1,571 research outputs found
The Neron-Severi group of a proper seminormal complex variety
We prove a Lefschetz (1,1)-Theorem for proper seminormal varieties over the
complex numbers. The proof is a non-trivial geometric argument applied to the
isogeny class of the Lefschetz 1-motive associated to the mixed Hodge structure
on H^2.Comment: 16 pages; Mathematische Zeitschrift (2008
Reduced coherence in double-slit diffraction of neutrons
In diffraction experiments with particle beams, several effects lead to a
fringe visibility reduction of the interference pattern. We theoretically
describe the intensity one can measure in a double-slit setup and compare the
results with the experimental data obtained with cold neutrons. Our conclusion
is that for cold neutrons the fringe visibility reduction is due not to
decoherence, but to initial incoherence.Comment: 4 pages LaTeX, 2 figure
A Proof of Concept of the Usefulness of a TDM-Guided Strategy for Optimizing Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Ampicillin-Based Regimens in a Case Series of Patients with Enterococcal Bloodstream Infections and/or Endocarditis
(1) Objective: To describe the usefulness of a real-time therapeutic drug monitoring (TDM)-based strategy for optimizing pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ampicillin-based regimens in a case series of patients affected by suspected or documented enterococcal bloodstream infections (BSIs) and/or infective endocarditis (IE). (2) Methods: Patients treated with CI ampicillin-based regimens for documented or suspected enterococcal BSI/IE who underwent real-time therapeutic drug monitoring (TDM)-based expert clinical pharmacological advice (ECPA) between June 2021 and May 2022 were retrospectively assessed. Ampicillin concentrations were determined at steady state, and the free fraction (fC(ss)) was calculated according to a plasma protein binding of 20%. The fC(ss)/MIC ratio was selected as the PD parameter for ampicillin efficacy and was defined as optimal for values between 4 and 8. The requirement for TDM-guided ampicillin dosing adjustments was assessed. (3) Results: Data for 12 patients with documented (n = 10) or suspected (n = 2) enterococcal infections (7 with BSIs and 5 with IE) were retrieved. The ampicillin PK/PD target was optimal over time in all of the 10 documented infections. None of the enterococcal BSIs persisted. Following the first real-time TDM-based ECPA, ampicillin dosage was decreased by >50% in 11 out of 12 patients (91.7%). (4) Conclusions: CI may be helpful in attaining aggressive ampicillin PK/PD targets in patients affected by enterococcal BSIs and/or IE. Administration of CI ampicillin after loading coupled with real-time TDM-based ECPA could be a valuable strategy for managing enterococcal infections
Master-equations for the study of decoherence
Different structures of master-equation used for the description of
decoherence of a microsystem interacting through collisions with a surrounding
environment are considered and compared. These results are connected to the
general expression of the generator of a quantum dynamical semigroup in
presence of translation invariance recently found by Holevo.Comment: 10 pages, latex, no figures, to appear in Int. J. Theor. Phy
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