Challenging the Dynamics of Time: Generate and Evaluate Real-World Time Series to estimate NOx Emissions in a Turbo Machine

Estimating accurate NOx emissions is essential to monitor pollution and health condition of a turbo machine. We use a virtual sensor to correctly estimate the particle pollution value in real-time, leveraging modern machine learning approaches. It is well known that machine learning heavily relies on data, but real-world applications encounter datarelated issues. In this work, we address the cited business use case scenario where limited data hamper an optimal regression quality. We investigate the application of time series generative models, with a particular emphasis on evaluating their performance using a comprehensive set of quantitative and qualitative metrics. We also conduct a critical analysis of the evaluation metrics commonly employed in the literature for validating and assessing the effectiveness of generative models. The analysis highlights the limitations of these metrics, as they do not take into account the temporal dependencies present in time series data and rely heavily on the specific implementation of the evaluation model. Finally, task-specific metrics are proposed to assess the effectiveness of generated data in supporting an industrial application. By delving into those pillars, this work aims to contribute to the advancement of knowledge on temporal synthetic data generation, showing how it can impact environmental care

I distretti del Mezzogiorno

CAP. 1. Definizione e caratteristiche del distretto; CAP. 2. Come sono nati i distretti nel Mezzogiorno: fattori di successo ed insuccesso;2.1.Lo sviluppo dei distretti del Mezzogiorno: Brevi cenni storici; CAP. 3. I Distretti del Mezzogiorno; Il "Triangolo del Salotto"; Il polo calzaturiero aversano; La corsetteria di Lavello ;Il TAC del tacco Il distretto barlettano delle calzature; L'abbigliamento della Puglia centrale; La percezione del fenomeno "distretto" dei piccoli e medi imprenditori in Campania, il caso di S. Giuseppe vesuviano e Solofra; Il distretto industriale di Solofra; Conclusioni

IL RUOLO DELLA DIMENSIONE ISTITUZIONALE NELLA DEFINIZIONE DI POLITICHE DI SVILUPPO SOSTENIBILE PER L’ITALIA

The study aims to go beyond the traditional conception of development as economic growth, integrating theoretical perspectives on local development and sustainability, and broadening it to consider other dimensions. In particu-lar, the study focuses on the institutional component of Sustainable Devel-opment. To this end, the component was defined by a set of indicators ex-tracted from the open data offered by the OpenCivitas platform promoted by the Ministry of Economy and Finance and SOSE (Soluzioni per il Sistema Economico S.p.A.). The goodness of the matching of the variables is meas-ured both by a correlation analysis and a spatial cluster analysis aimed at de-tecting high-high and low-low clusters

Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil

BACKGROUND AND OBJECTIVES: Thymidylate synthase (TS) expression levels appear to be related to response to 5-fluorouracil-(5-FU)-based chemotherapy in colorectal cancer (CRC) patients. Three polymorphisms have been proposed as modulators of TS expression: a tandemly repeated sequence (2R/3R) in the 5' UTR, a SNP (G>C) within the 3R allele and a 6bp deletion in the 3' UTR. To evaluate the influence of TS expression and polymorphisms on clinical outcome of 5-FU-treated patients we performed a comprehensive genetic analysis on 63 CRC patients. METHODS: TS expression levels were analyzed in normal and tumor tissues. TS coding sequence and UTR polymorphisms were investigated on DNA from normal tissue. LOH analysis was performed to determine tumor genotype. RESULTS: A difference in disease-free survival (DFS), although not statistically significant, was observed between high and low mRNA expression levels: patients with low levels showed longer DFS. The 2R2R genotype showed significantly lower expression than the 3R3R and 2R3R genotypes in normal tissue. No other TS polymorphism was associated with mRNA expression or clinical outcome. CONCLUSIONS: The results obtained in this pilot study indicate that the number of 5' UTR repeats is the major genetic determinant of TS expression. The lack of association with other polymorphisms might be partially explained by the existence of linkage disequilibrium in the TS gene. Our data support the growing evidence that TS control may require multiple mechanisms acting in close coordination with one another and suggest that TS genotyping alone in tumor samples is not sufficient to accurately predict response to 5-FU

High resolution melting analysis for a rapid identification of heterozygous and homozygous sequence changes in the MUTYH gene

Background: MUTYH-associated polyposis (MAP) is an autosomal recessive form of intestinal polyposis predisposing to colorectal carcinoma. High resolution melting analysis (HRMA) is a mutation scanning method that allows detection of heterozygous sequence changes with high sensitivity, whereas homozygosity for a nucleotide change may not lead to significant curve shape or melting temperature changes compared to homozygous wildtype samples. Therefore, HRMA has been mainly applied to the detection of mutations associated with autosomal dominant or X-linked disorders, while applications to autosomal recessive conditions are less common. Methods: MUTYH coding sequence and UTRs were analyzed by both HRMA and sequencing on 88 leukocyte genomic DNA samples. Twenty-six samples were also examined by SSCP. Experiments were performed both with and without mixing the test samples with wild-type DNA. Results: The results show that all MUTYH sequence variations, including G > C and A > T homozygous changes, can be reliably identified by HRMA when a condition of artificial heterozygosity is created by mixing test and reference DNA. HRMA had a sensitivity comparable to sequencing and higher than SSCP. Conclusions: The availability of a rapid and inexpensive method for the identification of MUTYH sequence variants is relevant for the diagnosis of colorectal cancer susceptibility, since the MAP phenotype is highly variable