Formation of long-lived reactive products in blood serum under heat treatment and low-intensity laser irradiation, their role in hydrogen peroxide generation and DNA damage

Long-lived reactive protein products were shown to be evolved under heat treatment and low-intensity laser irradiation in blood serum in presence of dissolved oxygen from the air. These reactive protein products generate hydrogen peroxide for a long time, which results from conjugated electron-radical chain reactions. Long-lived reactive protein species play an important role in the adaptation of living systems to stress factors. Apparently, the formation of visible light- and heat-induced reactive protein species is not specific to just blood serum proteins, rather than it could also be a feature of other proteins

Formation of long-lived reactive products in blood serum under heat treatment and low-intensity laser irradiation, their role in hydrogen peroxide generation and DNA damage

214-223Long-lived reactive protein products were shown to be evolved under heat treatment and low-intensity laser irradiation in blood serum in presence of dissolved oxygen from the air. These reactive protein products generate hydrogen peroxide for a long time, which results from conjugated electron-radical chain reactions. Long-lived reactive protein species play an important role in the adaptation of living systems to stress factors. Apparently, the formation of visible light- and heat-induced reactive protein species is not specific to just blood serum proteins, rather than it could also be a feature of other proteins

Conformal mechanics inspired by extremal black holes in d=4

A canonical transformation which relates the model of a massive relativistic particle moving near the horizon of an extremal black hole in four dimensions and the conventional conformal mechanics is constructed in two different ways. The first approach makes use of the action-angle variables in the angular sector. The second scheme relies upon integrability of the system in the sense of Liouville.Comment: V2: presentation improved, new material and references added; the version to appear in JHE

An overview of new supersymmetric gauge theories with 2-form gauge potentials

An overview of new 4d supersymmetric gauge theories with 2-form gauge potentials constructed by various authors during the past five years is given. The key role of three particular types of interaction vertices is emphasized. These vertices are used to develop a connecting perspective on the new models and to distinguish between them. One example is presented in detail to illustrate characteristic features of the models. A new result on couplings of 2-form gauge potentials to Chern-Simons forms is presented.Comment: 11 pages; to appear in the proceedings of NATO ARW "Noncommutative structures in mathematics and physics" (Kiev 09/00); table in section 3 correcte

Постать Тараса Шевченка в рецепції Ліни Костенко

У статті розглядається поетика творення Ліною Костенко образу Кобзаря крізь призму власного "я", через пережиті відчуття поета-шістдесятника, що своєю проекцією нагадують душевні терзання великого поета.В статье рассмотрена поэтика создания Линой Костенко образа Тараса Шевченко сквозь призму собственного "я", через пережитые ощущения поэта-шестидесятника, своей проекцией напоминающие душевные терзания великого поэта.The article deals with the problem of the poetics creation by Lina Kostenko Taras Shevchenko’ image through a prism her own mind, through sensations of the poet-sixtier, by the projection reminding sincere torments the great poet is considered

Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+

The COMPASS experiment at the CERN SPS has studied the diffractive dissociation of negative pions into the pi- pi- pi+ final state using a 190 GeV/c pion beam hitting a lead target. A partial wave analysis has been performed on a sample of 420000 events taken at values of the squared 4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data show a significant natural parity exchange production of a resonance with spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The resonant nature of this wave is evident from the mass-dependent phase differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2 is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged; version 3 updated authors, text shortened, data unchange

On Propagation of Excitation Waves in Moving Media: The FitzHugh-Nagumo Model

BACKGROUND: Existence of flows and convection is an essential and integral feature of many excitable media with wave propagation modes, such as blood coagulation or bioreactors. METHODS/RESULTS: Here, propagation of two-dimensional waves is studied in parabolic channel flow of excitable medium of the FitzHugh-Nagumo type. Even if the stream velocity is hundreds of times higher that the wave velocity in motionless medium (), steady propagation of an excitation wave is eventually established. At high stream velocities, the wave does not span the channel from wall to wall, forming isolated excited regions, which we called "restrictons". They are especially easy to observe when the model parameters are close to critical ones, at which waves disappear in still medium. In the subcritical region of parameters, a sufficiently fast stream can result in the survival of excitation moving, as a rule, in the form of "restrictons". For downstream excitation waves, the axial portion of the channel is the most important one in determining their behavior. For upstream waves, the most important region of the channel is the near-wall boundary layers. The roles of transversal diffusion, and of approximate similarity with respect to stream velocity are discussed. CONCLUSIONS: These findings clarify mechanisms of wave propagation and survival in flow

Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells (RGCs) express high levels of Panx1 and are susceptible to ischemic induced injury, we hypothesized that Panx1 contributes to rapid and selective loss of these neurons in ischemia. To test this hypothesis, we induced experimental retinal ischemia followed by reperfusion in live animals with the Panx1 channel genetically ablated either in the entire mouse (Panx1 KO), or only in neurons using the conditional knockout (Panx1 CKO) technology. Here we report that two distinct neurotoxic processes are induced in RGCs by ischemia in the wild type mice but are inactivated in Panx1KO and Panx1 CKO animals. First, the post-ischemic permeation of RGC plasma membranes is suppressed, as assessed by dye transfer and calcium imaging assays ex vivo and in vitro. Second, the inflammasome-mediated activation of caspase-1 and the production of interleukin-1β in the Panx1 KO retinas are inhibited. Our findings indicate that post-ischemic neurotoxicity in the retina is mediated by previously uncharacterized pathways, which involve neuronal Panx1 and are intrinsic to RGCs. Thus, our work presents the in vivo evidence for neurotoxicity elicited by neuronal Panx1, and identifies this channel as a new therapeutic target in ischemic pathologies