Algebraic construction of semi bent function via known power function

The study of semi bent functions (2- plateaued Boolean function) has attracted the attention of many researchers due to their cryptographic and combinatorial properties. In this paper, we have given the algebraic construction of semi bent functions defined over the finite field F₂ⁿ (n even) using the notion of trace function and Gold power exponent. Algebraically constructed semi bent functions have some special cryptographical properties such as high nonlinearity, algebraic immunity, and low correlation immunity as expected to use them effectively in cryptosystems. We have illustrated the existence of these properties with suitable examples.Publisher's Versio

Permutation Polynomials modulo n

Based on preliminary numerical computations, we give complete results for linear and quadratic polynomials. Rivest’s result holds in the linear case while there are plenty of counterexamples in the quadratic case

A Study of Diabetes among Inmates of Old Age Homes in Mysore City

The human population is graying, and with it concerns about the aged have been growing. Even as birth rates fall steeply, improved healthcare systems have contributed to unprecedented longevity levels. The challenges of taking care of the elderly now increasingly face developing nations. The boundary of old age cannot be defined exactly because it does not have the same meaning in all societies. The United Nations International Assembly on Ageing has taken 60 years as the boundary to define old age.1 Globally, the number of older persons (aged 60 years or over) is expected to be more than double, from 841 million people in 2013 to more than 2 billion in 2050. Presently, about two-thirds of the world’s elderly live in developing countries. By 2050, nearly 8 in 10 of the world’s older population will live in the less developed regions.2 India, as the second most populous country, is witnessing an “aging revolution.” The major issues in India aging are: rapid growth of older segment; feminization of aging; poverty in old age; high growth of 80 + group and decline in family support base.

Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone anddl-camphorone in rats

R-(+)-Pulegone, a monoterpene ketone, is a potent hepatotoxin. The present study was designed to evaluate whether the reduction of the ring size in R-(+)-pulegone would affect its mode of metabolism and its hepatotoxic potential. Metabolic fate ofR-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone (I) and 5-methyl-2-(1-methylethylidene)-cyclopentanone (dl-camphorone; II) were examined in rats. Compounds I and II were administered orally (250 mg/kg of b.wt./day) to rats for 5 to 7 days. The following metabolites were isolated and identified from the urine of rats dosed with I: 3-methyl-5-(1-methylethylidene)-cyclopent-2-enone (Ie), Z-4-methyl-2-(1-hydroxymethylethylidene)-cyclopentanone (Ib), E-4-methyl-2-(1-hydroxymethylethylidene)-cyclopentanone (Ia), 3-hydroxy-4-methyl-2-(1-methylethylidene)-cyclopentanone (If), 4-hydroxy-4-methyl-2-(1-methylethylidene)-cyclopentanone (Ic), and E-4-methyl-2-(1-carboxyethylidene)-cyclopentanone (Id). Phenobarbital (PB)-induced rat liver microsomes in the presence of NADPH transformed compound I into metabolites, which were identified as Ia, Ib, Ic, Ie, and If. The following urinary metabolites were isolated and identified from compound II: 5-hydroxy-5-methyl-2-(1-methylethylidene)-cyclopentanone (IIc), 5-hydroxy-5-methyl-2-(1-methylethyl)-cyclopentanone (IIg), Z-5-methyl-2-(1-hydroxymethylethylidene)-cyclopentanone (IIb), 5-methyl-2-(1-hydroxymethylethyl)-cyclopentanone (IIf), E-5-methyl-2-(1-hydroxymethylethylidene)-cyclopentanone (IIa), E-5-methyl-2-(1-carboxyethylidene)-cyclopentanone (IId), and 5-methyl-2-(1-carboxyethyl)-cyclopentanone (IIe). PB-induced rat liver microsomes in the presence of NADPH were shown to transform compound II to IIa, IIb, and IIc. Studies carried out in vitro demonstrated that hydroxylation at the tertiary carbon atom or oxidation of the isopropylidene methyl groups in II can be specifically blocked through structural modifications as seen in compounds 2,2-dimethyl-5-(1-methylethylidene)-cyclopentanone (III) and 5-methyl-2-(1-ethyl-1-propylidene)-cyclopentanone (IV). Similar observation was also made when isopropylidene methyl groups inR-(+)-pulegone were replaced by ethyl groups. Intraperitoneal administration of a single dose (250 mg/kg) of I and II to rats did not elicit hepatotoxicity as judged by serum alanine aminotransaminase levels and liver microsomal drug metabolizing enzyme activities

Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach

<p>Abstract</p> <p>Background</p> <p>We and others have previously reported that resveratrol (RSV) suppresses colon cancer cell proliferation and elevates apoptosis <it>in vitro </it>and/or <it>in vivo</it>, however molecular mechanisms are not fully elucidated. Particularly, little information is available on RSV's effects on metabolic pathways and the cell-extra cellular matrix (ECM) communication that are critical for cancer cell growth. To identify important targets of RSV, we analyzed whole protein fractions from HT-29 advanced human colon cancer cell line treated with solvent control, IGF-1 (10 nM) and RSV (150 μM) using LC/MS/MS-Mud PIT (Multidimensional Protein Identification Technology).</p> <p>Results</p> <p>Pentose phosphate pathway (PPP), a vital metabolic pathway for cell cycle progression, was elevated and suppressed by IGF-1 and RSV, respectively in the HT-29 cell line. Enzymatic assays confirmed RSV suppression of glucose-6 phosphate dehydrogenase (rate limiting) and transketolase, key enzymes of the PPP. RSV (150 μM) suppressed, whereas IGF-1 (10 nM) elevated focal adhesion complex (FAC) proteins, talin and pFAK, critical for the cell-ECM communication. Western blotting analyses confirmed the suppression or elevation of these proteins in HT-29 cancer cells treated with RSV or IGF-1, respectively.</p> <p>Conclusions</p> <p>Proteomic analysis enabled us to establish PPP and the talin-pFAK as targets of RSV which suppress cancer cell proliferation and induce apoptosis in the colon cancer cell line HT-29. RSV (150 μM) suppressed these pathways in the presence and absence of IGF-1, suggesting its role as a chemo-preventive agent even in obese condition.</p

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration

Protein S-nitrosation (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an important regulatory mechanism of protein function in both physiological and pathological pathways. A key first step toward elucidating the mechanism by which S-nitrosation modulates a protein's function is identification of the targeted cysteine residues. Here, we present a strategy for the simultaneous identification of SNO-cysteine sites and their cognate proteins to profile the brain of the CK-p25-inducible mouse model of Alzheimer's disease-like neurodegeneration. The approach-SNOTRAP (SNO trapping by triaryl phosphine)-is a direct tagging strategy that uses phosphinebased chemical probes, allowing enrichment of SNO-peptides and their identification by liquid chromatography tandem mass spectrometry. SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. The SNO-proteome during early neurodegeneration identified increased S-nitrosation of proteins important for synapse function, metabolism, and Alzheimer's disease pathology. In the latter case, proteins related to amyloid precursor protein processing and secretion are S-nitrosated, correlating with increased amyloid formation. Sequence analysis of SNO-cysteine sites identified potential linear motifs that are altered under pathological conditions. Collectively, SNOTRAP is a direct tagging tool for global elucidation of the SNO-proteome, providing functional insights of endogenous SNO proteins in the brain and its dysregulation during neurodegeneration.National Institutes of Health (U.S.) (Grant CA26731)National Institutes of Health (U.S.) (Grant R01 NS051874

A recent survey of permutation trinomials over finite fields

Constructing permutation polynomials is a hot topic in the area of finite fields, and permutation polynomials have many applications in different areas. Recently, several classes of permutation trinomials were constructed. In 2015, Hou surveyed the achievements of permutation polynomials and novel methods. But, very few were known at that time. Recently, many permutation binomials and trinomials have been constructed. Here we survey the significant contribution made to the construction of permutation trinomials over finite fields in recent years. Emphasis is placed on significant results and novel methods. The covered material is split into three aspects: the existence of permutation trinomials of the respective forms $x^{r}h(x^{s})$, $\lambda_{1}x^{a}+\lambda_{2}x^{b}+\lambda_{3}x^{c}$ and $x+x^{s(q^{m}-1)+1} +x^{t(q^{m}-1)+1}$, with Niho-type exponents $s, t$