Assessing the Intensity of Late Holocene Montane Settlement and Subsistence Strategies in the Northern Sierra Nevada, California

This thesis investigates the precontact settlement patterns of the Nisenan in the northern Sierra Nevada and compares these patterns to studies of Mono and Miwok settlement patterns in the central and southern Sierra Nevada. I assess the degree to which Nisenan settlement and subsistence strategies in the montane environment of the Sierra Nevada differs from other groups occupying similar environments in the Sierra. I predicted the Nisenan would share a similar settlement and subsistence strategy to the Miwok based on both groups sharing similar population densities and culture histories in broadly similar environments. The Nisenan, however, use a settlement pattern that more closely resembles the Mono in intensity but differs in important ways. The Nisenan primarily occupied lower elevation ecozones and relied on lower intensity logistical mobility in the montane ecozones above snowline. Comparatively the Mono were more residentially mobile above snowline and the Miwok use a much more intensive residentially mobile strategy above and below snowline. This study indicates that population density and occupational time depth alone are not sufficient predictors of montane settlement and subsistence strategies. Factors like climate, environment, sociopolitical structures, territoriality, culture history, and seasonal resource availability likely also influence hunter-gatherer decision making when it comes to settlement and subsistence. The Nisenan appear to be a group that was more oriented toward the valley margin and foothills of the Sierra Nevada than montane environments. Additionally, montane environments within the study area may have been used by the Nisenan and the Washoe of the Tahoe region as backup resource patches during times of scarcity in lower elevation environments. This project contributes to our understanding of human adaptations in montane environments and the factors that contribute to group decision-making when it comes to determining settlement and subsistence strategies

Assessing the effective connectivity of premotor areas during real vs imagined grasping: a DCM-PEB approach

The parieto-frontal circuit underlying grasping, which requires the serial involvement of the anterior intraparietal area (aIPs) and the ventral premotor cortex (PMv), has been recently extended enlightening the role of the dorsal premotor cortex (PMd). The supplementary motor area (SMA) has been also suggested to encode grip force for grasping actions; furthermore, both PMd and SMA are known to play a crucial role in motor imagery. Here, we aimed at assessing the dynamic couplings between left aIPs, PMv, PMd, SMA and primary motor cortex (M1) by comparing executed and imagined right-hand grasping, using Dynamic Causal Modelling (DCM) and Parametrical Empirical Bayes (PEB) analyses. 24 subjects underwent an fMRI exam (3T) during which they were asked to perform or imagine a grasping movement visually cued by photographs of commonly used objects. We tested whether the two conditions a) exert a modulatory effect on both forward and feedback couplings among our areas of interest, and b) differ in terms of strength and sign of these parameters. Results of the real condition confirmed the serial involvement of aIPs, PMv and M1. PMv also exerted a positive influence on PMd and SMA, but received an inhibitory feedback only from PMd. Our results suggest that a general motor program for grasping is planned by the aIPs-PMv circuit; then, PMd and SMA encode high-level features of the movement. During imagery, the connection strength from aIPs to PMv was weaker and the information flow stopped in PMv; thus, a less complex motor program was planned. Moreover, results suggest that SMA and PMd cooperate to prevent motor execution. In conclusion, the comparison between execution and imagery reveals that during grasping premotor areas dynamically interplay in different ways, depending on task demands

Headache as presenting symptom of neurosarcoidosis

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Occipital neurostimulation in primary headaches: update

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Application of an early warning to detect enteropathies in intensive broiler farming

Remote and wearable sensors can be combined with smart algorithms to continuously monitor a wide range of animal responses linked with stress, health status and welfare. The idea of real time monitoring assumes a simple way to measure variable that can give an early warning for the farmer providing clear and suitable alerts to help them in their routine. The prompt reaction to any change in health, welfare and productive status is the key for the reduction in drugs usage and for the improvement of animal wellbeing. In intensive poultry farms, enteric disorders represent a major health issue; these pathologies could be multifactorial and are a major cause of performances reduction. Monitoring poultry health status takes a key role for management to reduce chemicals/drugs and their costs. Nowadays, the preventive use of antibiotics in intensive farming system is common and this practice could lead to the spreading of drugs in the environment, contributing to the phenomenon of antibiotic resistance. Due to the high priority of this issue, it is of great importance the early detection of any health problem in intensive farming. Precision Livestock Farming, through the combination of cheap technologies and specific algorithms, can provide valuable information for farmers starting from the huge amount of data collected in real time at farm level. This study was aimed to the application of a PLF diagnostic tool, sensible to the variation of volatile organic compounds, to promptly recognize enteric problems in intensive farming, supporting veterinarians and enabling specific treatments in case of disease

Frovatriptan versus zolmitriptan for the acute treatment of migraine with aura: a subgroup analysis of a double-blind, randomized, multicenter, Italian study

Migraine with aura affects ~20–30 % of migraineurs and it is much less common than migraine without aura. The aim of this study was to compare the efficacy of frovatriptan 2.5 mg and zolmitriptan 2.5 mg in the treatment of migraine with aura. Analysis was carried out in a subset of 18 subjects with migraine with aura (HIS criteria) out of the 107 enrolled in a multicenter, randomized, double-blind, cross-over study. According to the study design, each patient had to treat three episodes of migraine in no more than 3 months with one drug, before switching to the other treatment. The rate of pain-free episodes at 2 h was significantly (p < 0.05) larger under frovatriptan (45.8 %) than under zolmitriptan (16.7 %). Pain free at 4 h, pain relief at 2 and 4 h and recurrent episodes were similar between the two treatments, while sustained pain-free episode was significantly (p < 0.05) more frequent during frovatriptan treatment (33.3 vs. 8.3 % zolmitriptan). Our study suggests that frovatriptan is superior to zolmitriptan in the immediate treatment of patients with migraine with aura, and it is capable of maintaining its acute analgesic effect over 48 h

Whole-Exome and Transcriptome Sequencing Expands the Genotype of Majewski Osteodysplastic Primordial Dwarfism Type II

Microcephalic Osteodysplastic Primordial Dwarfism type II (MOPDII) represents the most common form of primordial dwarfism. MOPD clinical features include severe prenatal and postnatal growth retardation, postnatal severe microcephaly, hypotonia, and an increased risk for cerebrovascular disease and insulin resistance. Autosomal recessive biallelic loss-of-function genomic variants in the centrosomal pericentrin (PCNT) gene on chromosome 21q22 cause MOPDII. Over the past decade, exome sequencing (ES) and massive RNA sequencing have been effectively employed for both the discovery of novel disease genes and to expand the genotypes of well-known diseases. In this paper we report the results both the RNA sequencing and ES of three patients affected by MOPDII with the aim of exploring whether differentially expressed genes and previously uncharacterized gene variants, in addition to PCNT pathogenic variants, could be associated with the complex phenotype of this disease. We discovered a downregulation of key factors involved in growth, such as IGF1R, IGF2R, and RAF1, in all three investigated patients. Moreover, ES identified a shortlist of genes associated with deleterious, rare variants in MOPDII patients. Our results suggest that Next Generation Sequencing (NGS) technologies can be successfully applied for the molecular characterization of the complex genotypic background of MOPDII

Study of parafunctions in patients with chronic daily headache.

The purpose of this paper is to present the results of a questionnaire investigating parafunctions (particularly clenching and grinding). The questionnaire was elaborated by the Dental Clinic of the University of Milano and completed by 125 patients experiencing chronic daily headache and attending the Neurological Institute Carlo Besta for an inpatient withdrawal protocol to treat medication overuse related to chronic headaches. Our results showed high percentages of parafunctions, which were present in 80% of patients with chronic daily headache. We noted that patient information on possible behaviours and coexisting conditions which may be involved in the mechanisms of chronic headaches, as well as education about these factors, are crucial aspects in the management of chronic headache patients. It is important for clinicians to perform a thorough evaluation (based upon history taking and clinical examination) aimed at identifying parafunctions. Several studies showed that cranio-mandibular dysfunction (CMD) is prevalent in different headache forms, such as tension-type headache and migraine, and may have a role in their chronification. Overall, our data encourage the early diagnosis and treatment of muscular and mechanical aspects of CMD. All the diagnostic and therapeutic proposals over the years suggested that converting a dysfunctional stomatognathic system into a physiological and functional one is an appropriate and effective approach to the treatment of headaches. The achievement of a good muscular activity during clenching and a low activity at rest represent the main goals of our therapy. We suggest that patients suffering from chronic headaches are be evaluated as far as the need for interocclusal devices (as pointed out in previous studies of our group) is concerned, and in relation to the possible presence of parafunctions: their analysis, correction and prevention will ultimately limit their role as trigger factors or as coexisting conditions influencing the development/maintaining of headache chronification

Aedes albopictus bionomics data collection by citizen participation on procida island, a promising mediterranean site for the assessment of innovative and community-based integrated pest management methods

In the last decades, the colonization of Mediterranean Europe and of other temperate regions by Aedes albopictus created an unprecedented nuisance problem in highly infested areas and new public health threats due to the vector competence of the species. The Sterile Insect Technique (SIT) and the Incompatible Insect Technique (IIT) are insecticide-free mosquito-control methods, relying on mass release of irradiated/manipulated males, able to complement existing and only partially effective control tools. The validation of these approaches in the field requires appropriate experimental settings, possibly isolated to avoid mosquito immigration from other infested areas, and preliminary ecological and entomological data. We carried out a 4-year study in the island of Procida (Gulf of Naples, Italy) in strict collaboration with local administrators and citizens to estimate the temporal dynamics, spatial distribution, and population size of Ae. albopictus and the dispersal and survival of irradiated males. We applied ovitrap monitoring, geo-spatial analyses, mark-release-recapture technique, and a citizen-science approach. Results allow to predict the seasonal (from April to October, with peaks of 928-9,757 males/ha) and spatial distribution of the species, highlighting the capacity of Ae. albopictus population of Procida to colonize and maintain high frequencies in urban as well as in sylvatic inhabited environments. Irradiated males shown limited ability to disperse (mean daily distance travelled &lt;60m) and daily survival estimates ranging between 0.80 and 0.95. Overall, the ecological characteristics of the island, the acquired knowledge on Ae. albopictus spatial and temporal distribution, the high human and Ae. albopictus densities and the positive attitude of the resident population in being active parts in innovative mosquito control projects provide the ground for evidence-based planning of the interventions and for the assessment of their effectiveness. In addition, the results highlight the value of creating synergies between research groups, local administrators, and citizens for affordable monitoring (and, in the future, control) of mosquito populations