rac-5-Acetyl-6-hy­droxy-3,6-dimethyl-4-phenyl-4,5,6,7-tetra­hydro-2H-indazole

The title compound, C17H20N2O2, is chiral but crystallizes in a centrosymmetric space group as a racemate, the relative configuration at the stereogenic centres being 2S*,3R*,4S*. The cyclo­hexane ring adopts a half-chair conformation while the pyrazole ring has an envelope conformation. The crystal packing displays inter­molecular O—H⋯N and N—H⋯O hydrogen bonding

INTERNET PARA OS GANHOS DOS ESTUDANTES: LOCAL DE TRABALHO OU ESPAÇO DE COMUNICAÇÃO

La sobrecarga de trabajo de los docentes puede ocasionar desafíos para los docentes que provoquen agotamiento a largo plazo si no se abordan. En consecuencia, el presente estudio tiene como objetivo examinar las fuentes de prevención del agotamiento desde las perspectivas de los supervisores EFL (inglés como lengua extranjera). Los participantes fueron 85 supervisores de EFL iraníes cuyo trabajo consistía en observar y dar retroalimentación a los maestros sobre su desempeño docente en varios niveles de dominio del idioma, desde los niveles de primaria hasta los avanzados. En este estudio se empleó un diseño secuencial de método mixto. Primero, la recopilación de datos cualitativos se realizó mediante entrevistas con 30 participantes para determinar las fuentes de prevención del agotamiento desde la perspectiva de los supervisores. A continuación, se diseñó un cuestionario de prevención de agotamiento utilizando los resultados de las entrevistas, después de lo cual se administró a los participantes restantes. Los datos recopilados fueron analizados por factores para identificar los componentes de la construcción de prevención de agotamiento. Los resultados del análisis de contenido de los datos de la entrevista indicaron que el apoyo de los maestros por parte de sus colegas, la situación menos estresante y la satisfacción laboral fueron las principales fuentes de prevención del agotamiento. El análisis factorial mostró las mismas fuentes de agotamiento que los componentes principales de la construcción de prevención de agotamiento. Los hallazgos de este estudio enfatizan la contribución del apoyo educativo y emocional de los maestros, proporcionando un lugar de trabajo constructivo y saludable, así como ingresos deseables como formas de prevención del agotamiento en los maestros de EFL.Teacher work overload can cause challenges for teachers leading to burnout in the long term if not addressed. Consequently, the present study aims at examining the sources of burnout prevention from EFL (English as a foreign Language) supervisors’ perspectives. The participants were 85 Iranian EFL supervisors whose job was observing and giving feedback to teachers about their teaching performance at various levels of language proficiencies from elementary to advanced levels. A sequential mixed method design was employed in this study. First, collection of qualitative data was performed using interviews with 30 participants in order to determine the sources of burnout prevention from supervisors’ perspectives. Next, a burnout prevention questionnaire was designed using the results of the interviews, after which it was administered to the remaining participants. The collected data were factor analyzed to identify the components of burnout prevention construct. Results of content analysis of the interview data indicated that teachers’ support from their colleagues, less stressful situation, and job satisfaction were the main sources of burnout prevention. Factor analysis showed the same sources of burnout as the main components of the burnout prevention construct. The findings of this study emphasize on the contribution of teachers’ educational and emotional support, providing constructive and healthy working place, as well as desirable income as ways for prevention of burnout in EFL teachers.A sobrecarga de trabalho do professor pode causar desafios para os professores, levando a esgotamento a longo prazo, se não forem abordados. Consequentemente, o presente estudo tem como objetivo examinar as fontes de prevenção de burnout das perspectivas dos supervisores de EFL (inglês como língua estrangeira). Os participantes foram 85 supervisores iranianos de EFL, cujo trabalho era observar e dar feedback aos professores sobre seu desempenho no ensino em vários níveis de proficiência linguística, do nível básico ao avançado. Um método misto sequencial foi empregado neste estudo. Primeiro, a coleta de dados qualitativos foi realizada por meio de entrevistas com 30 participantes, a fim de determinar as fontes de prevenção de burnout na perspectiva dos supervisores. Em seguida, foi elaborado um questionário de prevenção de burnout, utilizando os resultados das entrevistas, após o qual foi aplicado aos demais participantes. Os dados coletados foram analisados por fatores para identificar os componentes do construto de prevenção de burnout. Os resultados da análise de conteúdo dos dados da entrevista indicaram que o apoio dos professores de seus colegas, a situação menos estressante e a satisfação no trabalho foram as principais fontes de prevenção de burnout. A análise fatorial mostrou as mesmas fontes de burnout que os principais componentes do construto de prevenção de burnout. As conclusões deste estudo enfatizam a contribuição do apoio educacional e emocional dos professores, proporcionando um local de trabalho construtivo e saudável, bem como a renda desejável como formas de prevenção do esgotamento nos professores de EFL

The change in the intensity of products of lipid peroxidation have simultaneously enucleation and epiphysectomical animals

As noted in previous studies, the intensity of lipid peroxidation (LP) is dependent on the functional state of organs and tissues, the impact of such factors as the postnatal development of the body, adaptation to extreme factors — ionizing radiation, breach of the oxygen supply, poisoning, change of endocrine status of the organism, stress greatly increase the LP. Increased lipid peroxidation causes structural and functional modifications in the cell membranes, compounding pathological processes. We studied the violation of intensity of lipid peroxidation in different brain structures have epiphysectomical animals after the enucleation of the optical organ. Found that epiphysectomical animal’s lipid peroxidation is enhanced. Simultaneous epiphysectomy and enucleation weakens lipid peroxidation

Development of differentiated surgical technique for treating patients with multilevel degenerative diseases of cervical spine

Background. Currently, there is no uniform tactics for the differentiated use of dorsal decompressive-stabilizing techniques for multilevel degenerative diseases of the cervical spine, and the results of these technologies application are largely controversial.Aim. Analysis of the unsatisfactory outcomes of dorsal decompressive-stabilizing interventions in the treatment of patients with multilevel degenerative diseases of the cervical spine and development of a clinical-instrumental algorithm for differentiated surgical tactics.Material and Methods. A retrospective study included 112 patients with degenerative diseases of the cervical spine at two levels or more due to hernias of intervertebral discs, yellow ligament hypertrophy and arthrosis of facet joints, which in 2007–2014 underwent dorsal decompressive-stabilizing interventions in the volume of laminotomy with laminoplasty (LP) and laminectomy with fixation for lateral masses (LF). A correlation analysis of clinical parameters with anamnestic data, instrumental parameters, a feature of accepted surgical tactics and postoperative adverse effects.Results. In the analysis, it was established that "satisfactory" postoperative outcomes of LP are associated with a neutral or lordotic configuration of the cervical spine, the preservation of segmental movements without clinical and instrumental signs of instability. In addition, the use of LF is possible with mobile kyphotization of the cervical spine and the presence of translational instability of the cervical segments. The "unsatisfactory" postoperative results of the LP and LF are in direct correlation with the duration of the disease, the presence of myelopathic focus and rigid kyphosis of the cervical region.Conclusion. Differential use of dorsal decompressive-stabilizing techniques based on a comprehensive assessment of disease duration, configuration of the cervical spine, spinal cord condition and volume of segmental movements allows to reduce neurological symptoms, improve the level of pain and improve the functional status of patients, as well as significantly reduce the number of adverse outcomes associated with the progression of kyphotic deformity, deterioration of neurological symptoms and revision on-line decompressive-stabilizing interventions

Prognostic resources of mineral deposits by geophysical methods

In the framework of non-equilibrium statistical thermodynamics a relation between the concentration of component of the ore to its physical properties.On the basis of this communication formulas for calculation of the differentiated and predicted stocks of deposits of minerals are received on the basis of the geophysical data. Methods of magnetic investigation, electric investigation, gravitational investigation and seismic prospecting, and also nuclear physical methods are considered. A comparison of the calculated expected resources with proven for a number of fields in Kazakhstan. The proposed method allows to perform predictive assessment of stocks of deposits in the early stages of prospects with using the results of geophysical methods, while it has a rapidity and to be sufficiently accurate. Non-equilibrium thermodynamics, geophysical methods, and estimated resources, deposits of minerals

Laparoscopic radical prostatectomy with sparing of the proximal prostatic urethra

Introduction. The most common treatment option for prostate cancer is radical prostatectomy, which involves the removal of the prostate itself and the prostatic urethra in a single block, followed by the formation of a vesicourethral anastomosis. This approach is fraught with postoperative complications, such as urinary incontinence and strictures of anastomosis. In this sense, the clinic's staff faced the question of the possibility of a urethral-sparing variant of operative benefit for a certain category of patients.Objective. To assess the possibility of performing radical prostatectomy with sparing of the proximal prostatic urethra in the laparoscopic version, its advantages, and disadvantages.Materials & methods. From 2021 to 2022, 18 successful laparoscopic operations were performed using this technique at the St. Luke Clinical Multidisciplinary Medical Centre. Patients were selected according to the above criteria. In the preoperative period, patients underwent a standard examination in accordance with guidelines, including a blood test for prostate-specific antigen (PSA), ultrasound, magnetic resonance imaging (MRI) with 3D-modelling, data from a multifocal prostate biopsy, the International Prostate Symptom Score (IPSS), the International Index of Erectile Function (IIEF), the Quality of Life (QoL) index due to urinary disorders, assessment by the Partin’s nomogram. Intraoperative ratios, early and late postoperative complications, length of hospital stay, day of catheter removal, and time to complete urethral recovery were evaluated to study the effectiveness of this surgery type. PSA testing, uroflowmetry with post-void residual urine measurement and IPSS questionnaire were carried out one month after surgery.Results. There was an improvement in all measurements one month after surgery: median values of the mean urine flow rate increased by 1.7 ml/s, median values of the max urine flow rate increased by 3.7 ml/s, the IPSS decreased by 12 points.Conclusion. Based on the results of the study, clinical observations, and statistical analysis of the data obtained, it can be concluded that laparoscopic radical prostatectomy with sparing of the proximal prostatic urethra is the preferred surgical option for this pathology, due to its organ-preserving nature

THE COMPLETE PATHOMORPHOLOGICAL RESPONSE TO NEOADJUVANT THERAPY AND ITS ROLE IN THE TREATMENT STRATEGY FOR RECTAL CANCER

The therapeutic strategy in rectal cancer has substantially changed in the past decade. Total mesorectumectomy has been widely used. Many specialized health facilities have accepted radio/chemoradiotherapy for locally advanced rectal cancer as a standard. At the same time as high as one quarter of the patients receiving neoadjuvant therapy demonstrate a complete pathomorphological regression of a tumor. In this connection, the current literature discusses whether medical treatment is permissible in this group of patients

Electron-phonon renormalization of the absorption edge of the cuprous halides

Compared to most tetrahedral semiconductors, the temperature dependence of the absorption edges of the cuprous halides (CuCl, CuBr, CuI) is very small. CuCl and CuBr show a small increase of the gap $E_0$ with increasing temperature, with a change in the slope of $E_0$ vs. $T$ at around 150 K: above this temperature, the variation of $E_0$ with $T$ becomes even smaller. This unusual behavior has been clarified for CuCl by measurements of the low temperature gap vs. the isotopic masses of both constituents, yielding an anomalous negative shift with increasing copper mass. Here we report the isotope effects of Cu and Br on the gap of CuBr, and that of Cu on the gap of CuI. The measured isotope effects allow us to understand the corresponding temperature dependences, which we also report, to our knowledge for the first time, in the case of CuI. These results enable us to develop a more quantitative understanding of the phenomena mentioned for the three halides, and to interpret other anomalies reported for the temperature dependence of the absorption gap in copper and silver chalcogenides; similarities to the behavior observed for the copper chalcopyrites are also pointed out.Comment: 14 pages, 5 figures, submitted to Phys. Rev.

Costs and Benefits of Labour Mobility between the EU and the Eastern Partnership Partner Countries - Country Report: Azerbaijan

This Report is one of the six studies in the first phase of the EU project on the "Costs and Benefits of Labour Mobility between the EU and the Eastern Partnership Partner Countries". It aims at providing an informed view of the potential for increased migration flows and their consequences as a result of possible changes in the migration policies of the European Union with regard to Azerbaijan. The Report is comprised of 7 Chapters. Chapters 1 and 2 provide a discussion of relevant developments in the economy and labour market in the period since independence, with emphasis on developments over the last ten years or so. Chapter 3 provides a detailed discussion of trends in migration, and discusses the labour migration profile. Chapter 4 analyses remittances and their impact on income, investment and consumption. Chapter 5 provides a discussion of the available evidence on the costs and benefits of labour migration, emphasising the economic, social and demographic costs and consequences. Chapter 6 discusses current migration policies and institutions, while Chapter 7 discusses various factors that may be useful in forecasting key migration trends in the future