Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer

is the first targeted alpha therapy for patients with castration resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach. We provide straightforward and practical recommendations for European nuclear medicine centres to optimize radium-223 service provision. Methods An independent research consultancy agency observed radium-223 procedures and conducted interviews with all key staff members involved in radium-223 treatment delivery in 11 nuclear medicine centres across six countries (Germany, Italy, the Netherlands, Spain, Switzerland and the UK) experienced in administering radium-223. The findings were collated and discussed at a meeting of experts from these centres, during which key consensus recommendations were defined. Results The recommendations cover centre organization and preparation; patient referral; radium-223 ordering, preparation and disposal; radium-223 treatment delivery/administration; and patient experience. Guidance includes structured coordination and communication within centres and multidisciplinary teams, focusing on sharing best practice to provide high quality, patient-centred care throughout the treatment pathway. Conclusions These expert recommendations are intended to complement existing management guidelines. Sharing best practice and experience will help nuclear medicine centres to optimize radium-223 service provision and improve patient care

Untersuchungen zur Moeglichkeit der Reduzierung von Fegedampfverlusten bei der thermischen Entgasung von Kesselspeisewasser Abschlussbericht

SIGLEAvailable from TIB Hannover: F02B585 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDeutsche Bundesstiftung Umwelt, Osnabrueck (Germany)DEGerman

Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer

Radium Ra 223 dichloride (radium-223, Xofigo®) is the first targeted alpha therapy for patients with castration-resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach. We provide straightforward and practical recommendations for European nuclear medicine centres to optimize radium-223 service provision. An independent research consultancy agency observed radium-223 procedures and conducted interviews with all key staff members involved in radium-223 treatment delivery in 11 nuclear medicine centres across six countries (Germany, Italy, the Netherlands, Spain, Switzerland and the UK) experienced in administering radium-223. The findings were collated and discussed at a meeting of experts from these centres, during which key consensus recommendations were defined. The recommendations cover centre organization and preparation; patient referral; radium-223 ordering, preparation and disposal; radium-223 treatment delivery/administration; and patient experience. Guidance includes structured coordination and communication within centres and multidisciplinary teams, focusing on sharing best practice to provide high-quality, patient-centred care throughout the treatment pathway. These expert recommendations are intended to complement existing management guidelines. Sharing best practice and experience will help nuclear medicine centres to optimize radium-223 service provision and improve patient care

Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer

Contains fulltext : 189943.pdf (Publisher’s version ) (Open Access

Nuclear medicine innovations help (drive) healthcare (benefits)

Through-air bonding is one of the thermal methods of bonding fibres in the production of non-woven webs. A computational study of the formation of bond point between two bicomponent fibres during the through-air bonding process is reported in this paper. The computational method involves solving the Navier–Stokes equations for two-phase flows of air and molten polymer in a three-dimensional configuration. The heating, melting, and bonding of fibres are modelled by the volume of fluid model together with a melting model. The simulated results show the formation of the bond between two fibres in contact and the change of shape of the bond with time at different bonding temperatures. The computation shows that the rate of bonding increases slightly at higher temperature