The Investigation of Machinability and Surface Properties of Aluminium Alloy Matrix Composites

Aluminum matrix composites (AMCs) are crucial to the progress of composite application areas due to their remarkable mechanical properties. Their usage has expanded into different fields such as the aerospace, automobile, and defense industries. The present study used wrought Al alloy AA6061 as the matrix, while ilmenite (FeTiO3) particles were used as reinforcement at different weight percentages to prepare metal matrix composites. One of the most economical and simple casting routes among the several available fabrication techniques for the preparation of composites is the stir casting method, which was applied in the present investigation to prepare the AMCs. The machinability of the fabricated composites and the surface roughness property after machining were studied to understand the effect of speed and feed during machining. The results showed that an increase in speed decreased the cutting forces and the surface roughness. Meanwhile, an increase in surface roughness was observed with an increase in feed

DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE MUCOADHESIVE MICROBEADS CONTAINING SIMVASTATIN WITH DIFFERENT CROSS LINKING AGENTS

Objective: The aim of the present work was to prepare and examine drug release of the oral controlled release microbeads using different curing agents by emulsification internal ionic gelation technique. Methods: Cross-linked alginate microbeads were prepared with different cross linking agents by using mucoadhesive properties. The formation and compatibility of microbeads were confirmed by compatibility studies. Prepared microbeads evaluated for encapsulated efficiency, micromeritic properties, drug loading, in vitro wash off studies, in vitro dissolution studies, drug release kinetics and stability studies Results: The in vitro drug release was influenced by both type of curing agents and type of polymers and no significant changes in characterization parameters was observed after 3 mo stability studies. The sustained release profile of optimized batch was found to be 99.66±0.18% in comparison to pure drug profile of 28.64±0.02% at 12 h release study. Results of both wash-off and in vitro studies suggests that batch (SF2) prepared with aluminium chloride has shown better mucoadhesive property. Drug release of optimized batch follows zero order with non fickian mechanism according to Korsmeyer-Peppas equation. Conclusion: The data suggest the use of simvastatin mucoadhesive cross linked microbeads to offer the potential for oral controlled drug delivery with improved gastric retention and capable to provide sustained drug release by using cross linking agents

Radiation and chemical reaction effects on MHD Casson fluid flow past a semi-infinite vertical moving porous plate

A speculative investigation has been presented to explore the significant features of MHD convective Casson fluid flow past a semi-infinite moving vertical porous plate with heat source/sink are included in the flow configuration. The governing partial differential equations are remodeled into ordinary differential equations using appropriate non-dimensional variables. The ensuing differential equations are solved analytically using two term perturbation technique method. The result of flow heat and mass transfer analysis on the velocity, temperature and concentration profiles and also physical parameters like Skin friction, Nusselt number, and Sherwood numbers are shown graphically, also shown in tabular form. The results shows that Casson parameter enhances the velocity, temperature and concentration fields are decreases for increasing the values radiation and chemical reaction. Under some restriction the resultant outcome were compared with previous published results and is found in admirable agreement

ANALYSIS OF GROUND WATER IN AND AROUND PYDIBHEEMAVARAM INDUSTRIAL AREA, SRIKAKULAM DIST, ANDHRA PRADESH, INDIA

ABSTRACT Over usage of ground water is influences quality of water. Present situation ground water quality is important factor at the time water shortage and human health in terms of water borne diseases. In the present study area, mainly focused on physic chemical parameters i.

Radiation and chemical reaction effects on MHD Casson fluid flow past a semi-infinite vertical moving porous plate

548-557A speculative investigation has been presented to explore the significant features of MHD convective Casson fluid flow past a semi-infinite moving vertical porous plate with heat source/sink are included in the flow configuration. The governing partial differential equations are remodeled into ordinary differential equations using appropriate non-dimensional variables. The ensuing differential equations are solved analytically using two term perturbation technique method. The result of flow heat and mass transfer analysis on the velocity, temperature and concentration profiles and also physical parameters like Skin friction, Nusselt number, and Sherwood numbers are shown graphically, also shown in tabular form. The results shows that Casson parameter enhances the velocity, temperature and concentration fields are decreases for increasing the values radiation and chemical reaction. Under some restriction the resultant outcome were compared with previous published results and is found in admirable agreement

A comparative study on placebo and trenaxamic acid for the prophylaxis is of post-partum hemorrhage: a randomised double-blind control study

Background: Obstetric haemorrhage accounts for 20-25% of maternal mortality and morbidity. Anti-fibrinolytics are being widely used in field of surgery. It is also used to reduce heavy menstrual blood loss. The aim of this study was to analyse the effectiveness of TXA in reducing blood loss during normal vaginal delivery.Methods: The randomized double-blind control study was done in the Labour ward. It was conducted on 100 women undergoing Normal vaginal delivery. They were allocated to either Study or Control group by randomization. TXA was given during the Third stage of delivery in study group in addition to the routine care whereas the control group had routine care alone. Blood loss was measured in both groups by bag method.Results: The significant of reduction in blood loss calculated from placental delivery to 2hrs. 141.9 ml in study group versus 270.4 ml in control group. Among primi patients, the control group average blood loss was 325ml, the study group avg blood loss was 169ml. Among G2 patients, the control group average blood loss was 248.5ml. The study group average blood loss was 128.25ml. Among G3 patients, the control group average blood loss was 203ml, the study group average blood loss was 115ml.Conclusions: TXA significantly reduced the amount of blood loss during normal vaginal delivery. Thus, TXA can be used safely and effectively in subjects undergoing normal vaginal delivery

DEVELOPMENT AND VALIDATION OF SEVEN PHENYL HYDRAZINE CHLORO ESTER ISOMERS (PGIs) BY RP-HPLC-UV METHOD IN ANTICOAGULANT DRUG SUBSTANCE; APIXABAN

Objective: The objective of this work was to develop and validate a simple and sensitive reverse-phase high-pressure liquid chromatography method for the determination of seven potential genotoxic impurities in Apixaban drug substance. Methods: The optimized separation was achieved by using ACE 3 C18 PFP (150 mm×4.6 mm, 3 µm) HPLC column. The mobile phase-A was a degassed mixture of 0.01M Ammonium acetate buffer(PH adjusted 4.9±0.05 with diluted glacial acetic acid) and mobile phase-B was a degassed mixture of Acetonitrile, Isopropyl alcohol and Buffer PH 4.9 in the ratio of 60:20:20 v/v/v. The gradient program was operated at a flow rate of 1.0 ml/min and UV detection was at 330 nm. Results: The method was superior at linearity for seven impurities and correlation coefficient values were larger than 0.999, moreover, in the separation point of view, this method further achieved no matrix interference through chromatography by better resolution of the other impurities from the Apixaban drug substance and its related impurities for the accurate analysis of seven potential genotoxic impurities. The established limits of detection (LOD), limits of quantification (LOQ) values for the seven mutagenic impurities were each of 5 ppm (0.015µg/ml) and15 ppm (0.045µg/ml) respectively. The developed method was validated as per ICH guidelines and applied as a generic method to determine these seven potential genotoxic impurities for the pharmaceutical process control and drug material release. Conclusion: Validation of this analytical method was carried out including stability, selectivity, linearity, accuracy, system precision, method precision and intermediate precision thus proving that the described RP-HPLC method could be employed for fast and simple analysis of sevenphenyl hydrazine chloro ester isomers in Apixaban drug substance