Supporting Indigenous Students: A Critical Analysis of the Sociocultural Context of Nursing Education

The purpose of this study was to critically examine the sociocultural context of nursing education as an institution. Using a postcolonial feminist theoretical framework and institutional ethnography, I illuminated the institutional complex of nursing education. This study addressed the following research questions: 1) How do practices, programs, and policies coordinate social relations within the institution of nursing education; and 2) How are Indigenous students’ everyday lives shaped by the institution of nursing education? Multiple methods were used to collect data, including: interviews, observations, and text analysis. Interviews were conducted with students, educators, and administrators and others involved in nursing education. Observations were conducted both formally, during interviews and meetings and informally, during my daily work within nursing education. Texts were collected to further explicate the institutional complex. The findings from this study revealed that race and class ruled the institution. Analysis exposed two irreconcilable social relations: Identifying as Indigenous and Identifying as a Nurse, that were central work processes within nursing education. The intersection of race and class was organized around Cultural Competence that was prevalent throughout institutional discourse. Cultural competence reproduced colonial ideology that provided the basis for dominant knowledge and shaped inclusionary/exclusionary practices. Thus, idealized practices that were aimed at the inclusion of Indigenous students ran contrary to intentions, as students were socially stratified based upon race and class relations. The findings illuminate the need to cultivate additional attentiveness and action related to social inequities within nursing education. Recommendations have been made related to education, policy, and research

Magnetic fields at the periphery of UCHII regions from carbon recombination line observations

Several indirect evidences indicate a magnetic origin for the non-thermal width of spectral lines observed toward molecular clouds. In this letter, I suggest that the origin of the non-thermal width of carbon recombination lines (CRLs) observed from photo-dissociation regions (PDRs) near ultra-compact \HII\ regions is magnetic and that the magnitude of the line width is an estimate of the \alfven speed. The magnetic field strengths estimated based on this suggestion compare well with those measured toward molecular clouds with densities similar to PDR densities. I conclude that multi-frequency CRL observations have the potential to form a new tool to determine the field strength near star forming regions.Comment: To appear in ApJ Letter

Distances to the high galactic latitude molecular clouds G192-67 and MBM 23-24

We report on distance determinations for two high Galactic latitude cloud complexes, G192-67 and MBM 23-24. No distance determination exists in the literature for either cloud. Thirty-four early type stars were observed towards the two clouds, more than half of which have parallaxes measured by the Hipparcos satellite. For the remaining stars we have made spectroscopic distance estimates. The data consist of high resolution echelle spectra centered on the Na I D lines, and were obtained over six nights at the Coude Feed telescope at Kitt Peak National Observatory. Interstellar absorption lines were detected towards some of the stars, enabling estimates of the distances to the clouds of 109 +/- 14 pc for G192-67, and of 139 +/- 33 pc for MBM 23-24. We discuss the relationship of these clouds to other ISM features such as the Local Hot Bubble and the local cavity in neutral hydrogen.Comment: 15 pages, 6 embedded figures, to be published in the ApJ Vol. 516, No.

Identification of Materials’ Mechanical parameters

The purpose of this study is to set the numerical bases before approaching the study of the identification of the mechanical parameters of materials’ elastic behavior. Indeed, most part of the mechanical tests do not allow to identify these mechanical parameters, the use of finite elements method calculations to design structures is limited by a poor knowledge of the mechanical properties. It is in this context that arises the inverse analysis problematic [ 1 ] [ 2 ]. For the parameters of the behaviour laws of material ; what information can be obtained from the in situ measures ? Besides what are the numerical techniques needed to obtain a determination of these parameters precisely and systematically. In this work we present a new way of proceeding by proposing an easy useful formulation by a treatment of the inverse problem. The problem so found is a differential system instead of a partial derivative problem. The resolution of the direct problem leads to obtain convincing results. These latters are in agreement with the simulation by a commercial code. This will allow us afterward to approach, without apprehension, the inverse problem. This is achieves through proposing a technique of systematic identification by using the database beforehand definite [3]

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function

Mutations in the human LIS1 gene cause type I lissencephaly, a severe brain developmental disease involving gross disorganization of cortical neurons. In lower eukaryotes, LIS1 participates in cytoplasmic dynein-mediated nuclear migration. We previously reported that mammalian LIS1 functions in cell division and coimmunoprecipitates with cytoplasmic dynein and dynactin. We also localized LIS1 to the cell cortex and kinetochores of mitotic cells, known sites of dynein action. We now find that the COOH-terminal WD repeat region of LIS1 is sufficient for kinetochore targeting. Overexpression of this domain or full-length LIS1 displaces CLIP-170 from this site without affecting dynein and other kinetochore markers. The NH2-terminal self-association domain of LIS1 displaces endogenous LIS1 from the kinetochore, with no effect on CLIP-170, dynein, and dynactin. Displacement of the latter proteins by dynamitin overexpression, however, removes LIS1, suggesting that LIS1 binds to the kinetochore through the motor protein complexes and may interact with them directly. We find that of 12 distinct dynein and dynactin subunits, the dynein heavy and intermediate chains, as well as dynamitin, interact with the WD repeat region of LIS1 in coexpression/coimmunoprecipitation and two-hybrid assays. Within the heavy chain, interactions are with the first AAA repeat, a site strongly implicated in motor function, and the NH2-terminal cargo-binding region. Together, our data suggest a novel role for LIS1 in mediating CLIP-170–dynein interactions and in coordinating dynein cargo-binding and motor activities

Acid-Labile Traceless Click Linker for Protein Transduction

Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of reversible pH-sensitive bonds. The azidomethyl-methylmaleic anhydride (AzMMMan) linker was found compatible with different click chemistries, demonstrated in bioreversible protein modification with dyes, polyethylene glycol, or a transduction carrier. Linkages were stable at physiological pH but reversible at the mild acidic pH of endosomes or lysosomes. We show that pH-reversible attachment of a defined endosome-destabilizing three-arm oligo(ethane amino)amide carrier generates an effective shuttle for protein delivery. The cargo protein nlsEGFP, when coupled via the traceless AzMMMan linker, experiences efficient cellular uptake and endosomal escape into the cytosol, followed by import into the nucleus. In contrast, irreversible linkage to the same shuttle hampers nuclear delivery of nlsEGFP which after uptake remains trapped in the cytosol. Successful intracellular delivery of bioactive ß-galactosidase as a model enzyme was also demonstrated using the pH-controlled shuttle system

A Magnetized Local Supercluster and the Origin of the Highest Energy Cosmic Rays

A sufficiently magnetized Local Supercluster can explain the spectrum and angular distribution of ultra-high energy cosmic rays. We show that the spectrum of extragalactic cosmic rays with energies below $\sim 10^{20}$ eV may be due to the diffusive propagation in the Local Supercluster with fields of $\sim 10^{-8} - 10^{-7}$ Gauss. Above $\sim 10^{20}$ eV, cosmic rays propagate in an almost rectilinear way which is evidenced by the change in shape of the spectrum at the highest energies. The fit to the spectrum requires that at least one source be located relatively nearby at $\sim 10-15$ Mpc away from the Milky Way. We discuss the origin of magnetic fields in the Local Supercluster and the observable predictions of this model.Comment: 11 pages, 2 figures, submitted to PR