New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia

Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy. The animals were observed increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the placenta of ischemic origin. Introduction of tetrahydrobiopterin, a selective inhibitor of arginase II of, recombinant erythropoietin, tadalafil, erythromycin, azithromycin, and playback systems polivitaminnomineralnyh distant ischemic preconditioning resulted in a pronounced correction of morphological and functional disorders arise when modeling the experimental preeclampsi

Correction of morphofunctional disturbances arising when modelling Preeclampsia with resveratrol and nicorandil

Preeclampsia is one of the most serious diseases of the second half of pregnancy and is surely amongst the top three causes of maternal mortality. Therefore, the creation of new drugs for preventing and correcting preeclampsia is an urgent tas

Simulation of total brain ischemia in rats

This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. The obtained results demonstrate a tendency to deterioration of neuropsychiatric status of the animals with increasing severity of ischemic brain damage that allows suggesting the severity of ischemic brain damage and its correction by the degree of behavioral disorder

Study of the effect of selective inhibitor of arginase II KUD 975 and of low doses of acetylsalicylic acid on the functional parameters of the cardiovascular system In experimental preeclampsia

The article considers study of the effect of selective inhibitor of Arginase II KUD 975 and of low doses of acetylsalicylic acid on the functional parameters of the cardiovascular system In experimental preeclampsi

The effect of humoral factors released by hypoperfused placenta on fetal development

Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of fetal weight and length as well as in fetal death after implantation. The obtained data complement the overall understanding of the pathogenesis of preeclampsia and placental insufficiency and create preconditions for development of new areas of creation of effective drugs for treatment and prevention of these pathologie

Correction of adma-induced preeclampsia with the use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010

Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the ischemic placenta. The use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010 leads to the expression of morphological and functional correction of violations occurring in modeling of experimental preeclampsi

Evaluation of pharmacological correction of L-NAME-induced endothelial dysfunction, platelet aggregation and venous tone with diosmin detralex 1000 mg

Chronic venous diseases are one of the urgent problems of modern medicine. Recent studies have shown high significance of endothelial dysfunction (ED) and oxidative stress in their pathogenesis. For the correction of the occurring changes, drugs of the flavonoid group, particularly diosmin and hesperidin, are currently use

Mathematical model of liquid vapor compression system for multicircuit cooling systems of high mobile platform

© Research India Publications. The descriptions of the structure, the principle of operation and the mathematical model of the liquid-vapor compression cooling system, through which an effective cooling of a mobile platform power plant at elevated ambient temperature is possible. The proposed model allows to simulate the thermodynamic processes of heat and mass transfer and heat transfer, depending on the system load, its design parameters and the material of heat exchangers, the mass flow of refrigerant and coolant flow, taking into account the ambient temperature. The result of mathematical modeling showed that by the coolant temperature increase up to 127 °C, an average temperature pressure in a heat exchanger-condenser between the refrigerant and air increased. Therefore the amount of waste heat to the atmosphere was significantly increased. This will ensure an efficient operation of a cooling system at an elevated ambient temperature and will improve the weight and size of a cooling system in general

Integrated evaluation of the endothelioprotective activity of an innovative peptide simulating the alpha-helix of B-erythropoethin in L-name-induced nitrogen oxide deficiency at the late gestation period

To study the efficiency of using carbamylated darbepoetin, asialized erythropoietin and an 11-amino acid peptide that simulating the spatial structure of the B-erythropoietin alpha-helix in the correction of L-NAME-induced nitric oxide deficiency in the late gestation perio

THE MAIN PREREQUISITES FOR THE IMPLEMENTATION OF THE WORKFORCE MANAGEMENT SYSTEM TO OPTIMIZE STAFF WORKING HOURS

The purpose of the article is to study the principles of managing staff working time to reduce costs and increase efficiency, optimize labor processes, manage and predict the workload of staff, and implement methods and tools to improve efficiency. The article describes the main prerequisites for the implementation of the Workforce Management system (WFM), which is a methodology for planning employees’ working hours, which is a component of the personnel management concept. As a metric for evaluating the effect of using WFM systems, the planned or actual number of employees` hours per month is used – a comparison of the planned schedules before and after using the system is made. The effect of implementing WFM is as follows: increased staff efficiency, improved service level, revenue growth as a result of lower costs and more competent traffic coverage, increased staff involvement and saving management time