1976 Water Quality Hillsborough County, Florida

The Hillsborough County Environmental Protection Ac t charges the Environmental Prote ction Commission with the function of establishing, operating and maintaining a continuous program for monitoring water pollution. A county-wide water quality surveillance network has been designed to provide accurate data and information as t o whether the requirements of the Act are being complied with and whether the level of water pollution is increasing or decreasing throughout the county. This broad base of water data obtained during 1972-1976 provides useful background data for eventual development, revision and enforcement of regulations, standard effluent limitation plans, or programs established under the Federal Water Pollution Control Act of 1972

Sandwich composite of aluminum alloy and magnesium alloy through accumulative roll bonding technique

Aluminum and magnesium alloys are lightweight materials with outstanding technical uses. Due to their combined qualities, composites built of aluminum and magnesium alloys have surpassed the utilization of these elements individually. Accumulative Roll Bonding was used to create a three-layered sandwich composite structure made of Al-alloy/Mg-alloy/Al-alloy. The composite structure's microstructure and mechanical characteristics were studied. A fine-grained AZ31 layer was formed, according to the microstructural study. At the Al-alloy/Mg-alloy contact, a diffusion layer was also seen. On the broken surface, fractography exhibited both ductile and brittle failure characteristics

Tribological Performance of the Continuous Steel Fiber-reinforced Cu based Friction Material for Heavy-duty Braking Applications

Brake pads are the major components of the wind turbine, which primarily consists of metal matrix and ceramic reinforcements. The ceramic particles plunge out during the application of brakes, which in turn leads to the transformation of the wear mechanism from adhesive to abrasive wear. This increases the wear rate and therefore the study investigates the possible replacement of ceramic reinforcements with continuous fibers that exhibit high strength and compatibility. In recent years, Cu-based brake pads that are fabricated by powder metallurgy route are widely used in wind turbines. In this study, continuous fibers of stainless steel SS304 are reinforced in the Cu matrix by the casting method to preserve the fiber alignment. The fabricated composite is characterized for microstructure, microhardness, and tribological behavior. Besides, a comprehensive analysis of the wear mechanism in the developed composite is presented based on the surface morphology, elemental composition, and phase analysis

The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori

We investigated the effects of two novel copper-based inorganic formulations for their activity against 60 isolates of Helicobacter pylori (Hp). The two copper-based formulations were tested against three NCTC Helicobacter pylori isolates and 57 clinical strains isolated from the UK and Italy in time-kill assays. Both copper-based formulations were bio-cidal against all Helicobacter pylori strains tested reducing the viable count by 4\u20135 log within 2 h. These two copper-based anti-microbial agents deserve further study in relation to the treatment of H. pylori-related gastric disease

Exploring the use of pegylated liposomal doxorubicin (Caelyx®) as pressurized intraperitoneal aerosol chemotherapy

Background: Peritoneal carcinomatosis is a common metastatic pattern in ovarian, gastric, colorectal, and appendiceal cancer; systemic chemotherapy is the current standard of care for peritoneal metastatic disease; however, in a subset of patients its beneficial effect remains questionable. More effective perioperative chemotherapy is needed. Materials and methods: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new treatment that applies chemotherapeutic drugs into the peritoneal cavity as an aerosol under pressure. It's a safe and feasible approach that improves local bioavailability of chemotherapeutic drugs as compared with conventional intraperitoneal chemotherapy. Till now the drugs used in PIPAC for the treatment of the peritoneal carcinomatosis (PC) are cisplatin, doxorubicin, and oxaliplatin; as of yet, there are no in vivo data comparing different drug formulations and dosage schedules of PIPAC. Pegylated liposomal doxorubicin 1.5 mg/sm was aerosolized in PIPAC procedures. Results: Pharmacokinetics analysis of 10 procedures performed with conventional doxorubicin solution at the dose of 1.5 mg/m2 were compared to 15 procedures with the same dose of pegylated liposomal doxorubicin (PLD). Significant differences between experimental groups were detected by one-way ANOVA followed by Bonferroni correction; a p value < 0.05 was considered statistically significant. A statistically different doxorubicin tissue concentration was observed for the doxorubicin solution compared to pegylated liposomal doxorubicin in the right parietal peritoneum and right diaphragm. In the Caelyx\uae series a mean tissue concentration of 1.27 \ub1 1.33 mg/g was reported, while in the second one we registered a mean concentration of 3.1 \ub1 3.7 mg/g. Conclusions: The delivery of nano-particles in PIPAC was feasible, but pegylated liposomal concentrations are lower than standard doxorubicin formulation. Probably mechanical and physical properties of pressurized aerosol chemotherapy might alter their stability and cause structural disintegration

Identifying the use of a park based on clusters of visitors' movements from mobile phone data

none6noPlanning urban parks is a burdensome task, requiring knowledge of countless variables that are impossible to consider all at the same time. One of these variables is the set of people who use the parks. Despite information and communication technologies being a valuable source of data, a standardized method which enables landscape planners to use such information to design urban parks is still broadly missing. The objective of this study is to design an approach that can identify how an urban green park is used by its visitors in order to provide planners and the managing authorities with a standardized method. The investigation was conducted by exploiting tracking data from an existing mobile application developed for Cardeto Park, an urban green area in the heart of the old town of Ancona, Italy. A trajectory clustering algorithm is used to infer the most common trajectories of visitors, exploiting global positioning system and sensor-based tracks. The data used are made publicly available in an open dataset, which is the first one based on real data in this field. On the basis of these user-generated data, the proposed datadriven approach can determine the mission of the park by processing visitors' trajectories whilst using a mobile application specifically designed for this purpose. The reliability of the clustering method has also been confirmed by an additional statistical analysis. This investigation reveals other important user behavioral patterns or trends.openPierdicca R.; Paolanti M.; Vaira R.; Marcheggiani E.; Malinverni E.S.; Frontoni E.Pierdicca, R.; Paolanti, M.; Vaira, R.; Marcheggiani, E.; Malinverni, E. S.; Frontoni, E

A neuronal network of mitochondrial dynamics regulates metastasis.

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. When expressed in tumours, SNPH inhibits the speed and distance travelled by individual mitochondria, suppresses organelle dynamics, and blocks chemotaxis and metastasis, in vivo. Tumour progression in humans is associated with downregulation or loss of SNPH, which correlates with shortened patient survival, increased mitochondrial trafficking to the cortical cytoskeleton, greater membrane dynamics and heightened cell invasion. Therefore, a SNPH network regulates metastatic competence and may provide a therapeutic target in cancer

Clinical Performance of the Automated LIAISON® Meridian H. pylori SA Stool Antigen Test

Background. Antigens derived from Helicobacter pylori can be used as stool biomarkers to assist in the diagnosis of H. pylori infection. Since current assays have variable performance, we assessed the clinical performance of the automated LIAISON® Meridian H. pylori SA chemiluminescent immunoassay against more invasive biopsy tests that are considered to be the "gold standard" (Composite Reference Method). Methods. This prospective multisite study enrolled patients undergoing an esophagogastroduodenoscopy with collection of biopsy and stool specimens. Adult patients (≥22 years) participated in the study from February 2017 to August 2018. Specimens of the stomach were tested by three methods, known as the Composite Reference Method: (1) histological evaluation, (2) culture of the organism, and (3) rapid urease detection test. H. pylori in stool was detected using the automated LIAISON® Meridian H. pylori SA assay, a chemiluminescent immunoassay. Statistical analyses were performed using MedCalc 18.11.6. Results. 277 patients (63% female) were included in the study. The prevalence of infected subjects was 24.2% in this study cohort. Clinical performance assessed against the Composite Reference Method showed very good agreement (Cohen's kappa=0.922), with good sensitivity (95.5%) and specificity (97.6%). Reproducibility study results showed total imprecision ranging from 3.1% to 13.9% CV. Conclusion. The automated LIAISON® Meridian H. pylori SA assay brings reliable noninvasive testing for H. pylori to the laboratory that is in very good agreement with the current, more invasive biopsy-based methods such as histology, culture, or rapid urease test. The clinical trial identifiers are NCT03060746 (pretherapy) and NCT03060733 (posttherapy)