Formation of a disk-structure and jets in the symbiotic prototype Z And during its 2006-2010 active phase

We present an analysis of spectrophotometric observations of the latest cycle of activity of the symbiotic binary Z And from 2006 to 2010. We estimate the temperature of the hot component of Z And to be \approx 150000 - 170000 K at minimum brightness, decreasing to \approx 90000 K at the brightness maximum. Our estimate of the electron density in the gaseous nebula is N_{e}=10^{10}-10^{12} cm^{-3} in the region of formation of lines of neutral helium and 10^6-10^7 cm^{-3} in the region of formation of the [OIII] and [NeIII] nebular lines. A trend for the gas density derived from helium lines to increase and the gas density derived from [OIII] and [NeIII] lines to simultaneously decrease with increasing brightness of the system was observed. Our estimates show that the ratios of the theoretical and observed fluxes in the [OIII] and [NeIII] lines agree best when the O/Ne ratio is similar to its value for planetary nebulae. The model spectral energy distribution showed that, in addition to a cool component and gaseous nebula, a relatively cool pseudophotosphere (5250-11 500 K) is present in the system. The simultaneous presence of a relatively cool pseudophotosphere and high-ionization spectral lines is probably related to a disk-like structure of the pseudophotosphere. The pseudophotosphere formed very rapidly, over several weeks, during a period of increasing brightness of Z And. We infer that in 2009, as in 2006, the activity of the system was accompanied by a collimated bipolar ejection of matter. In contrast to the situation in 2006, the jets were detected even before the system reached its maximum brightness. Moreover, components with velocities close to 1200 km/s disappeared at the maximum, while those with velocities close to 1800 km/s appeared.Comment: 18 pages, 19 figures, Accepted for publication in Astronomy Report

Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice

© 2018 Bannerman, Borchardt, Jensen, Rozov, Haj-Yasein, Burnashev, Zamanillo, Bus, Grube, Adelmann, Rawlins and Sprengel. The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (Gria1R/R), expressing the “trafficking compromised” GluA1(Q600R) point mutation. Our analysis revealed somatic accumulation and reduction of GluA1(Q600R) and GluA2, but only slightly reduced CA1 synaptic localization in hippocampi of adult Gria1R/R mice. These immunohistological changes were accompanied by a strong reduction of somatic AMPAR currents in CA1, and a reduction of plasticity (short-term and long-term potentiation, STP and LTP, respectively) in the CA1 subfield following tetanic and theta-burst stimulation. Nevertheless, spatial reference memory acquisition in the Morris water-maze and on an appetitive Y-maze task was unaffected in Gria1R/R mice. In contrast, spatial working/short-term memory during both spontaneous and rewarded alternation tasks was dramatically impaired. These findings identify the GluA1(Q600R) mutation as a loss of function mutation that provides independent evidence for the selective role of GluA1 in the expression of short-term memory

Physical Orbit for Lambda Virginis and a Test of Stellar Evolution Models

Lambda Virginis (LamVir) is a well-known double-lined spectroscopic Am binary with the interesting property that both stars are very similar in abundance but one is sharp-lined and the other is broad-lined. We present combined interferometric and spectroscopic studies of LamVir. The small scale of the LamVir orbit (~20 mas) is well resolved by the Infrared Optical Telescope Array (IOTA), allowing us to determine its elements as well as the physical properties of the components to high accuracy. The masses of the two stars are determined to be 1.897 Msun and 1.721 Msun, with 0.7% and 1.5% errors respectively, and the two stars are found to have the same temperature of 8280 +/- 200 K. The accurately determined properties of LamVir allow comparisons between observations and current stellar evolution models, and reasonable matches are found. The best-fit stellar model gives LamVir a subsolar metallicity of Z=0.0097, and an age of 935 Myr. The orbital and physical parameters of LamVir also allow us to study its tidal evolution time scales and status. Although currently atomic diffusion is considered to be the most plausible cause of the Am phenomenon, the issue is still being actively debated in the literature. With the present study of the properties and evolutionary status of LamVir, this system is an ideal candidate for further detailed abundance analyses that might shed more light on the source of the chemical anomalies in these A stars.Comment: 43 Pages, 13 figures. Accepted for publication in Ap

Multimode Pulsations of the λ Bootis Star 29 Cygni: The 1995 and 1996 Multisite Campaigns

In this paper we present the results of multisite photometric and spectroscopic campaigns, carried out during the years 1995 and 1996, to study the pulsations of a typical λ Bootis star, 29 Cyg. During the 1995 campaign we found well-defined multiperiodicity in 29 Cyg, which was studied in detail during a multilongitude campaign covering a 65 day time interval in 1996. The frequency analysis of the 1996 campaign's data easily revealed 11 excited low ℓ degree modes with frequencies of oscillation ranging from 20.3 to 37.4 cycles day-1 and mean photometric amplitudes ranging from 10.65 to 0.96 mmag in the V filter. After removing the well-identified frequencies, the discrete Fourier transform of the residuals showed excess power in the 20-40 cycle day-1 domain, which indicates the probable existence of unresolved rich p-mode spectra with photometric V amplitudes below 0.5 mmag. We found a regular spacing of 2.41 cycles day-1 within the modes of 29 Cyg, which was interpreted as the spacing of consecutive even and odd ℓ-values. The asteroseismic luminosity log L/L⊙ = 1.12, calculated from the frequency spacing, is in good agreement with the Hipparcos luminosity log L/L⊙ = 1.16 and with luminosities from photometric and spectroscopic calibrations. Using our multicolor photometry we tentatively identified the dominant f1 = 37.425 cycle day -1 mode as an ℓ= 2, n = 5 mode, and made radial overtone identification for all frequencies. These ranged from n = 2 to 5. Analysis of the photometric data shows the long-term (years) and probable short-term (days) variability of amplitudes for all of these modes in 29 Cyg. Using our multicolor WBVR filter photometry, we found the wavelength dependence of the pulsation amplitudes for the five highest amplitude modes. Based on the Hα line radial velocity observations of 29 Cyg, we detected multiperiodic radial velocity variations with frequencies of 38.36 and 29.99 cycles day-1 and semiamplitudes of 1.0 and 0.8 km s-1, respectively. These frequencies coincide within the errors with the photometric frequencies of the two highest amplitude modes, 37.425 and 29.775 cycles day-1. For the highest amplitude ℓ = 2, n = 5 mode (37.425 cycles day-1), the radial velocity-to-light amplitude ratio and velocity-to-light phase shift are equal to 2K(Hα)/ Δ V = 94 km mag-1 s-1 and Φf1 = φVr - φV = +0.08 ± 0.01, respectively, and are in good agreement with values for δ Scuti stars. The rich multiperiodic spectrum makes 29 Cyg a promising target for future multisite campaigns. © 2007. The American Astronomical Society. All rights reserved.M. D. E. and K. Y. W. acknowledge their work as part of the research activity of the Astrophysical Research Center for the Structure and Evolution of the Cosmos, which is supported by the Korean Science and Engineering Foundation. The participation of G. H., E. P., and W. W. was supported by the Austrian Fonds zur Förderung der wissenschaftlichen Forschung under grant S-7303. The spectroscopic observations described in this publication were made possible in part by grants R2Q000 and U1C000 from the International Science Foundation and by grant A-05-067 from the ESO C&EE programme. This work was supported in part by US Civilian and Research Development Foundation grant UP2-317.Peer reviewe

Lobe Specific Ca2+-Calmodulin Nano-Domain in Neuronal Spines: A Single Molecule Level Analysis

Calmodulin (CaM) is a ubiquitous Ca2+ buffer and second messenger that affects cellular function as diverse as cardiac excitability, synaptic plasticity, and gene transcription. In CA1 pyramidal neurons, CaM regulates two opposing Ca2+-dependent processes that underlie memory formation: long-term potentiation (LTP) and long-term depression (LTD). Induction of LTP and LTD require activation of Ca2+-CaM-dependent enzymes: Ca2+/CaM-dependent kinase II (CaMKII) and calcineurin, respectively. Yet, it remains unclear as to how Ca2+ and CaM produce these two opposing effects, LTP and LTD. CaM binds 4 Ca2+ ions: two in its N-terminal lobe and two in its C-terminal lobe. Experimental studies have shown that the N- and C-terminal lobes of CaM have different binding kinetics toward Ca2+ and its downstream targets. This may suggest that each lobe of CaM differentially responds to Ca2+ signal patterns. Here, we use a novel event-driven particle-based Monte Carlo simulation and statistical point pattern analysis to explore the spatial and temporal dynamics of lobe-specific Ca2+-CaM interaction at the single molecule level. We show that the N-lobe of CaM, but not the C-lobe, exhibits a nano-scale domain of activation that is highly sensitive to the location of Ca2+ channels, and to the microscopic injection rate of Ca2+ ions. We also demonstrate that Ca2+ saturation takes place via two different pathways depending on the Ca2+ injection rate, one dominated by the N-terminal lobe, and the other one by the C-terminal lobe. Taken together, these results suggest that the two lobes of CaM function as distinct Ca2+ sensors that can differentially transduce Ca2+ influx to downstream targets. We discuss a possible role of the N-terminal lobe-specific Ca2+-CaM nano-domain in CaMKII activation required for the induction of synaptic plasticity

Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.

Genetic and bioinformatic analyses have identified missense mutations in GRIN2B encoding the NMDA receptor GluN2B subunit in autism, intellectual disability, Lennox Gastaut and West Syndromes. Here, we investigated several such mutations using a near-complete, hybrid 3D model of the human NMDAR and studied their consequences with kinetic modelling and electrophysiology. The mutants revealed reductions in glutamate potency; increased receptor desensitisation; and ablation of voltage-dependent Mg block. In addition, we provide new views on Mg and NMDA channel blocker binding sites. We demonstrate that these mutants have significant impact on excitatory transmission in developing neurons, revealing profound changes that could underlie their associated neurological disorders. Of note, the NMDAR channel mutant GluN2B unusually allowed Mg permeation, whereas nearby N615I reduced Ca permeability. By identifying the binding site for an NMDAR antagonist that is used in the clinic to rescue gain-of-function phenotypes, we show that drug binding may be modified by some GluN2B disease-causing mutations