Mechanisms underlying the prereversal enhancement of the vertical plasma drift in the low-latitude ionosphere

The evening prereversal enhancement (PRE) of the vertical plasma drift has important consequences for the Appleton density anomaly and the stability of the nighttime ionosphere. Simplified simulations were used to review the three competing theories of the PRE origin, to explore their relative importance, and to indentify their interdependence. The mechanisms involved in the generation and climatology of the PRE are, first, a curl-free electric field response to rapid changes in the vertical electric field associated with the nighttime F region dynamo; second, a divergence of Hall currents in the E region away from the magnetic equator; and, third, the moderating effect of the large Cowling conductivities in the equatorial E region. The simulations indicate that the equatorial Cowling conductivity creates an important current path that limits the other two mechanisms prior to equatorial sunset and releases them after equatorial sunset. The curl-free mechanism is the dominant mechanism when the terminator and magnetic meridian are aligned in part due to the accelerating F region zonal wind. When the solar terminator is not aligned with the magnetic meridian, there is an interaction involving all three mechanisms contributing to the magnitude and timing of the PRE. Finally, the altitude profile of the PRE decays more quickly with altitude when the curl-free mechanism dominates as compared to when the Hall current mechanism dominates. ©2015. American Geophysical Union. All Rights Reserved

Space Weather Effects on Mid-Latitude HF Propagation Paths: Observations and a Data-Driven D-Region Model

A two-pronged study is under way to improve understanding of the D region response to space weather and its effects on HF propagation. One part, the HF Investigation of D region Ionospheric Variation Experiment (HIDIVE), is designed to obtain simultaneous, quantitative propagation and absorption data from an HF signal monitoring network along with solar X-ray flux from the NOAA GOES satellites. Observations have been made continuously since late December 2002 and include the severe disturbances of October–November 2003. GOES satellite X-ray observations and geophysical indices are assimilated into the Data-Driven D Region (DDDR) electron density model developed as the second part of this project. ACE satellite proton observations, the HIDIVE HF observations, and possibly other real-time space weather data will be assimilated into DDDR in the future. Together with the Ionospheric Forecast Model developed by the Space Environment Corporation, DDDR will provide improved specification of HF propagation and absorption characteristics when supplemented by near-real-time propagation observations from HIDIVE

Change in First Graders’ Science-Related Competence Beliefs During Digitally Intensive Science Workshops

The aim of this research was to examine if a set of three science and technology workshops would promote first-grade pupils’ science-related competence beliefs. The first workshop dealt with electric circuits and related handicraft tasks. The second workshop involved programming with Lego Mindstorms robots. The third workshop was related to computer-based data logging. Fifty-nine Finnish first graders (age 7–8 years) participated in the digitally intensive science workshops, and 38 pupils served as a control group. The data were analysed using a paired samples t-test. The analysis results reveal that the set of three workshops increased the pupils’ science and technology-related competence beliefs.Peer reviewe

Cognitive deficits and changes in gene expression of NMDA receptors after prenatal methylmercury exposure.

Previous studies showed learning and memory deficit in adult rats that were prenatally exposed to methylmercury chloride (MMC) in an advanced stage of pregnancy (15 days). Under these conditions, the cognitive deficits found at 60 days of age paralleled particularly changes in the N-methyl-D-aspartate (NMDA) receptor characteristics. In the present study, we report the behavioral effects of a single oral dose of MMC (8 mg/kg) administered earlier at gestational day 8. The use of different learning and memory tests (passive avoidance, object recognition, water maze) showed a general cognitive impairment in the in utero-exposed rats tested at 60 days of age compared with matched controls. Considering the importance of the glutamatergic receptor system and its endogenous ligands in learning and memory process regulation, we surmised that MMC could affect the gene expression of NMDA receptor subtypes. The use of a sensitive RNase protection assay allowed the evaluation of gene expression of two families of NMDA receptors (NR-1 and NR-2 subtypes). The result obtained in 60-day-old rats prenatally exposed to MMC, showed increased mRNA levels of the NR-2B subunit in the hippocampus but not in the frontal cortex. The data suggest that the behavioral abnormalities of MMC-exposed rats might be ascribed to a neurotoxic effect of the metal that alters the gene expression of a specific NMDA receptor subunit in the hippocampus

Understanding Mid-Latitude Space Weather: Storm Impacts Observed at BLO on 31 March 2001

On 30 March 2001 in the late evening an auroral display was observed over the United States of America. The Bear Lake Observatory (BLO) magnetometer in Utah measured changes of 550 nT in less than 30 min. During the same period, BLO ionosonde measurements showed deep high-frequency radio wave absorption up to 7 MHz. BLO\u27s GPS single-frequency receiver experienced geolocation errors of 20 m for over 3 hours. These storm signatures were also accompanied by L-band scintillation effects which approached an S4 value of 0.2, which is large for midlatitudes. Although such measurements have been have been made at midlatitude locations for many decades, our knowledge of the processes and couplings involved in such events remains incomplete and, at best, qualitative. The interpretation of key ionospheric parameters\u27 storm response is discussed in the context of present-day auroral and geospace electrodynamics understanding. We find that at BLO (L = 2.38) the available data raise more questions and can provide almost no answers without observational inputs from other locations. One solution to this impasse is to field a ground-based sensor network to resolve the spatial scales of the geospace electrodynamics. On the basis of the instrument complement at BLO, we argue for a contiguous U.S. deployment of modest magnetic/optical/RF observatories to observe the next solar maximum period\u27s geomagnetic storms and to use these data to explore the physical processes and couplings on space weather effective scales in assimilative models in conjunction with space-based observations

Stability of Nonlinear Control Systems by the Second Method of Liapunov

This report investigates the stability of autonomous closed-loop control systems containing nonlinear elements. An n-th order nonlinear autonomous system is described by a set of n first order differential equations of the type dxi/dt=xi(x1, x2, …xn) i=1,2,…n. Liapunov\u27s second (direct) method is used in the stability analysis of such systems. This method enables one to prove that a system is stable (or unstable) if a function V=V (x1, x2, … xn) can be found which, together with its time derivative, satisfies the requirements of Liapunov\u27s stability (or instability) theorems. At the present time, there are no generally applicable straight forward procedures available for constructing these Liapunov\u27s functions. Several Liapunov\u27s functions, applicable to systems described in the canonic form of differential equations, have been reported in the literature. In this report, it is shown that any autonomous closed-loop system containing a single nonlinear element can be described by canonic differential equations. The stability criteria derived from the Liapunov\u27s functions for canonic systems give sufficient and not necessary conditions for stability. It is known that these criteria reject many systems which are actually stable. The reasons why stable systems are sometimes rejected by these simplified stability criteria are investigated in the report. It is found that a closed-loop system will always be rejected by these simplified stabi1ity criteria if the root locus of the transfer function G(s), representing the linear portion of the system, is not confined to the left-half of the s-plane for all positive values of the loop gain. A pole-shifting technique and a zero-shifting technique, extending -the applicability of the simplified stability criteria to systems that are stable for sufficiently high and/or sufficiently low values of the loop gain, are proposed in this report. New simplified stability criteria have been developed which incorporate the changes in the canonic form of differential equations caused by the application of the zero-shifting technique. Other methods of constructing Liapunov\u27s functions for nonlinear control systems are presented in Chapter III, These include the work of Pliss, Aizerman and Krasovski. Numerous other procedures, which have been reported in literature, apply to only very special cases of automatic control systems. No attempt has been made to account for all of these special cases and the presentation of methods of constructing Liapunov’s functions is limited to only those which are more generally applicable. A pseudo-canonic transformation has been developed which enables one to find stability criteria of canonic systems without the use of complex variables. The results of this research indicate that the second method of Liapunov is a very powerfuI tool of exact stability analysis of nonlinear systems. Additional research, especially in the direction of the methods of construction of Liapunov’s functions, will not only yield new analysis and synthesis procedures, but also will aid in arriving at a set of meaningful performance specifications for nonlinear control systems

Specification and Data Presentation in Linear Control Systems-Part Two

This is the second part of a 2 volume report on the specification and data presentation in linear control systems. This volume deals with Sample Data Systems, Linear Time Variable Parameter Systems, and Performance Indices, which are respectively Chapter II, III, and IV of the volume. Since these subjects are somewhat unrelated, a separate abstract is given at the beginning of each chapter, with the exception of the introductory Chapter I. The separate chapter abstracts are repeated here for the convenience of the reader. Abstract - Linear Sampled Data Control Systems The specifications recommended, for use with sampled data control systems are those recommended for linear, continuous systems [1]. These specifications must be supplemented, as is dictated by the requirements of a particular system, by compatibility considerations that are detailed in the following sections. Abstract - The Specification of Linear Time Variable Parameter Systems Linear time variable parameter (LTVP) systems are defined and subdivided into those systems with fast or slow variations and/or large or small variations. The methods of analysis of such systems are reviewed, and the following recommendations are made. Specifications 1) Time Domain Specifications (a) LTVP systems with fast variation of parameters. Simulated unfrozen system step function responses should all lie within a prescribed envelope. Whenever possible, the actual system response should be obtained. (b) LTVP systems with slow variation of parameters. Simulated or actual frozen or unfrozen system step function responses should all lie within a prescribed envelope. 2) Frequency Domain Specifications (a) LTVP system with fast variation of parameters. Frequency domain specifications are not recommended. (b) LTFP system with slow variation of parameters. The family of frequency response curves of the system frozen at different instants should all lie within a predetermined envelope. Data Presentation It is recommended that the region of variation of closed loop poles of the frozen system be exhibited on the complex plane. Thus, for example, if the only varying parameter is an open loop gain, then the region of variation of the closed loop poles will correspond to the root loci over the total range of variation of gain. It is also recommended that a family of Nyquist diagrams corresponding to the system frozen at different instants be displayed in the case of system with slow variations of parameters. Abstract - Performance Index This study was undertaken to determine whether or not Performance Indices should be used to evaluate and specify control systems* It is recommended that they not be used at this time by the Air Force for the stated purpose. A performance index is defined and detailed discussions are presented for the various performance indices. Analytical methods for evaluating performance indices are presented

Ionospheric Assimilation Techniques for ARGOS Low-Resolution Airglow and Aurora Spectrograph (LORAAS) Tomographically Reconstructed Equatorial Electron Density Profiles

The LORAAS instrument aboard the ARGOS satellite observes line-of-sight ultraviolet limb intensities from ionosphere and thermosphere airglow. This study uses tomographically reconstructed electron density profiles (EDPs) from the nightside emissions. The ionospheric reconstruction is performed using a two-dimensional O+ 1356Å radiative recombination forward model and discrete inverse theory. The forward model assumes a Chapman layer for the vertical electron density distribution from which h m F 2, N m F 2, and topside scale height are derived for every 90 s limb scan, which is equivalent to 5° resolution in latitude. Since ARGOS is in a near Sun-synchronous orbit, these EDPs form a latitude slice through the equatorial anomaly structures at approximately 0230 LT. These data reflect ongoing ionospheric processes, and it is necessary to assimilate or compare with a model that contains appropriate ionospheric evolution such as the ionospheric forecast model (IFM). This study addresses the reasonableness of both the reconstructed EDPs and the IFM in describing the equatorial anomalies\u27 diurnal and weather variability. The comparison of the LORASS EDPs with those of IFM for October 2000 show that the EDP reconstruction results compare favorably to the IFM EDPs in peak height and topside scale height. Additionally, the sector-to-sector climatology of the observed and modeled equatorial anomalies is similar to within the resolution of the instrument and model. The variability observed in each pass of the satellite is much larger than the IFM variability. The LORASS observation variability indicates that careful assessment of the representation error of the observations should be addressed through supplemental observations

Brk expression may affect the differentiation status of breast cancer cells

The breast tumour kinase Brk (PTK6) is found in over two-thirds of breast cancer cell lines and tumours but is not expressed in normal mammary cells. Brk has previously been shown to play a role in regulating proliferation in breast tumour cells [1]. However, in vivo, the site of Brk expression in normal tissues is restricted to nonproliferating cells that are undergoing terminal differentiation such as those in the gut or the skin [2,3]. This led us to hypothesise that Brk expression in breast tumours could be reflective of a differentiation phenotype, especially as a previous study had shown that involucrin, a marker of terminal keratinocyte differentiation, was expressed in a subset of tumours [4]. We therefore examined involucrin expression in breast tumour cells lines and patient biopsy samples. In addition we investigated whether inducers of differentiation in keratinocytes such as prolonged culture in suspension or vitamin D3 treatment could also affect differentiation of breast tumour cells. We found that the expression of Brk in cultured cell lines correlated with involucrin expression. In addition the change in Brk expression, as a result of culture conditions, was accompanied by a change in involucrin levels. Moreover, treatment with vitamin D3 resulted in a decrease in cell numbers in the Brk-positive cell lines relative to the control treatments. The Brk-negative cell line was unaffected by vitamin D3 treatment. These data suggest that Brk and involucrin may be coregulated and that inducers of differentiation such as vitamin D3 could be considered potential therapeutic strategies