Additional spectroscopic redshift measurements for galaxy clusters from the First Planck Catalogue

We present the results of spectroscopic redshift measurements for the galaxy clusters from the first all-sky Planck catalogue of the Sunyaev-Zeldovich sources, that have been mostly identified by means of the optical observations performed previously by our team (Planck Collaboration, 2015a). The data on 13 galaxy clusters at redshifts from z=~0.2 to z=~0.8, including the improved identification and redshift measurement for the cluster PSZ1 G141.73+14.22 at z=0.828, are provided. The measurements were done using the data from Russian-Turkish 1.5-m telescope (RTT-150), 2.2-m Calar Alto Observatory telescope, and 6-m SAO RAS telescope (Bolshoy Teleskop Azimutalnyi, BTA).Comment: published in Astronomy Letter

The basic requirements for the profession of «teacher of vocational training»

В статье рассмотрены основные общие требования, которые должны предъявляться педагогу профессионального обучения в условиях современного образования, и закрепленных в Профессиональном стандарте педагога.The article accounts the basic general requirements for the teacher of Professional training in the conditions of contemporary education fixed in the Professional standard of the teacher

Development of the draft standard of organization «VALUE STREAM MAPPING»

The standard of organization « Value Stream Mapping» at the Kalinin Machine-Building Plant is developed. Using this standard, the enterprise will be able to reduce working losses, to increase production effectiveness and to take the leading positions in the marketРазработан проект стандарта организации «Картирование потока создания ценности» на ПАО «Машиностроительный завод имени М. И. Калинина». Используя данный стандарт, предприятие сможет сократить производственные потери, повысить производственную эффективность и занять лидирующие позиции на рынк

Functional interplay between chromatin remodeling complexes RSC, SWI/SNF and ISWI in regulation of yeast heat shock genes

Chromatin remodeling is an essential part of transcription initiation. We show that at heat shock gene promoters functional interactions between individual ATP-dependent chromatin remodeling complexes play critical role in both nucleosome displacement and Pol II recruitment. Using HSP12, HSP82 and SSA4 gene promoters as reporters, we demonstrated that while inactivation of SNF2, a critical ATPase of the SWI/SNF complex, primarily affects the HSP12 promoter, depletion of STH1- a SNF2 homolog from the RSC complex reduces histone displacement and abolishes the Pol II recruitment at all three promoters. From these results, we conclude that redundancy between SWI/SNF and RSC complexes is only partial and likely is affecting different chromatin remodeling steps. While inactivation of other individual ATP-dependent chromatin remodeling complexes negligibly affects reporter promoters, combinatorial inactivation of SNF2 and ISW1 has a synergistic effect by diminishing histone loss during heat induction and eliminating Pol II recruitment. Importantly, it also eliminates preloading of HSF on HSP82 and SSA4 promoters before heat shock and diminishes HSF binding during heat shock. These observations suggest that prior action of chromatin remodeling complexes is necessary for the activator binding

Endothelial function status in hypogonadal men

Background: Type 2 diabetes mellitus (T2DM) and hypogonadism are mutually aggravating diseases associated with the development and progression of cardiovascular pathology. The status of endothelial function in men with T2DM and hypogonadism hasn’t been studied.Aims: To assess the effect of hypogonadism on endothelial function in men with T2DM.Materials and methods: Patients underwent clinical studies, assessment of carbohydrate and lipid metabolism, the content of sex hormones (total testosterone (T), sex hormones binding globulin, free T, luteinizing hormone) and markers of endothelial function (nitric oxide (NO), endothelial nitric oxide synthase type 3 (eNOS3), endothelin, adhesion molecules ICAM-1, VCAM-1, p- and e-selectins, cadherin), ultrasound examinations of endothelium-dependent vasodilation (EDVD) of the brachial artery (BA) and carotid arteries with an assessment of the thickness of intima-media complex (TIM) were performed.Results: The study included 276 men with T2DM (age 54.0[49;60] years), who were divided into 2 groups: 1–124 patients with hypogonadism; 2–152 eugonadal patients. Reduction of the endothelial vasomotor function was detected in 32.4% of patients in the 2st group and in 55.3% of the 1nd group (χ2=6.1; p=0.01), which was associated with a decrease in EDVD by 29.8 % (p<0.001) and an increase in the time of development of maximal BA vasodilation by 30 seconds in patients with hypogonadism (p<0.001). The TIM of the carotid arteries was 10% more in group 1 compared with group 2 (p=0.03). The ­level of NO in the 1st group was reduced by 1.6 times (p=0.001), eNOS3–by 1.5 times (p=0.038) compared with the 2nd group. The concentrations of adhesion molecules were higher in group 1 compared to group 2: VCAM-1 by 32.5% (p<0.001), ICAM-1 by 43.5% (p<0.001), p-selectin–by 19.3% (p=0.004), cadherin–6 times (p<0.001).Conclusion: Hypogonadism in men with T2DM is associated with the development of endothelial dysfunction, which manifests in a weakening of the EDVD and a slowdown in its development, as well as disturbances of the secretory activity of endothelium–a decrease in NO synthesis and activation of the adhesion molecules expression, which can be regarded as an universal pathogenetic mechanism of the development of cardiovascular diseases in combination of T deficiency and T2DM

Anti-Stokes femtosecond photon echo in dye-doped polymer films and the possibility of coherent optical cooling

An anti-Stokes model is proposed to explain the known experimental data on the femtosecond photon echo in dye-doped polymer films at room temperature. The possibility of implementing the anti-Stokes mode of coherent laser cooling of such films is analyzed. © Allerton Press, Inc. 2008

The Social Sentiments of Workers of Ural Region in the Mid-1920s (with Reference to Information Bulletins of JSPD)

Поступила в редакцию 11.03.2019. Принята к печати 17.07.2019.Submitted on 11 March, 2019. Accepted on 17 July, 2019.В статье на основании информационных сводок ОГПУ рассматриваются социальные настроения рабочих Уральской области и их проявления в середине 1920-х гг. в условиях нэпа. Показаны основные причины негативных настроений рабочих (высокие нормы выработки, низкая зарплата, обеспечение спецодеждой, жилищный вопрос). Важными факторами недовольства рабочих являлись напряженные взаимоотношения с заводской администрацией, спровоцированные ее грубостью, и бездействие профсоюзных организаций, которые часто приводили к забастовкам. В этот период наблюдается неуклонный рост числа забастовок в Уральской области, в 1926 г. число забастовок выросло в три раза по сравнению с 1925 г. Значительное число конфликтов, которые приводили к забастовкам, имело экономическую основу — они возникали из-за невыполнения администрацией своих обязательств. Недовольство рабочих администрацией заводов и спецами подогревало их вызывающее, демонстративное поведение и злоупотребления служебным положением. Рабочие сравнивали современную ситуацию на заводах с царскими временами. В результате в среде промышленных рабочих Урала начинали возникать политическое недовольство, антисоветские и антикоммунистические настроения. Таким образом, социально-экономическое положение уральских рабочих слабо коррелировало с официальным статусом рабочего класса как класса-гегемона в Советской России. В то же время большинство рабочих лояльно относилось к советской власти, которую считали «своей». Рабочих в большей степени волновали экономические аспекты их повседневного существования. Социальные волнения могли приобрести более-менее широкий размах в случае ухудшения экономической обстановки в стране, но вряд ли могли перерасти в политические волнения.Referring to information reports of the Joint State Political Directorate (Rus. OGPU), this article examines the social sentiments of workers of Ural Region and their causes and manifestations in the mid-1920s in the conditions of the New Economic Policy (NEP). The paper illustrates the main causes of negative sentiments among workers (high production rates, low wages, protective clothing, housing issues, etc.). Among important factors for the workers’ discontent were their tense relations with the factory administration provoked by its rudeness, as well as the inaction of trade union organisations, which often led to strikes. The period faced a steady increase in the number of strikes in Ural Region. In 1926, the number of strikes tripled compared to 1925. A large number of conflicts that led to strikes had an economic basis, i.e. they arose from failure of the administration to fulfil its obligations. The defiant, demonstrative behaviour of the administration of factories and specialists and their malpractice fueled the workers’ dissatisfaction. Workers compared the situation in the factories with the times of the tsar. As a result, political discontent and anti-Soviet and anti-Communist moods began to arise among industrial workers of the Urals. Thus, the social and economic situation of workers had little to do with the official status of the working class as a hegemonic class in Soviet Russia. At the same time, most workers were loyal to the Soviet government which they considered “their own”. The workers were more concerned about the economic aspects of their daily existence. Social unrest could become more widespread in case of deterioration of economic situation in the country but could hardly develop into political unrest

ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER

The existing data on regulatory T cells (Tregs) in prostate cancer suggest that these cells may penetrate the prostate gland malignant tissue, suppressing antitumor immune response, thus promoting aggressive clinical course and low survival of the cancer patients. Evaluation of T cell subpopulations from the tumor microenvironment has shown that the number of CD4+Tregs is associated with inferior clinical prognosis. In particular, each additional CD4+Treg cell has been shown to cause a statistically significant increase in prostate cancer mortality by 12%, regardless of other clinical factors. There are several possible explanations for the increased infiltration of prostate cancer tissue with regulatory T cells. Firstly, malignant cells or tumor-associated macrophages are capable of secreting chemokine CCL22, which has an affinity for the CCR4 receptor expressed on Treg cells. Secondly, cytokines secreted by prostate tumors, such as TGF-β, may regulate the FoxP3 expression, thus expanding the Treg population. TGF-β, in turn, is a multifunctional cytokine that promotes survival and proliferation of transformed cells, including prostate epithelium, as evidenced by increased amounts in the patients with metastatic disease