Radio Quiet Pulsars with Ultra-Strong Magnetic Fields

The notable absence of radio pulsars having measured magnetic dipole surface field strengths above $B_0\sim 3\times 10^{13}$ Gauss naturally raises the question of whether this forms an upper limit to pulsar magnetization. Recently there has been increasing evidence that neutron stars possessing higher dipole spin-down fields do in fact exist, including a growing list of anomalous X-ray pulsars (AXPs) with long periods and spinning down with high period derivatives, implying surface fields of $10^{14}$--$10^{15}$ Gauss. Furthermore, the recently reported X-ray period and period derivative for the Soft Gamma-ray Repeater (SGR) source SGR1806-20 suggest a surface field around $10^{15}$ Gauss. None of these high-field pulsars have yet been detected as radio pulsars. We propose that high-field pulsars should be radio-quiet because electron-positron pair production in their magnetospheres, thought to be essential for radio emission, is efficiently suppressed in ultra-strong fields ($B_0\gtrsim 4\times 10^{13}$ Gauss) by the action of photon splitting, a quantum electrodynamical process in which a photon splits into two. Our computed radio quiescence boundary in the radio pulsar $P-\dot P$ diagram, where photon splitting overtakes pair creation, is located just above the boundary of the known radio pulsar population, neatly dividing them from the AXPs. We thus identify a physical mechanism that defines a new class of high-field radio-quiet neutron stars that should be detectable by their pulsed emission at X-ray and perhaps $\gamma$-ray energies.Comment: 4 pages, including one figure and one table, in AASTeX emulatapj format, Astrophysical Journal Letters, in pres

A summary of research relating to first grade reading, 1932-1963

Thesis (Ed.M.)--Boston UniversityProblem: An attempt to compare the rate of learning of colorful and abstract words of children in grade one. Materials: 1. Thirty words were selected to be used in three groups of ten words each. Each list consisted of five colorful and five abstract words. Colorful words are those which have much meaning for children and abstract words are those with little meaning. The words were printed on 3 x 11 inch flash cards in lower case letters. 2. Check sheets were made with spaces for checking the retention of words at three different times and pictures were made to enrich the colorful words. 3. Directions were prepared and given to each teacher who participated in the study. 4. Kuhlmann-Anderson Intelligence Test: Battery A. 5. Detroit Word Recognition Test: Form A [TRUNCATED

High Energy Neutrinos and Photons from Curvature Pions in Magnetars

We discuss the relevance of the curvature radiation of pions in strongly magnetized pulsars or magnetars, and their implications for the production of TeV energy neutrinos detectable by cubic kilometer scale detectors, as well as high energy photons.Comment: 19 pages, 4 figures, to appear in JCA

Strategies to improve retention in randomised trials: a Cochrane systematic review and meta-analysis

Objective: To quantify the effect of strategies to improve retention in randomised trials.<p></p> Design: Systematic review and meta-analysis.<p></p> Data sources Sources searched: MEDLINE, EMBASE, PsycINFO, DARE, CENTRAL, CINAHL, C2-SPECTR, ERIC, PreMEDLINE, Cochrane Methodology Register, Current Controlled Trials metaRegister, WHO trials platform, Society for Clinical Trials (SCT) conference proceedings and a survey of all UK clinical trial research units.<p></p> Review: methods Included trials were randomised evaluations of strategies to improve retention embedded within host randomised trials. The primary outcome was retention of trial participants. Data from trials were pooled using the fixed-effect model. Subgroup analyses were used to explore the heterogeneity and to determine whether there were any differences in effect by the type of strategy.<p></p> Results: 38 retention trials were identified. Six broad types of strategies were evaluated. Strategies that increased postal questionnaire responses were: adding, that is, giving a monetary incentive (RR 1.18; 95% CI 1.09 to 1.28) and higher valued incentives (RR 1.12; 95% CI 1.04 to 1.22). Offering a monetary incentive, that is, an incentive given on receipt of a completed questionnaire, also increased electronic questionnaire response (RR 1.25; 95% CI 1.14 to 1.38). The evidence for shorter questionnaires (RR 1.04; 95% CI 1.00 to 1.08) and questionnaires relevant to the disease/condition (RR 1.07; 95% CI 1.01 to 1.14) is less clear. On the basis of the results of single trials, the following strategies appeared effective at increasing questionnaire response: recorded delivery of questionnaires (RR 2.08; 95% CI 1.11 to 3.87); a ‘package’ of postal communication strategies (RR 1.43; 95% CI 1.22 to 1.67) and an open trial design (RR 1.37; 95% CI 1.16 to 1.63). There is no good evidence that the following strategies impact on trial response/retention: adding a non-monetary incentive (RR=1.00; 95% CI 0.98 to 1.02); offering a non-monetary incentive (RR=0.99; 95% CI 0.95 to 1.03); ‘enhanced’ letters (RR=1.01; 95% CI 0.97 to 1.05); monetary incentives compared with offering prize draw entry (RR=1.04; 95% CI 0.91 to 1.19); priority postal delivery (RR=1.02; 95% CI 0.95 to 1.09); behavioural motivational strategies (RR=1.08; 95% CI 0.93 to 1.24); additional reminders to participants (RR=1.03; 95% CI 0.99 to 1.06) and questionnaire question order (RR=1.00, 0.97 to 1.02). Also based on single trials, these strategies do not appear effective: a telephone survey compared with a monetary incentive plus questionnaire (RR=1.08; 95% CI 0.94 to 1.24); offering a charity donation (RR=1.02, 95% CI 0.78 to 1.32); sending sites reminders (RR=0.96; 95% CI 0.83 to 1.11); sending questionnaires early (RR=1.10; 95% CI 0.96 to 1.26); longer and clearer questionnaires (RR=1.01, 0.95 to 1.07) and participant case management by trial assistants (RR=1.00; 95% CI 0.97 to 1.04).<p></p> Conclusions: Most of the trials evaluated questionnaire response rather than ways to improve participants return to site for follow-up. Monetary incentives and offers of monetary incentives increase postal and electronic questionnaire response. Some strategies need further evaluation. Application of these results would depend on trial context and follow-up procedures.<p></p&gt

Spatial memory deficits in mild cognitive impairment: a virtual reality study of hippocampal and entorhinal functioning

This thesis explores the topic of Alzheimer’s disease (AD) and the earlier clinical state of mild cognitive impairment (MCI), with a particular focus on early identification and therapeutic intervention. The first part comprises a systematic review of the literature base examining the efficacy of transcranial direct current stimulation (tDCS; a form of non-invasive brain stimulation) in the treatment of MCI and AD. Specifically, this review focuses on the efficacy of tDCS for improving cognitive outcomes in MCI and AD patient groups. A database search identified fourteen studies that examined the relationship between tDCS and cognitive outcomes in these patient populations. The findings of these studies were summarised separately for MCI and AD patient groups. Results in both patient groups were found to be tentatively positive, however minimal research was carried out with MCI patient groups. Further, the heterogeneity of the identified research designs limited firm conclusions as to the factors associated with efficacy. Results are considered in tandem with an assessment of methodological quality. Consideration is given to the clinical implications of these findings, as well the areas that would benefit from further exploration in future research. In the second part of this thesis, an empirical paper is presented that examines the utility of a novel spatial memory task in the identification of early AD symptomatology. A virtual reality (VR) object-location memory task (OLT) was used to assess aspects of spatial memory that are underpinned by brain regions known to be affected in the earliest stages of AD: the hippocampus and entorhinal cortex (EC). In order to assess the utility of this task in a proof-of-concept study, the OLT was administered to patients diagnosed with amnestic MCI (aMCI), a diagnosis that represents a high-risk for conversion to AD, and healthy control participants. Alongside the OLT, a comparator battery of neuropsychological tests and a flat-screen measure of hippocampal function were administered as an index of the construct validity of the task. Results showed that there were significant group differences in performance on the OLT, and that task performance was able to predict group membership (aMCI or control) with a high degree of accuracy. Further, OLT performance was shown to be correlated with comparator measures of cognitive function. These results were interpreted as evidence for the utility of the OLT as a diagnostic measure. The implications of these findings were discussed in terms of the brain regions that the OLT may recruit, as well as the limitations of this study and how these might be addressed in future research. The third and final part of this thesis is a critical appraisal of the research process. This offers a reflective exploration of the experiential components of the OLT and how these might compare to more traditional measures of neuropsychological assessment. The emotional challenges associated with neuropsychological assessment are discussed, making use of quotes from the author and prominent AD spokesperson, Terry Pratchett. This section also includes reflections from the researcher on the process of carrying out this research, and the learning that took place as a result

Use of strategies to improve retention in primary care randomised trials: a qualitative study with in-depth interviews

Objective To explore the strategies used to improve retention in primary care randomised trials.<p></p> Design Qualitative in-depth interviews and thematic analysis.<p></p> Participants 29 UK primary care chief and principal investigators, trial managers and research nurses.<p></p> Methods In-depth face-to-face interviews.<p></p> Results Primary care researchers use incentive and communication strategies to improve retention in trials, but were unsure of their effect. Small monetary incentives were used to increase response to postal questionnaires. Non-monetary incentives were used although there was scepticism about the impact of these on retention. Nurses routinely used telephone communication to encourage participants to return for trial follow-up. Trial managers used first class post, shorter questionnaires and improved questionnaire designs with the aim of improving questionnaire response. Interviewees thought an open trial design could lead to biased results and were negative about using behavioural strategies to improve retention. There was consensus among the interviewees that effective communication and rapport with participants, participant altruism, respect for participant's time, flexibility of trial personnel and appointment schedules and trial information improve retention. Interviewees noted particular challenges with retention in mental health trials and those involving teenagers.<p></p> Conclusions The findings of this qualitative study have allowed us to reflect on research practice around retention and highlight a gap between such practice and current evidence. Interviewees describe acting from experience without evidence from the literature, which supports the use of small monetary incentives to improve the questionnaire response. No such evidence exists for non-monetary incentives or first class post, use of which may need reconsideration. An exploration of barriers and facilitators to retention in other research contexts may be justified.<p></p&gt