36 research outputs found
INTRODUCTION OF ELEMENTS OF PERSONALIZED EDUCATION IN SECONDARY VOCATIONAL EDUCATIONAL INSTITUTIONS
The article provides a brief analysis of the testing of elements of personalized education using the electronic digital platform Empower on the example of 173 students of the 3 course of the secondary vocational educational institution during one semester.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΊΡΠ°ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Π°ΠΏΡΠΎΠ±Π°ΡΠΈΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠΎΠ²ΠΎΠΉ ΠΏΠ»Π°ΡΡΠΎΡΠΌΡ Empower Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ΅ΠΌΠ΅ΡΡΡΠ°
Probation of the Digital Educational Platform Empower in the College
Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ, ΠΎΠΏΡΡ ΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΈΡΡΠΎΠ²ΠΎΠΉ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΠ»Π°ΡΡΠΎΡΠΌΡ Empower ΠΊΠ°ΠΊ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ° ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡΡ
ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ.The article presents the significance, opportunities, experience and recommendations of the use of the digital educational platform Empower as an element of a personalized model of education in secondary vocational education institutions
Designing the Implementation of a Personalized College Education Model
Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ Π΄Π»Ρ Π»ΠΈΡ, ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π·Π° ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΡΠΎΠ΅ΠΊΡΠ°.The article presents the features of designing the implementation of the elements of the personalized model of education in the educational institutions of secondary vocational education. Pprovides recommendations for those responsible for the implementation of the project
The Experience of Using Personalized Model Approaches of Education in the Development of New Software
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΠΊΡΡΠ²Π°Π΅ΡΡΡ ΠΎΠΏΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΠΈ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ ΠΊΠΎΠ»Π»Π΅Π΄ΠΆΠ° ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ Π°Π½Π°Π»ΠΈΠ· ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½Π½ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ².The article reveals the experience of using several tools of a personalized education model when college students master various software, analyzes the effectiveness of the applied approaches
Specific Cerebrovascular Risk Factors, Colon Microbiocenosis and its Correction in Patients Receiving Long-Term Programmed Hemodialysis
Introduction: The problem of acute and chronic cerebrovascular disorders in dialysis patients remains the most urgent. Risk factors for cerebrovascular diseases in CKD and dialysis patients can be conditionally divided into βtraditionalβ (arterial hypertension, diabetes mellitus, hypercholesterolemia) and βspecificβ (associated with renal pathology and dialysis procedures). The spectrum of specific factors of cerebrovascular risk in patients with dialysis stage of the CKD includes specific dialysis factors that form during programmed HD, as well as impaired phosphorus-calcium metabolism and calcification of the arterial microvasculature, increased blood levels of Ξ²2-microglobulin, homocysteine, malondialdehyde and superoxide dismutase, a decrease in the level of nitric oxide (II) metabolites, development of nephrogenic anemia and dysfunction of blood cells, malnutrition and dietary features of patients with renal pathology, accumulation of uremic toxins and toxins of intestinal bacteria, etc. Opportunistic gut microorganisms can produce uremic toxins, which are associated with an increased risk of inflammation, increased oxidative stress, and a higher risk of cardiovascular disease (CVD). Description of the spectrum of risk factors for cerebrovascular pathology in dialysis patients and effective control over them seems to be an effective strategy aimed at increasing the duration and quality of life in patients receiving renal replacement therapy. The aim of the investigation was to study the species composition of colon microbiocenosis in patients with CKD receiving programmed HD treatment and to evaluate the effectiveness of its correction using a new immobilized synbiotic. Materials and methods: Samples of colon microbiota from 62 patients undergoing programmed hemodialysis were studied before and after a course of diet therapy that included probiotic components, in particular, the immobilized synbiotic LB-complex L. Isolation of microorganisms was carried out according to our original method; for bacteria identification, a MALDI-TOF Autoflex speed mass spectrometer (Bruker Daltonik, Germany) was used in the Biotyper program mode. The results were assessed using the criteria proposed by the authors and based on the OST 91500.11.0004-2003. The efficacy of the immobilized synbiotic was determined based on the clinical data, questionnaires, and bacteriological tests. Results: In patients receiving programmed hemodialysis (before the start of the diet therapy), chronic moderate inflammation and azotemia were found. Dysbiotic changes in microbiocenosis were revealed in all the examined patients; in the absence or suppression of lacto- and bifidoflora, the number and diversity of Bacteroides spp., Clostridium spp., Collinsella spp., Eggerthella spp. and other bacteria increased, which was consistent with the theory of functional redundancy of gut microbiota. From the answers to the questionnaires, a decrease in the quality of life was found (up to 70 points out of 100) according to six of the eight scales used. After the combined therapy using the synbiotic LB-complex L in the study group, 56% of the examined patients showed their microbiocenosis restored to normal; no grade III dysbiosis was detected in any patient. There was a significant decrease in CRP and ESR in these patients and an improvement in the quality of life by criteria reflecting physical health. Conclusion: Acute/chronic CVD in patients with CKD of the pre-dialysis and dialysis periods are the most frequent and formidable complications. The spectrum of βtraditionalβ and βspecificβ CV risk factors in dialysis patients will be described in the chapter. Special attention will be paid to the intestinal microbiota and opportunistic intestinal microorganisms. The aim was to study the species composition of colon microbiocenosis in HD patients, and to evaluate the effectiveness of its correction using a new immobilized synbiotic. Materials and Methods. Samples of colon microbiota from 62 HD patients were studied before/after a course of diet therapy that included probiotic components, the immobilized synbiotic LB-complex L. MALDI-TOF Autoflex speed mass spectrometer was used in the Biotyper program mode. The efficacy of the immobilized synbiotic was determined based on the clinical data, questionnaires, and bacteriological tests. Results. Dysbiotic changes in microbiocenosis were revealed in all patients; in the absence/suppression of lacto-and bifidoflora, the number and diversity of Bacteroides spp.,Clostridium spp.,Collinsella spp.,Eggerthella spp. and other bacteria increased. After the combined therapy using the synbiotic LB-complex L in the study group, 56% of the examined patients showed their microbiocenosis restored to normal; no grade III dysbiosis was detected in any patient
7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces AβT transversions in Escherichia coli
14 pags., 9 figs.This work investigated the structural and biological properties of DNA containing 7,8-dihydro-8-oxo-1,N6-ethenoadenine (oxo-Ο΅A), a non-natural synthetic base that combines structural features of two naturally occurring DNA lesions (7,8-dihydro-8-oxoadenine and 1,N6-ethenoadenine). UV-, CD-, NMR spectroscopies and molecular modeling of DNA duplexes revealed that oxo-Ο΅A adopts the non-canonical syn conformation (Ο = 65ΒΊ) and fits very well among surrounding residues without inducing major distortions in local helical architecture. The adduct remarkably mimics the natural base thymine. When considered as an adenine-derived DNA lesion, oxo-Ο΅A wasΒ >99% mutagenic in living cells, causing predominantly AβT transversion mutations in Escherichia coli. The adduct in a single-stranded vector was not repaired by base excision repair enzymes (MutM and MutY glycosylases) or the AlkB dioxygenase and did not detectably affect the efficacy of DNA replication in vivo. When the biological and structural data are viewed together, it is likely that the nearly exclusive syn conformation and thymine mimicry of oxo-Ο΅A defines the selectivity of base pairing in vitro and in vivo, resulting in lesion pairing with A during replication. The base pairing properties of oxo-Ο΅A, its strong fluorescence and its invisibility to enzymatic repair systems in vivo are features that are sought in novel DNA-based probes and modulators of gene expression.MIT Skoltech Next Generation Program Pilot Grant (to J.M.E.); National Institutes of Health (NIH) [R01-CA080024 to J.M.E.]; NIEHS Center Grant [P30-ES002109 (to Center for Environmental Health Sciences, which provided access to NGS facilities)]; Skoltech (to T.S.Z.); MICINN [PID2020-116620GB-I00 to C.G.]; Ministry of Science and Higher Education Russian Federation [07515-2021-1049 to A.V.A. β synthesis and UV/CD studies]. Funding for open access charge: Skoltech.Peer reviewe
ΠΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ Π½Π° ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠΌ Π³Π΅ΠΌΠΎΠ΄ΠΈΠ°Π»ΠΈΠ·Π΅
The outcome of chronic kidney disease (CKD) is frequently development of end-stage kidney failure that requires program hemodialysis (PHD). Increase of the longevity of long-term PHD patients is associated with continuous somatic and psychic stress for the patient, which might adversely affect the quality of life (QoL) of an end-stage CKD patient.Purpose:Β to determine the influence of age and dialysis duration on the QoL of end-stage CKD patients receiving PHD.Materials and methods.Β 50 patients receiving PHD (23 men and 27 women), aged 31 to 79 years, were examined. The mean age was 56.72Β±11.26 years. The PHD duration ranged between 1 month to 20 years, the average figure being 5.26Β±4.82 years. The control group included 50 healthy subjects of comparable gender and age. The QoL evaluation data were gathered through survey using the Russian version of SF-36 Questionnaire (Short Form Medical Outcomes Study), validated by the Institute of Clinical and Pharmacological Studies (Saint Petersburg) and analysis of case records.Results.Β As regards the scales of physical health, a decrease of the QoL of PHD patients was found as follows: Π F-physical functioning (54.1Β±25.6 vs. 85.0Β±21.4), RP-role functioning related to physical condition (38.5Β±35.4 vs. 74.5Β±29.7), Pbodily pain (64.7Β±32.1 vs. 70.5Β±24.8), GH-general health condition (51.3Β±15.9 vs. 65.1Β±21.7). A trend towards inter-group difference was also discovered as regards the scales of vitality (VT) (53.7Β±19.5 vs. 61.0Β±19.4), social functioning (SF) (72.5Β±18.0 vs. 79.5Β±23.5). Multiple regression analysis established inverse relationship between the patientβs physical health component (PH) and age (rs=-0.317,Β P<0.05).Conclusion.Β In PHD patients, the physical health component is the one that suffers most of all, namely: physical functioning, role functioning related to physical condition, pain intensity, and general health condition. The tendency to statistic differences is observed for the scales of vitality and social functioning of the mental health component. Increase of the age and dialysis duration affect adversely the physical health whereas render no influence on the mental health.ΠΠ°ΡΠ°ΡΡΡΡ ΠΈΡΡ
ΠΎΠ΄ΠΎΠΌ Π₯ΠΠ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ, ΡΡΠ΅Π±ΡΡΡΠ΅ΠΉ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ³ΠΎ Π³Π΅ΠΌΠΎΠ΄ΠΈΠ°Π»ΠΈΠ·Π° (ΠΠ). Π£Π²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΡ
ΡΡ Π½Π° Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΠ, ΡΠΎΠΏΡΡΠΆΠ΅Π½ΠΎ Ρ ΠΏΠΎΡΡΠΎΡΠ½Π½ΡΠΌΠΈ ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΠΏΡΠΈΡ
ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π½Π°Π³ΡΡΠ·ΠΊΠ°ΠΌΠΈ Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎ Π²Π»ΠΈΡΡΡ Π½Π° ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ (ΠΠ) Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ Π₯ΠΠ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ:Β ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΈ ΡΡΠ°ΠΆΠ° Π΄ΠΈΠ°Π»ΠΈΠ·Π° Π½Π° ΠΠ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ Π₯ΠΠ, Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΡ
ΡΡ Π½Π° Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΠ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ.Β ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ 50 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°ΡΡΠΈΡ
Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΠ (23 ΠΌΡΠΆΡΠΈΠ½ ΠΈ 27 ΠΆΠ΅Π½ΡΠΈΠ½), Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 31 Π΄ΠΎ 79 Π»Π΅Ρ. Π‘ΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ ΡΠΎΡΡΠ°Π²ΠΈΠ» 56,72Β±11,26 Π»Π΅Ρ. ΠΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠ ΠΊΠΎΠ»Π΅Π±Π°Π»Π°ΡΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
ΠΎΡ 1 ΠΌΠ΅ΡΡΡΠ° Π΄ΠΎ 20 Π»Π΅Ρ, ΡΡΠΎ Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 5,26Β±4,82 Π»Π΅Ρ. Π Π³ΡΡΠΏΠΏΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π²ΠΊΠ»ΡΡΠΈΠ»ΠΈ 50 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΡΠ΄Π΅ΠΉ, ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡΡ
ΠΏΠΎ ΠΏΠΎΠ»Ρ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΡ. Π‘Π±ΠΎΡ Π΄Π°Π½Π½ΡΡ
ΠΏΠΎ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΠ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ ΠΏΡΡΠ΅ΠΌ Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎ ΡΡΡΡΠΊΠΎΡΠ·ΡΡΠ½ΠΎΠΉ Π²Π΅ΡΡΠΈΠΈ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠ° SF-36 (Short Form Medical Outcomes Study), Π²Π°Π»ΠΈΠ΄ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Β«ΠΠ½ΡΡΠΈΡΡΡΠΎΠΌ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉΒ» (Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³) ΠΈ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈΡΡΠΎΡΠΈΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ.Β Π ΡΡΠ΅ΡΠ΅ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π²ΡΡΠ²ΠΈΠ»ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΠ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΡ
ΡΡ Π½Π° ΠΠ, ΠΏΠΎ ΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΡΠΊΠ°Π»Π°ΠΌ: Π F-ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ (54,1Β±25,6 ΠΏΡΠΎΡΠΈΠ² 85,0Β±21,4), RP-ΡΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠ΅ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ (38,5Β±35,4 ΠΏΡΠΎΡΠΈΠ² 74,5Β±29,7), P-ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π±ΠΎΠ»ΠΈ (64,7Β±32,1 ΠΏΡΠΎΡΠΈΠ² 70,5Β±24,8), GH-ΠΎΠ±ΡΠ΅Π³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π·Π΄ΠΎΡΠΎΠ²ΡΡ (51,3Β±15,9 ΠΏΡΠΎΡΠΈΠ² 65,1Β±21,7). Π’Π΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΠΌΠ΅ΠΆΠ³ΡΡΠΏΠΏΠΎΠ²ΡΠΌ ΡΠ°Π·Π»ΠΈΡΠΈΡΠΌ ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ»ΠΈ ΠΏΠΎ ΡΠΊΠ°Π»Π°ΠΌ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ (VT) (53,7Β±19,5 ΠΏΡΠΎΡΠΈΠ² 61,0Β±19,4), ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ (SF) (72,5Β±18,0 ΠΏΡΠΎΡΠΈΠ² 79,5Β±23,5). ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³ΡΠ΅ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π²ΡΡΠ²ΠΈΠ»ΠΈ ΠΎΠ±ΡΠ°ΡΠ½ΡΡ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΌ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ° Π·Π΄ΠΎΡΠΎΠ²ΡΡ (PH) ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠΎΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² (rs=-0,317,Β p<0,05).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅.Β Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
, Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΡ
ΡΡ Π½Π° ΠΠ, Π² Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΡΠ°Π΄Π°Π΅Ρ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ: ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅, ΡΠΎΠ»Π΅Π²Π°Ρ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½Π°Ρ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ Π±ΠΎΠ»ΠΈ ΠΈ ΠΎΠ±ΡΠ΅Π΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π·Π΄ΠΎΡΠΎΠ²ΡΡ. Π’Π΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ°Π·Π»ΠΈΡΠΈΡΠΌ ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ ΠΏΠΎ ΡΠΊΠ°Π»Π°ΠΌ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ° Π·Π΄ΠΎΡΠΎΠ²ΡΡ. Π£Π²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΈ ΡΡΠ°ΠΆΠ° Π΄ΠΈΠ°Π»ΠΈΠ·Π° ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΡΡ Π½Π° ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ Π½Π΅ Π²Π»ΠΈΡΡΡ Π½Π° ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΠΡΡΡΡΠ΅ ΠΈ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄ΠΈΠ·ΠΈΠΌΠΌΡΠ½Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠ½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΠΈ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ COVID-19: ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ)
Dysimmune polyneuropathies are the etiologically heterogeneous group of diseases with autoimmune damage to the peripheral nervous system. The rarity of these diseases doesnβt exclude the possibility of their development or exacerbation in patients infected with SARSβCoVβ2, which will require timely differential diagnosis and urgent specific therapy. The article summarizes current information on the mechanisms of development, clinical features, diagnosis and management of acute and chronic dysimmune polyneuropathies in the context of the COVIDβ19 pandemic.ΠΠΈΠ·ΠΈΠΌΠΌΡΠ½Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠ½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΡΡ Π³ΡΡΠΏΠΏΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. Π Π΅Π΄ΠΊΠΎΡΡΡ Π΄Π°Π½Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π½Π΅ ΠΈΡΠΊΠ»ΡΡΠ°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡ
ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ»ΠΈ ΠΎΠ±ΠΎΡΡΡΠ΅Π½ΠΈΡ Ρ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
SARSβCoVβ2 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΡΠΎ, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, ΠΏΠΎΡΡΠ΅Π±ΡΠ΅Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π½Π° Π΄Π°Π½Π½ΡΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΠΊΠ°ΡΠ°ΡΡΠΈΠ΅ΡΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΎΡΡΡΡΡ
ΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄ΠΈΠ·ΠΈΠΌΠΌΡΠ½Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠ½Π΅Π²ΡΠΎΠΏΠ°ΡΠΈΠΉ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ COVIDβ19