente trabajo ha permitido conocer las causas y efectos resultantes de todo el análisis realizado a la información, ya que el BSC como solución al problema de gestión de la Facultad de Salud Pública, nos ayudará a saber cómo ejecutar una estrategia con éxito para alcanzar la visión, con sus objetivos estrechamente relacionados. Después de explicar los aspectos teóricos del BSC, estos se ponen en práctica con la implementación en la Facultad de Salud Pública (FSP) con el software EasyPHP-12.1, partiendo con el diseño del Mapa Estratégico, como herramienta utilizada el diagnóstico situacional, además considerando el Modelo del CEAACES, y determinación de indicadores desplegados para la facultad. Las conclusiones nos ayudó a conocer que en la gestión de la facultad, por la no aplicación de modelos de gestión contemporáneos no ha permitido una efectiva toma de decisiones, por lo que hemos recomendado la alimentación constante y planificada de información y evaluación de sus indicadores en el tiempo y momento que sean requeridos de tal manera que agilite los procesos de gestión en la facultad, para que esta se convierta en una organización inteligente.As a part of the present study the “Implemantation of the Balanced Scorecard (BSC) and its Control Panel as management tool were develop for the Faculty of the Public Health, of Escuela Superior Politécnica de Chimborazo for the period 2014-2018”, whose objective is that organizations at the current time do not depend only on the operative efficiency. The methodology used (analytic-synthetic) in the work has allowed to know the causes and effects resulting from the analysis carried out the information, since the BSC as a solution to the problem of management of the Faculty of Public Health, will help to know how to implement a successful strategy to achieve the vision with its closely related objectives. After explaining the theoretical aspects of the BSC, these are put into practice with the implementation in the Faculty of Public Health (FPH) with the software Easy PHP-12.1, starting with the desing of the Strategic Map like tool used for the situational diagnosis, it is also considered the model of the CEAACES and the identification of indicators deployed for the faculty. The conclusions helped to know that it the management for the faculty, the non-application of contemporary management models haven´t permitted and effective decision making, that is why has been recommended the constant and planned flowing of information and evaluation of its indicators at time and moment that be required in such a way that expedites the management processes in the faculty, so this becomes a smart organization

Non-specific vaccination exerts anti-tumor effect through CD11c (+) cells stimulation in a breast cancer model

Background: Immunotherapy by using non-specific vaccines has proven to be effective in experimental animal models and also in patients suffering cancer. In the present work, the effectiveness of this immunotherapy was evaluated using a murine breast cancer model and a polymicrobial vaccine. Methodology/Principal: Mice bearing injected with tumor cells from the spontaneous syngeneic mammary adeno carcinoma M3 were used as breast cancer model. The immune adjuvant effect of the vaccine was analyzed in comparison or in the presence of doxorubicin. Tumor volume was calculated. Tumor, spleen and lymph nodes were processed for histological observations and to determinate the percentage of CD11c (+) cells. Results: Mice treated with the vaccine or with doxorubicin decreased tumor growth, with less tumor cell invasion. Tumor tissues showed decreased necrosis and nuclear areas in mice that received any of the treatments under study, compared with the control group. The benefits of vaccination were associated to stimulation of the immune response. More hyperplasia of the red and white pulp, and increased marginal megakaryocytes were observed in the spleens from mice treated with the vaccine. CD11c (+) cells did not increase  in tumor draining nodes by the immune stimulating effect of the vaccine; however,  his treatment increased CD11c (+) cells in the spleen and tumor. Conclusions: A non-specific vaccine used as immunotherapy can be used to prolong an equilibrium phase in  he tumor growth, similar to the doxorubicin treatment used in the model, although by different mechanisms. Non synergic effect was observed in the group treated with both vaccine and doxorubicin (low dose). Future studies should be necessary to evaluate the correct combination of vaccination and cytotoxic drug can be used for this purpose and to achieve increased activated dendritic cells in the tumor draining lymph nodes.Fil: de Gregorio, Vanessa Elizabeth. Universidad Nacional de Tucumán. Facultad de Odontología; ArgentinaFil: Carino, Silvia. Universidad Nacional de Tucumán. Facultad de Odontología; ArgentinaFil: Valdéz, Juan Carlos. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Microbiologia. Cátedra de Inmunología; ArgentinaFil: Castillo, Silvio Eugenio. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentin

Immunobiotic lactobacilli improve resistance of respiratory epithelial cells to sars-cov-2 infection

Previously, we reported that immunomodulatory lactobacilli, nasally administered, benefi-cially regulated the lung antiviral innate immune response induced by Toll-like receptor 3 (TLR3) activation and improved protection against the respiratory pathogens, influenza virus and respiratory syncytial virus in mice. Here, we assessed the immunomodulatory effects of viable and non-viable Lactiplantibacillus plantarum strains in human respiratory epithelial cells (Calu-3 cells) and the capacity of these immunobiotic lactobacilli to reduce their susceptibility to the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immunobiotic L. plantarum MPL16 and CRL1506 differentially modulated IFN-β, IL-6, CXCL8, CCL5 and CXCL10 production and IFNAR2, DDX58, Mx1 and OAS1 expression in Calu-3 cells stimulated with the TLR3 agonist poly(I:C). Furthermore, the MPL16 and CRL1506 strains increased the resistance of Calu-3 cells to the challenge with SARS-CoV-2. L. plantarum MPL16 induced these beneficial effects more efficiently than the CRL1506 strain. Of note, neither non-viable MPL16 and CRL1506 strains nor the non-immunomodulatory strains L. plantarum CRL1905 and MPL18 could modify the resistance of Calu-3 cells to SARS-CoV-2 infection or the immune response to poly(I:C) challenge. To date, the potential beneficial effects of immunomodulatory probiotics on SARS-CoV-2 infection and COVID-19 outcome have been extrapolated from studies carried out in the context of other viral pathogens. To the best of our knowledge, this is the first demonstration of the ability of immunomodulatory lactobacilli to positively influence the replication of the new coronavirus. Further mechanistic studies and in vivo experiments in animal models of SARS-CoV-2 infection are necessary to identify specific strains of beneficial immunobiotic lactobacilli like L. plantarum MPL16 or CRL1506 for the prevention or treatment of the COVID-19.Fil: Islam, Md Aminul. Tohoku University; JapónFil: Albarracín, Leonardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Tomokiyo, Mikado. Tohoku University; JapónFil: Valdéz, Juan Carlos. Universidad Nacional de Tucumán; ArgentinaFil: Sacur, Jacinto Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Andrade, Bruno G. N.. No especifíca;Fil: Cuadrat, Rafael R. C.. No especifíca;Fil: Kitazawa, Haruki. Tohoku University; JapónFil: Villena, Julio Cesar. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentin

Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes

Elderly individuals, especially those with pre-existing conditions like diabetes mellitus (DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥ 60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman during the second peak of the pandemic. Blood samples were taken at the time of admission (d0) and five days after (d5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had DM while 50% had arterial hypertension. At d0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA-DR+CD25+ cells, CD4+ and CD8+ T cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). The treatment normalized the levels of BIC (d5) in 30% of patients who were those with no comorbidities. In patients with DM, BIC recovery was variable. In DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA-DR+CD25+, CD4+ and CD8+ cells were observed between d0 and d5. In line with previous studies, our results shows that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with DM.Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Kolling, Yanina Noralí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Argañaraz, Nicolás. Universidad Nacional de Tucumán; ArgentinaFil: Rocchia Novillo, María Pía. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Rocchia Novillo, María del Milagro. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Albarracin, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Charubi, Jacqueline Elizabeth. Instituto de Maternidad “Ntra. Sra. De las Mercedes”; ArgentinaFil: Casen, Alejandra. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Gobbato, Nadia Margarita. Universidad Nacional de Tucumán; ArgentinaFil: Rachid, Mirta Maria. Universidad Nacional de Tucumán; ArgentinaFil: Alvarez, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Valdéz, Juan Carlos. Universidad Nacional de Tucumán; ArgentinaAnnual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar)Buenos AiresArgentinaSociedad Argentina de InmunologíaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de Investigación ClínicaAsociación Argentina de Nanomedicin

A brief introduction to model-driven engineering

The software crisis is a concept that has started to be used in 1968, at the first conference organized by the North Atlantic Treaty Organization (NATO) on software development. There, Edsger Dijkstra criticized that projects were not completed in compliance with the classic triple constraint of project management (scope, time and cost), since most of them do not reach the expected requirements, are delivered out of time or exceeds the expected cost. Unfortunately, the current reality is that while there have been proposed new methodologies aimed at solving the usual problems related to software development, there is still no reliable method to estimate the development of computer systems. This work introduces the Model-Driven Engineering approach that, according to the experts, will help to solve many of the problems that thousands of software development teams have daily worldwid

Memoria del II Coloquio de verano de investigación de la Escuela de Negocios de ITESO, 2023

La memoria recoge cinco de las ponencias presentadas en el Coloquio de investigación de verano de la Escuela de Negocios, 2023. Durante las presentaciones y el diálogo quisimos hacer énfasis en dos aspectos de nuestra labor universitaria: 1) el fortalecimiento de la Escuela de Negocios como instancia interdepartamental que comparte una misión común; 2) el modo como las tres funciones sustantivas (docencia, investigación y vinculación) se retroalimentan y sostienen mutuamente. Se presentan resúmenes extendidos de los siguientes trabajos: Diagnóstico de cultura organizacional por alumnos del PAP de Gestión del cambio, del talento humano y la efectividad organizacional; Modelo estratégico de sostenibilidad basado en el modelo de flujos descontados (DCF); Laboratorios móviles: impulsando la industria creativa-cultural en Jalisco; Nueva estrategia de comunicación como proceso formativo para empresarios y emprendedores; Economía Social y Solidaria como un elemento para el desarrollo de talleres del sector artesanal.ITESO, A.C

Seminario de Economía Mexicana

Serie de ponencias referentes al Seminario de Economía Mexicana. Memorias del Seminario de Economía Mexicana de 199

Differences between Pseudomonas aeruginosa in a clinical sample and in a colony isolated from it: Comparison of virulence capacity and susceptibility of biofilm to inhibitors

We study the differences between Pseudomonas aeruginosa from an infected wound (clinical strain) and a colony isolated from it. We assessed the in vitro inhibition of these P. aeruginosa biofilms by DNase and filtrate of Lactobacillus plantarum cultures (acid = AF and neutralize = NF) with crystal violet technique. Inhibition by AF was greatest than DNase for clinical and isolated strain (p<0.001) and greatest than NF for clinical (p<0.05) and isolated strain (p<0.001).Using a burn model in mice, we compared the infection producing by clinical and isolated strains in planktonic and biofilm form. Deaths were quantified and the infection was assessed by determining CFU/g of tissue in the lesion, spleen and liver.The infections with planktonic bacteria tended to become systemic and more deadly than biofilm infections. All infected wounds required the same healing period (30 days). These findings were independent of the origin of the bacteria (clinical or colony isolated strain). © 2008 Elsevier Ltd.Fil: Ramos Vernieri, Alberto Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Microbiologia. Cátedra de Inmunología; ArgentinaFil: Peral, M.C.. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Valdéz, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Microbiologia. Cátedra de Inmunología; Argentin

Synthetic polymeric scaffolds design and fabrication for skin regeneration

Ulcers are a type of chronic wounds that are very susceptible to microbial infections of bacteria that produce biofilm, which makes them refractory to antibiotic and antiseptic treatment. It has been observed that treatment with Lactobacilus plantarum supernatant (SNLP) in venous ulcers, reduces wound healing time, significantly decreasing bacterial load, so it could be a good alternative as treatment for different types of chronic wounds. Polycaprolactone (PCL) is a biocompatible and biodegradable polymer, with excellent mechanical properties, whose effectiveness in dermatological applications has been widely demonstrated. In addition, with the electrospinning technique, PCL fibers can be created in micro and nanometric scale with acertain degree of porosity, very useful for different biomedical applications. Therefore, the purpose of this work is to manufacture polymeric nanomembranes incorporating the supernatant of Lactobacilus plantarum, as an antibiotic and healing substance to PCL nanofibers by means of the immersion technique. The method of manufacturing PCL nanomembranes was optimized by electrospinning using various polymeric supports. Different immersion methods were tested for supernatant incorporation, controlled release of the same was studied and its morphology was observed in a Scanning Microscope. The 10% concentration PCL nanomembranes are made up of uniform nanofibers of random distribution, with an average diameter of 169.06 ± 32.28 nm and an average pore size of 1266.74 ± 292.55 nm. According to these results, fiber morphology was adequate for encapsulation.On the other hand, these scaffolds show antimicrobial activity, however, SNLP release was almost instantaneous, so, we conclude that it is not a suitable biomaterial as a possible treatment for chronic wounds. Therefore, it is necessary to review the technique to incorporate and controlled release of this substance and apply coaxial electrospinning for hollow nanofibers filled manufacture with this bioactive substance as an alternative techniqueLas úlceras son un tipo de heridas crónicas muy susceptibles a infecciones microbianas de bacterias productoras de biofilm, lo que las hace refractarias al tratamiento antibiótico y antiséptico. Se ha observado que el tratamiento con sobrenadante de Lactobacilus plantarum (SNLP) en úlceras venosas, reduce el tiempo de cicatrización de heridas, disminuyendo significativamente la carga bacteriana, por lo que podría ser una buena alternativa como tratamiento para diferentes tipos de heridas crónicas. La policaprolactona (PCL) es un polímero biocompatible y biodegradable, con excelentes propiedades mecánicas, cuya eficacia en aplicaciones dermatológicas ha sido ampliamente demostrada. Además, con la técnica de electrospinning se pueden crear fibras PCL a escala micro y nanométrica con cierto grado de porosidad, muy útiles para diferentes aplicaciones biomédicas. Por tanto, el propósito de este trabajo es fabricar nanomembranas poliméricas incorporando el sobrenadante de Lactobacilus plantarum, como sustancia antibiótica y cicatrizante a las nanofibras de LCP mediante la técnica de inmersión. El método de fabricación de nanomembranas de PCL se optimizó mediante electrospinning utilizando varios soportes poliméricos. Se probaron diferentes métodos de inmersión para la incorporación del sobrenadante, se estudió la liberación controlada del mismo y se observó su morfología en Microscopio de Barrido. Las nanomembranas de PCL al 10% de concentración están compuestas por nanofibras uniformes de distribución aleatoria, con un diámetro medio de 169,06 ± 32,28 nm y un tamaño medio de poro de 1266,74 ± 292,55 nm. De acuerdo con estos resultados, la morfología de la fibra fue adecuada para la encapsulación. Por otro lado, estos andamios muestran actividad antimicrobiana, sin embargo, la liberación de SNLP fue casi instantánea, por lo que concluimos que no es un biomaterial adecuado como posible tratamiento para heridas crónicas. Por tanto, es necesario revisar la técnica de incorporación y liberación controlada de esta sustancia y aplicar el electrohilado coaxial para la fabricación de nanofibras huecas rellenas con esta sustancia bioactiva como técnica alternativa.Fil: Rodriguez, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; ArgentinaFil: Delgado Gonzalez, María Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; ArgentinaFil: Kozuszko, Silvia Noemi. Universidad Nacional de Tucuman. Facultad de Odontología. Cátedra de Anatomia Patologica; ArgentinaFil: Valdéz, Juan Carlos. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; ArgentinaFil: Rodriguez, Andrea Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentin