An Electromagnetic Study of the Impact of Brain Anatomy on Deep Brain Stimulation

An electromagnetic simulation was performed to assess the volume of tissue activated on deep brain stimulation for two patients randomly selected. The finite element method is used to calculate the electric field distribution that predicts the volume of tissue activated. High-resolution magnetic resonance images are utilized to create patient-specific anatomical models of the subthalamic nucleus and the internal pallidum. The results confirmed the influence of brain anatomy leading to different shape and volume of tissue activated despite similar technical features. Thus, a patient-specific model and an adequate choice of stimulation parameters are crucial on deep brain stimulation outcomes.S

Predicting the onset and persistence of episodes of depression in primary health care. The predictD-Spain study: Methodology

Background: The effects of putative risk factors on the onset and/or persistence of depression remain unclear. We aim to develop comprehensive models to predict the onset and persistence of episodes of depression in primary care. Here we explain the general methodology of the predictD-Spain study and evaluate the reliability of the questionnaires used. Methods: This is a prospective cohort study. A systematic random sample of general practice attendees aged 18 to 75 has been recruited in seven Spanish provinces. Depression is being measured with the CIDI at baseline, and at 6, 12, 24 and 36 months. A set of individual, environmental, genetic, professional and organizational risk factors are to be assessed at each follow-up point. In a separate reliability study, a proportional random sample of 401 participants completed the test-retest (251 researcher-administered and 150 self-administered) between October 2005 and February 2006. We have also checked 118,398 items for data entry from a random sample of 480 patients stratified by province. Results: All items and questionnaires had good test-retest reliability for both methods of administration, except for the use of recreational drugs over the previous six months. Cronbach's alphas were good and their factorial analyses coherent for the three scales evaluated (social support from family and friends, dissatisfaction with paid work, and dissatisfaction with unpaid work). There were 191 (0.16%) data entry errors. Conclusion: The items and questionnaires were reliable and data quality control was excellent. When we eventually obtain our risk index for the onset and persistence of depression, we will be able to determine the individual risk of each patient evaluated in primary health car

One year of AU Mic with HARPS: I - measuring the masses of the two transiting planets

The system of two transiting Neptune-sized planets around the bright, young M-dwarf AU Mic provides a unique opportunity to test models of planet formation, early evolution, and star-planet interaction. However, the intense magnetic activity of the host star makes measuring the masses of the planets via the radial velocity (RV) method very challenging. We report on a 1-year, intensive monitoring campaign of the system using 91 observations with the HARPS spectrograph, allowing for detailed modelling of the ∼600 m s−1 peak-to-peak activity-induced RV variations. We used a multidimensional Gaussian Process framework to model these and the planetary signals simultaneously. We detect the latter with semi-amplitudes of Kb = 5.8 ± 2.5 m s−1 and Kc = 8.5 ± 2.5 m s−1, respectively. The resulting mass estimates, Mb = 11.7 ± 5.0 M⊕ and Mc = 22.2 ± 6.7 M⊕, suggest that planet b might be less dense, and planet c considerably denser than previously thought. These results are in tension with the current standard models of core-accretion. They suggest that both planets accreted a H/He envelope that is smaller than expected, and the trend between the two planets’ envelope fractions is the opposite of what is predicted by theory

Planet Hunters TESS III: Two transiting planets around the bright G dwarf HD 152843

We report on the discovery and validation of a two-planet system around a bright (V = 8.85 mag) early G dwarf (1.43 $R_{\odot}$, 1.15 $M_{\odot}$, TOI 2319) using data from NASA's Transiting Exoplanet Survey Satellite (TESS). Three transit events from two planets were detected by citizen scientists in the month-long TESS light curve (sector 25), as part of the Planet Hunters TESS project. Modelling of the transits yields an orbital period of \Pb\ and radius of $3.41 _{ - 0.12 } ^ { + 0.14 }$ $R_{\oplus}$ for the inner planet, and a period in the range 19.26-35 days and a radius of $5.83 _{ - 0.14 } ^ { + 0.14 }$ $R_{\oplus}$ for the outer planet, which was only seen to transit once. Each signal was independently statistically validated, taking into consideration the TESS light curve as well as the ground-based spectroscopic follow-up observations. Radial velocities from HARPS-N and EXPRES yield a tentative detection of planet b, whose mass we estimate to be $11.56 _{ - 6.14 } ^ { + 6.58 }$ $M_{\oplus}$, and allow us to place an upper limit of $27.5$ $M_{\oplus}$ (99 per cent confidence) on the mass of planet c. Due to the brightness of the host star and the strong likelihood of an extended H/He atmosphere on both planets, this system offers excellent prospects for atmospheric characterisation and comparative planetology

Radial velocity confirmation of K2-100b: A young, highly irradiated, and low-density transiting hot Neptune

We present a detailed analysis of HARPS-N radial velocity observations of K2-100, a young and active star in the Praesepe cluster, which hosts a transiting planet with a period of 1.7 days. We model the activity-induced radial velocity variations of the host star with a multi-dimensional Gaussian Process framework and detect a planetary signal of $10.6 \pm 3.0 {\rm m\,s^{-1}}$, which matches the transit ephemeris, and translates to a planet mass of $21.8 \pm 6.2 M_\oplus$. We perform a suite of validation tests to confirm that our detected signal is genuine. This is the first mass measurement for a transiting planet in a young open cluster. The relatively low density of the planet, $2.04^{+0.66}_{-0.61} {\rm g\,cm^{-3}}$, implies that K2-100b retains a significant volatile envelope. We estimate that the planet is losing its atmosphere at a rate of $10^{11}-10^{12}\,{\rm g\,s^{-1}}$ due to the high level of radiation it receives from its host star.O.B. and S.Ai. acknowledge support from the UK Science and Technology Facilities Council (STFC) under grants ST/S000488/1 and ST/R004846/1. J.K., S.G. and A.P.H acknowledges support by Deutsche Forschungsgemeinschaft (DFG) grants PA525/18-1 and PA525/19-1 and HPA 3279/12-1 within the DFG Schwerpunkt SPP 1992, Exploring the Diversity of Extra-solar Planets. L.M. acknowledges support from PLATO ASI-INAF agreement n.2015-019-R.1-2018. S.Al. acknowledges the support from the Danish Council for Independent Research through the DFF Sapere Aude Starting Grant No. 4181-00487B, and the Stellar Astrophysics Centre which funding is provided by The Danish National Research Foundation (Grant agreement no.: DNRF106). This work is partly supported by JSPS KAKENHI Grant Numbers JP18H01265, JP18H05439, 15H02063, and 18H05442 and JST PRESTO Grant Number JPMJPR1775. M.C.V.F. and C.M.P. gratefully acknowledge the support of the Swedish National Space Agency (DNR 174/18)

PYANETI II: a multi-dimensional Gaussian process approach to analysing spectroscopic time-series

The two most successful methods for exoplanet detection rely on the detection of planetary signals in photometric and radial velocity time-series. This depends on numerical techniques that exploit the synergy between data and theory to estimate planetary, orbital, and/or stellar parameters. In this work we present a new version of the exoplanet modelling code pyaneti. This new release has a special emphasis on the modelling of stellar signals in radial velocity time-series. The code has a built-in multi-dimensional Gaussian process approach to modelling radial velocity and activity indicator time-series with different underlying covariance functions. This new version of the code also allows multi-band and single transit modelling; it runs on Python 3, and features overall improvements in performance. We describe the new implementation and provide tests to validate the new routines that have direct application to exoplanet detection and characterisation. We have made the code public and freely available at https://github.com/oscaribv/pyaneti. We also present the codes citlalicue and citlalatonac that allow one to create synthetic photometric and spectroscopic time-series, respectively, with planetary and stellar-like signals

Transport Phenomena in Particle Suspensions: Sedimentation and Thermophoresis

This chapter deals with transport phenomena induced in colloidal suspensions and complex fluids either by gravity, which is the well established but nevertheless still stimulating subject of sedimentation, or by thermophoresis, a subtler and very intriguing effect that is still partly understood. Specifically, I shall highlight the wealth of information one can get by investigating the particle concentration profiles generated at equilibrium by sedimentation, or at steady-state by thermophoresis, and discuss some novel optical techniques that have been fruitfully exploited to study them