804 research outputs found
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation
The innate immune system is the most ancestral and ubiquitous system of defence against microbial infection. The microbial sensing proteins involved in innate immunity recognize conserved and often structural components of microorganisms. One class of these pattern-recognition molecules, the Toll-like receptors (TLRs), are involved in detection of microbes in the extracellular compartment whereas a newly discovered family of proteins, the NBS-LRR proteins (for nucleotide-binding site and leucine-rich repeat), are involved in intracellular recognition of microbes and their products. NBS-LRR proteins are characterized by three structural domains: a C-terminal leucine-rich repeat (LRR) domain able to sense a microbial motif, an intermediary nucleotide binding site (NBS) essential for the oligomerization of the molecule that is necessary for the signal transduction induced by different N-terminal effector motifs, such as a pyrin domain (PYD), a caspase-activating and recruitment domain (CARD) or a baculovirus inhibitor of apoptosis protein repeat (BIR) domain. Two of these family members, Nod1 and Nod2, play a role in the regulation of pro-inflammatory pathways through NF-ÎșB induced by bacterial ligands. Recently, it was shown that Nod2 recognizes a specific peptidoglycan motif from bacteria, muramyl dipeptide (MDP). A surprising number of human genetic disorders have been linked to NBS-LRR proteins. For example, mutations in Nod2, which render the molecule insensitive to MDP and unable to induce NF-ÎșB activation when stimulated, are associated with susceptibility to a chronic intestinal inflammatory disorder, Crohn's disease. Conversely, mutations in the NBS region of Nod2 induce a constitutive activation of NF-ÎșB and are responsible for Blau syndrome, another auto-inflammatory disease. Nalp3, which is an NBS-LRR protein with an N-terminal Pyrin domain, is also implicated in rare auto-inflammatory disorders. In conclusion, NBS-LRR molecules appear as a new family of intracellular receptors of innate immunity able to detect specific bacterial compounds and induce inflammatory response; the dysregulation of these processes due to mutations in the genes encoding these proteins is involved in numerous auto-inflammatory disorders.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75732/1/j.1462-5822.2003.00304.x.pd
Converting sporting capacity to entrepreneurial capacity: A process perspective
Managing a personal sporting career and conducting an entrepreneurial initiative are two vitally connected processes. Most athletes require a second career and many engage in entrepreneurship. Research on the similarities and differences of the sports career management process and entrepreneurial process with a special emphasis on the necessary capacities will have a ready audience among practitioners. This study begins the task of closing a surprising gap. In entrepreneurship literature, there is (1) growing research on entrepreneurial process and entrepreneurial capacity as the key driver; (2) strong work in generic, descriptive and explanatory modelling of process as a whole and capacity as a sub-process; and (3) the presence of a generic model of entrepreneurial process based of what distinguishes entrepreneurial capacity from other human capacities. In sports management literature, these research strands are virtually absent. The study indicates how the deficiency might be remedied
Self-gravitating clouds of generalized Chaplygin and modified anti-Chaplygin Gases
The Chaplygin gas has been proposed as a possible dark energy, dark matter
candidate. As a working fluid in a Friedmann-Robertson-Walker universe, it
exhibits early behavior reminiscent of dark matter, but at later times is more
akin to a cosmological constant. In any such universe, however, one can expect
local perturbations to form. Here we obtain the general equations for a
self-gravitating relativistic Chaplygin gas. We solve these equations and
obtain the mass-radius relationship for such structures, showing that only in
the phantom regime is the mass-radius relationship large enough to be a serious
candidate for highly compact massive objects at the galaxy core. In addition,
we study the cosmology of a modified anti-Chaplygin gas. A self-gravitating
cloud of this matter is an exact solution to Einstein's equations.Comment: 16 page
PMS1 The Impact of Comorbidities on Utility Changes in Lower-Limb Osteoarthritis : Khoala Study
CH 3 GHz Observations of the Galactic Center
A 3 3 map of the Galactic Center was made at 9\arcmin resolution
and 10\arcmin spacing in the CH , J=1/2, F=1-1 transition at
3335 MHz. The CH emission shows a velocity extent that is nearly that of the
CO(1-0) line, but the CH line profiles differ markedly from the CO. The 3335
MHz CH transition primarily traces low-density molecular gas and our
observations indicate that the mass of this component within 30 pc of
the Galactic Center is 9 10 M. The CO-H
conversion factor obtained for the low-density gas in the mapped region is
greater than that thought to apply to the dense molecular gas at the Galactic
Center. In addition to tracing the low-density molecular gas at the Galactic
Center, the CH spectra show evidence of emission from molecular clouds along
the line of sight both in the foreground and background. The scale height of
these clouds ranges from 27 - 109 pc, consistent with previous work based on
observations of molecular clouds in the inner Galaxy.Comment: 29 pages, 12 figure
Dowe really need an accurate calibration pattern?
The metrology of calibration patterns is often a real problem in computer vision to obtain a reliable estimation of the intrinsic
and extrinsic parameters that model a video camera device . In order to take into account these errors a self-calibration method
is described, that enables us to compute in the same time the traditional calibration parameters and the 3D geometry of the
calibration pattern using a multi-images calibration algorithm . Experimental results shows that the proposed algorithm leads to
reliable calibration results and proves that calibration errors no longer depend on the accuracy of calibration point measurement,
but on the accuracy of calibration point detection in the image plane .Cet article soulĂšve le problĂšme de l'influence des erreurs introduites par la mĂ©trologie d'une mire d'Ă©talonnage sur la dĂ©termination des paramĂštres intrinsĂšques d'un capteur vidĂ©o. Afin de s'affranchir de ces erreurs, une approche d'autocalibrage est dĂ©crite permettant conjointement d'estimer les paramĂštres internes du capteur vidĂ©o et la gĂ©omĂ©trie de la mire, au sein d'un formalisme d'Ă©talonnage multi-images. Par la problĂ©matique qu'il soulĂšve, cet article cotoie les approches de Shape from Motion et d'Auto-calibrage des capteurs, en gardant cependant la spĂ©cificitĂ© d'ĂȘtre dĂ©crit selon un formalisme photogrammĂ©trique et donc d'intĂ©grer implicitement les aberrations gĂ©omĂ©triques des objectifs. Nous nous sommes attachĂ©s Ă insister sur l'aspect descriptif de la mĂ©thode pour permettre aux lecteurs une vision globale de la mise en oeuvre du procĂ©dĂ©
CN and HCN in Dense Interstellar Clouds
We present a theoretical investigation of CN and HCN molecule formation in
dense interstellar clouds. We study the gas-phase CN and HCN production
efficiencies from the outer photon-dominated regions (PDRs) into the opaque
cosmic-ray dominated cores. We calculate the equilibrium densities of CN and
HCN, and of the associated species C+, C, and CO, as functions of the
far-ultraviolet (FUV) optical depth. We consider isothermal gas at 50 K, with
hydrogen particle densities from 10^2 to 10^6 cm^-3. We study clouds that are
exposed to FUV fields with intensities 20 to 2*10^5 times the mean interstellar
FUV intensity. We assume cosmic-ray H2 ionization rates ranging from 5*10^-17
s^-1, to an enhanced value of 5*10^-16 s^-1. We also examine the sensitivity of
the density profiles to the gas-phase sulfur abundance.Comment: Accepted for publication in ApJ, 33 pages, 8 figure
Multi--Pressure Polytropes as Models for the Structure and Stability of Molecular Clouds. I. Theory
Molecular clouds are supported by thermal pressure, magnetic pressure, and
turbulent pressure. Each of these can be modeled with a polytropic equation of
state, so that overall the total pressure is the sum of the individual
components. We model the turbulent pressure as being due to a superposition of
Alfven waves. The theory of polytropes is generalized to allow for the flow of
entropy in response to a perturbation, as expected for the entropy associated
with wave pressure. The equation of state of molecular clouds is "soft", so
that the properties of the clouds are generally governed by the conditions at
the surface. In general, the polytropes are not isentropic, and this permits
large density and pressure drops to occur between the center and the edge of
the polytropes, as is observed.Comment: Submitted to ApJ with 10 figure
Magneto-Acoustic Waves of Small Amplitude in Optically Thin Quasi-Isentropic Plasmas
The evolution of quasi-isentropic magnetohydrodynamic waves of small but
finite amplitude in an optically thin plasma is analyzed. The plasma is assumed
to be initially homogeneous, in thermal equilibrium and with a straight and
homogeneous magnetic field frozen in. Depending on the particular form of the
heating/cooling function, the plasma may act as a dissipative or active medium
for magnetoacoustic waves, while Alfven waves are not directly affected. An
evolutionary equation for fast and slow magnetoacoustic waves in the single
wave limit, has been derived and solved, allowing us to analyse the wave
modification by competition of weakly nonlinear and quasi-isentropic effects.
It was shown that the sign of the quasi-isentropic term determines the scenario
of the evolution, either dissipative or active. In the dissipative case, when
the plasma is first order isentropically stable the magnetoacoustic waves are
damped and the time for shock wave formation is delayed. However, in the active
case when the plasma is isentropically overstable, the wave amplitude grows,
the strength of the shock increases and the breaking time decreases. The
magnitude of the above effects depends upon the angle between the wave vector
and the magnetic field. For hot (T > 10^4 K) atomic plasmas with solar
abundances either in the interstellar medium or in the solar atmosphere, as
well as for the cold (T < 10^3 K) ISM molecular gas, the range of temperature
where the plasma is isentropically unstable and the corresponding time and
length-scale for wave breaking have been found.Comment: 14 pages, 10 figures. To appear in ApJ January 200
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