13 research outputs found
Π‘ΠΈΠ½ΡΡΠ½ΡΠΉ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ· (Π±ΠΎΠ»Π΅Π·Π½ΡΠ ΠΎΠ·Π°ΠΈ - ΠΠΎΡΡΠΌΠ°Π½Π°): ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅
The authors characterized a heterogeneous group of a rare disease - Langerhans and non-Langerhans cell histiocytosis,
and analyzed key differential and diagnostic differences between these forms of the disease. A very rare case of non-
Langerhans cell histiocytosis (Rosai-Dorfman disease) in a female patient aged 63 with the subsequent spontaneous
regression of eruptions was described. Key skin manifestations of the Rosai-Dorfman disease included papular eruptions
of the typical intense pink color with a yellowish and brown tint. Morphologic changes were characterized by proliferation
of histiocytes and accumulation of different lipids and pentalamellar markers (S-100 protein, Π‘D 14, Π‘D 68, lysozyme)
in their cytoplasm. Though the Rosai-Dorfman disease usually involves lymph nodes, this case was characterized by
unaffected nodular structures.ΠΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Π° Π½Π΅ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½Π°Ρ Π³ΡΡΠΏΠΏΠ° ΡΠ΅Π΄ΠΊΠΈΡ
Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ·ΠΎΠ² Π»Π°Π½Π³Π΅ΡΠ³Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΈ Π½Π΅Π»Π°Π½Π³Π΅ΡΠ³Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠΈΠΏΠΎΠ²;
ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΈΡ
ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ. ΠΠΏΠΈΡΠ°Π½ΠΎ ΡΡΠ΅Π·Π²ΡΡΠ°ΠΉΠ½ΠΎ ΡΠ΅Π΄ΠΊΠΎΠ΅
Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ·Π° Π½Π΅Π»Π°Π½Π³Π΅ΡΠ³Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (Π±ΠΎΠ»Π΅Π·Π½Ρ Π ΠΎΠ·Π°ΠΈ - ΠΠΎΡΡΠΌΠ°Π½Π°) Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ 63 Π»Π΅Ρ Ρ
ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΡΠΏΠΎΠ½ΡΠ°Π½Π½ΡΠΌ ΡΠ΅Π³ΡΠ΅ΡΡΠΎΠΌ Π²ΡΡΡΠΏΠ°Π½ΠΈΠΉ. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΊΠΎΠΆΠ½ΡΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π ΠΎΠ·Π°ΠΈ - ΠΠΎΡΡΠΌΠ°Π½Π°
Π±ΡΠ»ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΏΠ°ΠΏΡΠ»Π΅Π·Π½ΡΠΌΠΈ Π²ΡΡΡΠΏΠ°Π½ΠΈΡΠΌΠΈ ΡΠΈΠΏΠΈΡΠ½ΠΎΠ³ΠΎ Π½Π°ΡΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠΎΠ·ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ° Ρ ΠΆΠ΅Π»ΡΠΎΠ²Π°ΡΠΎ-ΠΊΠΎΡΠΈΡΠ½Π΅Π²ΡΠΌ
ΠΎΡΡΠ΅Π½ΠΊΠΎΠΌ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ΅ΠΉ Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ² ΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ
Π² ΠΈΡ
ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΏΠ΅Π½ΡΠ°Π»Π°ΠΌΠ΅Π»Π»ΡΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² (ΠΏΡΠΎΡΠ΅ΠΈΠ½ S-100, Π‘D14, Π‘D 68, Π»ΠΈΠ·ΠΎΡΠΈΠΌ).
ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΠΎ ΡΡΠΎ Π±ΠΎΠ»Π΅Π·Π½Ρ Π ΠΎΠ·Π°ΠΈ - ΠΠΎΡΡΠΌΠ°Π½Π°, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΏΡΠΎΡΠ΅ΠΊΠ°Π΅Ρ Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π»ΠΈΠΌΡΠΎΡΠ·Π»ΠΎΠ²,
ΠΎΡΠ»ΠΈΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΡ Π½ΠΎΠ΄ΡΠ»ΡΡΠ½ΡΡ
ΡΡΡΡΠΊΡΡΡ
Multiple pseudotumorous crystalline deposits in small intestine, mesentery and lungs in terminal heart failure patent without gouty arthritis
Multiple pseudotumorous crystalline deposits in small intestine, mesentery and lungs in terminal heart failure patent without gouty arthritis
Multiple pseudotumorous crystalline deposits in small intestine, mesentery and lungs in terminal heart failure patent without gouty arthritis
Giant abdominal urate tumor-like mass with multiple crystalline deposits in the bowel and lung walls in a patent with terminal heart failure
The paper describes a unique case of a large abdominal urate mass with a peculiar inflammatory process with giant cells and smaller urate deposits in the lung and small bowel without articular changes and kidney injury in a patient with terminal heart failure
Giant abdominal urate tumor-like mass with multiple crystalline deposits in the bowel and lung walls in a patent with terminal heart failure
The paper describes a unique case of a large abdominal urate mass with a peculiar inflammatory process with giant cells and smaller urate deposits in the lung and small bowel without articular changes and kidney injury in a patient with terminal heart failure
ΠΠ°Π½Π³ΡΠ΅Π½ΠΎΠ·Π½Π°Ρ ΠΏΠΈΠΎΠ΄Π΅ΡΠΌΠΈΡ, ΠΈΠΌΠΈΡΠΈΡΡΡΡΠ°Ρ Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ· Ρ ΠΏΠΎΠ»ΠΈΠ°Π½Π³ΠΈΠΈΡΠΎΠΌ: ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ»ΡΡΠ°ΠΉ ΠΈ ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
Pyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissection of which subsequently leads to the formation of ulcers with irregular, violaceous, undermined borders. In rare cases, the diagnosis of the disease can also be complicated by the rapid development of internal organs damage symptoms, which must be regarded as extracutaneous manifestations of PG. Extracutaneous lesions can occur before, during or after the appearance of skin rashes, and the detection of sterile neutrophil infiltrates in the defeat of internal organs confirm the concept of PG as a multisystemic disease. The presented case of a rare course of PG with multiple skin lesions and extracutaneous manifestations, simulating systemic vasculitis, emphasizes the importance of a detailed examination of patients in order to make a correct diagnosis and prescribe timely adequate treatment.ΠΠ°Π½Π³ΡΠ΅Π½ΠΎΠ·Π½Π°Ρ ΠΏΠΈΠΎΠ΄Π΅ΡΠΌΠΈΡ (ΠΠ) ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ Π°ΡΡΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΡΠ½ΡΠΉ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ·. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π΄ΠΎ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΎΡΡΠ°Π΅ΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ Π² ΡΠ²ΡΠ·ΠΈ Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ ΡΡΠ°Π½Π΄Π°ΡΡΠ° ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ². ΠΠ΅ΡΠ²ΠΈΡΠ½ΡΠΌΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ ΠΏΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΠ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠ°ΠΏΡΠ»Ρ, ΠΏΡΡΡΡΠ»Ρ ΠΈΠ»ΠΈ Π±ΡΠ»Π»Ρ, Π²ΡΠΊΡΡΡΠΈΠ΅ ΠΊΠΎΡΠΎΡΡΡ
Π²ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ·Π² Ρ Π²Π°Π»ΠΈΠΊΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎ ΠΏΡΠΈΠΏΠΎΠ΄Π½ΡΡΡΠΌΠΈ ΠΊΡΠ°ΡΠΌΠΈ Π±Π°Π³ΡΠΎΠ²ΠΎ-ΡΠΈΠ½ΡΡΠ½ΠΎΠΉ ΠΎΠΊΡΠ°ΡΠΊΠΈ. Π ΡΠ΅Π΄ΠΊΠΈΡ
ΡΠ»ΡΡΠ°ΡΡ
Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠ°ΠΊΠΆΠ΅ ΠΌΠΎΠΆΠ΅Ρ ΡΡΠ»ΠΎΠΆΠ½ΠΈΡΡ Π±ΡΡΡΡΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΠ°ΡΡΠ΅Π½ΠΈΠ²Π°ΡΡ ΠΊΠ°ΠΊ Π²Π½Π΅ΠΊΠΎΠΆΠ½ΡΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΠ. ΠΠ½Π΅ΠΊΠΎΠΆΠ½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΌΠΎΠ³ΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡ ΠΊΠ°ΠΊ Π΄ΠΎ, ΡΠ°ΠΊ ΠΈ Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΠΈΠ»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΊΠΎΠΆΠ½ΡΡ
Π²ΡΡΡΠΏΠ°Π½ΠΈΠΉ, Π° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠ΅ΡΠΈΠ»ΡΠ½ΡΡ
Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΡΠ½ΡΡ
ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠΎΠ² ΠΏΡΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅Ρ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ ΠΠ ΠΊΠ°ΠΊ ΠΌΡΠ»ΡΡΠΈΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ ΡΠ»ΡΡΠ°ΠΉ ΡΠ΅Π΄ΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠ Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡΠΌΠΈ ΠΊΠΎΠΆΠΈ ΠΈ Π²Π½Π΅ΠΊΠΎΠΆΠ½ΡΠΌΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ, ΠΈΠΌΠΈΡΠΈΡΡΡΡΠΈΠΉ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΉ Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ·Π½ΡΠΉ Π²Π°ΡΠΊΡΠ»ΠΈΡ (Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ· Ρ ΠΏΠΎΠ»ΠΈΠ°Π½Π³ΠΈΠΈΡΠΎΠΌ Π³ΡΠ°Π½ΡΠ»Π΅ΠΌΠ°ΡΠΎΠ· ΠΠ΅Π³Π΅Π½Π΅ΡΠ°), ΠΏΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°Π΅Ρ Π²Π°ΠΆΠ½ΠΎΡΡΡ ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ΅Π»ΡΡ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΏΡΠ°Π²ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΈ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ