444 research outputs found
Dynamic Investment Behavior Taking into Account Ageing of the Capital Good
In standard capital accumulation models all capital goods are equally productive and produce goods of the same quality.However, due to ageing, in reality it holds most of the time that newer capital goods are more productive. Implications of this feature for the firm's investment policies are investigated in an optimal control problem with distributed parameters.It turns out that investing in capital goods of di¤erent age is done such that the net present value of marginal investment equals zero.Comparing the returns of investment in capital goods of different age, the higher productivity of younger capital goods has to be weighed against the lower costs of depreciation, discounting and acquisition of older capital goods.In the steady state it holds that, in the most reasonable scenario, the firm should invest at the highest rate in new capital goods, and dis-investment can only be optimal when costs of acquisition are large and machines are old.investment;capital goods;ageing
Environmental Policy, the Porter Hypothesis and the Composition of Capital: Effects of Learning and Technological Progress
In this paper the e.ect of environmental policy on the composition of capital is investigated.By allowing for non-linearities it generalizes Xepapadeas and De Zeeuw (Journal of Environmental Economics and Management, 1999) and determines scenarios in which their results do not carry over.In particular, we show that the way acquisition cost of investment decreases with the age of the capital stock is of crucial importance.Also it is obtained that environmental policy has opposite e.ects on the average age of the capital stock in the case of either deterioration or depreciation.We also focus more explicitly on learning and technological progress.Among others we obtain that in the presence of learning, implementing a stricter environmental policy with the aim to reach a certain target of emissions reduction has a stronger negative e.ect on industry pro.ts, which implies quite the opposite as to what is described by the Porter hypothesis.environmental policy;capital;learning;technological change
Dynamic Investment Behavior Taking into Account Ageing of the Capital Good
In standard capital accumulation models all capital goods are equally productive and produce goods of the same quality.However, due to ageing, in reality it holds most of the time that newer capital goods are more productive. Implications of this feature for the firm's investment policies are investigated in an optimal control problem with distributed parameters.It turns out that investing in capital goods of di¤erent age is done such that the net present value of marginal investment equals zero.Comparing the returns of investment in capital goods of different age, the higher productivity of younger capital goods has to be weighed against the lower costs of depreciation, discounting and acquisition of older capital goods.In the steady state it holds that, in the most reasonable scenario, the firm should invest at the highest rate in new capital goods, and dis-investment can only be optimal when costs of acquisition are large and machines are old.
Environmental Policy, the Porter Hypothesis and the Composition of Capital:Effects of Learning and Technological Progress
In this paper the e.ect of environmental policy on the composition of capital is investigated.By allowing for non-linearities it generalizes Xepapadeas and De Zeeuw (Journal of Environmental Economics and Management, 1999) and determines scenarios in which their results do not carry over.In particular, we show that the way acquisition cost of investment decreases with the age of the capital stock is of crucial importance.Also it is obtained that environmental policy has opposite e.ects on the average age of the capital stock in the case of either deterioration or depreciation.We also focus more explicitly on learning and technological progress.Among others we obtain that in the presence of learning, implementing a stricter environmental policy with the aim to reach a certain target of emissions reduction has a stronger negative e.ect on industry pro.ts, which implies quite the opposite as to what is described by the Porter hypothesis.
Image method in the calculation of the van der Waals force between an atom and a conducting surface
Initially, we make a detailed historical survey of van der Waals forces,
collecting the main references on the subject. Then, we review a method
recently proposed by Eberlein and Zietal to compute the dispersion van der
Waals interaction between a neutral but polarizable atom and a perfectly
conducting surface of arbitrary shape. This method has the advantage of
relating the quantum problem to a corresponding classical one in electrostatics
so that all one needs is to compute an appropriate Green function. We show how
the image method of electrostatics can be conveniently used together with the
Eberlein and Zietal mehtod (when the problem admits an image solution). We then
illustrate this method in a couple of simple but important cases, including the
atom-sphere system. Particularly, in our last example, we present an original
result, namely, the van der Waals force between an atom and a boss hat made of
a grounded conducting material.Comment: This is a pedagogical and introductory paper on van der Waals forces
between an atom and a conducting surfac
Chemotactic response and adaptation dynamics in Escherichia coli
Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia
coli is integral for detecting chemicals over a wide range of background
concentrations, ultimately allowing cells to swim towards sources of attractant
and away from repellents. Its biochemical mechanism based on methylation and
demethylation of chemoreceptors has long been known. Despite the importance of
adaptation for cell memory and behavior, the dynamics of adaptation are
difficult to reconcile with current models of precise adaptation. Here, we
follow time courses of signaling in response to concentration step changes of
attractant using in vivo fluorescence resonance energy transfer measurements.
Specifically, we use a condensed representation of adaptation time courses for
efficient evaluation of different adaptation models. To quantitatively explain
the data, we finally develop a dynamic model for signaling and adaptation based
on the attractant flow in the experiment, signaling by cooperative receptor
complexes, and multiple layers of feedback regulation for adaptation. We
experimentally confirm the predicted effects of changing the enzyme-expression
level and bypassing the negative feedback for demethylation. Our data analysis
suggests significant imprecision in adaptation for large additions.
Furthermore, our model predicts highly regulated, ultrafast adaptation in
response to removal of attractant, which may be useful for fast reorientation
of the cell and noise reduction in adaptation.Comment: accepted for publication in PLoS Computational Biology; manuscript
(19 pages, 5 figures) and supplementary information; added additional
clarification on alternative adaptation models in supplementary informatio
Fano resonances in plasmonic core-shell particles and the Purcell effect
Despite a long history, light scattering by particles with size comparable
with the light wavelength still unveils surprising optical phenomena, and many
of them are related to the Fano effect. Originally described in the context of
atomic physics, the Fano resonance in light scattering arises from the
interference between a narrow subradiant mode and a spectrally broad radiation
line. Here, we present an overview of Fano resonances in coated spherical
scatterers within the framework of the Lorenz-Mie theory. We briefly introduce
the concept of conventional and unconventional Fano resonances in light
scattering. These resonances are associated with the interference between
electromagnetic modes excited in the particle with different or the same
multipole moment, respectively. In addition, we investigate the modification of
the spontaneous-emission rate of an optical emitter at the presence of a
plasmonic nanoshell. This modification of decay rate due to electromagnetic
environment is referred to as the Purcell effect. We analytically show that the
Purcell factor related to a dipole emitter oriented orthogonal or tangential to
the spherical surface can exhibit Fano or Lorentzian line shapes in the near
field, respectively.Comment: 28 pages, 10 figures; invited book chapter to appear in "Fano
Resonances in Optics and Microwaves: Physics and Application", Springer
Series in Optical Sciences (2018), edited by E. O. Kamenetskii, A. Sadreev,
and A. Miroshnichenk
Molecular Assessment of Bacterial Vaginosis by Lactobacillus Abundance and Species Diversity
Background
To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods.
Methods
Evaluation of indicators for BV was carried out by 16S rRNA amplicon sequencing of the V5-V7 region, a tailor-made 16S rRNA oligonucleotide-based microarray, and a PCR-based profiling technique termed IS-profiling, which is based on fragment variability of the 16S-23S rRNA intergenic spacer region. An inventory of vaginal bacterial species was obtained from 40 females attending a Dutch sexually transmitted infection outpatient clinic, of which 20 diagnosed with BV (Nugent score 7â10), and 20 BV negative (Nugent score 0â3).
Results
Analysis of the bacterial communities by 16S rRNA amplicon sequencing revealed two clusters in the BV negative women, dominated by either Lactobacillus iners or Lactobacillus crispatus and three distinct clusters in the BV positive women. In the former, there was a virtually complete, negative correlation between L. crispatus and L. iners. BV positive subjects showed cluster profiles that were relatively high in bacterial species diversity and dominated by anaerobic species, including Gardnerella vaginalis, and those belonging to the Families of Lachnospiraceae and Leptotrichiaceae. Accordingly, the Gini-Simpson index of species diversity, and the relative abundance Lactobacillus species appeared consistent indicators for BV. Under the conditions used, only the 16S rRNA amplicon sequencing method was suitable to assess species diversity, while all three molecular composition profiling methods were able to indicate Lactobacillus abundance in the vaginal microbiota.
Conclusion
An affordable and simple molecular test showing a depletion of the genus Lactobacillus in combination with an increased species diversity of vaginal microbiota could serve as an alternative and practical diagnostic method for the assessment of BV
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