Charting the TeV Milky Way: H.E.S.S. Galactic plane survey maps, catalog and source populations

Very-high-energy (VHE, E>100 GeV) gamma-rays provide a unique view of the non-thermal universe, tracing the most violent and energetic phenomena at work inside our Galaxy and beyond. The latest results of the H.E.S.S. Galactic Plane Survey (HGPS) undertaken by the High Energy Stereoscopic System (H.E.S.S.), an array of four imaging atmospheric Cherenkov telescopes located in Namibia, are described here. The HGPS aims at the detection of cosmic accelerators with environments suitable for the production of photons at the highest energies and has led to the discovery of an unexpectedly large and diverse population of over 60 sources of TeV gamma rays within its current range of l = 250 to 65 degrees in longitude and |b|<3.5 degrees in latitude. The data set of the HGPS comprises 2800 hours of high-quality data, taken in the years 2004 to 2013. The sensitivity for the detection of point-like sources, assuming a power-law spectrum with a spectral index of 2.3 at a statistical significance of 5 sigma, is now at the level of 2% Crab or better in the core HGPS region. The latest maps of the inner Galaxy at TeV energies are shown alongside an introduction to the first H.E.S.S. Galactic Plane Survey catalog. Finally, in addition to an overview of the H.E.S.S. Galactic source population a few remarkable, recently discovered sources will be highlighted.Comment: 8 pages, 6 figures, in Proceedings of the 48th Rencontres de Moriond (2013), La Thuile (Italy

Effects of Rumen Fill on Intake and Milk Production in Dairy Cows Fed Perennial Ryegrass

Physical limitation often limits dry matter intake (DMI) of high producing cows or cows fed high forage diets. The extent to which DMI is regulated by distention in the rumen depends upon the cow’s energy requirement and filling effects of the diet offered (Allen, 2000). The objective here was to challenge middle lactation dairy cows with rumen fill (rumen inert bulk – RIB) feeding ryegrass fresh cut (indoors) or grazed to determine whether RIB affects intake and milk production

Metabolic and transcriptomic analysis of Huntington's disease model reveal changes in intracellular glucose levels and related genes.

Huntington's Disease (HD) is a neurodegenerative disorder caused by an expansion in a CAG-tri-nucleotide repeat that introduces a poly-glutamine stretch into the huntingtin protein (mHTT). Mutant huntingtin (mHTT) has been associated with several phenotypes including mood disorders and depression. Additionally, HD patients are known to be more susceptible to type II diabetes mellitus (T2DM), and HD mice model develops diabetes. However, the mechanism and pathways that link Huntington's disease and diabetes have not been well established. Understanding the underlying mechanisms can reveal potential targets for drug development in HD. In this study, we investigated the transcriptome of mHTT cell populations alongside intracellular glucose measurements using a functionalized nanopipette. Several genes related to glucose uptake and glucose homeostasis are affected. We observed changes in intracellular glucose concentrations and identified altered transcript levels of certain genes including Sorcs1, Hh-II and Vldlr. Our data suggest that these can be used as markers for HD progression. Sorcs1 may not only have a role in glucose metabolism and trafficking but also in glutamatergic pathways affecting trafficking of synaptic components

Phantom energy from graded algebras

We construct a model of phantom energy using the graded Lie algebra SU(2/1). The negative kinetic energy of the phantom field emerges naturally from the graded Lie algebra, resulting in an equation of state with w<-1. The model also contains ordinary scalar fields and anti-commuting (Grassmann) vector fields which can be taken as two component dark matter. A potential term is generated for both the phantom fields and the ordinary scalar fields via a postulated condensate of the Grassmann vector fields. Since the phantom energy and dark matter arise from the same Lagrangian the phantom energy and dark matter of this model are coupled via the Grassman vector fields. In the model presented here phantom energy and dark matter come from a gauge principle rather than being introduced in an ad hoc manner.Comment: 8 pages no figures; references added and discussion on condensate of vector grassman fields added. To be published MPL

Conditions for non-monotonic vortex interaction in two-band superconductors

We describe a semi-analytic approach to the two-band Ginzburg-Landau theory, which predicts the behavior of vortices in two-band superconductors. We show that the character of the short-range vortex-vortex interaction is determined by the sign of the normal domain - superconductor interface energy, in analogy with the conventional differentiation between type-I and type-II superconductors. However, we also show that the long-range interaction is determined by a modified Ginzburg-Landau parameter $\kappa^*$, different from the standard $\kappa$ of a bulk superconductor. This opens the possibility for non-monotonic vortex-vortex interaction, which is temperature-dependent, and can be further tuned by alterations of the material on the microscopic scale

Structural determinants for NF-Y/DNA interaction at the CCAAT box

The recently determined crystal structures of the sequence-specific transcription factor NF-Y have illuminated the structural mechanism underlying transcription at the CCAAT box. NF-Y is a trimeric protein complex composed by the NF-YA, NF-YB, and NF-YC subunits. NF-YB and NF-YC contain a histone-like domain and assemble on a head-to-tail fashion to form a dimer, which provides the structural scaffold for the DNA sugar-phosphate backbone binding (mimicking the nucleosome H2A/H2B\ue2\u80\u93DNA assembly) and for the interaction with NF-YA. The NF-YA subunit hosts two structurally extended \uce\ub1-helices; one is involved in NF-YB/NF-YC binding and the other inserts deeply into the DNA minor groove, providing exquisite sequence-specificity for recognition and binding of the CCAAT box. The analysis of these structural data is expected to serve as a powerful guide for future experiments aimed at understanding the role of post-translational modification at NF-Y regulation sites and to unravel the three-dimensional architecture of higher order complexes formed between NF-Y and other transcription factors that act synergistically for transcription activation. Moreover, these structures represent an excellent starting point to challenge the formation of a stable hybrid nucleosome between NF-Y and core histone proteins, and to rationalize the fine molecular details associated with the wide combinatorial association of plant NF-Y subunits

Bound vortex states and exotic lattices in multi-component Bose-Einstein condensates: The role of vortex-vortex interaction

We numerically study the vortex-vortex interaction in multi-component homogeneous Bose-Einstein condensates within the realm of the Gross-Pitaevskii theory. We provide strong evidences that pairwise vortex interaction captures the underlying mechanisms which determine the geometric configuration of the vortices, such as different lattices in many-vortex states, as well as the bound vortex states with two (dimer) or three (trimer) vortices. Specifically, we discuss and apply our theoretical approach to investigate intra- and inter-component vortex-vortex interactions in two- and three-component Bose-Einstein condensates, thereby shedding light on the formation of the exotic vortex configurations. These results correlate with current experimental efforts in multi-component Bose-Einstein condensates, and the understanding of the role of vortex interactions in multiband superconductors.Comment: Published in PR