Stray dog meat consumption and rabies

No Abstract

Usage of U7 snRNA in gene therapy of hemoglobin C disorder: feasibility by gene ontology tool

Hemoglobin (Hb) C disorder is an important hemoglobinopathy with the highest endemicity in Middle East. The red blood cell abnormality is attributed to the beta thalassemic nature of the beta C (bC) globingene. Here, a bioinformatic analysis was performed to study the effect of co-expression between human Hb C b-globin chain gene and U7.623. The gene ontological results show that full recovery of hemoglobin function and biological process can be derived. This confirms that U7 snRNA can be agood tool for gene therapy in Hb C disorder

Analysis of binding energy activity of TIBO and HIV-RT based on simple consideration for conformational change

Tetrahydro-imidazo[4,5,l-jk][1,4]-benzodiazepin-2 (1 H)one (TIBO) is a noncompetitive non nucleotide antiretroviral drug with a specific allosteric binding site of HIV-1 RT. The conformational analysis showsthat the effect of the drug depends on the potential energy which varied due to the beta rotatable dihedral angles (N6 - C15 - C16 = C17) of the TIBO side chain. The change of binding energy between TIBO and HIV-RT due to the variation in beta rotatable dihedral angles was determined. The theoretical simulation for a step size of 30 degrees variation from 0 to 90 degree changes was performed. The derived binding energies range from 0 to 8 kcal/mol. Changes in the beta dihedral angle conformationcritically affects the binding energy. TIBO derivatives that affect the beta angle can change the binding energy between drug and HIV-RT and this can affect drug activity

Acute organo-phosphorus pesticide poisoning, oxidative damage, haemoglobin level and total leukocyte

No Abstract

GeneXpert in the diagnosis of smear-negative PTB

No Abstract

Letter to the Editor

Ebola outbreak in west Afric