Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment

In this work, a molecular hydrogel made of gelator (S)-4-((3-methyl-1-(nonylamino)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid (SVN) has been employed as soft container to modify the photochemical and photophysical behavior of the antipsychotic drug cyamemazine (CMZ). The interaction of CMZ with the gel network has been evidenced by fluorescence spectroscopy through a hypsochromic shift of the emission band (from λ = 521 nm in solution to λ = 511 nm in the gel) and an increase of the fluorescence lifetime (5.6 ns in PBS vs. 7.2 ns in the gel). In the laser flash photolysis experiments on CMZ/SVN systems, the CMZ triplet excited state (CMZ*), monitored at λ = 320 nm, has been more efficiently generated and became much longer-lived than in solution (2.7 μs vs. 0.7 μs); besides, photochemical ionization leading to the radical cation CMZ was disfavored. In the steady-state experiments, photooxidation of CMZ to afford the N,S-dioxide derivative CMZ-SONO has been retarded in the gel, which provides a more lipophilic and constrained microenvironment. Both the photophysical properties and the photoreactivity are in agreement with CMZ located in a less polar domain when entrapped in the supramolecular gel, as result of the interaction of the drug with the fibers of the supramolecular SVN gel.Financial support from the Spanish Government (CTQ2016-78875-P and CTQ2015-71004-R), the Generalitat Valenciana (PROMETEO/2017/075) and the European Union is gratefully acknowledged

Ambipolar Multi-Stripe Organic Field-Effect Transistors

Organic field-effect transistors (OFETs) based on molecular multiwires are obtained by driving the self-organization of two types of molecular semiconductors inside an electronic device structure by means of a stamp-assisted deposition, followed by vacuum sublimation of a second OS, to yield an ambipolar OFET

Photoinduced processes in nucleic acids

Photoinduced processes in nucleic acids are phenomena of fundamental interest in diverse fields, from prebiotic studies, through medical research on carcinogenesis, to the development of bioorganic photodevices. In this contribution we survey many aspects of the research across the boundaries. Starting from a historical background, where the main milestones are identified, we review the main findings of the physical-​chemical research of photoinduced processes on several types of nucleic-​acid fragments, from monomers to duplexes. We also discuss a number of different issues which are still under debate

DNA Photodamage and Repair: Computational Photobiology in Action

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