55 research outputs found
Activation of learning and creative activity of the vocational pedagogical university students
The relevance of the problem under study is based on the societyβs demand for training students - future professional training teachers ready to solve in a creative manner a wide range of professional and pedagogical tasks, as well as to develop professionally-oriented creative work in the process of training; it is also caused by the insufficient extent of the prior research within the vocational training theory of scientific and methodological mechanisms required for implementing this process. The purpose of the article is to develop a conceptual structural model of professionally-oriented learning and creative activity of the vocational pedagogical university students. Leading method for studying this problem is modelling which allows to consider this problem as the process of goaloriented and deliberate acquiring by future professionals the creative approaches to implementation of professional activity. The article presents a structural model of learning and creative activity of vocational pedagogical university students, justifies the necessity to single out in the structure of the studentsβ learning and creative activity three interconnected components (creative, professional-pedagogical and personal-acmeological), proves the productivity of activating the learning and creative activity of the vocational pedagogical university students by organizing it as quasi-professional process of searching and solving professional tasks which are subjectively and objectively new, on the basis of using synectics including association methods of activating creative thinking integrated into the its structure. The article can be useful for teachers within the vocational and pedagogical education system, as well as for professionals who develop creative abilities of students based on the heuristic creativity methods. Β© 2016 Krayukhina et al
Study of Phase Composition Homogeneity in Depth of Tungsten Carbide Ceramics Produced by Spark Plasma Sintering
Tungsten carbide (WC) ceramics obtained by spark plasma sintering were investigated by layer-by-layer X-ray diffraction analysis. It was found that the phase composition of WC ceramics varies with the distance from the sample surface.The study was supported by the Russian Foundation for Basic Research under Scientific Project β20-33-90214
Polymerization of Lactic Acid Using Microwave and Conventional Heating
The polymerization of lactic acid (LA) has been investigated by two methods: conventional heating and under microwave irradiation. The reactions of polymerization have been carried out in two stages: at the beginning water is removed and oligomer is obtained; then, the catalysts/co-catalysts are added and reactions are carried out. Tin octoate, toluene sulfonic acid, 2-aminopropanoic acid (alanine) have been investigated as polymerization catalysts and the derivatives of 2,4,6,8- tetramethilol -2,4,6,8- tetraazabicyclo[3.3.0]octane -3,7-dion (Tetraol), comprising atoms of Mg, Zn, Al have been synthesized for the first time. The structure of the synthesized catalyst has been investigated using the method of IR, {1}H NMR. It has been shown that the process of obtaining polylactic acid (PLA) by microwave irradiation proceeds hundreds of times faster. PLA samples synthesized by this method have the same optical characteristics as the PLA obtained by conventional heating
Results of screening for antibodies to varicella-zoster virus in healthcare workers of a multidisciplinary hospital in Moscow
Introduction. Given the unfavorable epidemic situation with chickenpox and shingles in Russia, there is a high risk of virus introduction and spread in healthcare settings, including among medical staff who are not immune to varicella zoster virus (VZV).
The objective of this study is to assess the immunity of employees of a multidisciplinary hospital in Moscow to VZV.
Materials and methods. A selective screening study was carried out. Venous blood serum samples were taken from 1546 hospital employees as material for detection of IgG antibodies to VZV antigens using a commercial solid-phase enzyme immunoassay (ELISA) test system "Vecto VZV-IgG". All employees were questioned to obtain information about their infectious and vaccine history in relation to VZV.
Results and discussion. Screening for antibodies to VZV in the hospital workers revealed that 6.3% of those workers are not immune to VZV. The proportion of seronegative individuals was the highest (12.6 Β± 2.4%) in the age group of 29 years and younger. VZV seronegative healthcare workers were found in various departments, but the presence of non-immune individuals among the staff of the obstetrics and gynecology departments (6.5%) is of epidemiologic concern. The results of the survey showed that documented data on infection and vaccination history cannot be used to assess the protection of healthcare workers against VZV infection.
Conclusion. The results of serologic screening for antibodies to VZV made it possible to identify a significant number of susceptible employees of the multidisciplinary hospital. In order to prevent the formation of multiple epidemic foci of varicella in medical organizations, it is advisable to include anti-VZV testing of medical staff in the state prevention programs with subsequent vaccination of non-immune individuals
A comparative study of the effectiveness of magnesium orotate tautomers to com-pensate magnesium deficiency. Part I. The influence of magnesium orotate tautomers on laboratory animals and humans isolated cells
The objects of the research were erythrocytes and lymphocytes of humans and rats and human buccal epitheliocites. The hemolysis of erythrocytes and microelectrophoresic cell mobility in solutions of saline with the orotate magnesium tautomers was studied. The mobility of erythrocytes in the solution with the dihydroxy-form showed negative dynamics (the number of active erythrocytes decreased in 2 times), the activity of cells increased in hydroxy-forms solutions: the amplitude of vibrations of the erythrocyte membrane increased more than in 2 times. Moreover, in solutions with hydroxy- and dihydroxy-forms the active forms of lymphocytes appeared. In oxo-form solution this effect was not observed. Buccal epithelium cells react in a similar way. The amplitude cytolemma and the nuclear membrane vibrations is higher in solution with hydroxy-form magnesium orotate. Activation of nucleated buccal cells in solutions of hydroxy-form are more pronounced than activation of red blood cells. The stability of the erythrocyte membrane of animals with experimental magnesium deficiency to the action of a hypotonic solution is restored on the 10th day after taking tautomers and is more pronounced when taking the hydroxyl-form of magnesium orotate.Magnesium orotate tautomers have different mechanisms of absorption and have different properties in relation to participation in biochemical processes.ΠΠ±ΡΠ΅ΠΊΡΠ°ΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ»ΠΈΡΡ ΡΡΠΈΡΡΠΎΡΠΈΡΡ ΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΡ ΠΊΡΡΡ ΠΈ ΡΠΏΠΈΡΠ΅Π»ΠΈΠΎΡΠΈΡΡ Π±ΡΠΊΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈΡΡ Π³Π΅ΠΌΠΎΠ»ΠΈΠ· ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΌΠΈΠΊΡΠΎΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΏΠΎΠ΄Π²ΠΈΠΆΠ½ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΡΠΈΠ·ΡΠ°ΡΡΠ²ΠΎΡΠ΅ Ρ ΡΠ°ΡΡΠΎΠΌΠ΅ΡΠ°ΠΌΠΈ ΠΎΡΠΎΡΠ°ΡΠ° ΠΌΠ°Π³Π½ΠΈΡ. ΠΠΎΠ΄Π²ΠΈΠΆΠ½ΠΎΡΡΡ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² Π² ΡΠ°ΡΡΠ²ΠΎΡΠ΅ Ρ Π΄ΠΈΠ³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΠΎΠΉ ΠΏΠΎΠΊΠ°Π·Π°Π»Π° ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ (ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΡΠ½ΠΈΠΆΠ°Π»ΠΎΡΡ Π² 2 ΡΠ°Π·Π°), Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»Π°ΡΡ Π² ΡΠ°ΡΡΠ²ΠΎΡΠ΅ Ρ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΠΎΠΉ: Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Π° ΠΊΠΎΠ»Π΅Π±Π°Π½ΠΈΠΉ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅, ΡΠ΅ΠΌ Π² 2 ΡΠ°Π·Π°. ΠΊΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π² ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
Ρ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ- ΠΈ Π΄ΠΈΠ³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΏΠΎΡΠ²ΠΈΠ»ΠΈΡΡ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ². Π ΡΠ°ΡΡΠ²ΠΎΡΠ΅ Ρ ΠΎΠΊΡΠΎ-ΡΠΎΡΠΌΠΎΠΉ ΠΈΡ
Π½Π΅Ρ. Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΠΎ ΡΠ΅Π°Π³ΠΈΡΡΡΡ ΠΊΠ»Π΅ΡΠΊΠΈ Π±ΡΠΊΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ. Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Π° ΠΊΠΎΠ»Π΅Π±Π°Π½ΠΈΠΉ ΡΠΈΡΠΎΠ»Π΅ΠΌΠΌΡ ΠΈ ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ Π²ΡΡΠ΅ Π² ΡΠ°ΡΡΠ²ΠΎΡΠ΅ Ρ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΠΎΠΉ ΠΎΡΠΎΡΠ°ΡΠ° ΠΌΠ°Π³Π½ΠΈΡ. Π°ΠΊΡΠΈΠ²ΠΈΠ·Π°ΡΠΈΡ ΡΠ΄ΡΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π±ΡΠΊΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ Π² ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΡ ΠΎΡΠΎΡΠ°ΡΠ° ΠΌΠ°Π³Π½ΠΈΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π° Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ, ΡΠ΅ΠΌ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ². Π£ΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ ΠΌΠ°Π³Π½ΠΈΡ ΠΊ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΈΠΏΠΎΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅ΡΡΡ Π½Π° 10-ΠΉ Π΄Π΅Π½Ρ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΈΠ΅ΠΌΠ° ΡΠ°ΡΡΠΎΠΌΠ΅ΡΠΎΠ² ΠΈ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π° ΠΏΡΠΈ ΠΏΡΠΈΠ΅ΠΌΠ΅ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΡ ΠΎΡΠΎΡΠ°ΡΠ° ΠΌΠ°Π³Π½ΠΈΡ. ΡΠ°ΡΡΠΎΠΌΠ΅ΡΡ ΠΎΡΠΎΡΠ°ΡΠ° ΠΌΠ°Π³Π½ΠΈΡ ΠΈΠΌΠ΅ΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π²ΡΠ°ΡΡΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΠ°ΡΡΠΈΡ Π² Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
A comparative study of the effectiveness of magnesium orotate tautomers to compen-sate magnesium deficiency. II. The influence of oxo β and hydroxyforms of magnesium orotate on laboratory animals blood and tissues elemental composition
Under fusemide-induced hypomagnesemia in animals, the hydroxy form of magnesium orotate shows a higher rate of compensation for magnesium deficiency in the blood compared to the oxo form. Furosemide load is accompanied not only by hypomagnesia, but also by the development diselementosis of the body. Changes in elemental status are different depending on the organ. The amount of magnesium in the furosemide load decreases in serum, does not change in the heart, rises in the spleen and thymus. The injection of the hydroxy form of magnesium orotate levels the ratio of micro- and macronutrients in blood plasma and organ tissues. Magnesium deficiency is accompanied by signs of immuno-inflammatory reaction, leuko- and lymphocytosis, eosinophilia, a decrease in the number of erythrocytes and a decrease in the level of hemoglobin. An earlier and complete restoration of cytological parameters is noted in the group of animals with the introduction of hydroxy form of magnesium orotate.ΠΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΠ° ΠΎΡΠΎΡΠ°ΡΠ° ΠΌΠ°Π³Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΡΡ ΡΠΊΠΎΡΠΎΡΡΡ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠ°Π³Π½ΠΈΡ Π² ΠΊΡΠΎΠ²ΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΎΠΊΡΠΎ-ΡΠΎΡΠΌΠΎΠΉ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΌΠΎΠ΄Π΅Π»ΠΈΡΡΠ΅ΠΌΠΎΠΉ ΡΡΡΠΎΡΠ΅ΠΌΠΈΠ΄-ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΌΠ°Π³Π½Π΅Π·ΠΈΠ΅ΠΌΠΈΠΈ ΠΊΡΡΡ. Π€ΡΡΠΎΡΠ΅ΠΌΠΈΠ΄Π½Π°Ρ Π½Π°Π³ΡΡΠ·ΠΊΠ° ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π³ΠΈΠΏΠΎΠΌΠ°Π³Π½Π΅Π·ΠΈΠ΅ΠΌΠΈΠ΅ΠΉ, Π½ΠΎ ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠΈΠΌΡΡ Π΄ΠΈΡΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ·ΠΎΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΊΡΡΡ ΡΠ°Π·Π½ΠΎΠ½Π°ΠΏΡΠ°Π²Π»Π΅Π½Ρ. ΠΡΠΈ ΡΡΡΠΎΡΠ΅ΠΌΠΈΠ΄Π½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΌΠ°Π³Π½ΠΈΡ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅ΡΡΡ Π² ΡΠ΅ΡΠ΄ΡΠ΅, ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ Π² ΡΠ΅Π»Π΅Π·Π΅Π½ΠΊΠ΅ ΠΈ ΡΠΈΠΌΡΡΠ΅. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΡ ΠΌΠ°Π³Π½ΠΈΡ ΠΎΡΠΎΡΠ°ΡΠ° Π²ΡΡΠ°Π²Π½ΠΈΠ²Π°Π΅Ρ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΌΠΈΠΊΡΠΎ- ΠΈ ΠΌΠ°ΠΊΡΠΎΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΡΠΊΠ°Π½ΠΈ ΠΎΡΠ³Π°Π½ΠΎΠ² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΊΡΡΡ. ΠΠ°Π³Π½ΠΈΠ΅Π²ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ, Π»Π΅ΠΉΠΊΠΎ- ΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ·ΠΎΠΌ, ΡΠΎΠ·ΠΈΠ½ΠΎΡΠΈΠ»ΠΈΠ΅ΠΉ, ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠΎΠ²Π½Ρ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π°. Π Π³ΡΡΠΏΠΏΠ΅ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΊΠΎΡΠΎΡΡΠΌ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈ-ΡΠΎΡΠΌΡ ΠΌΠ°Π³Π½ΠΈΡ ΠΎΡΠΎΡΠ°ΡΠ° Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½Π΅Π΅ ΠΈ ΠΏΠΎΠ»Π½ΠΎΠ΅ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π² ΠΊΡΠΎΠ²ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½Ρ
STUDY OF THE PHASE CONTENT HOMOGENEITY OF CERAMICS OBTAINED BY SPARK PLASMA SINTERING OF POWDERWC + 10 %Co
The phase content of ceramic samples WC + 10 % Co was studied. Samples were obtained in different sintering modes. The isothermal holding in the sintering process did not affect on the depth distribution of the main phases.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΡΠ°Π·ΠΎΠ²ΡΠΉ ΡΠΎΡΡΠ°Π² ΠΊΠ΅ΡΠ°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π² ΡΠ°Π·Π½ΡΡ
ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
ΡΠΏΠ΅ΠΊΠ°Π½ΠΈΡ ΠΏΠΎΡΠΎΡΠΊΠ° WC+10 %Co. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈΠ·ΠΎΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²ΡΠ΄Π΅ΡΠΆΠΊΠΈ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΏΠ΅ΠΊΠ°Π½ΠΈΡ Π½Π΅ ΠΏΠΎΠ²Π»ΠΈΡΠ»ΠΎ Π½Π° ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠ°Π· ΠΏΠΎ Π³Π»ΡΠ±ΠΈΠ½Π΅ ΠΎΠ±ΡΠ°Π·ΡΠ°.Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΏΡΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ Π ΠΠ€ Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π³ΡΠ°Π½ΡΠ° β 18-73-10177
Effect of mechanoactivation of creatine and creatinine on buccal epithelium cells and erythrocytes electrokinetic activity
The influence of ball milling on the structure and biological activity of creatine and creatinine in relation to buccal epithelial cells and erythrocytes was studied. Mechanoactivation of creatine and creatinine does not change the type of crystal lattice, thus changing the lattice parameters. When creatine is mechanically activated, the steric position of the nitrogen-containing part of the molecule changes. The new structural state of the creatine molecule is unstable and breaks down after a few days in the powder sample, and the aqueous solution after 15 minutes. Ball milling leads to tautomeric transformation of a molecule of creatinine. It is revealed the interrelation of microelectrophoretic mobility with: 1) chemical structure of molecules: molecules with-N= and OH - groups and a large number of double bonds showed a slightly higher activity compared to tautomers with -NH and C=O groups; 2) charge state of nitrogen and oxygen atoms in molecules: increasing the charge on the nitrogen atom and lowering the charge on the oxygen atom is accompanied by an increase in the activity of cells in aqueous solutions of substances; 3) increased hydrophobicity and, consequently, lipophilicity of molecules of the dissolved substance leads to an increase the cells activity in the solution; 4) it is possible that the greatest activity of cells is shown in solutions having electrical conductivity in the region of ~80-90 Π‘ΠΌ; in solutions with lower (~25Π‘ΠΌ) and higher (~120Π‘ΠΌ) electrical conductivity the activity of cells is lower; it is possible that this effect is associated with the peculiarities of the interaction of charged functional groups of different nature with the cell membrane.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΎΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π² ΡΠ°ΡΠΎΠ²ΠΎΠΉ ΠΏΠ»Π°Π½Π΅ΡΠ°ΡΠ½ΠΎΠΉ ΠΌΠ΅Π»ΡΠ½ΠΈΡΠ΅ Π½Π° ΡΡΡΡΠΊΡΡΡΡ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΡΠ΅Π°ΡΠΈΠ½Π° ΠΈ ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π° ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ Π±ΡΠΊΠΊΠ°Π»ΡΠ½ΡΠΌ ΡΠΏΠΈΡΠ΅Π»ΠΈΠΎΡΠΈΡΠ°ΠΌ ΠΈ ΡΡΠΈΡΡΠΎΡΠΈΡΠ°ΠΌ. ΠΠ΅Ρ
Π°Π½ΠΎΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΊΡΠ΅Π°ΡΠΈΠ½Π° ΠΈ ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π° Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅Ρ ΡΠΈΠΏ ΠΊΡΠΈΡΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ΅ΡΠΊΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΈΠ·ΠΌΠ΅Π½ΡΡΡΡΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΡΠ΅ΡΠ΅ΡΠΊΠΈ. ΠΡΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΎΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΊΡΠ΅Π°ΡΠΈΠ½Π° ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π°Π·ΠΎΡ-ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅ΠΉ ΡΠ°ΡΡΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ. ΠΠ΅Ρ
Π°Π½ΠΎΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ°ΡΡΠΎΠΌΠ΅ΡΠ½ΠΎΠΌΡ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π°. ΠΡΡΠ²Π»Π΅Π½Π° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠΈΠΊΡΠΎΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π²ΠΈΠΆΠ½ΠΎΡΡΠΈ Ρ: 1) Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠΎΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»: ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Ρ βN= ΠΈ OH- Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ ΠΈ Π±ΠΎΠ»ΡΡΠΈΠΌ ΡΠΈΡΠ»ΠΎΠΌ Π΄Π²ΠΎΠΉΠ½ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΏΡΠΎΡΠ²Π»ΡΠ»ΠΈ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ Π±ΠΎΠ»ΡΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΠ°ΡΡΠΎΠΌΠ΅ΡΠ°ΠΌΠΈ Ρ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ βNH ΠΈ C=O; 2) Π·Π°ΡΡΠ΄ΠΎΠ²ΡΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ Π°Π·ΠΎΡΠ° ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π°Ρ
: ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π·Π°ΡΡΠ΄Π° Π½Π° Π°ΡΠΎΠΌΠ΅ Π°Π·ΠΎΡΠ° ΠΈ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π·Π°ΡΡΠ΄Π° Π½Π° Π°ΡΠΎΠΌΠ΅ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π²ΠΎΠ΄Π½ΡΡ
ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
Π²Π΅ΡΠ΅ΡΡΠ²; 3) ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΈΠ΄ΡΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ, Π°, ΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎ, ΠΈ Π»ΠΈΠΏΠΎΡΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ» ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΡΠ°ΡΡΠ²ΠΎΡΠ΅; 4) Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΡΠΎΡΠ²Π»ΡΡΡ Π² ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
, ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΠ»Π΅ΠΊΡΡΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΎΡΡΡ Π² ΠΎΠ±Π»Π°ΡΡΠΈ 80-90; Π² ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
Ρ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ (25) ΠΈ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΎΠΉ (120) ΡΠ»Π΅ΠΊΡΡΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΎΡΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π½ΠΈΠΆΠ΅; Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΡΡΠΎ Π΄Π°Π½Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΡΠ²ΡΠ·Π°Π½ Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π·Π°ΡΡΠΆΠ΅Π½Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΡΠ°Π·Π½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ Ρ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°ΠΌΠ½Π΅Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΈΠΊΡΠΎΠ΄ΠΎΠ²ΡΠΌ ΠΊΠ»Π΅ΡΠ΅Π²ΡΠΌ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·ΠΎΠΌ Π² Π³. ΠΠΎΡΠΊΠ²Π΅
In the treatment of Lyme borreliosis (LB), early diagnosis is a key component. The epidemiological history of the patient plays one of the leading roles in suspected borreliosis and at the same time is an important criterion for clinical diagnosis.Purpose. Analysis of epidemiological history data in outpatient cases of LB in Moscow.Material and methods. We conducted a retrospective, non-randomized, single-center cohort study, based on the analysis of data from 660 outpatient records of patients, referred by local physician with tick bite or suspicion of LB, and consulted by an infectious disease specialist on the basis of the Infectious clinical hospital No.1 in Moscow. For further analysis, patients were divided by age and the presence or absence of LB. Confirmation of LB was based on clinical and/or laboratory criteria using methods of enzyme immunoassay and immune blot.Results. We have updated the epidemiological features of the LB for Moscow, such as: the relative number of cases in the administrative districts of Moscow, places and seasonality of tick bites. Among children, compared with adults, cases of a tick bite without the development of LB was predominant, which must be taken into account in order to avoid overdiagnosis of LB. In patients with LB, an indication of the fact of tick bite in the anamnesis was much less common than going to its habitats.Conclusion. Our data clarify the epidemiological features of LB for residents of Moscow. In the absence of a history of indications of tick bite, an informative sign for clinical diagnosis is a visit to its habitats, including not only trips to wooded areas, but also to suburban areas and parks.ΠΠ»ΡΡΠ΅Π²ΡΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠΌ ΡΡΠΏΠ΅ΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈΠΊΡΠΎΠ΄ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·Π° (ΠΠΠ) ΡΠ²Π»ΡΠ΅ΡΡΡ Π΅Π³ΠΎ ΡΠ°Π½Π½ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°, Π²Π°ΠΆΠ½ΡΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ ΠΊΠΎΡΠΎΡΠΎΠΉ ΡΠ»ΡΠΆΠ°Ρ Π΄Π°Π½Π½ΡΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°ΠΌΠ½Π΅Π·Π°.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β Π°Π½Π°Π»ΠΈΠ· Π΄Π°Π½Π½ΡΡ
ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°ΠΌΠ½Π΅Π·Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΠ Π² Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΠΎ-ΠΏΠΎΠ»ΠΈΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π² Π³. ΠΠΎΡΠΊΠ²Π΅.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅, Π½Π΅ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅, ΠΎΠ΄Π½ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ΅ ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠ΅ Π½Π° Π°Π½Π°Π»ΠΈΠ·Π΅ Π΄Π°Π½Π½ΡΡ
660 Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΡΡ
ΠΊΠ°ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠΎΠ½ΡΡΠ»ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π²ΡΠ°ΡΠΎΠΌ-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½ΠΈΡΡΠΎΠΌ Π½Π° Π±Π°Π·Π΅ ΠΠΠ£Π Β«ΠΠΠ β1 ΠΠΠΒ» ΠΏΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΡΠ°ΡΡΠΊΠΎΠ²ΠΎΠ³ΠΎ Π²ΡΠ°ΡΠ° Π² ΡΠ²ΡΠ·ΠΈ Ρ ΠΏΡΠΈΡΠ°ΡΡΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΠ»Π΅ΡΠ° ΠΈ/ΠΈΠ»ΠΈ ΠΏΠΎΠ΄ΠΎΠ·ΡΠ΅Π½ΠΈΠ΅ΠΌ Π½Π° ΠΠΠ. ΠΠ»Ρ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°ΠΌΠ½Π΅Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ ΠΏΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΡ ΠΈ Π½Π°Π»ΠΈΡΠΈΡ ΠΈΠ»ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΡ ΠΠΠ. ΠΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΈΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΠΠ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈ/ΠΈΠ»ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ Π±Π»ΠΎΡΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ°ΠΌΠΈ Π°ΠΊΡΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΠΠ Π΄Π»Ρ Π³. ΠΠΎΡΠΊΠ²Ρ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ
Π² Π°Π΄ΠΌΠΈΠ½ΠΈΡΡΡΠ°ΡΠΈΠ²Π½ΡΡ
ΠΎΠΊΡΡΠ³Π°Ρ
Π³. ΠΠΎΡΠΊΠ²Ρ, Π³Π΅ΠΎΠ³ΡΠ°ΡΠΈΡ ΠΈ ΡΠ΅Π·ΠΎΠ½Π½ΠΎΡΡΡ Π½Π°ΠΏΠ°Π΄Π΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠ΅ΠΉ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ Π΄Π°Π½Π½ΡΡ
ΡΠΏΠΈΠ΄Π°Π½Π°ΠΌΠ½Π΅Π·Π° Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
. Π‘ΡΠ΅Π΄ΠΈ Π΄Π΅ΡΠ΅ΠΉ, ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ Π²Π·ΡΠΎΡΠ»ΡΠΌΠΈ, ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ ΠΏΡΠΈΡΠ°ΡΡΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠ° Π±Π΅Π· ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠΠ, Π·Π½Π°ΡΠΈΠΌΠΎ ΡΠ°ΡΠ΅ Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠΈΡΠ°ΡΡΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠ΅ΠΉ Π½Π° ΠΊΠΎΠΆΠ΅ Π³ΠΎΠ»ΠΎΠ²Ρ. Π Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΠ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ°ΡΠ΅ Π±ΡΠ»ΠΎ ΡΠΊΠ°Π·Π°Π½ΠΈΠ΅ Π½Π° ΠΏΠΎΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π°ΡΠ΅Π°Π»ΠΎΠ² ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠ°, ΡΠ΅ΠΌ ΡΠΊΠ°Π·Π°Π½ΠΈΠ΅ Π½Π° ΡΠ°ΠΊΡ ΠΏΡΠΈΡΠ°ΡΡΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠ°.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π½Π°ΠΌΠΈ Π΄Π°Π½Π½ΡΠ΅ ΡΡΠΎΡΠ½ΡΡΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠΊΡΠΎΠ΄ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠ»Π΅ΡΠ΅Π²ΠΎΠ³ΠΎ Π±ΠΎΡΡΠ΅Π»ΠΈΠΎΠ·Π° Π΄Π»Ρ ΠΆΠΈΡΠ΅Π»Π΅ΠΉ Π³. ΠΠΎΡΠΊΠ²Ρ. Π ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΏΡΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ ΡΠΊΠ°Π·Π°Π½ΠΈΡ Π½Π° ΠΏΡΠΈΡΠ°ΡΡΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠ° ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π°ΡΠ΅Π°Π»ΠΎΠ² Π΅Π³ΠΎ ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ, Π²ΠΊΠ»ΡΡΠ°Ρ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π²ΡΠ΅Π·Π΄Ρ Π² Π»Π΅ΡΠΈΡΡΡΡ ΠΌΠ΅ΡΡΠ½ΠΎΡΡΡ, Π½ΠΎ ΠΈ Π½Π° Π·Π°Π³ΠΎΡΠΎΠ΄Π½ΡΠ΅ ΡΡΠ°ΡΡΠΊΠΈ, Π² ΠΏΠ°ΡΠΊΠΎΠ²ΡΠ΅ Π·ΠΎΠ½Ρ. Π£ΡΠΈΡΡΠ²Π°Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΈΡΠ°ΡΡΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠ΅ΠΉ, ΠΏΡΠΈ ΠΏΠΎΠΈΡΠΊΠ΅ ΠΌΠΈΠ³ΡΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠΈΡΠ΅ΠΌΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΠΎ ΠΎΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ Π²ΠΎΠ»ΠΎΡΠΈΡΡΡΡ ΡΠ°ΡΡΡ Π³ΠΎΠ»ΠΎΠ²Ρ
Effect of use of water, supersaturated with air, to reduce the severity of the cvonsequence of laboratory animals oxidative stress. II. The hypoglycemic action of artesian water with gas nanobubble phase studied on lab rats in conditions of hypercaloric diet and experimental diabet
The influence of water with gas nanobubbles on the condition and biochemical parameters of blood of rats in conditions of hypercaloric diet and experimental diabetes was studied. The beneficial effect of water with gas nanobubbles on rats in conditions of a reduced-calorie diet and streptozocin and experimental alloxan diabetes is observed. In rats, which were on an unbalanced diet, including excess fat and carbohydrates, the use of water with nanobubbles maintains a balance in terms of glycosylated hemoglobin, helps to reduce the weight and amount of cholesterol in the serum. In rats with experimental diabetes, the intake of treated water by rats, in the absence of hypoglycemic therapy, leads to a decrease in glucose levels and glycosylated hemoglobin. The effect of water intake is more pronounced in rats with alloxan diabetes. The action of the gas nanobubbles similarly the action of drugs-antioxidants.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π²ΠΎΠ΄Ρ Ρ Π³Π°Π·ΠΎΠ²ΡΠΌΠΈ Π½Π°Π½ΠΎΠΏΡΠ·ΡΡΡΠΊΠ°ΠΌΠΈ Π½Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΊΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π³ΠΈΠΏΠ΅ΡΠΊΠ°Π»ΠΎΡΠΈΠΉΠ½ΠΎΠΉ Π΄ΠΈΠ΅ΡΡ ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π±Π΅ΡΠ°. ΠΠ°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π²ΠΎΠ΄Ρ Ρ Π½Π°Π½ΠΎΠΏΡΠ·ΡΡΡΠΊΠ°ΠΌΠΈ Π½Π° ΠΊΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π³ΠΈΠΏΠ΅ΡΠΊΠ°Π»ΠΎΡΠΈΠΉΠ½ΠΎΠΉ Π΄ΠΈΠ΅ΡΡ ΠΈ Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π°Π»Π»ΠΎΠΊΡΠ°Π½ΠΎΠ²ΡΠΌ ΠΈ ΡΡΡΠ΅ΠΏΡΠΎΠ·ΠΎΡΠΈΠ½ΠΎΠ²ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ. Π£ ΠΊΡΡΡ, Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΡ
ΡΡ Π½Π° Π½Π΅ΡΠ±Π°Π»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ ΡΠ°ΡΠΈΠΎΠ½Π΅ ΠΏΠΈΡΠ°Π½ΠΈΡ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅ΠΌ ΠΈΠ·Π±ΡΡΠΎΠΊ ΠΆΠΈΡΠΎΠ² ΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΠ², ΡΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΠ΅ Π²ΠΎΠ΄Ρ Ρ Π½Π°Π½ΠΎΠΏΡΠ·ΡΡΡΠΊΠΎΠ²ΠΎΠΉ ΡΠ°Π·ΠΎΠΉ ΡΠΎΡ
ΡΠ°Π½ΡΠ΅Ρ Π±Π°Π»Π°Π½Ρ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π°, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π²Π΅ΡΠ° ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅. Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ ΠΏΡΠΈΠ΅ΠΌ ΠΎΠ±ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ Π²ΠΎΠ΄Ρ Π² ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠ°Ρ
Π°ΡΠΎΡΠ½ΠΈΠΆΠ°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Π΅ΠΉ Π³Π»ΡΠΊΠΎΠ·Ρ ΠΈ Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π°. ΠΡΡΠ΅ΠΊΡ ΠΎΡ ΠΏΡΠΈΠ΅ΠΌΠ° Π²ΠΎΠ΄Ρ Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π° ΠΊΡΡΡΠ°Ρ
Ρ Π°Π»Π»ΠΎΠΊΡΠ°Π½ΠΎΠ²ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ Π³Π°Π·ΠΎΠ²ΡΡ
Π½Π°Π½ΠΎΠΏΡΠ·ΡΡΡΠΊΠΎΠ² ΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ²-Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ²
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