Advanced Timing Circuit for Magnetization of AMR Magnetometer

This contribution describes the invention of Magnetometer with protection against detection by electronic countermeasure (ECM) registered by Czech patent office as patent no. 305322.[1] Magnetic sensors are often part of dual use or security instruments and equipment. For this purpose, it is very interesting to build a sensor, which is hidden against electronic countermeasure. In this case, the level and behavior of electromagnetic noise produced by a sensor has become very important. Further, there has been a significant growth of the electromagnetic compatibility of electronic devices. As the consequence of this growth, there is a continuous process of making strict standards focused on the electromagnetic radiation of electronic devices. Sensors technology begins to be a part of these issues due to the increasing usage of sensors bandwidth and the approach to frequency of radio communication band. Nowadays, microcontrollers and similar digital circuits are integrated into sensors devices and it brings new sources of electromagnetic radiation in modern smart sensors

Measurements of generated energy/electrical quantities from locomotion activities using piezoelectric wearable sensors for body motion energy harvesting

In this paper, two different piezoelectric transducers—a ceramic piezoelectric, lead zirconate titanate (PZT), and a polymeric piezoelectric, polyvinylidene fluoride (PVDF)—were compared in terms of energy that could be harvested during locomotion activities. The transducers were placed into a tight suit in proximity of the main body joints. Initial testing was performed by placing the transducers on the neck, shoulder, elbow, wrist, hip, knee and ankle; then, five locomotion activities—walking, walking up and down stairs, jogging and running—were chosen for the tests. The values of the power output measured during the five activities were in the range 6 W–74 W using both transducers for each joint.Web of Science164art. no. 52

Re-partitioning of Cu and Zn isotopes by modified protein expression

Cu and Zn have naturally occurring non radioactive isotopes, and their isotopic systematics in a biological context are poorly understood. In this study we used double focussing mass spectroscopy to determine the ratios for these isotopes for the first time in mouse brain. The Cu and Zn isotope ratios for four strains of wild-type mice showed no significant difference (δ65Cu -0.12 to -0.78 permil; δ66Zn -0.23 to -0.48 permil). We also looked at how altering the expression of a single copper binding protein, the prion protein (PrP), alters the isotope ratios. Both knockout and overexpression of PrP had no significant effect on the ratio of Cu isotopes. Mice brains expressing mutant PrP lacking the known metal binding domain have δ65Cu isotope values of on average 0.57 permil higher than wild-type mouse brains. This implies that loss of the copper binding domain of PrP increases the level of 65Cu in the brain. δ66Zn isotope values of the transgenic mouse brains are enriched for 66Zn to the wild-type mouse brains. Here we show for the first time that the expression of a single protein can alter the partitioning of metal isotopes in mouse brains. The results imply that the expression of the prion protein can alter cellular Cu isotope content

USING PVDF FILMS AS FLEXIBLE PIEZOELECTRIC GENERATORS FOR BIOMECHANICAL ENERGY HARVESTING

In this paper, a commercial polymeric piezoelectric film, the polyvinylidene fluoride (PVDF) was used to harvest electrical energy during the execution of five locomotion activities (walking, going down and up the stairs, jogging and running). The PVDF film transducer was placed into a tight suit in proximity of four body joints (shoulder, elbow, knee and ankle). The RMS values of the power output measured during the five activities were in the range 0.1 – 10 µW depending on the position of the film transducer on the body. This amount of electrical power allows increasing the operation time of wearable systems, and it may be used to prolong the monitoring of human vital signals for personalized health, wellness, and safety applications

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer’s lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n =11) received RL solution (25 mL/kg) and Group 2 (n = 11) received HES 130/0.4 solution (20 mL/kg). Additionally, Group 3 (n = 6) was not submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and immunohistochemical analyses. Minimal to moderate glomerular, tubular, and interstitial changes, as well as papillary necrosis, were observed in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that received HES 130/0.4, indicating a higher renal insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES 13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this effect can be dose related.info:eu-repo/semantics/publishedVersio

Modulation of attention and stress with arousal: The mental and physical effects of riding a motorcycle

Existing theories suggest that moderate arousal improves selective attention, as would be expected in the context of competitive sports or sensation-seeking activities. Here we investigated how riding a motorcycle, an attention-demanding physical activity, affects sensory processing. To do so, we implemented the passive auditory oddball paradigm and measured the EEG response of participants as they rode a motorcycle, drove a car, and sat at rest. Specifically, we measured the N1 and mismatch negativity to auditory tones, as well as alpha power during periods of no tones. We investigated whether riding and driving modulated non-CNS metrics including heart rate and concentrations of the hormones epinephrine, cortisol, DHEA-S, and testosterone. While participants were riding, we found a decrease in N1 amplitude, increase in mismatch negativity, and decrease in relative alpha power, together suggesting enhancement of sensory processing and visual attention. Riding increased epinephrine levels, increased heart rate, and decreased the ratio of cortisol to DHEA-S. Together, these results suggest that riding increases focus, heightens the brain’s passive monitoring of changes in the sensory environment, and alters HPA axis response. More generally, our findings suggest that selective attention and sensory monitoring seem to be separable neural processes

American Family Cohort, a data resource description

This manuscript is a research resource description and presents a large and novel Electronic Health Records (EHR) data resource, American Family Cohort (AFC). The AFC data is derived from Centers for Medicare and Medicaid Services (CMS) certified American Board of Family Medicine (ABFM) PRIME registry. The PRIME registry is the largest national Qualified Clinical Data Registry (QCDR) for Primary Care. The data is converted to a popular common data model, the Observational Health Data Sciences and Informatics (OHDSI) Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). The resource presents approximately 90 million encounters for 7.5 million patients. All 100% of the patients present age, gender, and address information, and 73% report race. Nealy 93% of patients have lab data in LOINC, 86% have medication data in RxNorm, 93% have diagnosis in SNOWMED and ICD, 81% have procedures in HCPCS or CPT, and 61% have insurance information. The richness, breadth, and diversity of this research accessible and research ready data is expected to accelerate observational studies in many diverse areas. We expect this resource to facilitate research in many years to come

Clinical Registries Could Improve Influenza Like Illness and COVID-19 Surveillance

Capacity for tracking COVID-19 prevalence patterns is hampered by insufficient data, particularly from rural and small communities. The PRIME Registry holds data for 5.4 million patients in 47 states who made 638,983 Influenza-Like Illness (ILI) visits in 2019, mirroring CDC’s ILINet temporal patterns but with higher volume and greater rural penetration. Clinical data registries are viable partners that could fill gaps for epidemic sentinel functions and have rich patient data which may identify factors predictive of COVID-19 morbidity and mortality.https://deepblue.lib.umich.edu/bitstream/2027.42/154853/1/ILI-PRIME_AnnalsFamMed_FINAL.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154853/2/RehkopfILIFig1.docxhttps://deepblue.lib.umich.edu/bitstream/2027.42/154853/3/RehkopfILIFig2.docxDescription of ILI-PRIME_AnnalsFamMed_FINAL.pdf : Main ArticleDescription of RehkopfILIFig1.docx : Figure 1Description of RehkopfILIFig2.docx : Figure

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer’s lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n = 11) received RL solution (25 mL/kg) and Group 2 (n = 11) received HES 130/0.4 solution (20 mL/kg). Additionally, Group 3 (n = 6) was not submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and immunohistochemical analyses. Minimal to moderate glomerular, tubular, and interstitial changes, as well as papillary necrosis, were observed in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that received HES 130/0.4, indicating a higher renal insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES 13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this effect can be dose relate