Switching of Magnetic Moments of Nanoparticles by Surface Acoustic Waves

We report evidence of the magnetization reversal in nanoparticles by surface acoustic waves (SAWs). The experimental system consists of isolated magnetite nanoparticles dispersed on a piezoelectric substrate. Magnetic relaxation from a saturated state becomes significantly enhanced in the presence of the SAW at a constant temperature of the substrate. The dependence of the relaxation on SAW power and frequency has been investigated. The effect is explained by the effective ac magnetic field generated by the SAW in the nanoparticles.Comment: Accepted in Europhysics Letter

Prótesis de pirocarbono en fracturas complejas de cabeza de radio.

Presentamos los resultados de un estudio observacional retrospectivo sobre 23 casos de fracturas complejas de cabeza de radio tratadas mediante la implantación de una prótesis cabeza radio de pircocarbono (Mo - Pyc). La distribución por sexos fue 10 hombres y 13 mujeres, y la edad media de 54 años. El seguimiento medio fue de 70 meses (48-93 meses). La principal causa fue una fractura de cabeza de radio no reconstruible con inestabilidad asociada de codo. La evaluación clínica se realizó con la Mayo Elbow Performance Score (MEPS). Radiográficamen - te se valoró la congruencia articular, el tamaño de la prótesis, la radiolucencia periprotésica, la osificación heterotópica y la osteoartritis. Al final del seguimiento la media de la escale MEPS fue 82/100, con 84 % resultados de excelentes y buenos. La flexión media fue de 130º, extensión -30º, pronación 76º y supinación 77º. La estabilidad del codo fue buena en todos los casos y no observamos migración proximal del radio. Observamos radiolucencia alrededor del vástago en 5 pacientes, pero sin aparente repercusión clínica. Las complicaciones fueron una paresia del nervio interóseo posterior con recuperación funcional al cabo de 11 semanas, 2 pacientes presentaron "overstuffing" con subluxación posterior asociada que necesitó realizar exéresis de la cabeza y una osificación heterotópica con repercu - sión sobre el balance articular que necesitó 2 cirugías, todos ellos con resultados clínicos aceptables. Los resultados son alentadores.The authors present the results of a retrospective observational study of 23 cases of a complex radial head fractures treated by pyrocarbon radial head prosthesis (MoPyc). This modular radial head prosthesis is compo - sed of a cementless titanium stem and a 15º angulated neck. The gender distribution was 10 men and 13 women, ave - rage age 54 years. The mean follow-up was 70 months (48-93 months). The main etiology was a radial head fracture with elbow instability. Clinical evaluation was performed using the Mayo Elbow Performance Score (MEPS). Was assessed radiographically joint congruity, the size of the prosthesis, periprosthetic radiolucency, heterotopic ossifica - tion and osteoarthritis. At follow-up, the MEPS average was 82/100, with 84% of good and excellent results. Elbow flexion averaged 130º, extension -30º, pronation 76º and supination 77º. Elbow stability was good in all the cases, and no proximal migration of the radius occurred. Asymptomatic bone lucencies were found in five cases around the stem. Complications included paresis of the posterior interosseous nerve with functional recovery after 11 weeks, 2 patients had "overstuffing" associated with posterior subluxation and they need to perform excision of the head and one heterotopic ossification with articular impact on balance that needs two surgeries, all of them with acceptable clinical results. The preliminary results are encouragin

Tratamiento quirúrgico de las metástasis diafisarias de huesos largos en pacientes oncológicos estadio IV

La incidencia de enfermedad metastásica ósea se ha incrementado debido a la mayor supervivencia de los pacientes con cáncer. El esqueleto es la tercera localización mas frecuente de metástasis procedentes de tumores primarios. Se evalúan las indicaciones quirúrgicas para evitar la aparición de fracturas patológicas y los resultados obtenidos en metástasis diafisarias de huesos largos. Cincuenta lesiones han sido tratadas en 48 pacientes. En todos los casos se estabilizó con un clavo intramedular. La supervivencia media fue de 11 meses (2 días-48 meses). Al final del seguimiento la puntuación media en la escala MSTS fue 25/30 y 27/30 para miembro superior e inferior respectivamente. Debe considerarse la radioterapia postoperatoria para disminuir la progre - sión de la enfermedad. Hay múltiples factores a tener en cuenta en el tratamiento de pacientes con metástasis óseas incluyendo comorbilidades, características histológicas del tumor primario, la expectativa de vida y acti - vidad del paciente y el dolor.The incidence of metastatic bone disease is increasing as patients with cancer living longer. The skeleton is the third most common site for metastasis that originates from primary carcinomas. We evaluated the indications for surgery to prevent pathological fractures and the results obtained in metastases of the diaphyseal long bones. Fifty metastases bone lesion were treated in 48 patients. In all cases an intramedullary nail was in - serted. The chance of surviving was 11 moths average (2 days-48 moths). At follow-up, the MSTS average was 25/30 and 27/30 for superior and inferior limb respectively. To minimize disease progression postoperative ex - ternal-beam irradiation should be considered. There are multiples factors to consider in the treatment of patients with bone metastasic, including comorbidities, the histological characteristics of the primary tumor, the expected life span of the patient, the patient ?s activity level and pain

Vástagos monobloque de recubrimiento completo en cirugía de revisión femoral. Resultados a largo plazo de 80 casos.

Bone stock lost and anatomical changes in the proximal femur make femoral revision surgery a complex procedure where the implant chooses will be essential. With the aim of evaluating the clinical and radiological results of the fully coated monoblock stems, we retrospectively studied 80 consecutive cases of femoral revision surgery operated by our hip team. The mean follow-up was 8.6 years. The average score on the Harris Hip Score was 81,2 points. We achieved better results in patients with less bone defects (Paprosky I, II and IIIA) in contrast to those with Paprosky type IIIB defects (p=0.005), in patients with a single previous surgery (p=0.031), in patients under 65 years (p=0.009) and in those who did not suffer complications (p=0.024). The survival rate was 96.1% at 10 years if we consider as failure the removal of the stem due to aseptic loosening and 89.9% if we consider revision of the stem as a failure due to any cause. After the results obtained, we think that fully coated stems provide a solid and stable fixation in femoral revision surgery. However, worst results obtained in patients with bigger bone defects make other options to be considered

Case Report Skin Abscess due to Serratia marcescens in an Immunocompetent Patient after Receiving a Tattoo

The incidence of skin infections caused by Serratia marcescens is extremely low and such infections are typically observed in immunocompromised patients. The clinical manifestations of these infections include cellulitis, abscesses, fluctuant nodules, or granulomatous lesions. Infections caused by S. marcescens are very difficult to treat due to their resistance to many antibiotics, which often leads to specific and prolonged treatment. Infections after receiving a tattoo are very rare and are caused by unhygienic conditions or the inexperience of the tattooist. In this paper we present the case of a 32-year-old male with no comorbidity, who presented an abscess caused by S. marcescens in a area that was tattooed one month earlier. The case was resolved with surgery and antimicrobial therapy that was based on the antibiogram. To our knowledge, this is the first reported case of a S. marcescens skin infection following a tattoo, in the absence of immunosuppression

Manual para la obtención del carné de manipulador de plaguicidas de uso fitosanitario. Nivel cualificado.

El encargo de la Comisión para el Desarrollo y la Aplicación de la Reglamentación sobre Plaguicidas, de las Consellerias de Agricultura, Pesca y Alimentación y de Sanidad, de tutelar la edición de este libro, conllevaba un objetivo claro: renovar y actualizar el Manual para la obtención del carné de manipulador de plaguicidas de uso fitosanitario. Nivel cualificado. Esta tarea suponía un difícil reto. El manual original, editado en 1989, fue un texto novedoso, bien acogido por los usuarios y los profesionales relacionados con los plaguicidas agrícolas, pero sólo había tenido modificaciones parciales en sus reediciones. En estos trece años, otras Administraciones públicas y organismos privados han publicado sus correspondientes materiales de trabajo, muchos de ellos de gran calidad e interés. La tarea del Comité de Redacción ha consistido en unificar tanto la terminología como los conceptos expuestos por los diferentes autores. La diversidad de titulaciones, actividades profesionales y ámbitos de trabajo ha hecho especialmente compleja nuestra labor. Sólo la comprensión de los autores ha permitido presentar un texto común sin que pierda la riqueza que aporta la autoría múltiple. El temario normativo se ha complementado con dos elementos necesarios, a nuestro juicio: una bibliografía actualizada (Para saber más) y un Glosario de los términos técnicos más utilizados en los temas. La bibliografía es una selección de textos en idioma español que permite al lector interesado profundizar en los temas tratados; su elección se ha basado en la utilidad práctica, es decir, precisión, claridad y accesibilidad de los materiales. El glosario no pretende ser exhaustivo ni sustituir a los diccionarios académicos o técnicos, su único objetivo es facilitar la lectura mediante la aclaración de conceptos específicos en el área de los plaguicidas y la prevención de sus riesgos

Tratamiento de oligometástasis mediante cirugía oncológica con intención curativa

Oligometastasis is a clinical condition characterized by the presence of one to five metastases in a controlled or potentially controllable neoplasm, which can be treated at a local level through ablative therapy. Material and methods. We report the case of a 49 years old male who is diagnosed of a renal cell carcinoma, and presents metastases in the left humerus and the right radius. Two-stage surgery is carried out with the placement of tumor prosthesis in the humerus and reconstruction by using the fibula and osteosynthesis with a plate in the radius. Results. In the course of two years of monitoring, the patient is now disease free at both a local and systemic levels with a good clinical, functional and radiological condition. Conclusions. The management of patients with metastatic cancer has changed. Patients affected by oligometastasis can be treated with oncology surgery with a curative intention, increasing the chances of survival and even achieving the recovery of the patient

Insight dimensions and cognitive function in psychosis: a longitudinal study

BACKGROUND: It has been reported that lack of insight is significantly associated with cognitive disturbance in schizophrenia. This study examines the longitudinal relationships between insight dimensions and cognitive performance in psychosis. METHODS: Participants were 75 consecutively admitted inpatients with schizophrenia, affective disorder with psychotic symptoms or schizoaffective disorder. Assessments were conducted at two time points during the study: at the time of hospital discharge after an acute psychotic episode and at a follow-up time that occurred more than 6 months after discharge. A multidimensional approach of insight was chosen and three instruments for its assessment were used: the Scale to Assess Unawareness of Mental Disorder (SUMD), three items concerning insight on the Assessment and Documentation in Psychopathology (AMDP) system and the Insight and Treatment Attitudes Questionnaire. The neuropsychological battery included a wide range of tests that assessed global cognitive function, attention, memory, and executive functions. RESULTS: After conducting adequate statistical correction to avoid Type I bias, insight dimensions and cognitive performance were not found to be significantly associated at cross-sectional and longitudinal assessments. In addition, baseline cognitive performance did not explain changes in insight dimensions at follow-up. Similar results were found in the subset of patients with schizophrenia (n = 37). The possibility of a Type II error might have increased due to sample attrition at follow-up. CONCLUSION: These results suggest that lack of insight dimensions and cognitive functioning may be unrelated phenomena in psychosis

The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways

Research in the J.C. Reyes lab was funded by the Spanish Ministry of Economy and Competitiveness MCIN/AEI/10.13039/501100011033/ [PID2020-118516GB-I00]; Junta de Andalucía [P18-FR-1962 and BIO-321]; Fundación Vencer El Cancer (VEC); European Union FEDER 'A way to build Europe' program; research at Buschbeck lab is further supported by FEDER/Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación [RTI2018-094005-B-I00]; Marie Skłodowska Curie Training network 'INTERCEPT-MDS' [H2020-MSCA-ITN-2020-953407]; Deutsche José Carreras Leukämie Stiftung [DJCLS 14R/2018, AGAUR 2017-SGR-305]; Fundació La Marató de TV3 257/C/2019; CABIMER is a Center partially funded by the Junta de Andalucía; E.G.-M. is the recipient of an FPI fellowship from the Spanish Ministry of Science and Innovation; L.B.-C. is the recipient of an FPU fellowship from the Spanish Ministry of Education; M.P.M. was funded by an AGAUR FI-2010 fellowship. Funding for open access charge: Spanish Ministry of Economy and Competitiveness MCIN/AEI/10.13039/501100011033/ [PID2020-118516GB-I00]. Conflict of interest statement. None declared.High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements, which we have functionally characterized: i) an amino-terminal, intrinsically disordered domain with transactivation activity; ii) an HMG box with higher binding affinity for double-stranded, four-way-junction DNA than for linear DNA; and iii) a long coiled-coil domain. Our proteomic study followed by a deletion analysis and structural modeling demonstrates that HMG20A forms a complex with the histone reader PHF14, via the establishment of a two-stranded alpha-helical coiled-coil structure. siRNA-mediated knockdown of either PHF14 or HMG20A in MDA-MB-231 cells causes similar defects in cellmigration, invasion and homotypic cell-cell adhesion ability, but neither affects proliferation. Transcriptomic analyses demonstrate that PHF14 and HMG20A share a large subset of targets. We show that the PHF14-HMG20A complex modulates the Hippo pathway through a direct interaction with the TEAD1 transcription factor. PHF14 or HMG20A deficiency increases epithelial markers, including E-cadherin and the epithelial master regulator TP63 and impaired normal TGFβ-trigged epithelial-to-mesenchymal transition. Taken together, these data indicate that PHF14 and HMG20A cooperate in regulating several pathways involved in epithelial-mesenchymal plasticity