Individual opinions and collective deliberations

Traducción al inglés de la paradoja doctrinal expuesta por Roberto Vacca

Inclusive One Jet Production With Multiple Interactions in the Regge Limit of pQCD

DIS on a two nucleon system in the regge limit is considered. In this framework a review is given of a pQCD approach for the computation of the corrections to the inclusive one jet production cross section at finite number of colors and discuss the general results.Comment: 4 pages, latex, aicproc format, Contribution to the proceedings of "Diffraction 2008", 9-14 Sep. 2008, La Londe-les-Maures, Franc

Opiniones individuales y deliberaciones colectivas

Traducción al español de la paradoja doctrinal expuesta por Roberto Vacca

The bone marrow niche landscape: a journey through aging, extrinsic and intrinsic stressors in the haemopoietic milieu

Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems, thought to properly sustain blood cell production and distinguish between friend and foe, can actively sustain a corrupted neighborhood within a chronic aberrant inflamed state. The bone marrow niche hijacks the physiologic hematopoiesis. The interactions between the hematopoietic stem cells and the niche in the bone marrow are critical determinants of quiescence. We examined several approaches to confront the available evidence; three key points emerged, pointing to the chronic inflammation process, especially the chronic infection and systemic inflammatory states, as leading causes of hematopoietic stem cell depletion. Clonal hematopoiesis, defined as a relative expansion of individual clones, is caused by somatic alterations in essential hematopoietic genes, which increase stem cell fitness. Moreover, terminal differentiation plays a significant role in progenitor loss and inflammatory signaling, promoting clonal selection and clonal hematopoiesis conditions. Specific myeloid malignancies as paradigmatic examples are discussed as a condition associated with inflammation, including the 5q-syndrome, Philadelphia negative myeloproliferative neoplasms, and chronic myeloid leukemia. Aging with increased fitness and hematopoietic stem cell attrition, extrinsic stress, enhanced stressor-specific fitness, and intrinsic defect across the hematopoietic process represent the route for novel insights in defective hematopoiesis. The discussion in this review also points out that the hematopoietic niches' inflammatory stimulation may affect differentiation patterns and the function of downstream cells

peripheral blood progenitor cells mobilization in patients with multiple myeloma

Autologous stem cell transplantation (ASCT) is considered the standard therapy for younger patients with newly diagnosed symptomatic multiple myeloma (MM). The introduction into clinical practice of novel agents (i.e.: proteasome inhibitors and immunomodulatory derivatives [IMiDs]) has significantly contributed to major advances in MM therapy and prognosis. These novel agents are incorporated into induction regimens to enhance the depth of response before ASCT and further improve post-ASCT outcomes. Collection of adequate hematopoietic stem cells (HSCs) is necessary for successful autologous transplantation. The mobilizing regimen usually consists of cyclophosphamide or disease-specific agents, in combination with a hematopoietic cytokine, usually G-CSF, which mobilizes HPSCs into the bloodstream, in particular when administered after myelosuppressive chemotherapy. In some patients, the number of mobilized CD34+ cells is not sufficient to perform successful stem cell transplantation due to bone marrow damage by neoplastic proliferation and/or chemoradiotherapy. To improve the collection of CD34+ cells, the mobilization procedure can be repeated or an alternative chemotherapy regimen can be chosen. Recently, the new drug plerixafor (Mozobil®) has been introduced to increase the number of circulating CD34+ cells. Its use increases the level of functional HPCs in the peripheral blood, with long-term resettlemen

Ciudades inteligentes en colaboración con internet de las cosas

The use of the Internet has Reached a point in the world in Which it has Become essential in everyday life, the need to Have information at hand in the shortest possible time has generated a technological revolution That incurs the constant connection to this tool, from our Personal life to the same objects That we use in daily life, creating a need to check what surrounds us to Improve our quality of life, reason for the birth of the Internet of Things (IoT, for acronym in English), as well as the convergence of our environment through the creation with Technology of smart cities (Smart City in English). In view of the above, this article addresses concepts about the future of smart cities in collaboration with the Internet of things, the advantages and Disadvantages of these, their comparison, reception, adaptability.El uso de Internet ha llegado a un punto en el mundo en el que se ha vuelto esencial en la vida cotidiana, la necesidad de tener información a la mano en el menor tiempo posible ha generado una revolución tecnológica que incurre en la conexión constante a Internet, creando la necesidad de verificar lo que nos rodea para mejorar nuestra calidad de vida, razón por la cual nace Internet de las cosas (IoT, por sus siglas en inglés), también como la convergencia de nuestro entorno a través de la creación con de ciudades inteligentes (Smart City en inglés). En vista de lo anterior, este artículo aborda conceptos sobre el futuro de las ciudades inteligentes en colaboración con Internet de las Cosas, las ventajas y desventajas de estas, su comparación, recepción, adaptabilidad

Angiogenesis and Antiangiogenesis in Multiple Myeloma

Multiple myeloma progression is characterized by a dense interaction between cancer cells and bone marrow microenvironment. The interactions of myeloma cells with various stromal cells and extracellular matrix components are the main regulator of the biological processes that underlie the progression of the disease and of the classic symptomatology correlated. The bone marrow of myeloma patients has recognized autocrine and paracrine loops that regulate multiple signaling pathways and the malignant phenotype of plasma cells. One of the pivotal biological processes which are responsible for myeloma progression is the formation of new vessels from existing ones, known as angiogenesis. It represents a constant hallmark of disease progression and a characteristic feature of the active phase of the disease. Near angiogenesis, other two ancestral processes were active in the bone marrow: vasculogenesis and vasculogenic mimicry. These processes are mediated by the angiogenic cytokines, interleukins, and inflammatory cytokines directly secreted by plasma cells and stromal cells. Neovascularization is also mediated by direct interaction between plasma cells and the various components of bone marrow microenvironment. The observation of the increased bone marrow angiogenesis in multiple myeloma and its correlation with disease activity and overall survival led to consider angiogenesis as a new target in the treatment of multiple myeloma

Trasporto di metalli verso i laghi del sistema Flumendosa Campidano in conseguenza dell'erosione dei suoli

Weathering of mine tailings represents an important metal source in Sardinia. The accumulation of mobilized metals onto soil in the mineralized areas and the subsequent erosional transport of soil towards the freshwater reservoirs endangers the quality of drinking water. The here described study on the Flumendosa-Campidano system shows the prescence and spatial distribution of metals in the system and underlines the necessity to control the more mobile and dangerous metals, as for exampIe cadmium