3,728 research outputs found
On the Geroch-Traschen class of metrics
We compare two approaches to semi-Riemannian metrics of low regularity. The maximally 'reasonable' distributional setting of Geroch and Traschen is shown to be consistently contained in the more general setting of nonlinear distributional geometry in the sense of Colombea
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Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function.
Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective. The major impediment in developing effective treatments is our limited understanding of the underlying mechanisms. Preclinical evidence suggests that glial changes are crucial for the development of NP and a recent study reported oscillatory activity differences within the ascending pain pathway at frequencies similar to that of cyclic gliotransmission in NP. Furthermore, there is evidence that glial modifying medications may be effective in treating NP. The aim of this Phase I open-label clinical trial is to determine whether glial modifying medication palmitoylethanolamide (PEA) will reduce NP and whether this is associated with reductions in oscillatory activity within the pain pathway. Methods: We investigated whether 6 weeks of PEA treatment would reduce pain and infra-slow oscillatory activity within the ascending trigeminal pathway in 22 individuals (17 females) with chronic orofacial NP. Results: PEA reduced pain in 16 (73%) of the 22 subjects, 11 subjects showed pain reduction of over 20%. Whilst both the responders and non-responders showed reductions in infra-slow oscillatory activity where orofacial nociceptor afferents terminate in the brainstem, only responders displayed reductions in the thalamus. Furthermore, functional connections between the brainstem and thalamus were altered only in responders. Conclusion: PEA is effective at relieving NP. This reduction is coupled to a reduction in resting oscillations along the ascending pain pathway that are likely driven by rhythmic astrocytic gliotransmission
Comparison of photoexcited p-InAs THz radiation source with conventional thermal radiation sources
P-type InAs excited by ultrashort optical pulses has been shown to be a strong emitter of terahertz radiation. In a direct comparison between a p-InAs emitter and conventional thermal radiation sources, we demonstrate that under typical excitation conditions p-InAs produces more radiation below 1.2 THz than a globar. By treating the globar as a blackbody emitter we calibrate a silicon bolometer which is used to determine the power of the p-InAs emitter. The emitted terahertz power was found to be 98±10 nW in this experiment
Systematic reviews of complementary therapies - an annotated bibliography. Part 1: Acupuncture
Background Complementary therapies are widespread but controversial. We aim to provide a comprehensive collection and a summary of systematic reviews of clinical trials in three major complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with acupuncture. Potentially relevant reviews were searched through the register of the Cochrane Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and books. To be included articles had to review prospective clinical trials of acupuncture; had to describe review methods explicitly; had to be published; and had to focus on treatment effects. Information on conditions, interventions, methods, results and conclusions was extracted using a pretested form and summarized descriptively. Results From a total of 48 potentially relevant reviews preselected in a screeening process 39 met the inclusion criteria. 22 were on various pain syndromes or rheumatic diseases. Other topics addressed by more than one review were addiction, nausea, asthma and tinnitus. Almost unanimously the reviews state that acupuncture trials include too few patients. Often included trials are heterogeneous regarding patients, interventions and outcome measures, are considered to have insufficient quality and contradictory results. Convincing evidence is available only for postoperative nausea, for which acupuncture appears to be of benefit, and smoking cessation, where acupuncture is no more effective than sham acupuncture. Conclusions A large number of systematic reviews on acupuncture exists. What is most obvious from these reviews is the need for (the funding of) well-designed, larger clinical trials
Giant and reversible extrinsic magnetocaloric effects in La0.7Ca0.3MnO3 films due to strain
Large thermal changes driven by a magnetic field have been proposed for
environmentally friendly energy efficient refrigeration, but only a few
materials which suffer hysteresis show these giant magnetocaloric effects. Here
we create giant and reversible extrinsic magnetocaloric effects in epitaxial
films of the ferromagnetic manganite La0.7Ca0.3MnO3 using strain mediated
feedback from BaTiO3 substrates near a first-order structural phase transition.
Our findings should inspire the discovery of giant magnetocaloric effects in a
wide range of magnetic materials, and the parallel development of
nanostructured bulk samples for practical applications.Comment: 32 pages, 1 Table, 5 figures, supplementary informatio
Comparison of photoexcited p-InAs THz radiation source with conventional thermal radiation sources
P-type InAs excited by ultrashort optical pulses has been shown to be a strong emitter of terahertz radiation. In a direct comparison between a p-InAs emitter and conventional thermal radiationsources, we demonstrate that under typical excitation conditions p-InAs produces more radiation below 1.2 THz than a globar. By treating the globar as a blackbody emitter we calibrate a siliconbolometer which is used to determine the power of the p-InAs emitter. The emitted terahertz power was found to be 98±10 nW in this experiment
A topos for algebraic quantum theory
The aim of this paper is to relate algebraic quantum mechanics to topos
theory, so as to construct new foundations for quantum logic and quantum
spaces. Motivated by Bohr's idea that the empirical content of quantum physics
is accessible only through classical physics, we show how a C*-algebra of
observables A induces a topos T(A) in which the amalgamation of all of its
commutative subalgebras comprises a single commutative C*-algebra. According to
the constructive Gelfand duality theorem of Banaschewski and Mulvey, the latter
has an internal spectrum S(A) in T(A), which in our approach plays the role of
a quantum phase space of the system. Thus we associate a locale (which is the
topos-theoretical notion of a space and which intrinsically carries the
intuitionistic logical structure of a Heyting algebra) to a C*-algebra (which
is the noncommutative notion of a space). In this setting, states on A become
probability measures (more precisely, valuations) on S(A), and self-adjoint
elements of A define continuous functions (more precisely, locale maps) from
S(A) to Scott's interval domain. Noting that open subsets of S(A) correspond to
propositions about the system, the pairing map that assigns a (generalized)
truth value to a state and a proposition assumes an extremely simple
categorical form. Formulated in this way, the quantum theory defined by A is
essentially turned into a classical theory, internal to the topos T(A).Comment: 52 pages, final version, to appear in Communications in Mathematical
Physic
Painting the ideal home: using art to express visions of technologically supported independent living for older people in North East England
This paper describes the investigation of the development of future technological products to support older people in everyday living through the agency of a community art group. Recent research has identified a number of challenges facing designers seeking to use traditional participatory design approaches to gather technology requirements data from older people. Here, a project is described that sought to get a group of older people to think creatively about their needs and desires for technological support through the medium of paint. The artistic expression technique described in this article allowed the identification of issues that had also been found by previous research that used a range of different techniques. This indicates that the approach shows promise, as it allows information to be gathered in an environment that is comfortable and familiar using methods already known by the participants and which they find enjoyable. It provides a complement (or possible alternative) to standard protocols and has the potential benefit of extracting even richer information as the primary task for participants is enjoyable in its own right and is not associated with an interrogative process. Furthermore, it is argued that some of the key risks of traditional approaches are lessened or removed by the naturalistic setting of this approach
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