A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog

A 10-year-old crossbred dog was presented with a 6-week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as hyperglobulinemia. Cytologic and histopathologic analyses were consistent with a round cell neoplasm; neoplastic cells showed nuclear immunoreactivity for MUM1 and diffuse cytoplasmic reactivity for CD3. Polymerase chain reactions performed on fixed and fresh tissue identified a clonal rearrangement with an IgH primer set. An extramedullary plasmacytoma (EMP) was confirmed by cellular morphology and molecular diagnostics. Following an objective response to chemotherapy, the dog was euthanized 8 months after diagnosis, and a postmortem examination confirmed the clinical findings. This is the first reported case of a monoclonal gammopathy secondary to a gastric EMP coupled with aberrant expression of CD3 in an aggressive plasmacytic tumor, and highlights the utility of molecular diagnostics for classifying atypical hemolymphoid neoplasms

Dynamic scaling and universality in evolution of fluctuating random networks

We found that models of evolving random networks exhibit dynamic scaling similar to scaling of growing surfaces. It is demonstrated by numerical simulations of two variants of the model in which nodes are added as well as removed [Phys. Rev. Lett. 83, 5587 (1999)]. The averaged size and connectivity of the network increase as power-laws in early times but later saturate. Saturated values and times of saturation change with paramaters controlling the local evolution of the network topology. Both saturated values and times of saturation obey also power-law dependences on controlling parameters. Scaling exponents are calculated and universal features are discussed.Comment: 7 pages, 6 figures, Europhysics Letters for

Radiation hardness of small-pitch 3D pixel sensors up to HL-LHC fluences

A new generation of 3D silicon pixel detectors with a small pixel size of 50$\times$50 and 25$\times$100 $\mu$m$^{2}$ is being developed for the HL-LHC tracker upgrades. The radiation hardness of such detectors was studied in beam tests after irradiation to HL-LHC fluences up to $1.4\times10^{16}$ n$_{\mathrm{eq}}$/cm$^2$. At this fluence, an operation voltage of only 100 V is needed to achieve 97% hit efficiency, with a power dissipation of 13 mW/cm$^2$ at -25$^{\circ}$C, considerably lower than for previous 3D sensor generations and planar sensors.Comment: 5 pages, 2 figures, Proceedings of TIPP 2017, Beijing (International Conference on The Technology and Instrumentation in Particle Physics 2017

Generic Absorbing Transition in Coevolution Dynamics

We study a coevolution voter model on a network that evolves according to the state of the nodes. In a single update, a link between opposite-state nodes is rewired with probability $p$, while with probability $1-p$ one of the nodes takes its neighbor's state. A mean-field approximation reveals an absorbing transition from an active to a frozen phase at a critical value $p_c=\frac{\mu-2}{\mu-1}$ that only depends on the average degree $\mu$ of the network. The approach to the final state is characterized by a time scale that diverges at the critical point as $\tau \sim |p_c-p|^{-1}$. We find that the active and frozen phases correspond to a connected and a fragmented network respectively. We show that the transition in finite-size systems can be seen as the sudden change in the trajectory of an equivalent random walk at the critical rewiring rate $p_c$, highlighting the fact that the mechanism behind the transition is a competition between the rates at which the network and the state of the nodes evolve.Comment: 5 pages, 4 figure

Divergent Time Scale in Axelrod Model Dynamics

We study the evolution of the Axelrod model for cultural diversity. We consider a simple version of the model in which each individual is characterized by two features, each of which can assume q possibilities. Within a mean-field description, we find a transition at a critical value q_c between an active state of diversity and a frozen state. For q just below q_c, the density of active links between interaction partners is non-monotonic in time and the asymptotic approach to the steady state is controlled by a time scale that diverges as (q-q_c)^{-1/2}.Comment: 4 pages, 5 figures, 2-column revtex4 forma

Modeling two-language competition dynamics

During the last decade, much attention has been paid to language competition in the complex systems community, that is, how the fractions of speakers of several competing languages evolve in time. In this paper we review recent advances in this direction and focus on three aspects. First we consider the shift from two-state models to three state models that include the possibility of bilingual individuals. The understanding of the role played by bilingualism is essential in sociolinguistics. In particular, the question addressed is whether bilingualism facilitates the coexistence of languages. Second, we will analyze the effect of social interaction networks and physical barriers. Finally, we will show how to analyze the issue of bilingualism from a game theoretical perspective.Comment: 15 pages, 5 figures; published in the Special Issue of Advances in Complex Systems "Language Dynamics

The Bak-Sneppen Model on Scale-Free Networks

We investigate by numerical simulations and analytical calculations the Bak-Sneppen model for biological evolution in scale-free networks. By using large scale numerical simulations, we study the avalanche size distribution and the activity time behavior at nodes with different connectivities. We argue the absence of a critical barrier and its associated critical behavior for infinite size systems. These findings are supported by a single site mean-field analytic treatment of the model.Comment: 5 pages and 3 eps figures. Final version appeared in Europhys. Let

Mass media destabilizes the cultural homogeneous regime in Axelrod's model

An important feature of Axelrod's model for culture dissemination or social influence is the emergence of many multicultural absorbing states, despite the fact that the local rules that specify the agents interactions are explicitly designed to decrease the cultural differences between agents. Here we re-examine the problem of introducing an external, global interaction -- the mass media -- in the rules of Axelrod's model: in addition to their nearest-neighbors, each agent has a certain probability $p$ to interact with a virtual neighbor whose cultural features are fixed from the outset. Most surprisingly, this apparently homogenizing effect actually increases the cultural diversity of the population. We show that, contrary to previous claims in the literature, even a vanishingly small value of $p$ is sufficient to destabilize the homogeneous regime for very large lattice sizes

Polyimide foams

A fully imidized, solvent-free polyimide foam having excellent mechanical, acoustic, thermal, and flame resistant properties is produced. A first solution is provided, which includes one or more aromatic dianhydrides or derivatives of aromatic dianhydrides, and may include one or more aromatic diamines, dissolved in one or more polar solvents, along with an effective amount of one or more blowing agents. This first solution may also advantageously include effective amounts respectively of one or mores catalysts, one or more surfactants, and one or more fire retardants. A second solution is also provided which includes one or more isocyanates. The first and second solutions are rapidly and thoroughly mixed to produce an admixture, which is allowed to foam--in an open container, or in a closed mold--under ambient conditions to completion produce a foamed product. This foamed product is then cured by high frequency electromagnetic radiation, thermal energy, or a combination thereof. Alternatively, the process is adapted for spraying or extrusion