Tropical and mid-latitude teleconnections interacting with the Indian summer monsoon rainfall: a theory-guided causal effect network approach

The alternation of active and break phases in Indian summer monsoon (ISM) rainfall at intraseasonal timescales characterizes each ISM season. Both tropical and mid-latitude drivers influence this intraseasonal ISM variability. The circumglobal teleconnection observed in boreal summer drives intraseasonal variability across the mid-latitudes, and a two-way interaction between the ISM and the circumglobal teleconnection pattern has been hypothesized. We use causal discovery algorithms to test the ISM circumglobal teleconnection hypothesis in a causal framework. A robust causal link from the circumglobal teleconnection pattern and the North Atlantic region to ISM rainfall is identified, and we estimate the normalized causal effect (CE) of this link to be about 0.2 (a 1 standard deviation shift in the circumglobal teleconnection causes a 0.2 standard deviation shift in the ISM rainfall 1 week later). The ISM rainfall feeds back on the circumglobal teleconnection pattern, however weakly. Moreover, we identify a negative feedback between strong updraft located over India and the Bay of Bengal and the ISM rainfall acting at a biweekly timescale, with enhanced ISM rainfall following strong updraft by 1 week. This mechanism is possibly related to the boreal summer intraseasonal oscillation. The updraft has the strongest CE of 0.5, while the Madden–Julian oscillation variability has a CE of 0.2–0.3. Our results show that most of the ISM variability on weekly timescales comes from these tropical drivers, though the mid-latitude teleconnection also exerts a substantial influence. Identifying these local and remote drivers paves the way for improved subseasonal forecasts

Automation and data processing with the immucor Galileo (R) system in a university blood bank

Background: The implementation of automated techniques improves the workflow and quality of immuno-hematological results. The workflows of our university blood bank were reviewed during the implementation of an automated immunohematological testing system. Methods: Work impact of blood grouping and subgrouping, cross- matching and antibody search using the Immucor Galileo system was compared to the previous used standard manual and semi- automated methods. Results: The redesign of our workflow did not achieve a significant reduction of the specimen's working process time, the operator's time however was reduced by 23%. Corresponding results were achieved for blood grouping, Rhesus typing, antibody screen and for autocontrol when changing from two semi- automated to the Galileo system. Because of the higher sensitivity of the Immucor antibody detection system, the rate of the initial positive antibody screens rose from 4 to 6% Conclusion: The Immucor Galileo system automates routine blood bank testing with high reliability, specificity and higher sensitivity compared to our previous used standard manual and semi- automated methods

High precision 89^{89}Y(α\alpha,α\alpha)89^{89}Y scattering at low energies

Elastic scattering cross sections of the $^{89}$Y($\alpha$,$\alpha$)$^{89}$Y reaction have been measured at energies E$_{c.m.}$ = 15.51 and 18.63 MeV. The high precision data for the semi-magic $N = 50$ nucleus $^{89}$Y are used to derive a local potential and to evaluate the predictions of global and regional $\alpha$-nucleus potentials. The variation of the elastic alpha scattering cross sections along the $N = 50$ isotonic chain is investigated by a study of the ratios of angular distributions for $^{89}$Y($\alpha$,$\alpha$)$^{89}$Y and $^{92}$Mo($\alpha$,$\alpha$)$^{92}$Mo at E$_{c.m.} \approx$ 15.51 and 18.63 MeV. This ratio is a very sensitive probe at energies close to the Coulomb barrier, where scattering data alone is usually not enough to characterize the different potentials. Furthermore, $\alpha$-cluster states in $^{93}$Nb = $^{89}$Y $\otimes$ $\alpha$ are investigated

Canonical Expansion of PT-Symmetric Operators and Perturbation Theory

Let $H$ be any \PT symmetric Schr\"odinger operator of the type $-\hbar^2\Delta+(x_1^2+...+x_d^2)+igW(x_1,...,x_d)$ on $L^2(\R^d)$, where $W$ is any odd homogeneous polynomial and $g\in\R$. It is proved that $\P H$ is self-adjoint and that its eigenvalues coincide (up to a sign) with the singular values of $H$, i.e. the eigenvalues of $\sqrt{H^\ast H}$. Moreover we explicitly construct the canonical expansion of $H$ and determine the singular values $\mu_j$ of $H$ through the Borel summability of their divergent perturbation theory. The singular values yield estimates of the location of the eigenvalues \l_j of $H$ by Weyl's inequalities.Comment: 20 page

Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action: They sensitize sGC to endogenously produced nitric oxide (NO) and also directly stimulate sGC independently of NO. Little is known about their effects on tissue remodeling and degeneration and survival in experimental malignant hypertension.Mortality, hemodynamics and biomarkers of tissue remodeling and degeneration were assessed in Dahl salt-sensitive rats maintained on a high salt diet and treated with riociguat (3 or 10 mg/kg/d) for 14 weeks. Riociguat markedly attenuated systemic hypertension, improved systolic heart function and increased survival from 33% to 85%. Histological examination of the heart and kidneys revealed that riociguat significantly ameliorated fibrotic tissue remodeling and degeneration. Correspondingly, mRNA expression of the pro-fibrotic biomarkers osteopontin (OPN), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and plasminogen activator inhibitor-1 (PAI-1) in the myocardium and the renal cortex was attenuated by riociguat. In addition, riociguat reduced plasma and urinary levels of OPN, TIMP-1, and PAI-1.Stimulation of sGC by riociguat markedly improves survival and attenuates systemic hypertension and systolic dysfunction, as well as fibrotic tissue remodeling in the myocardium and the renal cortex in a rodent model of pressure and volume overload. These findings suggest a therapeutic potential of sGC stimulators in diseases associated with impaired cardiovascular and renal functions

PTPT symmetric non-selfadjoint operators, diagonalizable and non-diagonalizable, with real discrete spectrum

Consider in $L^2(R^d)$, $d\geq 1$, the operator family $H(g):=H_0+igW$. \ds H_0= a^\ast_1a_1+... +a^\ast_da_d+d/2 is the quantum harmonic oscillator with rational frequencies, $W$ a $P$ symmetric bounded potential, and $g$ a real coupling constant. We show that if $|g|<\rho$, $\rho$ being an explicitly determined constant, the spectrum of $H(g)$ is real and discrete. Moreover we show that the operator \ds H(g)=a^\ast_1 a_1+a^\ast_2a_2+ig a^\ast_2a_1 has real discrete spectrum but is not diagonalizable.Comment: 20 page