698pphase ii efficacy and safety data for the met inhibitor tepotinib in patients pts with sorafenib treated advanced hepatocellular carcinoma hcc

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phase i ii study of spartalizumab pdr001 an anti pd1 mab in patients with advanced melanoma or non small cell lung cancer

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Desenvolvimento inicial de três procedências de erva-mate em dois tipos de solos na região de Ponta Grossa, PR.

bitstream/CNPF-2009-09/15747/1/com_tec42.pd

Propostas de revisão e atualização do Sistema Brasileiro de Classificação de Solos.

Processo de revisão e atualização do Sistema Brasileiro de Classificação de Solos (SiBCS). Divulgação das propostas de alteração sobre critérios diagnósticos, conceitos e definições de atributos, bem como aquelas concernentes à reestruturação de classes de solos.bitstream/CNPS/11574/1/doc53_2003_revisao_sbcs.pd

Modifiable and non-modifiable factors related to HPV infection and cervical abnormalities in women at high risk: a cross-sectional analysis from the Valhidate Study

Abstract: Migrant women, and women infected with HIV, are at enhanced risk of cervical HPV infection and HPV-related cancers. We investigated factors that can reduce these risks through public health preventive and screening interventions. We compared prevalence and risk factors for cervical HPV infection/lesions in women with HIV-infection (HIW) and migrant women (RMW) with a control group of resident women (SPW) who were enrolled in the study for the eVALuation and monitoring of HPV Infections and relATEd cervical diseases in high-risk women (VALHIDATE). Among 3093 evaluable women, age-standardized HPV prevalence was 36.3% (95%CI: 28.1\u201344.4) in HIW, 21.6% (95%CI: 15.7\u201327.5) in RMW, and 14.3% (95%CI: 12.5\u201316.1) in SPW. Adjusted prevalence of HPV infection was 2.07 times higher among HIW (95%CI: 1.75\u20132.45), and 1.45 times higher among RMW (95%CI: 1.17\u20131.80) than in SPW. Prevalence-ratios of SIL and HG-SIL were 2.67 (95%CI: 2.06\u20133.45) and 2.82 (95%CI: 1.28\u20136.20), respectively, in HIW compared to controls. A multivariate log-binomial regression model showed modifiable risk factors associated with HPV infection/lesion to have different patterns among groups. Specific public-health intervention, including health and sexual-health education, safe-sex procedures, and improvements to screening programmes, could favorably affect these highly vulnerable women

Oval Domes: History, Geometry and Mechanics

An oval dome may be defined as a dome whose plan or profile (or both) has an oval form. The word Aoval@ comes from the latin Aovum@, egg. Then, an oval dome has an egg-shaped geometry. The first buildings with oval plans were built without a predetermined form, just trying to close an space in the most economical form. Eventually, the geometry was defined by using arcs of circle with common tangents in the points of change of curvature. Later the oval acquired a more regular form with two axis of symmetry. Therefore, an “oval” may be defined as an egg-shaped form, doubly symmetric, constructed with arcs of circle; an oval needs a minimum of four centres, but it is possible also to build polycentric ovals. The above definition corresponds with the origin and the use of oval forms in building and may be applied without problem until, say, the XVIIIth century. Since then, the teaching of conics in the elementary courses of geometry made the cultivated people to define the oval as an approximation to the ellipse, an “imperfect ellipse”: an oval was, then, a curve formed with arcs of circles which tries to approximate to the ellipse of the same axes. As we shall see, the ellipse has very rarely been used in building. Finally, in modern geometrical textbooks an oval is defined as a smooth closed convex curve, a more general definition which embraces the two previous, but which is of no particular use in the study of the employment of oval forms in building. The present paper contains the following parts: 1) an outline the origin and application of the oval in historical architecture; 2) a discussion of the spatial geometry of oval domes, i. e., the different methods employed to trace them; 3) a brief exposition of the mechanics of oval arches and domes; and 4) a final discussion of the role of Geometry in oval arch and dome design

Mapa de solos do estado do Paraná.

O Mapa de Solos do Estado do Paraná constitui vasta fonte de informação básica útil para a compreensão e a solução de problemas de solos que afetam o meio ambiente. Este estudo compreende a compilação, atualização e sistematização das informações de solos do Paraná conforme o Sistema Brasileiro de Classificação de Solos em sua 1° edição. A consolidação das informações sobre clima, cobertura vegetal, relevo e outras características que definem as unidades de mapeamento de solos são elementos auxiliares de grande valia no conhecimento das condições do regime hídrico dos solos e das suas possibilidades de uso sob diferentes níveis tecnológicos. Esse se constitui numa vasta fonte de informação para a compreensão e a solução de problemas de solos que afetam o meio ambiente. O uso da classificação dos solos dentro de um sistema taxonômico uniforme, associado ao conhecimento da distribuição espacial dos solos, faculta a confecção de mapas pedológicos, os quais permitem a extrapolação dos resultados da pesquisa para outras áreas de condições ambientais similares.bitstream/item/79053/1/doc96-2007-parana-final.pdf; bitstream/item/79285/1/MI-484.pdf; bitstream/item/79286/1/MI-485.pdf; bitstream/item/79287/1/MI-486.pdf; bitstream/item/79288/1/MI-494.pdf; bitstream/item/79289/1/MI-495.pdf; bitstream/item/79290/1/MI-496.pdf; bitstream/item/79291/1/MI-497.pdf; bitstream/item/79292/1/MI-503.pdf; bitstream/item/79293/1/MI-504.pdf; bitstream/item/79294/1/MI-505.pdf; bitstream/item/79295/1/MI-506.pdf; bitstream/item/79296/1/MI-507.pdf; bitstream/item/79297/1/MI-510.pdf; bitstream/item/79298/1/MI-511.pdf; bitstream/item/79299/1/MI-512.pdf; bitstream/item/79300/1/MI-513.pdf; bitstream/item/79301/1/MI-514.pdf; bitstream/item/79302/1/MI-516.pdf; bitstream/item/79303/1/MI-517.pdf; bitstream/item/79304/1/MI-518.pdf; bitstream/item/79305/1/MI-519.pdf; bitstream/item/79306/1/PR-600.pdfAcompanha 1 mapa, color. Escala 1:600.000 e 21 mapas, color. Escala 1:250.000

Levantamento de reconhecimento dos solos do Noroeste do Estado do Paraná: (informe preliminar).

A execucao do levantamento dos solos vem sendo realizada de maneira a atender as necessidades do estado e ao plano basico da EPFS, que visa ao inventario dos recursos potenciais dos solos do territorio nacional, consistindo na identificacao, classificacao, distribuicao e determinacao da area das diversas unidades de solos, de modo a proporcionar elementos basicos essenciais para planejamentos, principalmente os referntes a futuros trabalhos de levantamentos detalhados e ao estabelecimento racional de projetos de experimentacao e pesquisa, com possibilidades de aplicacao dos resultados em areas representativas de cada unidade que apresente expressao geografica importante, permitindo a extrapolacao dos resultados para solos semelhantes. O objetivo e o estudo dosdiferentes solos do Parana, atraves do reconhecimento da sua distribuicao geografica, delimitacao das areas por eles ocupadas e investigacao das suas caracteristicas morfologicas, fisicas e quimicas. O carater generalizado do mapeamento limita a precisao de detalhes cartograficos e nao pode ter por finalidade responder questoes de utilizacao de terras, problemas de fertilidade e produtividade em areas especificas. Procurou-se, tanto quanto possivel, elaborar a presente publicacao em forma simples, evitando ao maximo o excessivo emprego de termos tecnicos, a fim de poder atingir um maior numero de pessoas que dela possam fazer uso. Far-se-a, em seguida, a publicacao do levantamento do Noroeste e, finalmente, de todo o estado, abrangendo as suas varias regioes.bitstream/item/212067/1/EPFS-BT-14-1970.pdf; bitstream/item/125769/1/Levantamento-de-Reconhecimento-dos-Solos-do-Noroeste-do-Estado-do-Parana.pdfAcompanha 1 mapa, color. Escala 1:300.000