Violation of the Hormonal Spectrum in Polycystic Ovaries in Combination with Insulin Resistance. What is the Trigger: Insulin Resistance or Polycystic Ovary Disease?

متلازمة المبيض متعدد التكيسات هي السبب الرئيس للعقم لدى النساء. حيث يناقش البحث دور مقاومة الأنسولين في تطور تكيس المبايض. تم تحليل الطيف الهرموني للمرضى الذين يعانون من متلازمة تكيس المبايض و / أو مقاومة الأنسولين. اشتملت الدراسة على مرضى يعانون من متلازمة تكيس المبايض دون مقاومة الأنسولين (عددهم = 48) ومقاومة الأنسولين (عددهم = 39). كانت مجموعات المقارنة من المرضى الذين ليس لديهم تاريخ من متلازمة تكيس المبايض: مجموعة تحكم بدون مقاومة الأنسولين (عددهم = 46) ومجموعة من المرضى الذين يعانون من مقاومة الأنسولين (عددهم = 45). تم تحديد المعلمات التالية في المرضى: FSH ، LH ، TSH ، T3f ، T4f، PRL ، E2 ، 17-OHd ، Pr ، AMH ، مجموع الاختبار ، Testf ، DHEAS ، DHEAS ، SHBG ، ACTH ، الكورتيزول ، IRI ، IGF-1 ، C- الببتيد ، ومستوى الجلوكوز. تم حساب مؤشر HOMA-IR ونسبة LH / FSH واختبار إجمالي / SHBG. تم إجراء تحليل الارتباط أيضًا بين HOMA IR ومؤشرات المظهر الهرموني و IGF-1 و C-peptide. تم العثور على تغيرات أحادية الاتجاه في مستويات الهرمونات التالية في مقاومة الأنسولين و / أو متلازمة تكيس المبايض و / أو مقاومة الأنسولين بالنسبة لقيم التحكم: استراديول ، هرمون التستوستيرون الكلي ، الكورتيزول ، البرولاكتين ، AMG ، و SHBG. نتيجة لتحليل الارتباط ، تم إنشاء علاقات سلبية بين مؤشر HOMA .IR ومستويات E2 والكورتيزول و AMH في المرضى (باستثناء المجموعة الضابطة) تفترض الدراسة أن تكوين النمط الظاهري للمبيض المتعدد الكيسات مع مزيج من مقاومة الأنسولين يمكن أن يتشكل في المرضى الذين يعانون من مقاومة الأنسولين نتيجة لانخفاض مستوى الاستراديول ، SHBG وزيادة محتوى التستوستيرون الكلي و AMH.Polycystic ovary syndrome (PCOS) is the main cause of female infertility. The role of insulin resistance in the development of polycystic ovary is actively discussed here. The study included patients with PCOS without insulin resistance (n = 48) and with insulin resistance (n = 39). The comparison groups were patients with no history of PCOS: a control group without insulin resistance (n = 46) and a group of patients with insulin resistance (n = 45). The following parameters were determined in patients: FSH, LH, TSH, T3f, T4f, PRL, E2, 17-OHd, Pr, AMH, Test total, Testf, DHEAS, DHEASs, SHBG, ACTH, cortisol, IRI, IGF-1, C-peptide, and glucose level. The HOMA-IR index and the LH / FSH ratio and the total / SHBG test were calculated. Correlation analysis was also performed between HOMA IR and indicators of the hormonal profile, IGF-1, and C-peptide.Unidirectional changes in the levels of the following hormones were found in insulin resistance, PCOS and / or insulin resistance relative to control values: estradiol, total testosterone, cortisol, prolactin, AMG, and SHBG. As a result of the correlation analysis, negative relationships were established between the HOMA IR Index and the levels of E2, cortisol and AMH in patients (except for the control group).We assume that the formation of the phenotype of polycystic ovary with a combination of insulin resistance can be formed in patients with insulin resistance as a result of a decrease in the level of estradiol, SHBG and an increase in the content of total testosterone and AMH

Conceptual Design of Experimental Facility for Large-Diameter NTD-Si at the IRT-T Reactor

The IRT-T reactor has been conducting research in the field of irradiation of ingots of single-crystal semiconductor materials since 1987. The article describes the existing silicon doping facility. The results of studies on the possibility of creating an additional irradiation channel for neutron-transmutation doping of silicon are presented. It is shown that the use of a graphite reflector and a thermal neutron filter based on boron makes it possible to achieve non-uniformity of irradiation up to 5 %. The principal possibility of irradiating single-crystal silicon ingots with a diameter of up to 203 mm and a length of up to 500 mm is shown. The questions of optimizing the configuration of the core and the regime of reactors operation for increasing the neutron flux in the irradiation channels are discussed. In addition, applying the facility to produce base materials for neutron dosimeter in neutron capture therapy studies is proposed

The basic principles of pedagogical diagnostics in an assessment of the educational achievements of learners

The problem of pedagogical diagnostics which remains actual in modern pedagogical science and practice is considered in the article. Considering a state, properties and characteristics of learners, conditions in which the process of education and training is carried out, and also features of activity and professional and personal qualities of the teacher, the basic principles of pedagogical control at an assessment of educational achievements of students are defined in this scientific research. Module-rating assessment of educational achievements of students contributes to the quality of education in the University, because the educational process is carried out timely diagnosis, timely and objective, facilitating the timely introduction of changes in the educational process, the correct statement of teaching goals and the correct selection of pedagogical tools.Рассматривается проблема педагогической диагностики, которая остается актуальной и в современной педагогической науке и практике. Показано, что модульно-рейтинговая технология оценки учебных достижений студентов способствует повышению качества образования в вузе, так как в образовательном процессе осуществляется своевременная диагностика, оперативная и объективная, способствующая своевременному внесению изменений в учебный процесс, правильной постановке педагогических целей и корректному отбору педагогических средств

Reproductive effects of the tumor necrosis factor (TNF) deficiency in mice

TNF is a multifunctional cytokine that, at physiological concentrations, maintains the balance between apoptosis and survival of male germ cells and, at higher concentrations, has adverse effects on various stages of the reproductive process. Although ant-cytokine therapies have been used in millions of patients, the consequences of cytokine deficiency for reproductive functions are poorly understood and need attention. In this work, we have studied behavioral interactions between males and females, spermatogenesis, male fertility, and embryonic developmental characteristics of the progeny in TNFα knockout mice (TNF-/-). We have demonstrated that TNF is involved in the regulation of sexual behavior, spermatogenesis, pre- and postimplantation development. Complete TNF deficiency led to decreased reproductive efficiency: a lower number of viable embryos were observed in TNF-/- mice than in wild-type mice. The decrease in fertility was caused by preimplantation embryo loss in TNF-/- mice. Preimplantation loss in females might be caused by asospermia in TNF-/- males. Additionally, the sensitivity of reproductive functions to female stimuli was different between TNF-/- mice and wild-type mice, while interactions with females increased the concentrations of sper­matozoids in both TNF-/- and wild-type mice. Still higher levels were observed in knockout animals, which led to increase in the number of immature spermatozoids in epididymides

Influence of silicone mammoplasty on the immunoendocrine status of female recipients

The article concerns a study of early influence of silicone breast implants on the development of autoimmune reactions and dynamics of prolactin and thyroid hormone levels in women after mammoplasty. At the present time, this issue remains relevant for several reasons: more than 20 million pairs of implants have been installed in the world and the number of their implantations is constantly growing. Despite relative safety of the silicone implants, some of them are periodically banned by regulatory bodies in various countries. At the same time, there is a growing number of controversial publications in the scientific literature, about potential adverse consequences of their use. Some authors suggest an association between the silicone implants and risk of developing autoimmune conditions, connective tissue disorders, and occasional malignancies. On the other hand, the journals are full of publications about the overall safe tolerance of such medical devices by the patients. These considerations served as a pre-requisite to our research. As part of this project, we have assayed serum levels of autoantibodies to ten antigens, as well as contents of prolactin and thyroid hormones by means of ELISA technique in 27 patients before, 3 and 6 months after aesthetic and reconstructive mammoplastics performed within a period of September 2018 to November 2019. As a result, it was found that 5 out of 27 patients exhibited changes in the autoimmunity spectrum and intensity after mammoplasty. In particular, the concentrations of autoantibodies to modified citrullinated vimentin and IgM autoantibodies to cardiolipin exceeded the normal level at 3 and 6 months. In addition, the initially high prolactin concentration in mammoplasty recipients dropped to normal ranges by 3 months after breast surgery, even after several-fold increased initial levels. As for thyroid hormones, there were no statistically significant changes in their dynamics. The increase of autoantibodies to various target antigens after mammoplasty was statistically significant and positively correlated with each other. This can be explained, for example, by dependence on the adjuvant effect of silicone, which is not associated with antigen specificity. However, it may generally stimulate the immune responses

Increase of efficiency of radical treatment of chasse of urinary bladder

The article analytes the early results of the surgical treatment of patients with bladder cancer who underwent ileocystoplastyc by the original method, compared the functional characteristics of urinary reservoirs in the groups studied patien.В статье проанализированы результаты хирургического лечения больных раком мочевого пузыря, которым была выполнена илеоцистопластика по оригинальной методике, сравнены функциональные характеристики мочевых резервуаров в исследуемых группах больных. Проанализированы отдаленные результаты в группах больных с различными видами илеоцистопластики

Influenza (H5N1) Viruses in Poultry, Russian Federation, 2005–2006

Migrating waterfowl may be the primary source of influenza (H5N1) in western Siberia and the European part of the Russian Federation

a direct encoding for nnc polyhedra

We present an alternative Double Description representation for the domain of NNC (not necessarily closed) polyhedra, together with the corresponding Chernikova-like conversion procedure. The representation uses no slack variable at all and provides a solution to a few technical issues caused by the encoding of an NNC polyhedron as a closed polyhedron in a higher dimension space. A preliminary experimental evaluation shows that the new conversion algorithm is able to achieve significant efficiency improvements

Antinomic nature of the concept «life»

The article deals with the structure of axiological component of the concept «Life» structured in accordance with the concept`s antinomic nature. The antinomy of the concept «Life» causes its wide axiological variation of the concept and becomes ethnical specific characteristic, which is related in numerous antonymic oppositions in the Russian Language