Reporte Geofísico Ingemmet : Proyecto A.N.A.D. Limamayo, departamento de Cuzco, Perú

Este estudio de magnetometría tuvo como objetivo la detección y delineación en profundidad de formaciones intrusivas favorables a la ocurrencia de mineralización de tipo skarn de magnetita con contenido económico de Cu, Ag, Pb, Zn, Au. Más específicamente el levantamiento de magnetometría tuvo como objetivo la detección directa de concentraciones de magnetita asociada a este tipo de yacimientos. Complementariamente, se busca asistir en el mapeo de contactos y estructuras asociadas al tipo de yacimiento geológico mencionado

D,L-cis-2,3-pyrrolidine dicarboxylate alters [H-3]-L-glutamate binding and induces convulsions in mice

This study investigated whether D,L-cis-2,3-Pyrrolidine dicarboxylate (D,L-cis-2,3-PDC), a new glutamate analogue, alters glutamate binding to cerebral plasma membranes and whether N-methyl-D-aspartate (NMDA) receptors are involved in the convulsant effect of this compound. D,L-cis-2,3-PDC reduced sodium-independent [H-3]-L-glutamate binding to lysed membrane preparations from adult rat cortex and had no effect on sodium-dependent glutamate binding. Intracerebroventricular administration Of D,L-cis-2,3-PDC (7.5-25 nmol/5 mul) induced generalized tonic-clonic convulsions in mice in a dose-dependent manner. The coadministration of MK-801 (7 nmol/2.5 mul), with D,L-cis-2,3-PDC (16.5 nmol/2.5 mul), fully protected the animals against D,L-cis-2,3-PDC-induced convulsions, while the coadministration of DNQX (10 nmol/2.5 mul) increased the latency to convulsions but did not alter the percentage of animals that had convulsions. These results suggest that D,L-cis-2,3-PDC-induced effects are mediated predominantly by NMDA receptors. (C) 2003 Elsevier Inc. All rights reserved.76229529

EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials

At a meeting of the EU/US/Clinical Trials in Alzheimer’s Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trials, which will help guide future clinical trials of AD treatments, particularly in the pre-clinical space. The Task Force discussed challenges that need to be addressed across all aspects of clinical trials, calling for innovation in recruitment and retention, infrastructure development, and the selection of outcome measures. While cognitive change provides a marker of disease progression across the disease continuum, there remains a need to identify the optimal assessment tools that provide clinically meaningful endpoints. Patient- and informant-reported assessments of cognition and function may be useful but present additional challenges. Imaging and other biomarkers are also essential to maximize the efficiency of and the information learned from clinical trials

Die weisse Giesserei Verschiedene Wege - und ein Ziel: Arbeitsplaetze in der Putzerei

Available from TIB Hannover: F94B0087 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Computergestuetzte innovative Technologie im Modellbau fuer Giessereien -CITIM

Available from TIB Hannover: RO 619(68) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Unterlagen fuer ein giessereispezifisches Qualitaetssicherungs-Handbuch

TIB Hannover: RO 619(42) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Zum Verhalten von Eisengusswerkstoffen unter dynamischer Beanspruchung

TIB Hannover: RO 619(44) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

SO -Verfahren Vortragsveranstaltung der VDG-Fachgruppe Fertigungsverfahren

TIB: RO 619 (34) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Luftreinhaltung und Druckgiessereien

TIB: RO 619(46) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Layout-Planung fuer Giessereien

SIGLETIB: RO 619(40) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman