6.3 MeV fast neutrons in the treatment of patients with locally advanced and locally recurrent breast cancer

The study included 135 breast cancer patients (70 patients with locally recurrent breast cancer and 65 patients with locally advanced breast cancer with unfavorable prognostic factors) who received the neutron therapy alone or in combination with the photon therapy. The neutron therapy was shown to be effective in multimodality treatment of patients with locally advanced and locally recurrent breast cancer.The 8-year survival rate in patients without repeated breast cancer recurrence was 87.6±8.7% after the neutron and neutron-photon therapy and 54.3±9.2% after the electron beam therapy

6.3 MeV fast neutrons in the treatment of patients with locally advanced and locally recurrent breast cancer

The study included 135 breast cancer patients (70 patients with locally recurrent breast cancer and 65 patients with locally advanced breast cancer with unfavorable prognostic factors) who received the neutron therapy alone or in combination with the photon therapy. The neutron therapy was shown to be effective in multimodality treatment of patients with locally advanced and locally recurrent breast cancer.The 8-year survival rate in patients without repeated breast cancer recurrence was 87.6±8.7% after the neutron and neutron-photon therapy and 54.3±9.2% after the electron beam therapy

Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron

The analysis of clinical use of neutron therapy with 6 MeV fast neutrons compared to conventional radiation therapy was carried out. The experience of using neutron and mixed neutron and photon therapy in patients with different radio-resistant malignant tumors shows the necessity of further studies and development of the novel approaches to densely-ionizing radiation. The results of dosimetry and radiobiological studies have been the basis for planning clinical programs for neutron therapy. Clinical trials over the past 30 years have shown that neutron therapy successfully destroys radio-resistant cancers, including salivary gland tumors, adenoidcystic carcinoma, inoperable sarcomas, locally advanced head and neck tumors, and locally advanced prostate cancer. Radiation therapy with 6.3 MeV fast neutrons used alone and in combination with photon therapy resulted in improved long-term treatment outcomes in patients with radio-resistant malignant tumors

The role of MRI in the diagnosis of acute radiation reaction in breast cancer patient

A clinical case with acute radiation reaction of the left breast after organ-preserving surgery with 10 Gy IORT (24.8 Gy) conventional radiation therapy has been presented. Comprehensive MRI examination showed signs of radiation- induced damage to skin, soft tissues and vessels of the residual breast

Physical therapy methods in the treatment and rehabilitation of cancer patients

The results of the effective use of magnetic laser therapy in the treatment and rehabilitation of cancer patients were presented. The effect of magnetic-laser therapy in the treatment of radiation-induced reactions in the patients with head and neck cancer and in the patients with breast cancer was analyzed. High efficiency of lymphedema and lymphorrhea treatment in the postoperative period in the patients with breast cancer was proved. The results of rehabilitation of the patients with gastric cancer after surgical treatment were presented. These data indicate a high effectiveness of different physical methods of treatment and rehabilitation of cancer patients

THE FACADE COLOR’S INFLUENCE ON A HUMAN’S PERCEPTION

There is total idea about the colour of facade’s influence of a building on a human’s perception and its physiological mental condition. The literal building integration into the environment is able to decrease the load on the general state ang health of a human. The choice of colour decision depends on the locality of a building, climatic conditions and other factors analysed in the article

Anomalous optical absorption in overdoped cuprates near the charge-ordering instability

We propose an interpretation for the hump observed in the optical conductivity at or below a few hundreds of cm$^{-1}$, in overdoped cuprates like the electron-doped Nd_{2-x}Ce_xCuO_{4-y} at x\gtrsim 0.15 and the hole-doped Bi_2Sr_2CuO_6 and La_{2-x}Sr_xCuO_4. This interpretation is based on the direct excitation of charge collective modes, which become nearly critical in the proximity to a charge-ordering instability. The nearly critical character of these excitations entails a peculiar temperature dependence and a pseudo-scaling form of the lineshapes, which are in agreement with the experimental data.Comment: 5 pages, 3 figure

Concurrent thermochemoradiotherapy for brain high-grade glioma

Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas

Synthesis of new pinane-type hetarylsulfides

© 2014 Springer Science+Business Media New York. New bicyclic thioterpenoids with heterocyclic fragments were prepared via reactions of (-)-β-pinene and its oxide with 1-phenyl-1H-tetrazole-5-thiol, 1-methylimidazole-2-thiol, and 4,6-dimethyl-2-pyrimidinesulfenylchloride